Drugs / Semustine

Trials 6

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PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 11 trial
Phase 1 NCT06809712 Aug 2022 → Oct 2026 expected hematologic disorder He Huang Recruiting No outcome recorded
Phase 23 trials
Phase 2 NCT07677306 Jul 2026 → Dec 2027 expected myelodysplastic syndrome Peking University People's Hospital Recruiting No outcome recorded
Phase 2 NCT03412266 Feb 2018 → Mar 2023 myelodysplastic syndrome Peking University People's Hospital Unknown No outcome recorded
Phase 2 NCT03412409 Feb 2018 → Sep 2025 acute leukemia, myelodysplastic syndrome Peking University People's Hospital Unknown No outcome recorded
Phase 2/31 trial
Phase 2/3 NCT07583888 May 2026 → Aug 2027 expected acute myeloid leukemia, disease related to hematopoietic stem cell transplant The First Affiliated Hospital of Soochow University Recruiting No outcome recorded
Phase 31 trial
Phase 3 NCT00427570 Sep 1977 → May 2006 colorectal cancer NSABP Foundation Inc Completed No outcome recorded
Comparator or background therapy10 trials
Phase 1 NCT06809699 Background Aug 2022 → Oct 2026 expected hematologic disorder He Huang Recruiting No outcome recorded
Phase 2 NCT07575412 Background Jun 2026 → Jun 2029 expected acute lymphoblastic leukemia, acute myeloid leukemia, myelodysplastic syndrome The First Affiliated Hospital of Soochow University Not yet recruiting No outcome recorded
Phase 2 NCT07562568 Comparator Jun 2026 → Jun 2030 expected acute lymphoblastic leukemia, acute myeloid leukemia, myelodysplastic syndrome The First Affiliated Hospital of Soochow University Not yet recruiting No outcome recorded
Phase 2 NCT05504603 Background Jul 2020 → Jul 2023 mantle cell lymphoma The First Affiliated Hospital of Soochow University Unknown No outcome recorded
Phase 2/3 NCT03799224 Background Dec 2018 → Dec 2021 acute leukemia, disease related to hematopoietic stem cell transplant Peking University People's Hospital Unknown No outcome recorded

Evidence & citations 11 cited values

Every value below carries the sentence it was read from. 18 sources stand behind the page.

FieldValueCited text
Known as Semustine “RIC preconditioning regimen consisted of cytarabine (2 g/m2/day, days -10 to -9), busulfan (3.2 mg/kg/day on days -8 to -6), cyclophosphamide (1.0 g/m2/day, days -5 to -4),...” NCT03412266 ↗
15

“Semustine, 300 mg/m2,-6d; Etoposide, 100 mg/m2,-5~-2d; Cytarabine, 100mg/m2,q12h,-5~-2d; Cyclophosphamide, 1.5g/m2,-5~-2d” NCT04880746 ↗

“semustine 250mg/m2 PO d1; etoposide 200mg/m2 IV d2-5; cytarabine 400mg/m2 IV d2-5; melphalan 140mg/m2 IV d6.” NCT05504603 ↗

“semustine (Me-CCNU, 250 mg·m-2), orally once on day -3” NCT03793517 ↗

“semustine (Me-CCNU, 250 mg·m-2), orally once on day -3” NCT03799224 ↗

“Semustine: 250 mg/m² orally once on day -10.” NCT07583888 ↗

“semustine 250 mg/m²/day on day -9;” NCT03256071 ↗

“semustine 250 mg/m² on day -8” NCT07575412 ↗

“semustine (250 mg/m2, orally)” PMID 33718234 ↗ Feb 2021

“semustine 250 mg/m² on day -8” NCT07562568 ↗

“semustine (250 mg/m2, day-3)” NCT07677306 ↗

Show 5 more sources

Known as 1-(2-chloroethyl)-3-(4-trans-methylcyclohexyl)-1-nitrosourea “1-(2-chloroethyl)-3-(4-trans-methylcyclohexyl)-1-nitrosourea (i.e., MeCCNU or semustine), vincristine, and 5-fluorouracil was associated with better 5-year disease-free and...” PMID 15292384 ↗ Aug 2004
Known as ICIG 1110 ChEMBL registry synonym — accepted as the source's own label CHEMBL12948 ↗
Known as Me-CCNU “1-(2-chloroethyl)-3-(4-trans-methylcyclohexyl)-1-nitrosourea (i.e., MeCCNU or semustine), vincristine, and 5-fluorouracil was associated with better 5-year disease-free and...” PMID 15292384 ↗ Aug 2004
4

“semustine (Me-CCNU, 250 mg·m-2), orally once on day -3” NCT03793517 ↗

“semustine (Me-CCNU, 250 mg·m-2), orally once on day -3” NCT03799224 ↗

“Semustine (MeccNU)” NCT06809712 ↗

“Semustine (MeCCNU)” NCT06809699 ↗

Known as Methyl lomustine ChEMBL registry synonym — accepted as the source's own label CHEMBL12948 ↗
Known as Methyl-CCNU “5-Fluorouracil, 5-FU, NSC-19893; Methyl-CCNU, MeCCNU, NSC-95441; Vincristine, VCR, NSC-67574.” NCT00427570 ↗
Known as NSC-758471 ChEMBL registry synonym — accepted as the source's own label CHEMBL12948 ↗
Known as NSC-95441 “5-Fluorouracil, 5-FU, NSC-19893; Methyl-CCNU, MeCCNU, NSC-95441; Vincristine, VCR, NSC-67574.” NCT00427570 ↗
Known as Semustina ChEMBL registry synonym — accepted as the source's own label CHEMBL12948 ↗
Modality Small molecule — CHEMBL12948 ↗
Route Oral “Semustine orally once every 28 days” NCT00335075 ↗