drugset / Trial / NCT04424134
BromhexIne And Spironolactone For CoronаVirUs Infection Requiring HospiTalization
Phase 3
Unknown
80 enrolled
Lomonosov Moscow State University Medical Research and Educational Center
RandomizedParallel-groupSingle-blindTreatment
Summary
Patients with mild and severe COVID 19 will be randomized 1:1 into two groups: experimental, which will get bromhexine and spironolactone, and control. Patients will get investigated therapy for ten days. Change in clinical assessment score COVID 19 (CAS COVID 19) between baseline and 12th day will be evaluated as a primary endpoint. Forty-five-day risk of death or mechanical ventilation will also be assessed.
Timeline
- Start
- 2020-05-16
- Primary completion
- 2020-07-18
- Completion
- 2020-08-23
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Bromhexine | Small molecule | 8 mg | — |
| Subject | Spironolactone | Small molecule | 50 mg | — |