Chlorhexidine gluconate

also known as CHG · Chlorhexidine Digluconate · CHX · Hibiclens · PerioChip · Antigerm Solution · ChloraPrep · chlorhexidine · +16 more

Other / unclassified

Developed for: nosocomial infection · gingivitis · periodontitis · bacterial infectious disease · dental caries · methicillin-resistant staphylococcus aureus infectious disease · staphylococcus aureus infection · COVID-19
+40 more
· cystic fibrosis · HIV infectious disease · infectious disease · infectious disease with sepsis · periodontal disorder · periprosthetic joint infection · pneumonia · respiratory tract infectious disorder · smooth surface dental caries · urinary tract infection · abscess · bacterial pneumonia · Clostridium difficile colitis · endometritis · Enterococcus infectious disease · gingival recession · impacted teeth, multiple · mouth mucosa disorder · mucositis · neonatal sepsis · oral candidiasis · periapical periodontitis · periodontitis, chronic, adult · pharyngitis · primary bacterial infectious disease · prosthesis-related infectious disease · pulmonary hypertension · soft tissue sarcoma · tracheobronchitis · ulcer of lower limbs · ulcerative stomatitis · vulvovaginal candidiasis · acne · dental pulp necrosis · disease related to hematopoietic stem cell transplant · gingival disorder · skin infection · staphylococcal infection · suppurative periapical periodontitis · ulcer disease
Investigated by: Medline Industries · 3M · Sage Products, Inc. · C. R. Bard · Centers for Disease Control and Prevention · Children's Hospital of Philadelphia
+140 more
· Dexcel Pharma Technologies Ltd. · Solventum US LLC · University of Guanajuato · University of North Carolina, Chapel Hill · University of Washington · Washington University School of Medicine · Baylor College of Medicine · Boston University · Cook Children's Medical Center · Federal University of Rio Grande do Norte · GlaxoSmithKline · King Abdulaziz University · McMaster University · Molnlycke Health Care AB · National Cheng-Kung University Hospital · Northwestern University · St. Louis Children's Hospital · State University of New York at Buffalo · São Paulo Research Foundation · University of Alabama at Birmingham · University of Michigan · University of Pennsylvania · University of Texas Southwestern Medical Center · Zambia Center for Applied Health Research and Development · Academic Medical Center - University of Amsterdam · Adam Olson · Agency for Healthcare Research and Quality (AHRQ) · Alberta Health services · Anam Sattar · Angela Bianco · Ankara University · Antisepsia Central · Aqsa Afzal · Assistance Publique Hopitaux De Marseille · Aydin Adnan Menderes University · Bill and Melinda Gates Foundation · BioScience Laboratories, Inc. · Botswana-UPenn Partnership · CF Therapeutics Development Network Coordinating Center · Caroline Scott · Celeste Chandonnet · Centro Ortopedico y Quirurgico del Pie · Charles University, Czech Republic · Children's Hospital Medical Center, Cincinnati · Colgate Palmolive · Columbia University · Conselho Nacional de Desenvolvimento Científico e Tecnológico · Cook County Health · Dentaid SL · E-DA Hospital · Faculty Hospital Kralovske Vinohrady · Federal Teaching Hospital Abakaliki · Federal University of São Paulo · Gabriel John Culbert · Gladwin, Mark, MD · Göteborg University · HaEmek Medical Center, Israel · Hamilton Health Sciences Corporation · Harran University · Henry M. Jackson Foundation for the Advancement of Military Medicine · Hyagriv Simhan · Imperial College London · Indiana University · Istanbul University - Cerrahpasa · Jared Brooks · Johns Hopkins Bloomberg School of Public Health · Johns Hopkins University · Joseph Kim · Karabuk University · Karolinska Institutet · King Edward Memorial Hospital · Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center · M.D. Anderson Cancer Center · Medical University of Silesia · all 146 on the full record

Regulatory milestones approvals, filings & regulatory actions · 4 recorded

Milestone	Jurisdiction	Brand	Indication	Date	Sentence it was read from
Label expansions (2)	US (FDA)	DYNA-HEX 2	—	1989-12-27 – 2003-12-19	fda.gov ↗
Label expansion	US (FDA)	HIBICLENS	—	1982-03-01	fda.gov ↗
Approved	US (FDA)	HIBICLENS	—	1976-09-17	fda.gov ↗

Trials 109 · started per year

today

US approved 1976

197619771978197919801981198219831984198519861987198819891990199119921993199419951996199719981999200020012002200320042005200620072008200920102011201220132014201520162017201820192020202120222023202420252026202720282029

Phase	Registry id	Dates	Indication	Sponsor	Status	Outcome
Phase 18 trials
Phase 1	NCT03787082	Dec 2022 → Dec 2023	diastolic heart failure, pulmonary hypertension	Gladwin, Mark, MD	Withdrawn	No outcome recorded
Phase 1	NCT03331263	Jul → Aug 2017	—	Medline Industries	Completed	No outcome recorded
Phase 1	NCT02326467	Feb 2016 → Sep 2018	drug pseudoallergy, exanthem, infectious disease	Celeste Chandonnet	Completed	No outcome recorded
Phase 1	NCT02001311	Jan → Apr 2014	dental caries, malposition of teeth with or without hypodontia/oligodontia	King Abdulaziz University	Unknown	No outcome recorded
Phase 1	NCT02337192	Jan → Jun 2014	—	University of Sao Paulo	Completed	No outcome recorded
Phase 1	NCT01036412	Dec 2009 → Aug 2012	head and neck cancer	M.D. Anderson Cancer Center	Completed	No outcome recorded
Phase 1	NCT00130221	Jun 2005 → Jun 2006	Clostridium infectious disease, infectious disease with sepsis, nosocomial infection, pneumonia +1	Cook County Health	Completed	No outcome recorded
Phase 1	NCT01083407	Jun 2005 → Jun 2006	—	Federal University of São Paulo	Completed	No outcome recorded
Phase 1/21 trial
Phase 1/2	NCT03004196	Sep → Oct 2015	smooth surface dental caries	Peoples University, Bhanpur, Bhopal	Completed	No outcome recorded
Phase 219 trials
Phase 2	NCT06712433	Sep 2026 → Sep 2028 expected	soft tissue sarcoma	Adam Olson	Not yet recruiting	No outcome recorded
Phase 2	NCT05709015	Jan → Feb 2023	gingivitis	University of Ljubljana	Completed	No outcome recorded
Phase 2	NCT05059145	Apr 2022 → Dec 2024	vulvovaginal candidiasis	Karolinska Institutet	Unknown	No outcome recorded
Phase 2	NCT05090657	Feb → Aug 2022	nosocomial infection	Ondine Biomedical Inc.	Completed	No outcome recorded
Phase 2	NCT03423147	Oct 2018 → Feb 2021	nosocomial infection	Angela Bianco	Terminated	No outcome recorded
Phase 2	NCT03489629	Apr 2018 → Sep 2025	cystic fibrosis	University of North Carolina, Chapel Hill	Completed	No outcome recorded
Phase 2	NCT03681990	Jun → Jul 2017	—	Solventum US LLC	Completed	No outcome recorded
Phase 2	NCT03326726	Nov 2016	—	Medline Industries	Completed	No outcome recorded
Phase 2	NCT04830969	Nov 2016 → Jan 2021	periodontitis, type 2 diabetes mellitus	State University of New York at Buffalo	Completed	No outcome recorded
Phase 2	NCT02589067	Oct 2015 → Oct 2017	—	Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center	Completed	No outcome recorded
Phase 2	NCT02502682	Jul 2015 → Jun 2016	Clostridium difficile colitis	Jared Brooks	Completed	No outcome recorded
Phase 2	NCT02447497	Mar → Apr 2015	—	Solventum US LLC	Completed	No outcome recorded
Phase 2	NCT02605382	Oct 2012 → Dec 2013	mucositis	Federal University of Rio Grande do Norte	Completed	No outcome recorded
Phase 2	NCT02639377	Oct 2012 → Dec 2013	gingivitis	Federal University of Rio Grande do Norte	Completed	No outcome recorded
Phase 2	NCT02194023	Sep 2011 → Jul 2013	smooth surface dental caries	Universitat Internacional de Catalunya	Completed	No outcome recorded
Phase 2	NCT01349192	Apr 2011 → Jan 2015	cystic fibrosis, methicillin-resistant staphylococcus aureus infectious disease	University of North Carolina, Chapel Hill	Terminated	No outcome recorded
Phase 2	NCT01079663	Mar 2010 → Oct 2011	periodontal disorder	Dexcel Pharma Technologies Ltd.	Completed	No outcome recorded
Phase 2	NCT00123123	Mar 2004 → Nov 2007	pneumonia	State University of New York at Buffalo	Completed	No outcome recorded
Phase 2	NCT00006075	? → Aug 2007	HIV infectious disease	National Institute of Allergy and Infectious Diseases (NIAID)	Completed	No outcome recorded

Phase 2/34 trials
Phase 2/3	NCT01241318	Feb 2011 → Sep 2013	infectious disease with sepsis	Boston University	Completed	No outcome recorded
Phase 2/3	NCT00549393	Feb 2008 → Dec 2010	nosocomial infection	Johns Hopkins University	Completed	No outcome recorded
Phase 2/3	NCT00516906	Oct → Dec 2007	—	Solventum US LLC	Completed	No outcome recorded
Phase 2/3	NCT00272675	Aug 2003 → Sep 2005	nosocomial infection, respiratory tract infectious disorder	Academic Medical Center - University of Amsterdam	Completed	No outcome recorded
Phase 318 trials
Phase 3	NCT06126614	May 2024 → Nov 2028 expected	periprosthetic joint infection	Hamilton Health Sciences Corporation	Recruiting	No outcome recorded
Phase 3	NCT07142408	Mar 2023 → Oct 2030 expected	—	The Cooper Health System	Recruiting	No outcome recorded
Phase 3	NCT04218110	Feb → Mar 2020	—	Professional Disposables International, Inc.	Completed	No outcome recorded
Phase 3	NCT04048356	Jul 2019 → Feb 2021	female reproductive system disorder, pelvic organ prolapse, urinary tract infection	University of New Mexico	Completed	No outcome recorded
Phase 3	NCT03442023	Feb → Nov 2019	—	University of Guanajuato	Unknown	No outcome recorded
Phase 3	NCT02490631	Aug 2015 → Dec 2018	—	Vanderbilt University	Completed	No outcome recorded
Phase 3	NCT02526667	Aug → Dec 2015	—	Medline Industries	Completed	No outcome recorded
Phase 3	NCT02291601	Oct 2014 → Sep 2015	—	Medline Industries	Completed	No outcome recorded
Phase 3	NCT02224625	Aug 2014 → Jun 2015	—	Medline Industries	Completed	No outcome recorded
Phase 3	NCT02222896	Aug → Nov 2014	—	Medline Industries	Completed	No outcome recorded
Phase 3	NCT02080403	Jul 2014 → Oct 2018	periodontitis	Dexcel Pharma Technologies Ltd.	Completed	No outcome recorded
Phase 3	NCT01613365	May 2012 → May 2015	respiratory tract infectious disorder	Assistance Publique Hopitaux De Marseille	Completed	No outcome recorded
Phase 3	NCT01321125	Apr → Dec 2011	infectious disease	University of Guanajuato	Completed	No outcome recorded
Phase 3	NCT01249846	Dec 2010 → ?	periodontitis, chronic, adult	Dexcel Pharma Technologies Ltd.	Completed	No outcome recorded
Phase 3	NCT00799812	Nov 2007 → Apr 2008	—	C. R. Bard	Completed	No outcome recorded
Phase 3	NCT00692484	Oct 2007 → Feb 2008	—	C. R. Bard	Completed	No outcome recorded
Phase 3	NCT00636480	Oct 2007 → Mar 2008	—	C. R. Bard	Completed	No outcome recorded
Phase 3	NCT00066950	Mar 2003 → Jul 2005	dental caries	University of California, San Francisco	Completed	No outcome recorded

Phase 431 trials
Phase 4	NCT06942026	Apr → May 2025 overdue	mouth mucosa disorder	Aydin Adnan Menderes University	Not yet recruiting	No outcome recorded
Phase 4	NCT07203326	Feb 2025 → Aug 2026 overdue	gingival recession	Ohio State University	Active not recruiting	No outcome recorded
Phase 4	NCT06210594	Apr 2024 → Nov 2025	staphylococcus aureus infection	Johns Hopkins Bloomberg School of Public Health	Completed	No outcome recorded
Phase 4	NCT05920122	Oct 2023 → Oct 2025	—	Hyagriv Simhan	Completed	No outcome recorded
Phase 4	NCT04941131	May → Jul 2023	COVID-19	King Abdulaziz University	Completed	No outcome recorded
Phase 4	NCT05303805	May 2022 → Apr 2026 overdue	ulcer of lower limbs	Charles University, Czech Republic	Recruiting	No outcome recorded
Phase 4	NCT06144983	Feb → Sep 2022	impacted teeth, multiple	University of Baghdad	Completed	No outcome recorded
Phase 4	NCT04954313	Sep 2021 → Feb 2025	cardiovascular disorder, type 2 diabetes mellitus	University of North Carolina, Chapel Hill	Completed	No outcome recorded
Phase 4	NCT03938467	Mar 2021 → Jul 2023	—	Orthopaedic Associates of Michigan, PC	Completed	No outcome recorded
Phase 4	NCT04718922	Jan → Jun 2021	—	Seoul National University Hospital	Completed	No outcome recorded
Phase 4	NCT04654182	Nov → Dec 2020	—	Molnlycke Health Care AB	Completed	No outcome recorded
Phase 4	NCT04454619	Jul 2020	—	Centro Ortopedico y Quirurgico del Pie	Completed	No outcome recorded
Phase 4	NCT04235985	Jan → Apr 2020	—	Molnlycke Health Care AB	Completed	No outcome recorded
Phase 4	NCT03401749	Nov 2018 → Dec 2020	—	University of Alabama at Birmingham	Terminated	No outcome recorded
Phase 4	NCT06733506	Oct 2018 → May 2019	substance-related disorder	Gabriel John Culbert	Completed	No outcome recorded
Phase 4	NCT03385304	Apr 2018 → Oct 2021	—	University of Maryland, Baltimore	Completed	No outcome recorded
Phase 4	NCT03574246	Jan → Dec 2018	pharyngitis	Ankara University	Completed	No outcome recorded
Phase 4	NCT03372122	Dec 2017 → Jan 2018	—	Caroline Scott	Completed	No outcome recorded
Phase 4	NCT03305159	Aug 2017 → Apr 2018	—	Northwestern University	Completed	No outcome recorded
Phase 4	NCT03209466	May 2017 → Dec 2020	—	University of Guanajuato	Unknown	No outcome recorded
Phase 4	NCT03133312	May → Dec 2017	bacterial infectious disease	Metro Health, Michigan	Completed	No outcome recorded
Phase 4	NCT03014778	Jan 2017 → Dec 2018	—	HaEmek Medical Center, Israel	Unknown	No outcome recorded
Phase 4	NCT02319668	Feb → Jun 2015	—	GlaxoSmithKline	Completed	No outcome recorded
Phase 4	NCT02182115	Jul 2014 → Aug 2016	staphylococcus aureus infection	University of Minnesota	Completed	No outcome recorded
Phase 4	NCT02154594	Feb → Mar 2014	gingivitis	Tatyasaheb Kore Dental College	Completed	No outcome recorded
Phase 4	NCT02215473	Aug → Dec 2013	gingivitis, periodontitis	University of Taubate	Completed	No outcome recorded
Phase 4	NCT01857804	Jan 2013 → Nov 2014	periodontal disorder	Göteborg University	Completed	No outcome recorded
Phase 4	NCT01919593	Jan → Dec 2012	bacterial infectious disease	Thammasat University	Completed	No outcome recorded
Phase 4	NCT01537783	Sep 2011 → Sep 2013	abscess	Tufts Medical Center	Completed	No outcome recorded
Phase 4	NCT02446158	May 2010 → May 2011	—	E-DA Hospital	Completed	No outcome recorded
Phase 4	NCT00610324	May 2004 → Oct 2007	aspiration pneumonia, bacterial pneumonia, nosocomial infection	King Edward Memorial Hospital	Completed	No outcome recorded

Phase not applicable28 trials
—	NCT07252258	Jul 2025 → Feb 2026 overdue	periapical periodontitis	Aqsa Afzal	Active not recruiting	No outcome recorded
—	NCT06590675	Feb → Mar 2025	primary bacterial infectious disease	University of Pennsylvania	Terminated	No outcome recorded
—	NCT07364435	Sep 2024 → Jan 2025	Enterococcus infectious disease	Özkan Kasap	Completed	No outcome recorded
—	NCT06464770	Aug 2024 → Dec 2026 expected	periprosthetic joint infection	University of Washington	Recruiting	No outcome recorded
—	NCT06305546	Apr → Oct 2023	gingivitis	Anam Sattar	Completed	No outcome recorded
—	NCT06531720	Jan → Dec 2023	ulcerative stomatitis	Medical University of Silesia	Completed	No outcome recorded
—	NCT06691841	Sep 2022 → May 2023	—	Shanghai 10th People's Hospital	Completed	No outcome recorded
—	NCT05120739	Nov 2021 → May 2023	—	University Hospital, Grenoble	Completed	No outcome recorded
—	NCT04723446	May → Oct 2021	COVID-19	Queen Mary University of London	Completed	No outcome recorded
—	NCT06284174	Jan 2021 → Dec 2024 overdue	—	National Cheng-Kung University Hospital	Recruiting	No outcome recorded
—	NCT07365956	Jan 2021 → Jan 2022	—	Harran University	Completed	No outcome recorded
—	NCT06936475	Jun → Sep 2020	endometritis	Federal Teaching Hospital Abakaliki	Completed	No outcome recorded
—	NCT04483063	Mar 2020 → Dec 2021	—	National Cheng-Kung University Hospital	Unknown	No outcome recorded
—	NCT04505202	Apr 2019 → Mar 2020	tracheobronchitis	Karabuk University	Completed	No outcome recorded
—	NCT04821193	Nov 2017 → Jul 2020	dental caries, prosthesis-related infectious disease, toxic dermatosis	Istanbul University - Cerrahpasa	Completed	No outcome recorded
—	NCT03119831	Nov 2015 → Jul 2016	periodontitis	National and Kapodistrian University of Athens	Completed	No outcome recorded
—	NCT02386592	Sep 2015 → Apr 2017	neonatal sepsis	Boston University	Completed	No outcome recorded
—	NCT02513784	Aug 2015 → Dec 2017	Barrett esophagus, esophageal adenocarcinoma, peptic esophagitis	Columbia University	Completed	No outcome recorded
—	NCT02216227	Apr 2014 → Feb 2021	—	VA Office of Research and Development	Completed	No outcome recorded
—	NCT01893060	Jul 2013 → May 2014	—	University of Virginia	Unknown	No outcome recorded
—	NCT01563406	Mar 2012 → Jun 2013	bacterial infectious disease	Rush University Medical Center	Completed	No outcome recorded
—	NCT01472549	Sep 2011 → Jun 2015	—	Washington University School of Medicine	Completed	No outcome recorded
—	NCT01382446	Jul 2010 → Apr 2012	—	St. Joseph's Hospital and Medical Center, Phoenix	Completed	No outcome recorded
—	NCT01232231	Jul 2010 → Apr 2012	methicillin-resistant staphylococcus aureus infectious disease	Joseph Kim	Completed	No outcome recorded
—	NCT01090479	Jan → Aug 2010	—	Northwestern University	Completed	No outcome recorded
—	NCT00966446	Sep 2009 → Sep 2014	methicillin-resistant staphylococcus aureus infectious disease	University of Pennsylvania	Completed	No outcome recorded
—	NCT00475930	May → Nov 2007	staphylococcus aureus infection	Henry M. Jackson Foundation for the Advancement of Military Medicine	Completed	No outcome recorded
—	NCT00002431	—	HIV infectious disease, oral candidiasis	Procter and Gamble	Completed	No outcome recorded

Also used as a comparator or background therapy in 59 trials

Phase	Registry id	Dates	Indication	Sponsor	Status	Outcome
Phase 11 trial
Phase 1	NCT03410602 Comparator	Apr 2016 → Aug 2017	periodontitis	Meenakshi Ammal Dental College and Hospital	Completed	No outcome recorded
Phase 1/21 trial
Phase 1/2	NCT03115892 Comparator	Apr → Sep 2017	—	Cairo University	Unknown	No outcome recorded
Phase 27 trials
Phase 2	NCT06690814 Comparator	Oct → Nov 2024	skin infection, ulcer disease	Fight AIDS and Infectious Diseases Foundation	Completed	No outcome recorded
Phase 2	NCT04748783 Comparator	Mar → Apr 2021	COVID-19	University of North Carolina, Chapel Hill	Terminated	No outcome recorded
Phase 2	NCT03030989 Comparator	Jan 2017 → Jan 2019	disease related to hematopoietic stem cell transplant	University of Chicago	Completed	No outcome recorded
Phase 2	NCT03140254 Comparator	Sep 2016 → Mar 2017	—	C. R. Bard	Completed	No outcome recorded
Phase 2	NCT02598778 Comparator	Nov 2015 → Apr 2016	dental caries	Montefiore Medical Center	Terminated	No outcome recorded
Phase 2	NCT01594827 Background	Oct 2012 → Dec 2017	cystic fibrosis	Johns Hopkins University	Completed	No outcome recorded
Phase 2	NCT01014143 Comparator	Aug → Sep 2007	smooth surface dental caries	Colgate Palmolive	Completed	No outcome recorded

Phase 2/31 trial
Phase 2/3	NCT02943759 Comparator	Dec 2016 → Feb 2018	suppurative periapical periodontitis	Cairo University	Completed	No outcome recorded
Phase 39 trials
Phase 3	NCT05110001 Background	Aug 2022 → Dec 2024	Acanthamoeba keratitis, fungal keratitis	University of California, San Francisco	Completed	No outcome recorded
Phase 3	NCT04756804 Comparator	Jun 2021 → Sep 2022	—	Zurex Pharma, Inc.	Completed	No outcome recorded
Phase 3	NCT02848482 Background	May 2017 → May 2019	periodontal disorder	Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University	Completed	No outcome recorded
Phase 3	NCT03061916 Comparator	Mar → May 2017	dental caries	Cairo University	Unknown	No outcome recorded
Phase 3	NCT01495117 Comparator	Oct 2011 → Oct 2014	—	Seung Duk Lee	Completed	No outcome recorded
Phase 3	NCT00859235 Comparator	May → Nov 2009	—	Hillel Yaffe Medical Center	Unknown	No outcome recorded
Phase 3	NCT01024738 Comparator	Mar → Apr 2008	—	Colgate Palmolive	Completed	No outcome recorded
Phase 3	NCT00759187 Comparator	Jan → Apr 2008	gingival disorder	Colgate Palmolive	Completed	No outcome recorded
Phase 3	NCT00765167 Comparator	Nov → Dec 2007	—	Colgate Palmolive	Completed	No outcome recorded

Phase 420 trials
Phase 4	NCT05586776 Comparator	Jan 2023 → Jan 2027 expected	—	University of California, Irvine	Recruiting	No outcome recorded
Phase 4	NCT07489924 Comparator	Jan 2023 → Jul 2025 overdue	periodontitis, type 2 diabetes mellitus	University of Colima	Active not recruiting	No outcome recorded
Phase 4	NCT05408923 Comparator	Jul 2022 → Jul 2025	spondylosis	University of Missouri-Columbia	Withdrawn	No outcome recorded
Phase 4	NCT05401292 Comparator	Feb 2022 → Dec 2026 expected	—	University of Missouri-Columbia	Recruiting	No outcome recorded
Phase 4	NCT04942496 Comparator	Jun 2021	irritant dermatitis	Molnlycke Health Care AB	Unknown	No outcome recorded
Phase 4	NCT04683146 Comparator	Mar 2021	—	Centro Ortopedico y Quirurgico del Pie	Unknown	No outcome recorded
Phase 4	NCT04603794 Comparator	Oct → Nov 2020	COVID-19	Ohio State University	Unknown	No outcome recorded
Phase 4	NCT03859908 Comparator	Apr 2019 → Jan 2021	—	Universidad de El Salvador	Terminated	No outcome recorded
Phase 4	NCT04021524 Comparator	Sep 2018 → May 2019	acne	University of Washington	Completed	No outcome recorded
Phase 4	NCT03685604 Comparator	Sep 2018 → Jun 2020	—	University Hospital, Basel, Switzerland	Completed	No outcome recorded
Phase 4	NCT03118232 Comparator	Apr 2017 → Oct 2023	infectious disease	University of California, Irvine	Completed	No outcome recorded
Phase 4	NCT02029872 Comparator	Jan 2014 → Mar 2017	methicillin-resistant staphylococcus aureus infectious disease	Johns Hopkins University	Completed	No outcome recorded
Phase 4	NCT01962493 Background	Sep → Nov 2013	—	GlaxoSmithKline	Completed	No outcome recorded
Phase 4	NCT01717690 Comparator	Aug 2013 → Sep 2014	—	Baycrest	Completed	No outcome recorded
Phase 4	NCT01751178 Comparator	Oct 2012 → Mar 2013	gingivitis	GlaxoSmithKline	Completed	No outcome recorded
Phase 4	NCT01782573 Comparator	Oct 2011 → Sep 2012	liver and intrahepatic bile duct neoplasm	Changhua Christian Hospital	Completed	No outcome recorded
Phase 4	NCT02433899 Background	Oct 2010 → Apr 2012	gingival recession	Fluminense Federal University	Completed	No outcome recorded
Phase 4	NCT00739583 Comparator	Aug 2008 → Aug 2009	osteoarthritis, hip	Johns Hopkins University	Completed	No outcome recorded
Phase 4	NCT01030666 Background	Apr 2007 → Jan 2011	periodontitis	Peter Eickholz	Terminated	No outcome recorded
Phase 4	NCT02433912 Background	Jun 2002 → Dec 2011	gingival recession	Fluminense Federal University	Completed	No outcome recorded

Phase not applicable20 trials
—	NCT07529444 Comparator	Mar 2026 → Mar 2027 expected	periodontal disorder	University of Zagreb	Recruiting	No outcome recorded
—	NCT06731881 Background	Jun 2025 → Jun 2026 overdue	nasal disorder	Guy's and St Thomas' NHS Foundation Trust	Recruiting	No outcome recorded
—	NCT07180498 Comparator	Apr → Oct 2025 overdue	periodontal disorder	Harran University	Recruiting	No outcome recorded
—	NCT06521112 Background	May → Jul 2023	mucositis	TC Erciyes University	Completed	No outcome recorded
—	NCT05816512 Comparator	Apr → Sep 2023	dental caries, gingivitis, periodontitis	Ahmed Yousif Mahdi	Unknown	No outcome recorded
—	NCT07309679 Comparator	Mar → Jun 2023	gingivitis	Mansoura University	Completed	No outcome recorded
—	NCT07466992 Comparator	Dec 2021 → Jul 2022	impacted teeth, multiple	Yuzuncu Yil University	Completed	No outcome recorded
—	NCT07610603 Comparator	Jan → Mar 2021	smooth surface dental caries	Riyadh Elm University	Completed	No outcome recorded
—	NCT07689695 Comparator	Jun 2020 → Jul 2021	—	Yuzuncu Yil University	Completed	No outcome recorded
—	NCT03656588 Comparator	Apr 2018 → Jan 2019	bacterial infectious disease	Rothman Institute Orthopaedics	Unknown	No outcome recorded
—	NCT03588351 Comparator	Jan → Aug 2018	dental pulp necrosis	Ain Shams University	Unknown	No outcome recorded
—	NCT02385708 Comparator	Aug 2015 → Jun 2018	—	Vanderbilt University	Completed	No outcome recorded
—	NCT01640925 Comparator	Jul 2012 → May 2013	nosocomial infection, urinary tract infection	Joshua Swan	Completed	No outcome recorded
—	NCT02709824 Comparator	Dec 2011 → Feb 2012	—	University of Milan	Completed	No outcome recorded
—	NCT01233050 Comparator	Dec 2010 → Feb 2015	—	University of Pennsylvania	Completed	No outcome recorded
—	NCT01105767 Comparator	May 2010 → Jan 2012	methicillin-resistant staphylococcus aureus infectious disease	Henry M. Jackson Foundation for the Advancement of Military Medicine	Completed	No outcome recorded
—	NCT00779246 Comparator	Jun 2008 → Jul 2009	staphylococcal infection	Christiana Care Health Services	Completed	No outcome recorded
—	NCT01216761 Comparator	May 2008 → Sep 2009	bacterial infectious disease	University of Michigan	Completed	No outcome recorded
—	NCT00908817 Comparator	May 2008 → Apr 2009	—	Soonchunhyang University Hospital	Completed	No outcome recorded
—	NCT00867035 Comparator	Mar 2008 → Mar 2009	—	University of California, San Francisco	Completed	No outcome recorded

Evidence & citations 27 cited values

Every value below carries the sentence it was read from. 176 sources stand behind the page.

Field	Value	Cited text
Known as	Chlorhexidine Gluconate	“Three antiseptics will be tested: 2% chlorhexidine gluconate in 70% isopropyl alcohol, 10% sodium hypochlorite and 10% povidone-iodine, each one will be applied on the surface...” NCT01321125 ↗ 143 “Chlorhexidine gluconate 4% body scrub and 2% shampoo daily PLUS mupirocin 2%, fusidic acid 2%, or chlorhexidine gluconate 0.2% intranasally bid PLUS...” NCT01232231 ↗ “PerioChip®, consisting of 2.5 mg Chlorhexidine Gluconate PerioChips were inserted only to target pockets whose pocket depth (PD) at Baseline visit (Week 0), Week 2, Week 4,...” NCT01079663 ↗ “The purpose of this study is to assess the efficacy and the safety of Chlorhexidine Gluconate Chip (PerioChip®) in frequent treatment versus routine treatment in therapy of...” NCT01249846 ↗ “Antiseptic body cleanser - 2% Chlorhexidine Gluconate in a non-alcohol and non-alkaline base, delivered to skin surface through the bath cloths impregnated with this antiseptic...” NCT01717690 ↗ “3.15% chlorhexidine gluconate in 70% isopropyl alcohol pads will be used to disinfect catheter hubs prior to accessing central venous catheters during half of the study period.” NCT01563406 ↗ “The dose information for the Chlorhexidine gluconate will be 0.12% with 1 mL in each dental pocket at a frequency of every 3 months for the duration of the study (18 months).” NCT04954313 ↗ “Patients were randomly assigned to use 2% chlorhexidine gluconate-impregnated cloths (treatment group) or to shower with soap and water before surgery (control group).” PMID 21612945 ↗ May 2011 “A saturated swab containing 0.01% methylene blue and 0.25% chlorhexidine gluconate will be applied to nares, which is then activated by light.” NCT06731881 ↗ “Participants were randomly assigned to receive oral care with ozonated water, hypochlorous acid, or 0.12% chlorhexidine gluconate.” PMID 41853915 ↗ Mar 2026 “Skin preparation with 2% chlorhexidine gluconate with 70% alcohol (ChloraPrep, Cardinal Health) preoperative skin preparation” NCT01472549 ↗ “Chlorhexidine gluconate 2% vaginal scrub, to be applied vaginally and perineally immediately prior to surgery.” NCT04048356 ↗ “Chlorhexidine gluconate (CHG) 2% w/v and isopropyl alcohol (IPA) 70% v/v - 3 swabsticks applied sequentially” NCT00799812 ↗ “intranasal mupirocin ointment twice daily for 7 days and chlorhexidine gluconate on the first and last day” PMID 27465112 ↗ Jul 2016 “Chloraprep® (chlorhexidine gluconate 2% w/v and isopropyl alcohol 70% v/v; Enturia Inc., Leawood, KS, USA)” NCT00739583 ↗ “Chlorhexidine gluconate (CHG) 2% / Isopropyl alcohol (IPA) 70% solution applied topically to intact skin” NCT03681990 ↗ “0.2% chlorhexidine gluconate solution (Trade name: HEXIDINE), an antiseptic - antiplaque agent” NCT03410602 ↗ “The choice of antiseptic agent, povidone iodine or chlorhexidine gluconate, remains debated.” PMID 38884982 ↗ Aug 2024 “Contains 0.05% Chlorhexidine gluconate in sterile water for irrigation.” NCT03938467 ↗ “Chlorhexidine gluconate (CHG) impregnated cloths in this indication.” PMID 41291848 ↗ Nov 2025 “Chlorhexidine gluconate liquid soap for bathing daily.” NCT02182115 ↗ “Chlorhexidine gluconate 2% / Isopropyl alcohol 70%” NCT02447497 ↗ “2% Chlorhexidine Gluconate” NCT02385708 ↗ “Chlorhexidine Gluconate” NCT02224625 ↗ “Chlorhexidine Gluconate” NCT03326726 ↗ NCT06531720 ↗ NCT03588351 ↗ NCT07529444 ↗ NCT06521112 ↗ NCT03030989 ↗ NCT07364435 ↗ NCT01105767 ↗ NCT03574246 ↗ NCT02526667 ↗ NCT06305546 ↗ NCT03331263 ↗ NCT03859908 ↗ NCT04942496 ↗ NCT00692484 ↗ NCT04821193 ↗ NCT04603794 ↗ NCT02386592 ↗ NCT07365956 ↗ NCT04756804 ↗ NCT01349192 ↗ NCT07180498 ↗ NCT05816512 ↗ NCT02154594 ↗ NCT03656588 ↗ NCT02215473 ↗ NCT06733506 ↗ NCT00549393 ↗ NCT03385304 ↗ NCT05059145 ↗ NCT01537783 ↗ NCT03423147 ↗ NCT01036412 ↗ NCT01024738 ↗ NCT02490631 ↗ NCT04021524 ↗ NCT03442023 ↗ NCT00867035 ↗ NCT07610603 ↗ NCT06590675 ↗ NCT00636480 ↗ NCT01919593 ↗ NCT03119831 ↗ NCT03061916 ↗ NCT01382446 ↗ NCT00272675 ↗ NCT04505202 ↗ NCT06284174 ↗ NCT03133312 ↗ NCT00066950 ↗ NCT01495117 ↗ NCT00859235 ↗ NCT04830969 ↗ NCT02502682 ↗ NCT02589067 ↗ NCT02326467 ↗ NCT06210594 ↗ NCT02598778 ↗ NCT00002431 ↗ NCT05090657 ↗ NCT02216227 ↗ NCT07466992 ↗ NCT04235985 ↗ NCT01216761 ↗ NCT06464770 ↗ NCT00123123 ↗ NCT05920122 ↗ NCT04654182 ↗ NCT01857804 ↗ NCT03401749 ↗ NCT06144983 ↗ NCT00516906 ↗ NCT02709824 ↗ NCT06936475 ↗ NCT04718922 ↗ NCT02001311 ↗ NCT04483063 ↗ NCT02943759 ↗ NCT03489629 ↗ NCT01594827 ↗ NCT01613365 ↗ NCT01893060 ↗ NCT02029872 ↗ NCT00130221 ↗ NCT06691841 ↗ NCT05408923 ↗ NCT06126614 ↗ NCT02222896 ↗ NCT03140254 ↗ NCT00908817 ↗ NCT02605382 ↗ NCT05110001 ↗ NCT02080403 ↗ NCT02291601 ↗ NCT04218110 ↗ NCT03305159 ↗ NCT00759187 ↗ NCT06712433 ↗ NCT01782573 ↗ NCT01640925 ↗ NCT03209466 ↗ NCT00610324 ↗ NCT07689695 ↗ NCT01233050 ↗ NCT02446158 ↗ NCT00475930 ↗ NCT02433899 ↗ NCT02433912 ↗ NCT00765167 ↗ NCT01241318 ↗ NCT02513784 ↗ NCT00779246 ↗ NCT02337192 ↗ NCT07142408 ↗ NCT03118232 ↗ NCT02639377 ↗ NCT01030666 ↗ NCT05586776 ↗ NCT03014778 ↗ NCT00006075 ↗
Known as	Antigerm Solution	“application of 4% chlorhexidine (Antigerm Solution, Shining BioMedical Com. Ltd) with a swab” NCT02446158 ↗
Known as	CHG	“The overall aim of this study is to investigate if vaginally applied 1% chlorhexidine gluconate (CHG) could be an alternative treatment to oral fluconazole (FLZ), both during...” NCT05059145 ↗ 21 “The purpose of this study is to determine whether daily bathing with 2% chlorhexidine gluconate-impregnated antiseptic cleanser (CHG) significantly reduces incidence of...” NCT01717690 ↗ “OBJECTIVE: To determine whether patients bathed daily with chlorhexidine gluconate (CHG) have a lower incidence of primary bloodstream infections (BSIs) compared with patients...” PMID 17954801 ↗ Oct 2007 “We hypothesized that oropharyngeal and nasopharyngeal decontamination with chlorhexidine gluconate (CHG) would be an effective method to reduce these complications as reported...” PMID 29671041 ↗ Apr 2018 “This study will evaluate the amount of chlorhexidine gluconate (CHG) present on treated skin of human volunteers following different application times with a test material...” NCT04235985 ↗ “personal hygiene measures, including chlorhexidine (CHG) body wash, did not prevent overall and methicillin-resistant Staphylococcus aureus (MRSA) skin and soft-tissue...” PMID 25421482 ↗ Nov 2014 “Our objective was to assess whether daily bathing in chlorhexidine gluconate (CHG) compared with standard bathing practices would reduce bacteraemia in critically ill children.” PMID 23363666 ↗ Jan 2013 “Skin preparation for hip replacement with a Chlorhexidine based skin preparation solution, Chloraprep® (CHG 2% w/v and IPA 70% v/v; Enturia Inc., Leawood, KS, USA)” NCT00739583 ↗ “2% chlorhexidine gluconate/70% isopropyl alcohol packaged in a single 1.5 ml Frepp applicators (Enturia, Leewood KS) -- CHG” NCT01216761 ↗ “Chlorhexidine gluconate (CHG) 2% w/v and isopropyl alcohol (IPA) 70% v/v - 3 swabsticks applied sequentially” NCT00799812 ↗ “Apply Chlorhexidine (CHG) 2% / Isopropyl alcohol (IPA) 70% for 30 seconds and allow to dry for 3 minutes.” NCT02447497 ↗ “Chlorhexidine gluconate (CHG) is a cationic bisguanide that works through disruption of cell membranes.” NCT06733506 ↗ “2% no-rinse chlorhexidine gluconate (CHG) for bed bathing and 4% rinse-off CHG showering.” NCT03118232 ↗ “Chlorhexidine gluconate (CHG) impregnated cloths in this indication.” PMID 41291848 ↗ Nov 2025 “0.05% chlorhexidine gluconate (CHG) solution for soaking the wound” NCT06284174 ↗ “2% chlorhexidine gluconate (CHG) impregnated cloths” NCT00475930 ↗ “4% chlorhexidine gluconate (CHG) in purified water” NCT03385304 ↗ “0.2% chlorhexidine gluconate (CHG) solution” NCT00610324 ↗ “chlorhexidine gluconate [CHG] bathing” PMID 30037355 ↗ Jul 2018 “Chlorhexidine Gluconate in IMS, CHG” NCT02216227 ↗ “Chlorhexidine gluconate (CHG)” NCT02386592 ↗ “Chlorhexidine Gluconate (CHG)” NCT06590675 ↗
Known as	ChloraPrep	“The arm is composed of 30 human volunteers to test 2% chlorhexidine gluconate in 70% isopropyl alcohol (ChloraPrep ®, Enturia, Texas, USA ), hypochlorite 10% of electrochemical...” NCT01321125 ↗
Known as	chlorhexidine	“Self applied chlorhexidine body wash (4% chlorhexidine gluconate, Hibiclens®, Mӧlnlycke Heath Care, Norcross, Georgia) once a week to wash/cover the body (except the face and...” NCT01105767 ↗
Known as	Chlorhexidine Digluconate	“The standard therapy used in the control group will use only Cyteal TM lavage solution, which contains hexamidine diisetione 100 mg in 100 ml, chlorhexidine digluconate 20%...” NCT05303805 ↗ 16 “Hand antisepsis by scrub Surgical Hand scrubbing using chlorhexidine digluconate with the addition of an alcoholic solution of chlorhexidine digluconate and potassium sorbate.” NCT04454619 ↗ “0.12% Chlorhexidine Digluconate and 0.05% Cetylpyridinium Chloride vs Probiotics (Lactobacillus Reuteri Prodentis) on Porphyromonas Gingivalis.” NCT07489924 ↗ “new 0.05% Cetylpyridinium chloride (CPC) mouthrinse formulations containing 0.12% or 0.03% chlorhexidine digluconate (CHX)” NCT02194023 ↗ “0.2% chlorhexidine digluconate solution (Bioworld, Madision, US) will be irrigated at contaminated sites for 1 minute.” NCT02848482 ↗ NCT07309679 ↗ NCT04683146 ↗ NCT04723446 ↗ NCT01962493 ↗ NCT06690814 ↗ NCT07252258 ↗ NCT05709015 ↗ NCT01083407 ↗ NCT02319668 ↗ NCT01014143 ↗ NCT01751178 ↗ NCT04941131 ↗
Known as	Chlorhexidine Gluconate in IMS	“Chlorhexidine Gluconate in IMS, CHG” NCT02216227 ↗
Known as	Chlorhexidine Gluconate in IMS, CHG	“Chlorhexidine Gluconate in IMS, CHG” NCT02216227 ↗
Known as	Chlorhexidine Gluconate Mouthwash	ClinicalTrials.gov intervention name — accepted as the source's own label NCT03787082 ↗
Known as	Chlorhexidine mouthwash	ClinicalTrials.gov intervention name — accepted as the source's own label NCT03115892 ↗
Known as	chlorohexidine	“chlorohexidine mouthwash take two times per day for one week” NCT03115892 ↗
Known as	chorhexidine digluconate	“The aim of the study was comparing the effectiveness of oral mucosa healing properties of different preparations: CHX=0,2% chorhexidine digluconate, CHS=8,7% choline...” NCT06531720 ↗
Known as	CHX	“The aim of the study was comparing the effectiveness of oral mucosa healing properties of different preparations: CHX=0,2% chorhexidine digluconate, CHS=8,7% choline...” NCT06531720 ↗ 3 “new 0.05% Cetylpyridinium chloride (CPC) mouthrinse formulations containing 0.12% or 0.03% chlorhexidine digluconate (CHX)” NCT02194023 ↗ “rinsing with: Group 1-0.2% Chlorhexidine digluconate (CHX); Group 2-1.5% Hydrogen peroxide (H2O2);” PMID 37542087 ↗ Aug 2023 “such as those containing chlorhexidine digluconate (CHX)” PMID 27557865 ↗ Aug 2016
Known as	Clorhexidine digluconate	“Commercialized 0.12% Clorhexidine digluconate (Perio-Aid Treatment, Dentaid, Spain)” NCT02194023 ↗
Known as	Dr. Reddy's Clohex	ClinicalTrials.gov intervention name — accepted as the source's own label NCT03004196 ↗
Known as	DynaHex	“DynaHex (2% CHG)” NCT02224625 ↗
Known as	HEXIDINE	“0.2% chlorhexidine gluconate solution (Trade name: HEXIDINE), an antiseptic - antiplaque agent” NCT03410602 ↗
Known as	Hibiclens	“Self applied chlorhexidine body wash (4% chlorhexidine gluconate, Hibiclens®, Mӧlnlycke Heath Care, Norcross, Georgia) once a week to wash/cover the body (except the face and...” NCT01105767 ↗ 2 NCT05401292 ↗ NCT03372122 ↗
Known as	Kloroben	“Commercially available 0.2% chlorhexidine gluconate mouthrinse (Kloroben®, Drogsan, Ankara, Türkiye).” NCT07689695 ↗
Known as	MicroDerm	ClinicalTrials.gov intervention name — accepted as the source's own label NCT07203326 ↗
Known as	Perio-Aid Treatment	“Perio-Aid Treatment” NCT02194023 ↗
Known as	PerioChip	“The purpose of this study is to assess the efficacy and the safety of Chlorhexidine Gluconate Chip (PerioChip®) in frequent treatment versus routine treatment in therapy of...” NCT01249846 ↗ 1 “Chlorhexidine Gluconate chip (Periochip®)” NCT01079663 ↗
Known as	Periogard	ClinicalTrials.gov intervention name — accepted as the source's own label NCT04748783 ↗
Known as	ReadyPrep CHG	“Single Dose Pharmacokinetic Study to Assess the Systemic Exposure of Chlorhexidine From ReadyPrep® CHG (2% Chlorhexidine Gluconate Cloth)” NCT03331263 ↗
Known as	Softasept	“CHX (Softasept® Chlorhexidine solution 2% coloured, from B. Braun Medical AG)” NCT03685604 ↗
Modality	Other / unclassified	“rapid onset, broad spectrum, topical antiseptic” NCT02326467 ↗
Route	Oral	“an oral rinse containing chlorhexidine gluconate” NCT00002431 ↗