Drugs / PF-04634817
last change Aug 2015 re-read 2 minutes ago

PF-04634817

Small molecule targets CCR2, CCR5 via inhibition

Developed for
diabetic macular edema · diabetic kidney disease
Investigated by
Pfizer

Trials 4 · a red edge is where a trial was stopped

201020112012201320142015201620172018201920202021202220232024202520262027
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 13 trials
Phase 1 NCT01791855 May → Sep 2013 impaired renal function disease Pfizer Completed No outcome recorded
Phase 1 NCT01140672 Jun → Oct 2010 Pfizer Completed No outcome recorded
Phase 1 NCT01098877 Apr → Sep 2010 Pfizer Completed No outcome recorded
Phase 21 trial
Phase 2 NCT01994291 Nov 2013 → Aug 2015 diabetic macular edema Pfizer Terminated No outcome recorded
Also used as a comparator or background therapy in 2 trials
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 11 trial
Phase 1 NCT01247883 Comparator Oct → Dec 2010 Pfizer Completed No outcome recorded
Phase 21 trial
Phase 2 NCT01712061 Comparator Dec 2012 → Sep 2014 diabetic kidney disease Pfizer Completed No outcome recorded

Evidence & citations 6 cited values

Every value below carries the sentence it was read from. 7 sources stand behind the page.

FieldValueCited text
Known as Pf-04634817 “Chemokine Ccr2/5 Receptor Antagonist (Pf-04634817)” NCT01712061
6

NCT01791855

NCT01140672

NCT01247883

NCT01994291

NCT01098877

NCT01712061

Action Inhibit “C-C chemokine receptor type 5 antagonist” CHEMBL5095029
1

“administration of a CCR2/5 antagonist” NCT01712061

Modality Small molecule CHEMBL5095029
Route Oral Oral solution, 1mg, single dose” NCT01098877
Target CCR2 “administration of a CCR2/5 antagonist” NCT01712061
Target CCR5 “C-C chemokine receptor type 5 antagonist” CHEMBL5095029