Drugs / GISADENAFIL
GISADENAFIL
also known as
UK 369,003 · GISADENAFIL BESYLATE · Gisadenafilo · UK-369,003-26 · Uk-369003-26 besylate
Small molecule targets PDE5A via inhibition
Trials 5
| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 11 trial | ||||||
| Phase 1 | NCT00814736 | Aug → Sep 2008 | erectile dysfunction, hyperplasia, overactive bladder | Pfizer | Completed | No outcome recorded |
| Phase 1/21 trial | ||||||
| Phase 1/2 | NCT00163098 | Dec 2004 → Dec 2005 | chronic obstructive pulmonary disease | Pfizer | Completed | No outcome recorded |
| Phase 23 trials | ||||||
| Phase 2 | NCT00479505 | Jun 2007 → Jun 2008 | overactive bladder | Pfizer | Completed | No outcome recorded |
| Phase 2 | NCT00457457 | May 2007 → Apr 2008 | benign prostatic hyperplasia | Pfizer | Completed | No outcome recorded |
| Phase 2 | NCT00141349 | Feb → Aug 2005 | erectile dysfunction | Pfizer | Completed | No outcome recorded |
| Comparator or background therapy1 trial | ||||||
| Phase 2 | NCT00408954 Comparator | Mar 2007 → Jun 2008 | benign prostatic hyperplasia | Pfizer | Completed | No outcome recorded |
Evidence & citations 10 cited values
Every value below carries the sentence it was read from. 7 sources stand behind the page.
| Field | Value | Cited text |
|---|---|---|
| Known as | GISADENAFIL | ChEMBL registry synonym — accepted as the source's own label CHEMBL1928262 ↗ |
| Known as | GISADENAFIL BESYLATE | ChEMBL registry synonym — accepted as the source's own label CHEMBL1928262 ↗ |
| Known as | Gisadenafilo | ChEMBL registry synonym — accepted as the source's own label CHEMBL1928262 ↗ |
| Known as | UK 369,003 | “UK 369,003 is a highly selective and potent inhibitor of PDE5. It has increased selectivity for PDE5 over PDE6 (\>80 fold) compared to sildenafil (\~10 fold).” NCT00457457 ↗ |
| Known as | UK-369,003-26 | ChEMBL registry synonym — accepted as the source's own label CHEMBL1928262 ↗ |
| Known as | Uk-369003-26 besylate | ChEMBL registry synonym — accepted as the source's own label CHEMBL1928262 ↗ |
| Action | Inhibit | “UK 369,003 is a highly selective and potent inhibitor of PDE5” NCT00457457 ↗1“Phosphodiesterase 5A inhibitor” CHEMBL1928262 ↗ |
| Modality | Small molecule | — CHEMBL1928262 ↗ |
| Route | Oral | “oral tablet, once a day” NCT00814736 ↗ |
| Target | PDE5A | “Phosphodiesterase 5A inhibitor” CHEMBL1928262 ↗ |