Drugs / GSK1292263
last change Apr 2014 re-read 9 days ago

GSK1292263

also known as GSK-1292263A · GSK-263A · GSK263

Small molecule targets GPR119 via activation

Developed for
type 2 diabetes mellitus · hyperlipidemia
Investigated by
GlaxoSmithKline

Trials 5

2009201020112012201320142015201620172018201920202021202220232024202520262027
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 12 trials
Phase 1 NCT01101568 Apr → Jun 2010 type 2 diabetes mellitus GlaxoSmithKline Completed No outcome recorded
Phase 1 NCT00783549 Sep 2008 → Mar 2009 hyperlipidemia GlaxoSmithKline Completed No outcome recorded
Phase 23 trials · 1 missed
Phase 2 NCT01218204 Sep 2010 → Jun 2011 hyperlipidemia GlaxoSmithKline Completed Mixed
Phase 2 NCT01128621 Nov 2009 → Apr 2010 type 2 diabetes mellitus GlaxoSmithKline Completed Missed primary
Phase 2 NCT01119846 Jun 2009 → Mar 2010 type 2 diabetes mellitus GlaxoSmithKline Completed No outcome recorded

Evidence & citations 8 cited values

Every value below carries the sentence it was read from. 7 sources stand behind the page.

FieldValueCited text
Known as GSK1292263 ClinicalTrials.gov intervention name — accepted as the source's own label NCT01119846 ↗
4

NCT01128621 ↗

NCT00783549 ↗

NCT01218204 ↗

NCT01101568 ↗

Known as GSK-1292263A ChEMBL registry synonym — accepted as the source's own label CHEMBL3187503 ↗
Known as GSK-263A ChEMBL registry synonym — accepted as the source's own label CHEMBL3187503 ↗
Known as GSK263 “We therefore investigated the pharmacology of GSK1292263 (GSK263), a selective GPR119 agonist, in two randomized, placebo-controlled studies that enrolled subjects with type 2 diabetes.” PMID 24699248 ↗ Apr 2014
Action Activate “GSK1292263 (GSK263), a selective GPR119 agonist” PMID 24699248 ↗ Apr 2014
Modality Small molecule — CHEMBL3187503 ↗
Route Oral “Single Doses of Orally Administered Investigational Product” NCT00783549 ↗
Target GPR119 “We therefore investigated the pharmacology of GSK1292263 (GSK263), a selective GPR119 agonist, in two randomized, placebo-controlled studies that enrolled subjects with type 2 diabetes.” PMID 24699248 ↗ Apr 2014