Pupillary Reflex Measurement to Guide Intraoperative Analgesia During Laparoscopic Surgery

Completed 100 enrolled Central Hospital, Nancy, France

RandomizedParallel-groupOpen-labelTreatment

Summary

The purpose of this study is to determine whether analgesia guided by pupillary reflex during laparoscopic surgery is effective in opioid sparing (intraoperative remifentanil and postoperative morphine).This is a prospective, randomized, controlled study performed in two centers.

Timeline

Start: 2014-03
Primary completion: 2018-03
Completion: 2018-04

Publications

Guerci P, Jay G, Arnout C, Herbain D, Baka N, Poirel O, Novy E, Bouaziz H, Vial F. Effects of pupillary reflex dilation-guided opioid administration on remifentanil and morphine consumption during laparoscopic surgery: A randomised controlled trial. Eur J Anaesthesiol. 2021 Sep 1;38(9):975-984. doi: 10.1097/EJA.0000000000001491.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Esmolol	Other / unclassified	—	—
Subject	Nicardipine	Small molecule	—	—
Subject	Remifentanil	Small molecule	—	—
Subject	Urapidil	Small molecule	—	—

Indications

No indication recorded.