Drugs / Endoxifen
Endoxifen
also known as
Z-endoxifen · 4-hydroxy-n-desmethyltamoxifen · ENX · N-desmethyl-4-hydroxytamoxifen · NSC-749798 · Z endoxifen HCl
Trials 11 · a red edge is where a trial was stopped
Also used as a comparator or background therapy in 1 trial
| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 2 | NCT04616430 Comparator | Apr → Sep 2018 | breast disorder | Atossa Therapeutics, Inc. | Completed | No outcome recorded |
Evidence & citations 10 cited values
Every value below carries the sentence it was read from. 14 sources stand behind the page.
| Field | Value | Cited text |
|---|---|---|
| Known as | endoxifen | “The experimental drug Z-Endoxifen HCl (endoxifen) is related to tamoxifen” NCT01273168 ↗ |
| Known as | 4-hydroxy-n-desmethyltamoxifen | ChEMBL registry synonym — accepted as the source's own label CHEMBL1093458 ↗ |
| Known as | ENX | “endoxifen hydrochloride (endoxifen [ENX]) gel” NCT03317405 ↗ |
| Known as | N-desmethyl-4-hydroxytamoxifen | ChEMBL registry synonym — accepted as the source's own label CHEMBL1093458 ↗ |
| Known as | NSC-749798 | ChEMBL registry synonym — accepted as the source's own label CHEMBL1093458 ↗ |
| Known as | Z endoxifen HCl | “The experimental drug Z-Endoxifen HCl (endoxifen) is related to tamoxifen” NCT01273168 ↗ |
| Known as | Z-endoxifen | “Group 3: Patients will receive (Z)-endoxifen according to (Z)-endoxifen steady state plasma concentrations (phenotype) at screening (i.e. ≤ 15 nM receive 3 mg, \> 15 and ≤ 25...” NCT03931928 ↗10“BACKGROUND: (Z)-endoxifen is the tamoxifen metabolite that possesses the highest affinity to the estrogen receptor and is evolving as an alternative to tamoxifen.” PMID 42070780 ↗ Apr 2026 “(Z)-endoxifen is the most active metabolite of the selective estrogen receptor modulator (SERM), tamoxifen.” NCT06075953 ↗ “To describe the safety profile of Z-endoxifen (Z-endoxifen hydrochloride) at each of the doses examined.” NCT01327781 ↗ “The experimental drug Z-Endoxifen HCl (endoxifen) is related to tamoxifen” NCT01273168 ↗ |
| Action | Inhibit | “lowering the amount of estrogen the body makes” NCT02311933 ↗ |
| Modality | Small molecule | — CHEMBL1093458 ↗ |
| Route | Oral | “Z-endoxifen: 10 mg QD, p.o.” NCT01042379 ↗ |