The Effects of Antihistamines on Pre-Pulse Inhibition

Phase 1 Completed 117 enrolled Duke University Wallace H. Coulter Foundation · collab

RandomizedSingle-groupDouble-blindTreatment

Summary

The purpose of the investigators research is to test whether problems people have with processing their senses (feeling overwhelmed, distracted or upset by sounds and other stimuli) can be lessened by meclizine, a drug found in many over the counter antihistamines, which are medicines used for things like allergies, sleep problems, or the common cold.

Timeline

Start: 2012-01
Primary completion: 2012-09
Completion: 2012-09

Publications

Background Braff D, Stone C, Callaway E, Geyer M, Glick I, Bali L. Prestimulus effects on human startle reflex in normals and schizophrenics. Psychophysiology. 1978 Jul;15(4):339-43. doi: 10.1111/j.1469-8986.1978.tb01390.x. No abstract available.
Background Castellanos FX, Fine EJ, Kaysen D, Marsh WL, Rapoport JL, Hallett M. Sensorimotor gating in boys with Tourette's syndrome and ADHD: preliminary results. Biol Psychiatry. 1996 Jan 1;39(1):33-41. doi: 10.1016/0006-3223(95)00101-8.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Meclizine	Small molecule	12.5 mg	Oral
Subject	Meclizine	Small molecule	25 mg	Oral

Indications

No indication recorded.