A Study of LY2216684 and Theophylline in Healthy Subjects

Summary

The primary objective of this study is to confirm that LY2216684 is not an inhibitor of cytochrome P450 1A2 (CYP1A2) in healthy participants using theophylline as a probe substrate for the enzyme. Because LY2216684 has been observed to increase heart rate in some healthy participants, this study will also assess heart rate when coadministered with theophylline.

Timeline

Start

2010-12

Primary completion

2011-01

Completion

2011-01

Drugs

Indications