Pupillary Reflex Measurement to Guide Intraoperative Analgesia During Laparoscopic Surgery

Summary

The purpose of this study is to determine whether analgesia guided by pupillary reflex during laparoscopic surgery is effective in opioid sparing (intraoperative remifentanil and postoperative morphine).This is a prospective, randomized, controlled study performed in two centers.

Timeline

Start

2014-03

Primary completion

2018-03

Completion

2018-04

Outcome

Met primary endpoint

paper Intraoperative remifentanil consumption was lower in the PRD-guided group than in the control group: PMID 33913678 ↗

paper with a mean difference (95% confidence Interval, CI) of 0.048 (0.035 to 0.060) μg kg-1 min-1; P < 0.0001. PMID 33913678 ↗

Publications

• Guerci P, Jay G, Arnout C, Herbain D, Baka N, Poirel O, Novy E, Bouaziz H, Vial F. Effects of pupillary reflex dilation-guided opioid administration on remifentanil and morphine consumption during laparoscopic surgery: A randomised controlled trial. Eur J Anaesthesiol. 2021 Sep 1;38(9):975-984. doi: 10.1097/EJA.0000000000001491.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Esmolol	Other / unclassified	—	—
Subject	Nicardipine	Small molecule	—	—
Subject	Remifentanil	Small molecule	—	—
Subject	Urapidil	Small molecule	—	—

Indications

No indication recorded.