Drugs / Bromhexine
Bromhexine
also known as
BHH · Bisolvon · BMX · Brombenzonium · Bromehexine hydrochloride · Bromhexina · Bromhexine hcl · Bromhexine Hydrochloride · +3 more
Small molecule targets TMPRSS2 via inhibition
Trials 7
| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 01 trial | ||||||
| Phase 0 | NCT04340349 | Feb → May 2021 | malaria, toxic maculopathy due to antimalarial drugs | Instituto Nacional de Rehabilitacion | Unknown | No outcome recorded |
| Phase 11 trial | ||||||
| Phase 1 | NCT04672707 | Dec 2020 → Jul 2024 | — | Second Affiliated Hospital of Wenzhou Medical University | Completed | No outcome recorded |
| Phase 31 trial | ||||||
| Phase 3 | NCT04424134 | May → Jul 2020 | COVID-19 | Lomonosov Moscow State University Medical Research and Educational Center | Unknown | No outcome recorded |
| Phase 43 trials · 1 met primary · 1 missed | ||||||
| Phase 4 | NCT05087381 | Oct 2021 → Jun 2022 | — | Chulalongkorn University | Completed | Met primary |
| Phase 4 | NCT04405999 | May → Aug 2020 | — | Federal State Budgetary Institution, V. A. Almazov Federal North-West Medical Research Centre, of the Ministry of Health | Completed | Missed primary |
| Phase 4 | NCT04355026 | Apr → Jun 2020 | COVID-19 | General and Teaching Hospital Celje | Unknown | No outcome recorded |
| Phase not applicable1 trial | ||||||
| — | NCT04273763 | Feb → May 2020 | COVID-19 | Second Affiliated Hospital of Wenzhou Medical University | Unknown | No outcome recorded |
| Comparator or background therapy1 trial | ||||||
| Phase 3 | NCT04928495 Comparator | Jul 2021 → Apr 2022 | COVID-19 | Federal University of Ceará | Unknown | No outcome recorded |
Evidence & citations 16 cited values
Every value below carries the sentence it was read from. 10 sources stand behind the page.
| Field | Value | Cited text |
|---|---|---|
| Known as | Bromhexine | ClinicalTrials.gov intervention name — accepted as the source's own label NCT04424134 ↗ |
| Known as | BHH | “prophylactic treatment with hydroxychloroquine (HCQ) and bromhexine (BHH), which have been shown to be effective in preventing SARS-CoV-2 infection progression” PMID 34344672 ↗ Aug 2021 |
| Known as | Bisolvon | ChEMBL registry synonym — accepted as the source's own label CHEMBL253376 ↗ |
| Known as | BMX | “NAC + Bromhexine (BMX) 32 mg / day for ten days.” NCT04928495 ↗ |
| Known as | Brombenzonium | ChEMBL registry synonym — accepted as the source's own label CHEMBL253376 ↗ |
| Known as | Bromehexine hydrochloride | ChEMBL registry synonym — accepted as the source's own label CHEMBL253376 ↗ |
| Known as | Bromhexina | ChEMBL registry synonym — accepted as the source's own label CHEMBL253376 ↗ |
| Known as | Bromhexine hcl | ChEMBL registry synonym — accepted as the source's own label CHEMBL253376 ↗ |
| Known as | Bromhexine Hydrochloride | ClinicalTrials.gov intervention name — accepted as the source's own label NCT04405999 ↗ |
| Known as | Fluibron | ChEMBL registry synonym — accepted as the source's own label CHEMBL253376 ↗ |
| Known as | NA 274 | ChEMBL registry synonym — accepted as the source's own label CHEMBL253376 ↗ |
| Known as | NSC-758383 | ChEMBL registry synonym — accepted as the source's own label CHEMBL253376 ↗ |
| Action | Inhibit | “TMPRSS2 blocker” NCT04340349 ↗ |
| Modality | Small molecule | — CHEMBL253376 ↗ |
| Route | Oral | “Bromhexine Oral Tablet” NCT04355026 ↗ |
| Target | TMPRSS2 | “TMPRSS2 blocker” NCT04340349 ↗ |