Trimethobenzamide

also known as Ametik damla · NSC-37882 · Tigan · Trimethobenzamide hcl · Trimethobenzamide Hydrochloride · Trimethobenzamide hydrochloride preservative free · Trimetobenzamida

Small molecule

Investigated by: Ipsen · Karuna Therapeutics, Inc. · Research Inc

Regulatory milestones approvals, filings & regulatory actions · 2 recorded

Milestone	Jurisdiction	Brand	Indication	Date	Sentence it was read from
Label expansion	US (FDA)	TIGAN	—	2001-12-13	fda.gov ↗
Approved	US (FDA)	TIGAN	—	1974-07-12	fda.gov ↗

Trials 2

today

US approved 1974

NCT07681076 · Ph 4 NCT00489255 · Ph 4

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Phase	Registry id	Dates	Indication	Sponsor	Status	Outcome
Phase 42 trials · 1 missed
Phase 4	NCT07681076	Sep → Nov 2026 expected	—	Karuna Therapeutics, Inc.	Recruiting	No outcome recorded
Phase 4	NCT00489255	May 2007 → Dec 2011	Parkinson disease	Ipsen	Completed	Missed primary
Comparator or background therapy3 trials
Phase 1	NCT02373072 Background	Mar 2015 → Feb 2016	Parkinson disease	Pfizer	Completed	No outcome recorded
Phase 1	NCT02262767 Background	Nov → Dec 2014	—	Pfizer	Completed	No outcome recorded
Phase 4	NCT01770145 Background	Dec 2012 → Apr 2014	Parkinson disease, akinetopsia, movement disorder	Supernus Pharmaceuticals	Completed	No outcome recorded

Evidence & citations 10 cited values

Every value below carries the sentence it was read from. 6 sources stand behind the page.

Field	Value	Cited text
Known as	trimethobenzamide	“Tigan® (trimethobenzamide) in preventing nausea and vomiting when initiating therapy with Apokyn® (apomorphine)” NCT00489255 ↗ 3 NCT01770145 ↗ NCT07681076 ↗ NCT02262767 ↗
Known as	Ametik damla	ChEMBL registry synonym — accepted as the source's own label CHEMBL1201256 ↗
Known as	NSC-37882	ChEMBL registry synonym — accepted as the source's own label CHEMBL1201256 ↗
Known as	Tigan	“Tigan® (trimethobenzamide) in preventing nausea and vomiting when initiating therapy with Apokyn® (apomorphine)” NCT00489255 ↗
Known as	Trimethobenzamide hcl	ChEMBL registry synonym — accepted as the source's own label CHEMBL1201256 ↗
Known as	Trimethobenzamide Hydrochloride	ClinicalTrials.gov intervention name — accepted as the source's own label NCT02373072 ↗
Known as	Trimethobenzamide hydrochloride preservative free	ChEMBL registry synonym — accepted as the source's own label CHEMBL1201256 ↗
Known as	Trimetobenzamida	ChEMBL registry synonym — accepted as the source's own label CHEMBL1201256 ↗
Modality	Small molecule	— CHEMBL1201256 ↗
Route	Oral	“Oral capsule, 300mg three times daily” NCT00489255 ↗