drugset / Trial / NCT00158561
Chlorproguanil/Dapsone Compared With Chloroquine and SP for Vivax Malaria
Phase 3
Completed
750 enrolled
London School of Hygiene and Tropical Medicine
HealthNet TPO · collab
RandomizedParallel-groupOpen-label
Summary
To determine whether two cheap antifolates (chlorproguanil-dapsone and sulfadoxine-pyrimethamine) which work against falciparum malaria in this region are sufficiently effective against vivax malaria to be deployed in areas where diagnosis is poor and the burden of malaria is high, a randomised controlled trial of the three drugs is being undertaken comparing their efficacy in treating malaria.
Timeline
- Start
- 2004-02
- Primary completion
- —
- Completion
- 2006-03
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Dapsone | Small molecule | 2.5 mg/kg | — |
| Subject | chlorproguanil | Small molecule | 2 mg/kg | — |
| Subject | pyrimethamine | Small molecule | 25 mg/kg | — |
| Subject | sulfadoxine | Small molecule | 1.25 mg/kg | — |