Study of Chlorhexidine Gluconate as a Preoperative Antisepsis

Phase 3 Completed 534 enrolled Seung Duk Lee

RandomizedParallel-groupQuadruple-blindPrevention

Summary

The purpose of this study is to determine which drug (chlorhexidine gluconate vs. povidone iodine) as a preoperative antisepsis in clean-contaminated abdominal surgery (liver, hepatobiliary, small or large bowel, stomach) is effective.

Timeline

Start: 2011-10
Primary completion: 2014-10
Completion: 2014-10

Publications

Park HM, Han SS, Lee EC, Lee SD, Yoon HM, Eom BW, Kim SH, Ryu KW, Park SJ, Kim YW, Park B. Randomized clinical trial of preoperative skin antisepsis with chlorhexidine gluconate or povidone-iodine. Br J Surg. 2017 Jan;104(2):e145-e150. doi: 10.1002/bjs.10395. Epub 2016 Nov 23.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Chlorhexidine gluconate	Other / unclassified	2 %	Topical
Comparator	Chlorhexidine gluconate	Other / unclassified	4 %	Topical
Comparator	Povidone-Iodine	Other / unclassified	7.5 %	Topical
Comparator	Povidone-Iodine	Other / unclassified	10 %	Topical

Indications

No indication recorded.