Drugs / Hypochlorous acid
Hypochlorous acid
also known as
HClO · HOCl · Avenova · AvenovaTM with Neutrox · Crystalin · OCusoft Hypochlor GEL · S-HClO · Stabilized hypochlorous acid
Trials 11 · a red edge is where a trial was stopped
| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 12 trials | ||||||
| Phase 1 | NCT05188638 | Oct 2021 → Apr 2022 | — | SoftOx Solutions AS | Completed | No outcome recorded |
| Phase 1 | NCT02198963 | Jul → Aug 2014 | irritant dermatitis | Pulmatrix Inc. | Completed | No outcome recorded |
| Phase 22 trials | ||||||
| Phase 2 | NCT03174756 | Jan 2015 → Nov 2016 | — | Universidad El Bosque, Bogotá | Completed | No outcome recorded |
| Phase 2 | NCT00692757 | Jul 2008 → Jan 2009 | — | Universidad Tecnológica de Pereira | Unknown | No outcome recorded |
| Phase 2/31 trial | ||||||
| Phase 2/3 | NCT04684550 | Feb → Jun 2021 | COVID-19 | Hospital Universitario San Ignacio | Withdrawn | No outcome recorded |
| Phase 31 trial | ||||||
| Phase 3 | NCT04568213 | Oct 2020 → Dec 2022 | cataract, endophthalmitis | Loma Linda University | Completed | No outcome recorded |
| Phase 43 trials | ||||||
| Phase 4 | NCT06942026 | Apr → May 2025 overdue | mouth mucosa disorder | Aydin Adnan Menderes University | Not yet recruiting | No outcome recorded |
| Phase 4 | NCT05214196 | Sep → Dec 2021 | COVID-19 | Ataturk University | Completed | No outcome recorded |
| Phase 4 | NCT04981860 | Aug 2021 → Dec 2025 | bacterial conjunctivitis | University of Miami | Suspended | No outcome recorded |
| Phase not applicable2 trials | ||||||
| — | NCT06760403 | May → Oct 2023 | — | Ataturk University | Completed | No outcome recorded |
| — | NCT07689695 | Jun 2020 → Jul 2021 | — | Yuzuncu Yil University | Completed | No outcome recorded |
Also used as a comparator or background therapy in 4 trials
| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| — | NCT05608980 Comparator | Jul → Dec 2022 | blepharitis | Eye & ENT Hospital of Fudan University | Unknown | No outcome recorded |
| — | NCT05132179 Comparator | Feb 2022 → Dec 2026 expected | ulcer of lower limbs | Vastra Gotaland Region | Recruiting | No outcome recorded |
| — | NCT07466992 Comparator | Dec 2021 → Jul 2022 | impacted teeth, multiple | Yuzuncu Yil University | Completed | No outcome recorded |
| — | NCT05175027 Comparator | May → Oct 2021 | — | Hisar Intercontinental Hospital | Completed | No outcome recorded |
Evidence & citations 11 cited values
Every value below carries the sentence it was read from. 16 sources stand behind the page.
| Field | Value | Cited text |
|---|---|---|
| Known as | Hypochlorous acid | “Participants were randomly assigned to receive oral care with ozonated water, hypochlorous acid, or 0.12% chlorhexidine gluconate.” PMID 41853915 ↗ Mar 202613“Dakin´s Solution, with the active substance Hypochlorous Acid, HOCl was first invented 1915 for use on infected war wounds.” NCT05132179 ↗ “SIS consists of the active compound, hypochlorous acid (HOCl).” NCT05188638 ↗ |
| Known as | Avenova | ClinicalTrials.gov intervention name — accepted as the source's own label NCT04981860 ↗ |
| Known as | AvenovaTM with Neutrox | “AvenovaTM with Neutrox™ (0.01% HOCl)” NCT04981860 ↗ |
| Known as | Crystalin | “Hypochlorous acid (Crystalin), which is a less toxic and more physiological antiseptic solution.” NCT05175027 ↗ |
| Known as | HClO | “In the search for new therapeutic and prevention alternatives, the application of hypochlorous acid (HClO) to the nasal mucosa is proposed, a broad-spectrum and fast-acting...” NCT04684550 ↗2“The aim of this study was to clinically evaluate the effect of the hypochlorous acid (HClO) and povidone-iodine (PVP-I) solutions on the oral viral load of SARS-CoV-2.” PMID 35904769 ↗ Jul 2022 “202 Diabetic foot ulcers will be cleaned with either Hypochlorous Acid, HClO or Polyhexamethylene biguanide, PHMB twice a week until healed or 24 weeks.” NCT05132179 ↗ |
| Known as | HOCl | “Dakin´s Solution, with the active substance Hypochlorous Acid, HOCl was first invented 1915 for use on infected war wounds.” NCT05132179 ↗1“SIS consists of the active compound, hypochlorous acid (HOCl).” NCT05188638 ↗ |
| Known as | OCusoft Hypochlor GEL | “0.02% Hypochlorous Acid Gel (OCusoft Hypochlor GEL) will be sprayed onto the closed eyelid of the surgical eye” NCT04568213 ↗ |
| Known as | S-HClO | “Safety profiles in in vivo models have driven our initiative to use Stabilized Hypochlorous Acid (S-HClO), as an early therapeutic option in patients with SARS-Cov-2 infection...” NCT04684550 ↗ |
| Known as | Stabilized hypochlorous acid | “Safety profiles in in vivo models have driven our initiative to use Stabilized Hypochlorous Acid (S-HClO), as an early therapeutic option in patients with SARS-Cov-2 infection...” NCT04684550 ↗ |
| Modality | Other / unclassified | “Topical antimicrobial agent” NCT05132179 ↗ |
| Route | Topical | “A topical antimicrobial” NCT00692757 ↗ |