Chlorhexidine vs. Iodine for Vaginal Preparation in Urogynecologic Procedures

Phase 3 Completed 137 enrolled University of New Mexico

RandomizedParallel-groupSingle-blindTreatment

Summary

This is a randomized controlled trial to determine if there is a difference between chlorhexidine gluconate and povidone iodine vaginal preparations for urogynecological surgery post operative infections.

Timeline

Start: 2019-07-15
Primary completion: 2021-02-28
Completion: 2021-03-14

Outcome

Met primary endpoint

paper Chlorhexidine was not inferior to iodine concerning the primary outcome, symptomatic urinary tract infection at 2 weeks after surgery PMID 34973179 ↗

Publications

Rockefeller NF, Petersen TR, Komesu YM, Meriwether K, Dunivan G, Ninivaggio C, Jeppson PC. Chlorhexidine gluconate vs povidone-iodine vaginal antisepsis for urogynecologic surgery: a randomized controlled noninferiority trial. Am J Obstet Gynecol. 2022 Jul;227(1):66.e1-66.e9. doi: 10.1016/j.ajog.2021.12.260. Epub 2021 Dec 29.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Chlorhexidine gluconate	Other / unclassified	2 %	Other
Subject	Povidone-Iodine	Other / unclassified	—	Other