Drugs / chlorproguanil
chlorproguanil
Trials 13
| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 11 trial | ||||||
| Phase 1 | NCT00126971 | Jul 2005 → ? | Plasmodium falciparum malaria | Centers for Disease Control and Prevention | Terminated | No outcome recorded |
| Phase 2/31 trial · 1 met primary | ||||||
| Phase 2/3 | NCT00158574 | Jan 2005 → Apr 2008 | malaria | London School of Hygiene and Tropical Medicine | Completed | Met primary |
| Phase 36 trials · 1 met primary · 1 missed | ||||||
| Phase 3 | NCT00393679 | Jul 2007 → Dec 2009 | malaria | Institute of Tropical Medicine, Belgium | Completed | Mixed |
| Phase 3 | NCT00361114 | Jul 2006 → Aug 2007 | malaria | London School of Hygiene and Tropical Medicine | Terminated | No outcome recorded |
| Phase 3 | NCT00344006 | Jun 2006 → Aug 2007 | Plasmodium falciparum malaria | GlaxoSmithKline | Completed | Met primary |
| Phase 3 | NCT00118794 | Sep 2004 → Jun 2005 | malaria | London School of Hygiene and Tropical Medicine | Completed | Missed primary |
| Phase 3 | NCT00158561 | Feb 2004 → Mar 2006 | Plasmodium vivax malaria | London School of Hygiene and Tropical Medicine | Completed | No outcome recorded |
| Phase 3 | NCT00146731 | Jan 2004 → Sep 2007 | malaria | London School of Hygiene and Tropical Medicine | Completed | No outcome recorded |
| Phase 43 trials | ||||||
| Phase 4 | NCT00119145 | Jun 2005 → May 2006 | malaria | London School of Hygiene and Tropical Medicine | Completed | No outcome recorded |
| Phase 4 | NCT00164359 | Apr → Sep 2005 | Plasmodium falciparum malaria | Centers for Disease Control and Prevention | Completed | No outcome recorded |
| Phase 4 | NCT00164710 | Apr → Sep 2005 | Plasmodium falciparum malaria | Centers for Disease Control and Prevention | Completed | No outcome recorded |
| Phase not applicable2 trials · 1 missed | ||||||
| — | NCT00461578 | Apr 2005 → Oct 2006 | malaria | London School of Hygiene and Tropical Medicine | Completed | Missed primary |
| — | NCT00111163 | Mar 2004 → Mar 2006 | anemia, malaria | Centers for Disease Control and Prevention | Completed | Mixed |
| Comparator or background therapy2 trials | ||||||
| Phase 2 | NCT00519467 Background | Jun 2003 → Feb 2005 | Plasmodium falciparum malaria | GlaxoSmithKline | Completed | Met primary |
| Phase 3 | NCT00371735 Background | Apr 2006 → May 2007 | Plasmodium falciparum malaria | GlaxoSmithKline | Completed | No outcome recorded |
Evidence & citations 9 cited values
Every value below carries the sentence it was read from. 17 sources stand behind the page.
| Field | Value | Cited text |
|---|---|---|
| Known as | chlorproguanil | “Artesunate+chlorproguanil-dapsone (AS+CD) was a potential alternative for treatment of uncomplicated malaria.” PMID 18575626 ↗ Jun 2008 |
| Known as | chlorproguanil HCl | “The combination of chlorproguanil HCl (CPG) and dapsone (DDS) as chlorproguanil-dapsone has already been shown to be efficacious against P.falciparum in adults and children in...” NCT00371735 ↗ |
| Known as | CHLORPROGUANIL HYDROCHLORIDE | ChEMBL registry synonym — accepted as the source's own label CHEMBL1213553 ↗ |
| Known as | Clorproguanil | ChEMBL registry synonym — accepted as the source's own label CHEMBL1213553 ↗ |
| Known as | CPG | “The combination of chlorproguanil HCl (CPG) and dapsone (DDS) as chlorproguanil-dapsone has already been shown to be efficacious against P.falciparum in adults and children in...” NCT00371735 ↗1“Chlorproguanil (CPG)-dapsone (DDS)-artesunate was in development for the treatment of uncomplicated Plasmodium falciparum malaria.” PMID 19517101 ↗ Jun 2009 |
| Known as | Lapudrine | ChEMBL registry synonym — accepted as the source's own label CHEMBL1213553 ↗ |
| Known as | Proguanil hydrochloride related compound f | ChEMBL registry synonym — accepted as the source's own label CHEMBL1213553 ↗ |
| Known as | Proguanil related compound f | ChEMBL registry synonym — accepted as the source's own label CHEMBL1213553 ↗ |
| Modality | Small molecule | — CHEMBL1213553 ↗ |