drugset / Trial / NCT04424134

BromhexIne And Spironolactone For CoronаVirUs Infection Requiring HospiTalization

NCT04424134

RandomizedParallel-groupSingle-blindTreatment

Summary

Patients with mild and severe COVID 19 will be randomized 1:1 into two groups: experimental, which will get bromhexine and spironolactone, and control. Patients will get investigated therapy for ten days. Change in clinical assessment score COVID 19 (CAS COVID 19) between baseline and 12th day will be evaluated as a primary endpoint. Forty-five-day risk of death or mechanical ventilation will also be assessed.

Timeline

Start
2020-05-16
Primary completion
2020-07-18
Completion
2020-08-23

Drugs

EvaluationDrugModalityDoseRoute
Subject Bromhexine Small molecule 8 mg
Subject Spironolactone Small molecule 50 mg

Indications