Drugs / Meclizine
Meclizine
also known as
Meclizine hydrochloride · Agyrax · Ancolan · Ancoloxin · Antivert · Bonamine · Bonine · MECLIZINE DIHCL · +15 more
Small molecule targets HRH1 via inhibition
Regulatory milestones approvals, filings & regulatory actions · 3 recorded
| Milestone | Jurisdiction | Brand | Indication | Date | Sentence it was read from |
|---|---|---|---|---|---|
| Label expansions (2) | US (FDA) | ANTIVERT | — | 2018-04-13 – 2019-06-28 | fda.gov ↗ |
| Approved | US (FDA) | ANTIVERT | — | 1957-02-14 | fda.gov ↗ |
Trials 6
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| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 12 trials | ||||||
| Phase 1 | NCT03253289 | Oct 2017 → Mar 2023 | hepatocellular carcinoma | Tannaz Armaghnay | Completed | No outcome recorded |
| Phase 1 | NCT01537471 | Jan → Sep 2012 | — | Duke University | Completed | No outcome recorded |
| Phase 1/21 trial | ||||||
| Phase 1/2 | NCT04564144 | Jun → Nov 2020 | — | Mansoura University | Unknown | No outcome recorded |
| Phase 21 trial | ||||||
| Phase 2 | NCT01443858 | Aug 2011 → Dec 2012 | — | Duke University | Completed | No outcome recorded |
| Phase 31 trial | ||||||
| Phase 3 | NCT02112578 | Nov 2016 → Apr 2017 | peripheral vertigo | Apsen Farmaceutica S.A. | Completed | No outcome recorded |
| Phase 41 trial | ||||||
| Phase 4 | NCT07681076 | Sep → Nov 2026 expected | — | Karuna Therapeutics, Inc. | Recruiting | No outcome recorded |
| Comparator or background therapy5 trials | ||||||
| Phase 2 | NCT05852730 Background | Aug 2021 → Sep 2026 overdue | space motion sickness | Repurposed Therapeutics, Inc. | Recruiting | No outcome recorded |
| Phase 4 | NCT04482985 Comparator | Sep 2020 → Sep 2021 | motion sickness | Medical Corps, Israel Defense Force | Unknown | No outcome recorded |
| Phase 4 | NCT03270839 Comparator | Jun 2017 → Sep 2019 | — | Medical Corps, Israel Defense Force | Completed | No outcome recorded |
| — | NCT02625181 Background | Jul 2016 → Nov 2017 | — | Vanderbilt University | Completed | No outcome recorded |
| — | NCT00641797 Comparator | Nov 2006 → Dec 2010 | benign paroxysmal positional vertigo | Lehigh Valley Hospital | Completed | No outcome recorded |
Press releases naming this drug 1 release
| Date | Issuer | Release |
|---|---|---|
| 2022-08-12 | Lupin Limited | Lupin Receives Approval from U.S. FDA for Meclizine Hydrochloride Tablets USP lupin.com ↗ |
Evidence & citations 28 cited values
Every value below carries the sentence it was read from. 12 sources stand behind the page.
| Field | Value | Cited text |
|---|---|---|
| Known as | Meclizine | “Meclizine administration - subject will take 1 tablet per os (Bonine 25Mg Chewable Tablet, Meclizine Hydrochloride 25mg, 1\*day )” NCT03270839 ↗ |
| Known as | Agyrax | ChEMBL registry synonym — accepted as the source's own label CHEMBL1623 ↗ |
| Known as | Ancolan | ChEMBL registry synonym — accepted as the source's own label CHEMBL1623 ↗ |
| Known as | Ancoloxin | ChEMBL registry synonym — accepted as the source's own label CHEMBL1623 ↗ |
| Known as | Antivert | ChEMBL registry synonym — accepted as the source's own label CHEMBL1623 ↗ |
| Known as | Bonamine | ChEMBL registry synonym — accepted as the source's own label CHEMBL1623 ↗ |
| Known as | Bonine | “Meclizine administration - subject will take 1 tablet per os (Bonine 25Mg Chewable Tablet, Meclizine Hydrochloride 25mg, 1\*day )” NCT03270839 ↗ |
| Known as | MECLIZINE DIHCL | ChEMBL registry synonym — accepted as the source's own label CHEMBL1623 ↗ |
| Known as | Meclizine dihydrochloride monohydrate | ChEMBL registry synonym — accepted as the source's own label CHEMBL1623 ↗ |
| Known as | Meclizine HCL | “Meclizine HCL, an antihistamine, has been widely used for prophylactic treatment of nausea, vomiting and management of dizziness accompanying motion sickness.” NCT04564144 ↗ |
| Known as | Meclizine hydrochloride | “Meclizine administration - subject will take 1 tablet per os (Bonine 25Mg Chewable Tablet, Meclizine Hydrochloride 25mg, 1\*day )” NCT03270839 ↗3“Meclizine hydrochloride is an antihistamine widely used for treatment of vertigo and motion sickness.” NCT03253289 ↗ “Drug: Meclizine Hydrochloride” NCT04482985 ↗ “Drug: Meclizine Hydrochloride” NCT04564144 ↗ |
| Known as | Meclizine hydrochloride anhydrous | ChEMBL registry synonym — accepted as the source's own label CHEMBL1623 ↗ |
| Known as | Meclozina | ChEMBL registry synonym — accepted as the source's own label CHEMBL1623 ↗ |
| Known as | Meclozine | ChEMBL registry synonym — accepted as the source's own label CHEMBL1623 ↗ |
| Known as | Meclozine dihydrochloride | ChEMBL registry synonym — accepted as the source's own label CHEMBL1623 ↗ |
| Known as | Meclozine hydrochloride | ChEMBL registry synonym — accepted as the source's own label CHEMBL1623 ↗ |
| Known as | Meclozine hydrochloride monohydrate | ChEMBL registry synonym — accepted as the source's own label CHEMBL1623 ↗ |
| Known as | NSC-169189 | ChEMBL registry synonym — accepted as the source's own label CHEMBL1623 ↗ |
| Known as | NSC-28728 | ChEMBL registry synonym — accepted as the source's own label CHEMBL1623 ↗ |
| Known as | NSC-757094 | ChEMBL registry synonym — accepted as the source's own label CHEMBL1623 ↗ |
| Known as | Postafen | ChEMBL registry synonym — accepted as the source's own label CHEMBL1623 ↗ |
| Known as | Sea-legs | ChEMBL registry synonym — accepted as the source's own label CHEMBL1623 ↗ |
| Known as | Traveleeze | ChEMBL registry synonym — accepted as the source's own label CHEMBL1623 ↗ |
| Known as | UCB-5062 | ChEMBL registry synonym — accepted as the source's own label CHEMBL1623 ↗ |
| Action | Inhibit | “Meclizine, a widely used antihistamine medication for vertigo and motion sickness, is an inverse agonist ligand of human CAR.” NCT03253289 ↗1“Histamine H1 receptor antagonist” CHEMBL1623 ↗ |
| Modality | Small molecule | — CHEMBL1623 ↗ |
| Route | Oral | “Male participants (n = 20) will receive the study medication or placebo orally” NCT01537471 ↗ |
| Target | HRH1 | “Histamine H1 receptor antagonist” CHEMBL1623 ↗ |