Drugs / edivoxetine
last change Mar 2017 re-read 2 minutes ago

edivoxetine

Small molecule targets CYP2C19, SLC6A2 via inhibition

Developed for
major depressive disorder · attention deficit-hyperactivity disorder
Investigated by
Eli Lilly and Company

Trials 27 · a red edge is where a trial was stopped

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 116 trials
Phase 1 NCT01460407 Oct → Dec 2011 major depressive disorder Eli Lilly and Company Completed No outcome recorded
Phase 1 NCT01460381 Oct 2011 → Aug 2012 major depressive disorder Eli Lilly and Company Completed No outcome recorded
Phase 1 NCT01389752 Jul → Sep 2011 major depressive disorder Eli Lilly and Company Completed No outcome recorded
Phase 1 NCT01389765 Jul → Aug 2011 major depressive disorder Eli Lilly and Company Completed No outcome recorded
Phase 1 NCT01380691 Jun → Sep 2011 major depressive disorder Eli Lilly and Company Completed No outcome recorded
Phase 1 NCT01373931 Jun → Dec 2011 major depressive disorder Eli Lilly and Company Completed No outcome recorded
Phase 1 NCT01263106 Dec 2010 → Jan 2011 major depressive disorder Eli Lilly and Company Completed No outcome recorded
Phase 1 NCT01263197 Dec 2010 → Mar 2011 major depressive disorder Eli Lilly and Company Completed No outcome recorded
Phase 1 NCT01275144 Dec 2010 → Feb 2011 major depressive disorder Eli Lilly and Company Completed No outcome recorded
Phase 1 NCT01266590 Dec 2010 → Feb 2011 major depressive disorder Eli Lilly and Company Completed No outcome recorded
Phase 22 trials
Phase 2 NCT00840034 Feb 2009 → Jan 2010 major depressive disorder Eli Lilly and Company Completed No outcome recorded
Phase 2 NCT00420004 Dec 2006 → Mar 2008 major depressive disorder Eli Lilly and Company Completed No outcome recorded
Phase 2/33 trials
Phase 2/3 NCT00965419 Sep 2009 → Jul 2015 attention deficit-hyperactivity disorder Eli Lilly and Company Terminated No outcome recorded
Phase 2/3 NCT00922636 Jun 2009 → Dec 2010 attention deficit-hyperactivity disorder Eli Lilly and Company Completed No outcome recorded
Phase 2/3 NCT00795821 Dec 2008 → Feb 2010 major depressive disorder Eli Lilly and Company Completed No outcome recorded
Phase 36 trials
Phase 3 NCT01370499 Aug 2011 → Jan 2014 major depressive disorder Eli Lilly and Company Completed No outcome recorded
Phase 3 NCT01299272 May 2011 → Nov 2013 major depressive disorder Eli Lilly and Company Completed No outcome recorded
Phase 3 NCT01185340 Mar 2011 → Apr 2013 major depressive disorder Eli Lilly and Company Completed No outcome recorded
Phase 3 NCT01187407 Mar 2011 → Aug 2013 major depressive disorder Eli Lilly and Company Completed No outcome recorded
Phase 3 NCT01173601 Nov 2010 → Oct 2013 major depressive disorder Eli Lilly and Company Completed No outcome recorded
Phase 3 NCT01155661 Oct 2010 → Dec 2012 major depressive disorder Eli Lilly and Company Completed No outcome recorded

Evidence & citations 11 cited values

Every value below carries the sentence it was read from. 28 sources stand behind the page.

FieldValueCited text
Known as edivoxetine “selective norepinephrine reuptake inhibitor (NRI) edivoxetinePMID 27685842 Mar 2017
2

“LY2216684 (edivoxetine)” NCT01155661

NCT00965419

Known as Edivoxetina ChEMBL registry synonym — accepted as the source's own label CHEMBL2103857
Known as EDIVOXETINE HYDROCHLORIDE ChEMBL registry synonym — accepted as the source's own label CHEMBL2103857
Known as LY-2216684 HCL ChEMBL registry synonym — accepted as the source's own label CHEMBL2103857
Known as LY-2216684 HYDROCHLORIDE ChEMBL registry synonym — accepted as the source's own label CHEMBL2103857
Known as LY2216684 “Drug: LY2216684NCT00840034
24

NCT01263119

NCT01241435

NCT00922636

NCT01299272

NCT01263093

NCT01266590

NCT00420004

NCT01389752

NCT01263106

NCT01373931

NCT01370499

NCT01187407

NCT01380691

NCT01263197

NCT01389765

NCT01275144

NCT01460407

NCT01173601

NCT01185340

NCT01155661

NCT01263223

NCT01250873

NCT01243957

NCT01460381

Action Inhibit “selective norepinephrine reuptake inhibitor (NRI) edivoxetine” PMID 27685842 Mar 2017
1

“Norepinephrine transporter inhibitor” CHEMBL2103857

Modality Small molecule CHEMBL2103857
Route Oral “administered orally (PO)” NCT00840034
Target CYP2C19 “LY2216684 is only known to be a moderate inhibitor of CYP2C19NCT01250873
Target SLC6A2 “Norepinephrine transporter inhibitor” CHEMBL2103857