Drugs / Surufatinib
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Surufatinib

Small molecule targets CSF1R, FGFR1 via inhibition

Developed for
biliary tract cancer · neuroendocrine neoplasm · malignant pancreatic neoplasm · small cell lung carcinoma · non-small cell lung carcinoma · colorectal cancer · intrahepatic cholangiocarcinoma · gastric cancer
+44 more · neoplasm · neuroendocrine carcinoma · osteosarcoma · soft tissue sarcoma · esophageal squamous cell carcinoma · hepatocellular carcinoma · lung neuroendocrine neoplasm · ovarian cancer · pancreatic ductal adenocarcinoma · pancreatic neuroendocrine tumor · primary peritoneal carcinoma · appendix carcinoma · bile duct adenocarcinoma · cancer · cancer of unknown primary site · cancer-related condition · carcinoma · carcinoma of the ampulla of vater · colorectal neoplasm · differentiated thyroid carcinoma · digestive system carcinoma · Ewing sarcoma · female breast carcinoma · gallbladder cancer · gastric adenocarcinoma · gastroesophageal junction adenocarcinoma · head and neck squamous cell carcinoma · lymphoma · metastatic malignant neoplasm · metastatic neoplasm · nasopharyngeal carcinoma · neoplastic disease or syndrome · pancreas disorder · pancreatic exocrine neoplasm · rhabdomyosarcoma · salivary gland cancer · salivary gland carcinoma · sarcoma · small intestine adenocarcinoma · small intestine neuroendocrine neoplasm · thyroid cancer · thyroid gland carcinoma · thyroid gland undifferentiated (anaplastic) carcinoma · triple-negative breast carcinoma
Investigated by
Hutchison Medipharma Limited · Sun Yat-sen University · Fudan University · Hutchmed · Fujian Cancer Hospital · Tianjin Medical University Cancer Institute and Hospital
+40 more · Union Hospital, Tongji Medical College, Huazhong University of Science and Technology · Peking University · Second Affiliated Hospital, School of Medicine, Zhejiang University · Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University · BeiGene · Cancer Institute and Hospital, Chinese Academy of Medical Sciences · Qilu Hospital of Shandong University · Shanghai Zhongshan Hospital · The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School · Zhejiang Cancer Hospital · Affiliated Cancer Hospital & Institute of Guangzhou Medical University · Anhui Provincial Cancer Hospital · Bai-Rong Xia · Beijing Chest Hospital · Changhai Hospital · China Medical University, China · Chinese PLA General Hospital · Chonnam National University · Dai, Guanghai · Hubei Cancer Hospital · Huihua Xiong · Hunan Cancer Hospital · Innovent Biologics (Suzhou) Co. Ltd. · Jiangsu Cancer Institute & Hospital · Li Zhang, MD · National Cancer Center, China · Peking Union Medical College Hospital · Peking University People's Hospital · RenJi Hospital · Rui-hua Xu, MD, PhD · Ruijin Hospital · Shanghai Changzheng Hospital · Shanghai Chest Hospital · Shanghai Jiao Tong University Affiliated Sixth People's Hospital · The Affiliated Hospital of Xuzhou Medical University · The First Affiliated Hospital of Zhengzhou University · Tongji Hospital · Wuhan TongJi Hospital · Zhejiang University · Zhongnan Hospital

Trials 102 · started per year

today
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201020112012201320142015201620172018201920202021202220232024202520262027
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 01 trial
Phase 0 NCT03627520 Apr → Jul 2018 Hutchison Medipharma Limited Completed No outcome recorded
Phase 111 trials
Phase 1 NCT04755075 Feb → Oct 2021 Hutchison Medipharma Limited Completed No outcome recorded
Phase 1 NCT04755088 Feb → Aug 2021 impaired renal function disease Hutchison Medipharma Limited Completed No outcome recorded
Phase 1 NCT04372394 Aug → Oct 2020 Hutchison Medipharma Limited Completed No outcome recorded
Phase 1 NCT04510649 Jul → Sep 2020 Hutchison Medipharma Limited Completed No outcome recorded
Phase 1 NCT04372407 Jul → Sep 2020 Hutchison Medipharma Limited Completed No outcome recorded
Phase 1 NCT04427774 Jun 2020 → Feb 2021 Innovent Biologics (Suzhou) Co. Ltd. Terminated No outcome recorded
Phase 1 NCT03879057 Dec 2018 → Dec 2020 neoplasm Peking University Unknown No outcome recorded
Phase 1 NCT03483259 Apr → May 2018 Hutchison Medipharma Limited Completed No outcome recorded
Phase 1 NCT02320409 Dec 2014 → Jan 2015 Hutchison Medipharma Limited Completed No outcome recorded
Phase 1 NCT02267967 Oct 2014 → Aug 2017 neuroendocrine neoplasm Hutchison Medipharma Limited Completed No outcome recorded
Phase 1/216 trials
Phase 1/2 NCT06255262 Feb 2024 → Oct 2025 biliary tract cancer China Medical University, China Unknown No outcome recorded
Phase 1/2 NCT05832892 Nov 2023 → Nov 2024 neoplastic disease or syndrome Shanghai Zhongshan Hospital Unknown No outcome recorded
Phase 1/2 NCT06038461 Sep 2023 → Sep 2026 expected neuroendocrine neoplasm Cancer Institute and Hospital, Chinese Academy of Medical Sciences Recruiting No outcome recorded
Phase 1/2 NCT05747729 Jun 2023 → Oct 2026 expected neuroendocrine carcinoma Union Hospital, Tongji Medical College, Huazhong University of Science and Technology Recruiting No outcome recorded
Phase 1/2 NCT05882630 Jun 2023 → Jun 2025 small cell lung carcinoma Fujian Cancer Hospital Unknown No outcome recorded
Phase 1/2 NCT05746728 Apr 2023 → Aug 2024 triple-negative breast carcinoma Huihua Xiong Unknown No outcome recorded
Phase 1/2 NCT05590572 Jan 2023 → Dec 2026 expected osteosarcoma Second Affiliated Hospital, School of Medicine, Zhejiang University Not yet recruiting No outcome recorded
Phase 1/2 NCT05494580 Sep 2022 → Jun 2024 fallopian tube carcinosarcoma, ovarian carcinoma, primary peritoneal carcinoma Sun Yat-sen University Completed No outcome recorded
Phase 1/2 NCT05839275 Aug 2022 → Jul 2024 overdue soft tissue sarcoma Fudan University Recruiting No outcome recorded
Phase 1/2 NCT05093322 Nov 2021 → Apr 2023 Ewing sarcoma, lymphoma, osteosarcoma, rhabdomyosarcoma Hutchmed Completed No outcome recorded
Phase 262 trials
Phase 2 NCT07609121 Jun 2026 → May 2029 expected non-small cell lung carcinoma Sun Yat-sen University Recruiting No outcome recorded
Phase 2 NCT07469956 Mar 2026 → Jan 2028 expected pancreas disorder Sun Yat-sen University Not yet recruiting No outcome recorded
Phase 2 NCT07279532 Jan 2026 → Dec 2029 expected neuroendocrine neoplasm Second Affiliated Hospital, School of Medicine, Zhejiang University Not yet recruiting No outcome recorded
Phase 2 NCT07103395 Jan 2026 → Dec 2029 expected non-small cell lung carcinoma Sun Yat-sen University Recruiting No outcome recorded
Phase 2 NCT07156019 Oct 2025 → Dec 2026 expected neuroendocrine carcinoma Cancer Institute and Hospital, Chinese Academy of Medical Sciences Not yet recruiting No outcome recorded
Phase 2 NCT07357623 Sep 2025 → Sep 2027 expected lung neuroendocrine neoplasm Shanghai Chest Hospital Recruiting No outcome recorded
Phase 2 NCT07086469 Jul 2025 → Jul 2029 expected esophageal squamous cell carcinoma Sun Yat-sen University Recruiting No outcome recorded
Phase 2 NCT07086456 Jul 2025 → Jul 2029 expected non-small cell lung carcinoma Sun Yat-sen University Recruiting No outcome recorded
Phase 2 NCT06654947 Jan 2025 → Dec 2026 expected biliary tract cancer Fujian Cancer Hospital Not yet recruiting No outcome recorded
Phase 2 NCT06876844 Dec 2024 → Sep 2027 expected head and neck squamous cell carcinoma Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University Recruiting No outcome recorded
Phase 2/32 trials
Phase 2/3 NCT06361888 May 2024 → May 2028 expected malignant pancreatic neoplasm Hutchmed Recruiting No outcome recorded
Phase 2/3 NCT03873532 Jul 2018 → Jun 2021 biliary tract cancer Hutchison Medipharma Limited Unknown No outcome recorded
Phase 33 trials
Phase 3 NCT07436741 Mar 2026 → Sep 2028 expected malignant pancreatic neoplasm Tianjin Medical University Cancer Institute and Hospital Recruiting No outcome recorded
Phase 3 NCT02589821 Dec 2015 → Nov 2019 pancreatic neuroendocrine tumor Hutchison Medipharma Limited Completed No outcome recorded
Phase 3 NCT02588170 Dec 2015 → Mar 2019 neuroendocrine neoplasm Hutchison Medipharma Limited Completed No outcome recorded
Phase 41 trial
Phase 4 NCT07272512 Nov 2025 → Nov 2027 expected neuroendocrine neoplasm Shanghai Zhongshan Hospital Recruiting No outcome recorded
Phase not applicable5 trials
NCT06313554 May 2024 overdue intrahepatic cholangiocarcinoma Fudan University Not yet recruiting No outcome recorded
NCT06156332 Jan 2024 → Jan 2025 overdue neuroendocrine neoplasm Shanghai Changzheng Hospital Not yet recruiting No outcome recorded
NCT06110650 Nov 2023 → Aug 2024 soft tissue sarcoma Fudan University Unknown No outcome recorded
NCT05056116 Sep 2021 → Jun 2022 biliary tract cancer The Affiliated Hospital of Xuzhou Medical University Unknown No outcome recorded
NCT05013515 Aug 2021 → Sep 2022 salivary gland carcinoma Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University Unknown No outcome recorded
Phase not stated1 trial
NCT04814732 neuroendocrine neoplasm Hutchmed No longer available No outcome recorded
Also used as a comparator or background therapy in 1 trial
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 3 NCT05015621 Comparator Sep 2021 → May 2025 neuroendocrine carcinoma Hutchison Medipharma Limited Unknown No outcome recorded

Evidence & citations 9 cited values

Every value below carries the sentence it was read from. 103 sources stand behind the page.

FieldValueCited text
Known as Surufatinib “in Part A, all subjects will receive Surufatinib 300 mg in a single dose on study days 1 and 11 and receive Rabeprazole 30 mg single dose on study days 5 through 11” NCT04510649
96

“Consolidation therapy consists of iparomlimab and tuvonralimab, surufatinib and thymosin alpha 1, for a total duration of 1 year.” NCT07103395

Surufatinib 200 mg orally once daily (po, qd) on days 1-14, administered concurrently with immunochemotherapy.” NCT07086469

“Oral surufatinib 200 mg once daily (q.d.), given on days 1-14 of each chemotherapy cycle.” NCT06719700

Surufatinib is a multiple kinase inhibitor targeting VEGFR 1-3, FGFR1 and CSF1R.” NCT06375642

Surufatinib: 250 mg once daily, taken continuously.” NCT06437353

SurufatinibNCT06134193

NCT04372407

NCT04955886

NCT05509699

NCT07609121

NCT06531291

NCT06361030

NCT02549937

NCT07272512

NCT06313554

NCT04922658

NCT04929652

NCT04755088

NCT05926492

NCT05236699

NCT07279532

NCT05235906

NCT06708858

NCT04755075

NCT05527821

NCT05171439

NCT06239532

NCT06156332

NCT02588170

NCT05218889

NCT04524884

NCT05988372

NCT07086456

NCT05989425

NCT05722977

NCT05015621

NCT05093322

NCT05077384

NCT05186545

NCT05481463

NCT06110650

NCT05494580

NCT05481476

NCT07436741

NCT07357623

NCT05056116

NCT04579679

NCT05003037

NCT06158516

NCT02614495

NCT06038461

NCT06447636

NCT05106777

NCT06199882

NCT05839275

NCT04372394

NCT05030246

NCT06092645

NCT05282433

NCT06656559

NCT05652283

NCT05882630

NCT05746728

NCT04910854

NCT06654947

NCT06876844

NCT05013515

NCT05627427

NCT05832892

NCT05747729

NCT02966821

NCT04579757

NCT05165407

NCT04653480

NCT06329947

NCT03879057

NCT04169672

NCT06062485

NCT06414915

NCT04427774

NCT07469956

NCT05908747

NCT04734249

NCT05969171

NCT07156019

NCT02589821

NCT04996771

NCT06255262

NCT05668767

NCT06361888

NCT05372198

NCT05472948

NCT03873532

NCT04764006

NCT05595889

NCT04814732

Known as HMPL-012 “Surufatinib (Sulanda, HMPL-012) is an oral small-molecule tyrosine kinase inhibitor that selectively targets VEGFR1-3, FGFR1 and CSF1R, exerting both anti-angiogenic and...” NCT07272512
2

“Surufatinib(HMPL-012)” NCT04955886

“Surufatinib(HMPL-012)” NCT04734249

Known as Sulanda “Surufatinib (Sulanda, HMPL-012) is an oral small-molecule tyrosine kinase inhibitor that selectively targets VEGFR1-3, FGFR1 and CSF1R, exerting both anti-angiogenic and...” NCT07272512
Known as Sulfatinib ClinicalTrials.gov intervention name — accepted as the source's own label NCT02267967
5

NCT02320409

NCT02133157

NCT03627520

NCT03483259

NCT05590572

Known as Surufatinib hydrochloride “This is a non-randomized, phase II, open label study of Surufatinib hydrochloride capsules in recurrent/metastatic adenocarcinomas of head and neck.” NCT04910854
Action Inhibit “selectively inhibits vascular endothelial growth factor receptors (VEGFR) 1, 2, and 3 and inhibits FGFR kinase activity” NCT02133157
Modality Small molecule “Sulfatinib (HMPL-012) is a novel oral small moleculeNCT02133157
Route Oral “Sulfatinib is a capsule in the form of25, 50mg , 100mg; oral, once a day” NCT02133157
Target CSF1R “Surufatinib is a potent inhibitor of colony-stimulating factor 1 receptor(CSF-1R), which shows a promising tumor inhibition effect on sarcoma.” NCT05926492