Effects of Chlorhexidine Gluconate, Ozonated Water and Hypochlorous Acid Solutions Used in the Oral Care of Patients Supported by Mechanical Ventilation on the Integrity of the Oral Mucosa

Summary

The purpose of this clinical trial is to learn whether ozonated water and hypochlorous acid solution can restore the integrity of the oral mucosa. In addition, the investigators will learn about the safety of ozonated water and hypochlorous acid solution. The main questions that participants need to answer are: What medical conditions do participants have while taking ozonated water and hypochlorous acid solution? Investigators will compare ozonated water and hypochlorous acid solution with 0.12% chlorhexidine gluconate solution to see if it helps to restore the integrity of the oral mucosa. Participants: Participants will be asked to agree to receive oral care 4 times a day, every day for 1 week.

Timeline

Start

2025-04-27

Primary completion

2025-05-30

Completion

2025-09-30

Publications

• Background Ozdemir S, Turk G. The effect of different concentrations of chlorhexidine on microbial colonization: A double-blinded randomized controlled study. Int J Nurs Pract. 2022 Apr;28(2):e13025. doi: 10.1111/ijn.13025. Epub 2021 Oct 23.
• Turk G, Ozdemir S. Comparative Effects of Chlorhexidine, Ozonated Water, and Hypochlorous Acid Solutions for Oral Care on Mucosal Integrity in Mechanically Ventilated Patients. Oral Dis. 2026 Mar 19. doi: 10.1111/odi.70245. Online ahead of print.

Drugs

Indications