Project PROTECT: Protecting Nursing Homes From Infections and Hospitalization

Phase 4 Completed 13952 enrolled University of California, Irvine Agency for Healthcare Research and Quality (AHRQ) · collab Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center · collab University of Massachusetts, Amherst · collab

RandomizedParallel-groupOpen-labelPrevention

Summary

This is a cluster-randomized trial of nursing homes to assess whether decolonization with routine chlorhexidine bathing and periodic use of nasal antiseptics can reduce hospitalizations associated with infections, antibiotic utilization, and multi-drug resistant organism (MDRO) prevalence. The comparator arm will be routine bathing care.

Timeline

Start: 2017-04-03
Primary completion: 2023-10-10
Completion: 2023-10-10

Publications

Miller LG, McKinnell JA, Singh RD, Gussin GM, Kleinman K, Saavedra R, Mendez J, Catuna TD, Felix J, Chang J, Heim L, Franco R, Tjoa T, Stone ND, Steinberg K, Beecham N, Montgomery J, Walters D, Park S, Tam S, Gohil SK, Robinson PA, Estevez M, Lewis B, Shimabukuro JA, Tchakalian G, Miner A, Torres C, Evans KD, Bittencourt CE, He J, Lee E, Nedelcu C, Lu J, Agrawal S, Sturdevant SG, Peterson E, Huang SS. Decolonization in Nursing Homes to Prevent Infection and Hospitalization. N Engl J Med. 2023 Nov 9;389(19):1766-1777. doi: 10.1056/NEJMoa2215254. Epub 2023 Oct 10.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Chlorhexidine gluconate	Other / unclassified	2 %	Topical
Comparator	Chlorhexidine gluconate	Other / unclassified	4 %	Topical
Comparator	Povidone-Iodine	Other / unclassified	10 %	Topical

Project PROTECT: Protecting Nursing Homes From Infections and Hospitalization

Summary

Timeline

Publications

Drugs

Indications