drugset / Trial / NCT07681076
Study to Assess Safety and Tolerability of KarXT With Administration of Antiemetics in Healthy Volunteers
RandomizedParallel-groupOpen-labelTreatment
Summary
This study looks at how to reduce nausea and vomiting in people taking KarXT which is used to treat mental health conditions like schizophrenia. KarXT can cause stomach-related side effects, especially in the first couple of weeks. In this study, healthy volunteers will take KarXT along with anti-nausea medication, either regularly (to prevent symptoms) or as needed. The goal is to see how well these strategies help reduce nausea and vomiting and how safe the combination is. The results will help doctors better manage side effects and make treatment more comfortable for patients starting KarXT.
Timeline
- Start
- 2026-08-03
- Primary completion
- 2026-11-30
- Completion
- 2026-11-30
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Meclizine | Small molecule | — | — |
| Subject | Ondansetron | Other / unclassified | — | — |
| Subject | Trimethobenzamide | Small molecule | — | — |
| Subject | Trospium | Small molecule | — | — |
| Subject | Xanomeline | Small molecule | — | — |
Indications
No indication recorded.