Drugs / Propylthiouracil
Propylthiouracil
also known as
NSC-6498 · NSC-70461 · Propacil · Propiltiouracilo · Propylthiouracile · Prothyran · PTU · Thyreostat ii
Small molecule targets DIO1, TPO via inhibition
Regulatory milestones approvals, filings & regulatory actions · 1 recorded
| Milestone | Jurisdiction | Brand | Indication | Date | Sentence it was read from |
|---|---|---|---|---|---|
| Approved | US (FDA) | PROPYLTHIOURACIL | — | 1947-07-28 | fda.gov ↗ |
Trials 2
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| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 11 trial | ||||||
| Phase 1 | NCT04776499 | Mar 2021 → Feb 2022 | — | Maastricht University | Completed | No outcome recorded |
| Phase 21 trial | ||||||
| Phase 2 | NCT05762146 | Sep 2022 → Feb 2024 | ischemic stroke | Maastricht University | Unknown | No outcome recorded |
| Comparator or background therapy5 trials | ||||||
| Phase 3 | NCT05118542 Comparator | Jan 2019 → Jun 2020 | Graves disease, atherosclerosis | Indonesia University | Completed | No outcome recorded |
| Phase 3 | NCT03066076 Comparator | Mar 2017 → Feb 2019 | Graves disease, endocrine exophthalmos | Medical University of Vienna | Unknown | No outcome recorded |
| Phase 3 | NCT01436994 Comparator | Jul 2004 → Dec 2014 | thyroid gland disorder | Newcastle-upon-Tyne Hospitals NHS Trust | Completed | No outcome recorded |
| Phase 4 | NCT01056419 Comparator | Jan 2009 → Jun 2010 | disease of orbital part of eye adnexa | Ankara University | Unknown | No outcome recorded |
| — | NCT00846755 Comparator | Mar 2005 → Mar 2008 | pregnancy disorder, thyroid gland disorder | Ospedale V. Fazzi | Completed | No outcome recorded |
Evidence & citations 14 cited values
Every value below carries the sentence it was read from. 9 sources stand behind the page.
| Field | Value | Cited text |
|---|---|---|
| Known as | Propylthiouracil | “Carbimazole is the preferred treatment because of the increased risk of hepatotoxicity with propylthiouracil but patients who are treated with propylthiouracil can also be...” NCT01436994 ↗ |
| Known as | NSC-6498 | ChEMBL registry synonym — accepted as the source's own label CHEMBL1518 ↗ |
| Known as | NSC-70461 | ChEMBL registry synonym — accepted as the source's own label CHEMBL1518 ↗ |
| Known as | Propacil | ChEMBL registry synonym — accepted as the source's own label CHEMBL1518 ↗ |
| Known as | Propiltiouracilo | ChEMBL registry synonym — accepted as the source's own label CHEMBL1518 ↗ |
| Known as | Propylthiouracile | ClinicalTrials.gov intervention name — accepted as the source's own label NCT00846755 ↗ |
| Known as | Prothyran | ChEMBL registry synonym — accepted as the source's own label CHEMBL1518 ↗ |
| Known as | PTU | “Anti-thyroid drugs (ATDs), such as propylthiouracil (PTU) and methimazole (MMI), are commonly used for GD treatment, and studies have suggested a link between these drugs and...” PMID 39355401 ↗ Jun 2024 |
| Known as | Thyreostat ii | ChEMBL registry synonym — accepted as the source's own label CHEMBL1518 ↗ |
| Action | Inhibit | “perphenazine, a typical antipsychotic, and propylthiouracil, a thyroid peroxidase inhibitor used for the treatment of hyperthyroidism, have previously been identified as...” NCT04776499 ↗2“Type I iodothyronine deiodinase (Type-I 5'-deiodinase) (DIOI) (Type 1 DI) (5DI) inhibitor” CHEMBL1518 ↗ “Thyroid peroxidase inhibitor” CHEMBL1518 ↗ |
| Modality | Small molecule | — CHEMBL1518 ↗ |
| Route | Oral | “orally administered combination therapy of riociguat, propylthiouracil, and perphenazine” NCT05762146 ↗ |
| Target | DIO1 | “Type I iodothyronine deiodinase (Type-I 5'-deiodinase) (DIOI) (Type 1 DI) (5DI) inhibitor” CHEMBL1518 ↗ |
| Target | TPO | “Thyroid peroxidase inhibitor” CHEMBL1518 ↗ |