Bromhexine

also known as BHH · Bisolvon · BMX · Brombenzonium · Bromehexine hydrochloride · Bromhexina · Bromhexine hcl · Bromhexine Hydrochloride · +3 more

Small molecule targets TMPRSS2 via inhibition

Developed for: COVID-19
Investigated by: Second Affiliated Hospital of Wenzhou Medical University · Wanbangde Pharmaceutical Group Co., LTD · Chulalongkorn University · Department of Medical Services Ministry of Public Health of Thailand · Federal State Budgetary Institution, V. A. Almazov Federal North-West Medical Research Centre, of the Ministry of Health · General and Teaching Hospital Celje
+13 more
· Instituto Nacional de Rehabilitacion · King Chulalongkorn Memorial Hospital · Lomonosov Moscow State University Medical Research and Educational Center · Mae Fah Luang University · Mahidol University · Ministry of Health, Thailand · QIMR Berghofer Medical Research Institute · Ramathibodi Hospital · Thanyarak Pattani Hospital · The University of Western Australia · Vibhavadi Hospital · Washington University School of Medicine · Yamagata Prefectural Central Hospital

Trials 7 · a red edge is where a trial was stopped

today NCT05087381 · Ph 4 NCT04340349 · Ph 0 NCT04672707 · Ph 1 NCT04424134 · Ph 3 NCT04405999 · Ph 4 NCT04355026 · Ph 4 NCT04273763 · not/applicable

2020202120222023202420252026

Phase	Registry id	Dates	Indication	Sponsor	Status	Outcome
Phase 01 trial
Phase 0	NCT04340349	Feb → May 2021	malaria, toxic maculopathy due to antimalarial drugs	Instituto Nacional de Rehabilitacion	Unknown	No outcome recorded
Phase 11 trial
Phase 1	NCT04672707	Dec 2020 → Jul 2024	—	Second Affiliated Hospital of Wenzhou Medical University	Completed	No outcome recorded
Phase 31 trial
Phase 3	NCT04424134	May → Jul 2020	COVID-19	Lomonosov Moscow State University Medical Research and Educational Center	Unknown	No outcome recorded
Phase 43 trials
Phase 4	NCT05087381	Oct 2021 → Jun 2022	—	Chulalongkorn University	Completed	No outcome recorded
Phase 4	NCT04405999	May → Aug 2020	—	Federal State Budgetary Institution, V. A. Almazov Federal North-West Medical Research Centre, of the Ministry of Health	Completed	No outcome recorded
Phase 4	NCT04355026	Apr → Jun 2020	COVID-19	General and Teaching Hospital Celje	Unknown	No outcome recorded
Phase not applicable1 trial
—	NCT04273763	Feb → May 2020	COVID-19	Second Affiliated Hospital of Wenzhou Medical University	Unknown	No outcome recorded

Also used as a comparator or background therapy in 1 trial

Phase	Registry id	Dates	Indication	Sponsor	Status	Outcome
Phase 3	NCT04928495 Comparator	Jul 2021 → Apr 2022	COVID-19	Federal University of Ceará	Unknown	No outcome recorded

Evidence & citations 16 cited values

Every value below carries the sentence it was read from. 10 sources stand behind the page.

Field	Value	Cited text
Known as	Bromhexine	ClinicalTrials.gov intervention name — accepted as the source's own label NCT04928495 ↗ 6 NCT05087381 ↗ NCT04340349 ↗ NCT04424134 ↗ NCT04355026 ↗ NCT04672707 ↗ NCT04273763 ↗
Known as	BHH	“prophylactic treatment with hydroxychloroquine (HCQ) and bromhexine (BHH), which have been shown to be effective in preventing SARS-CoV-2 infection progression” PMID 34344672 ↗ Aug 2021
Known as	Bisolvon	ChEMBL registry synonym — accepted as the source's own label CHEMBL253376 ↗
Known as	BMX	“NAC + Bromhexine (BMX) 32 mg / day for ten days.” NCT04928495 ↗
Known as	Brombenzonium	ChEMBL registry synonym — accepted as the source's own label CHEMBL253376 ↗
Known as	Bromehexine hydrochloride	ChEMBL registry synonym — accepted as the source's own label CHEMBL253376 ↗
Known as	Bromhexina	ChEMBL registry synonym — accepted as the source's own label CHEMBL253376 ↗
Known as	Bromhexine hcl	ChEMBL registry synonym — accepted as the source's own label CHEMBL253376 ↗
Known as	Bromhexine Hydrochloride	ClinicalTrials.gov intervention name — accepted as the source's own label NCT04405999 ↗
Known as	Fluibron	ChEMBL registry synonym — accepted as the source's own label CHEMBL253376 ↗
Known as	NA 274	ChEMBL registry synonym — accepted as the source's own label CHEMBL253376 ↗
Known as	NSC-758383	ChEMBL registry synonym — accepted as the source's own label CHEMBL253376 ↗
Action	Inhibit	“TMPRSS2 blocker” NCT04340349 ↗
Modality	Small molecule	— CHEMBL253376 ↗
Route	Oral	“Bromhexine Oral Tablet” NCT04355026 ↗
Target	TMPRSS2	“TMPRSS2 blocker” NCT04340349 ↗