Drugs / pyrimethamine
last change Aug 2026 re-read 9 days ago

pyrimethamine

Small molecule targets DHFR, STAT3 via inhibition

Developed for
malaria · Plasmodium falciparum malaria · HIV infectious disease · anemia · cerebral toxoplasmosis · pregnancy disorder · autoimmune disease · lymphoproliferative syndrome
+19 more · Plasmodium vivax malaria · toxoplasmosis · chronic lymphocytic leukemia/small lymphocytic lymphoma · familial amyotrophic lateral sclerosis · head and neck cancer · iron deficiency anemia · lymphatic system disorder · major depressive disorder · myelodysplastic syndrome · pneumocystosis · Sandhoff disease · Schistosoma mansoni infectious disease · schizophrenia · sexually transmitted disease · Tay-Sachs disease · urinary schistosomiasis · chorioretinitis · congenital toxoplasmosis · parasitemia
Investigated by
London School of Hygiene and Tropical Medicine · National Institute of Allergy and Infectious Diseases (NIAID) · Cheikh Anta Diop University, Senegal · Dafra Pharma · Erasmus Medical Center · Global Fund
+96 more · Hospital Clinic of Barcelona · Institut de Recherche pour le Developpement, Senegal · Malaria Consortium · Medical Research Council, South Africa · Ministry of Health, Senegal · Radboud University Medical Center · University of California, San Francisco · Centers for Disease Control and Prevention · Department of State for Health and Social Welfare, The Gambia · Deutscher Akademischer Austausch Dienst · European Commission · Glaxo Wellcome · Institute of Tropical Medicine, Belgium · Kenya Medical Research Institute · Malaria Research and Training Center, Bamako, Mali · Medical Research Council Unit, The Gambia · Papua New Guinea Institute of Medical Research · Professor Karen I Barnes · QIMR Berghofer Medical Research Institute · Research Institute for Development · Sanaria Inc. · Swiss Tropical & Public Health Institute · The PATH Malaria Vaccine Initiative (MVI) · United States Agency for International Development (USAID) · Washington University School of Medicine · World Health Organization · AIDSfonds · Agencia Española de Cooperación Internacional · Albert Einstein College of Medicine · Alliance for International Medical Action · Alliance médicale contre le paludisme, Mali · Bernhard Nocht Institute for Tropical Medicine · Beth Israel Deaconess Medical Center · Bill and Melinda Gates Foundation · Brigham and Women's Hospital · Bristol-Myers Squibb · Center for Primary Care and Public Health (Unisante), University of Lausanne, Switzerland · Centre for Global Health Research, Ghana · Centre national de recherche et de formation sur le paludisme · Charite University, Berlin, Germany · Chiang Mai University · DBL -Institute for Health Research and Development · Dana-Farber Cancer Institute · Department for International Development, United Kingdom · Department of Medical Services Ministry of Public Health of Thailand · Division Controle Medicale Scolaire, Ministry of Education, Senegal · Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) · Faculté des Sciences de la Santé, Bénin · French National Institute of Health and Medical Research · German Federal Ministry of Education and Research · GlaxoSmithKline · Harvard University · HealthNet TPO · Heidelberg University · INDEPTH Network · Institut National d'Etude et d'Action pour le Developpement de l'Education, Senegal · Institut des Sciences Biomédicales Appliquées, Bénin · KEMRI-Wellcome Trust Collaborative Research Program · Kilimanjaro Christian Medical Centre, Tanzania · Kwame Nkrumah University of Science and Technology · Lymphoma Research Foundation · Malaria Consortium, UK · Medical Research Council · Ministry of Foreign Affairs, France · Ministry of Health, Malawi · Ministry of health, Mali · Montefiore Medical Center · Muscular Dystrophy Association · National Institute for Medical Research, Tanzania · National Malaria Control Program, Benin · National Malaria Control Program, Niger · Pfizer · Seoul National University Hospital · Stanley Medical Research Institute · all 102 on the full record

Regulatory milestones approvals, filings & regulatory actions · 1 recorded

MilestoneJurisdictionBrandIndicationDateSentence it was read from
Approved US (FDA) DARAPRIM — 1953-01-23 fda.gov ↗

Trials 75 · started per year

today
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PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 01 trial
Phase 0 NCT05678348 Aug 2023 → Jul 2025 head and neck cancer Washington University School of Medicine Completed No outcome recorded
Phase 110 trials
Phase 1 NCT04086719 Sep → Oct 2019 — Bristol-Myers Squibb Completed No outcome recorded
Phase 1 NCT03057990 Sep 2019 → Jun 2021 myelodysplastic syndrome Montefiore Medical Center Withdrawn No outcome recorded
Phase 1 NCT03258762 Sep → Nov 2017 toxoplasmosis GlaxoSmithKline Completed No outcome recorded
Phase 1 NCT03083847 Jun 2017 → Jun 2019 malaria National Institute of Allergy and Infectious Diseases (NIAID) Completed No outcome recorded
Phase 1 NCT02511054 Jul 2015 → Oct 2016 malaria National Institute of Allergy and Infectious Diseases (NIAID) Completed No outcome recorded
Phase 1 NCT01973933 Jun → Aug 2013 — Seoul National University Hospital Completed No outcome recorded
Phase 1 NCT00065390 Jul 2003 → Jun 2005 autoimmune disease, lymphatic system disorder, lymphoproliferative syndrome National Institute of Allergy and Infectious Diseases (NIAID) Completed No outcome recorded
Phase 1 NCT00013689 Mar 2001 → Mar 2003 autoimmune disease, lymphoproliferative syndrome National Institute of Allergy and Infectious Diseases (NIAID) Completed No outcome recorded
Phase 1 NCT00000966 — HIV infectious disease, cerebral toxoplasmosis Pfizer Completed No outcome recorded
Phase 1 NCT00000973 ? → Mar 1995 HIV infectious disease, cerebral toxoplasmosis National Institute of Allergy and Infectious Diseases (NIAID) Completed No outcome recorded
Phase 1/211 trials
Phase 1/2 NCT07384624 Apr 2026 → Jun 2028 expected HIV infectious disease Erasmus Medical Center Not yet recruiting No outcome recorded
Phase 1/2 NCT06240520 Apr 2024 → May 2025 HIV infectious disease Erasmus Medical Center Unknown No outcome recorded
Phase 1/2 NCT04280692 Aug 2022 → Dec 2025 Plasmodium falciparum malaria University of Oxford Suspended No outcome recorded
Phase 1/2 NCT03952650 May 2019 → Feb 2021 malaria National Institute of Allergy and Infectious Diseases (NIAID) Completed No outcome recorded
Phase 1/2 NCT03525730 Apr 2018 → Jul 2019 HIV infectious disease Erasmus Medical Center Completed No outcome recorded
Phase 1/2 NCT02836002 Jun 2016 → Jun 2017 malaria Radboud University Medical Center Completed No outcome recorded
Phase 1/2 NCT01319448 Sep 2011 → Apr 2013 malaria, sickle cell disease London School of Hygiene and Tropical Medicine Completed No outcome recorded
Phase 1/2 NCT01066663 Mar 2010 → Feb 2022 chronic lymphocytic leukemia/small lymphocytic lymphoma Dana-Farber Cancer Institute Completed No outcome recorded
Phase 1/2 NCT01083667 Nov 2009 → Dec 2014 familial amyotrophic lateral sclerosis Weill Medical College of Cornell University Completed No outcome recorded
Phase 1/2 NCT01102686 Aug 2009 → Nov 2010 Sandhoff disease, Tay-Sachs disease The Hospital for Sick Children Completed No outcome recorded
Phase 25 trials · 1 met primary
Phase 2 NCT05081089 Oct → Dec 2021 Plasmodium falciparum malaria London School of Hygiene and Tropical Medicine Completed No outcome recorded
Phase 2 NCT02831023 Jul 2016 → Jan 2017 malaria University of California, San Francisco Completed Met primary
Phase 2 NCT00322907 Apr 2000 → Jan 2003 malaria Center for Primary Care and Public Health (Unisante), University of Lausanne, Switzerland Terminated No outcome recorded
Phase 2 NCT00000794 ? → Apr 1998 HIV infectious disease, cerebral toxoplasmosis National Institute of Allergy and Infectious Diseases (NIAID) Completed No outcome recorded
Phase 2 NCT00000643 ? → May 1994 HIV infectious disease, cerebral toxoplasmosis National Institute of Allergy and Infectious Diseases (NIAID) Completed No outcome recorded
Phase 2/35 trials · 3 met primary
Phase 2/3 NCT00510159 Aug → Oct 2007 urinary schistosomiasis Dafra Pharma Completed No outcome recorded
Phase 2/3 NCT00561899 Aug 2007 → Feb 2008 malaria London School of Hygiene and Tropical Medicine Completed No outcome recorded
Phase 2/3 NCT00119132 Jun 2005 → Dec 2006 malaria London School of Hygiene and Tropical Medicine Completed Met primary
Phase 2/3 NCT00158574 Jan 2005 → Apr 2008 malaria London School of Hygiene and Tropical Medicine Completed Met primary
Phase 2/3 NCT00132561 Jun 2002 → Dec 2003 malaria London School of Hygiene and Tropical Medicine Completed Met primary
Phase 314 trials · 5 met primary · 1 missed
Phase 3 NCT05946642 Jul 2023 → May 2024 malaria Malaria Consortium Unknown No outcome recorded
Phase 3 NCT00948896 Jun 2010 → Apr 2014 malaria University of California, San Francisco Completed Mixed
Phase 3 NCT01136850 Nov 2009 → Dec 2012 anemia, malaria, sexually transmitted disease University of Melbourne Completed Met primary
Phase 3 NCT01054651 Oct → Dec 2009 Schistosoma mansoni infectious disease Kenya Medical Research Institute Completed Missed primary
Phase 3 NCT00432367 Feb 2007 → Feb 2009 anemia, malaria, pregnancy disorder London School of Hygiene and Tropical Medicine Completed Met primary
Phase 3 NCT00484900 May 2006 → May 2007 Plasmodium falciparum malaria Dafra Pharma Completed No outcome recorded
Phase 3 NCT00274235 Jul 2005 → Mar 2008 malaria Research Institute for Development Completed Met primary
Phase 3 NCT00123552 Nov 2004 → Jun 2006 malaria University of California, San Francisco Completed Met primary
Phase 3 NCT00132548 Jun → Dec 2004 malaria London School of Hygiene and Tropical Medicine Completed Met primary
Phase 3 NCT00158561 Feb 2004 → Mar 2006 Plasmodium vivax malaria London School of Hygiene and Tropical Medicine Completed No outcome recorded
Phase 413 trials · 1 met primary · 2 missed
Phase 4 NCT06337253 Mar → May 2024 Plasmodium falciparum malaria Malaria Consortium Unknown No outcome recorded
Phase 4 NCT05979896 Jul → Sep 2023 malaria Malaria Consortium Unknown No outcome recorded
Phase 4 NCT01651416 Jul → Dec 2012 anemia, malaria Centre for Global Health Research, Ghana Completed No outcome recorded
Phase 4 NCT01636895 Jan 2011 → Nov 2012 pregnancy disorder Malaria Consortium, UK Unknown No outcome recorded
Phase 4 NCT00376155 May 2006 → Feb 2007 malaria London School of Hygiene and Tropical Medicine Completed Missed primary
Phase 4 NCT00372632 Dec 2005 → Apr 2008 — Institute of Tropical Medicine, Belgium Completed No outcome recorded
Phase 4 NCT00125489 May → Dec 2005 Plasmodium falciparum malaria National Institute of Allergy and Infectious Diseases (NIAID) Completed Met primary
Phase 4 NCT00164710 Apr → Sep 2005 Plasmodium falciparum malaria Centers for Disease Control and Prevention Completed No outcome recorded
Phase 4 NCT00367081 May 2003 → Aug 2004 AIDS, cerebral toxoplasmosis Department of Medical Services Ministry of Public Health of Thailand Completed Missed primary
Phase 4 NCT00168948 Mar 2003 → Aug 2005 anemia, malaria Charite University, Berlin, Germany Unknown No outcome recorded
Phase not applicable16 trials · 2 met primary · 2 missed
— NCT03454048 May → Nov 2018 Plasmodium falciparum malaria Radboud University Medical Center Completed No outcome recorded
— NCT03079388 Feb 2017 → Sep 2019 nutritional disorder, pregnancy disorder Washington University School of Medicine Completed No outcome recorded
— NCT03035305 Aug → Nov 2016 malaria Alliance for International Medical Action Completed No outcome recorded
— NCT01634945 Apr 2012 → May 2013 anemia Swiss Federal Institute of Technology Completed Missed primary
— NCT01454752 Nov 2011 → Feb 2012 anemia, malaria London School of Hygiene and Tropical Medicine Completed No outcome recorded
— NCT00738946 Aug → Dec 2008 malaria London School of Hygiene and Tropical Medicine Completed Met primary
— NCT00380146 Sep 2006 → Feb 2008 malaria Professor Karen I Barnes Completed No outcome recorded
— NCT00331708 Apr 2006 → Jul 2007 malaria Professor Karen I Barnes Terminated No outcome recorded
— NCT00258024 Nov 2005 → Sep 2007 anemia, malaria DBL -Institute for Health Research and Development Completed No outcome recorded
— NCT00231452 Sep 2005 → Mar 2009 malaria Hospital Clinic of Barcelona Completed Missed primary
Comparator or background therapy35 trials
Phase 1 NCT03599596 Comparator Sep → Dec 2018 malaria University College Hospital, Ibadan Unknown No outcome recorded
Phase 1 NCT02527005 Comparator Sep 2015 → Aug 2016 HIV infectious disease, malaria University of Ibadan Completed No outcome recorded
Phase 1 NCT02524444 Comparator Sep 2015 → Aug 2016 — ORIYOMI OMOTOYOSI AKINYOTU Completed No outcome recorded
Phase 1 NCT00679744 Comparator May 2008 → Mar 2010 Sandhoff disease, Tay-Sachs disease Exsar Corporation Withdrawn No outcome recorded Stop: Business
Phase 2 NCT02909712 Comparator Sep 2016 → Jan 2020 malaria, parasitemia, poisoning London School of Hygiene and Tropical Medicine Completed No outcome recorded

Evidence & citations 19 cited values

Every value below carries the sentence it was read from. 111 sources stand behind the page.

FieldValueCited text
Known as Pyrimethamine “Patients with uncomplicated falciparum malaria and over six months of age were recruited in Cameroon, Mali, Rwanda and Sudan. 1,384 patients were randomly assigned to receive...” PMID 19366448 ↗ Apr 2009
109

“Treatment with a single dose of sulfadoxine /pyrimethamine plus three doses of amodiaquine or placebo was given to all study subjects at monthly intervals on three occasions...” NCT00944840 ↗

“antimalarial artemisinin-based combination therapy (ACT) artesunate +sulfamethoxypyrazine/pyrimethamine (As+SMP), administered in doses used for malaria, to treat Schistosoma...” PMID 19802383 ↗ Oct 2009

“Amodiaquine (10 mg/kg over 3 days) and Sulfadoxine Pyrimethamine (25 mg of sulfadoxine + 1.25 mg of pyrimethamine per kg in a single dose) or placebo administered over 3 rounds...” NCT00738946 ↗

“This preventive measures involves administering antimalarial drugs (Amodiaquine-Sulfadoxine-Pyrimethamine) to children aged 6- 59 months on a monthly basis during the high...” NCT04238845 ↗

“Sulfadoxine/Pyrimethanine-Amodiaquine (SP-AQ) is a combination therapy comprised of sulfadoxine and pyrimethamine (two antifolate antimicrobials) co-administered with amodiaquine.” NCT03178643 ↗

“IPTi doses 1 and 2, at ages 2 and 3 months, sulphadoxine 250mg, pyrimethamine 12.5mg IPTi doses 3, at 9 months of age, sulphadoxine 500mg, pyrimethamine 25mg” NCT00158574 ↗

“One cycle of SMC consisting of sulphadoxine - pyrimethamine (SP) 500mg/25 mg, and amodiaquine (AQ) 150mg on day 1, and AQ 150mg on days 2 and 3.” NCT04319380 ↗

“Intervention: Random assignment to receive either Cotrifazid, mefloquine or the standard treatment of quinine+sulfadoxine/pyrimethamine (SP).” NCT00322907 ↗

“Sulfadoxine-pyrimethamine (500 mg / 25 mg) given every 4 weeks, beginning at enrollment or at 13 weeks' gestation, whichever is later.” NCT03079388 ↗

“It is used in a fixed dose combination of 20 parts sulphadoxine with 1 part pyrimethamine given orally or intramuscularly.” NCT05979896 ↗

Show 99 more sources

Known as Chloridine ChEMBL registry synonym — accepted as the source's own label CHEMBL36 ↗
Known as Daraprim “Six to 8 individuals, with ALPS will be treated for up to 3 months, initially, with twice-weekly pyrimethamine (Daraprim) at escalating doses adjusted by weight” NCT00065390 ↗
Known as GNF-PF-5586 ChEMBL registry synonym — accepted as the source's own label CHEMBL36 ↗
Known as Malacide ChEMBL registry synonym — accepted as the source's own label CHEMBL36 ↗
Known as NSC-3061 ChEMBL registry synonym — accepted as the source's own label CHEMBL36 ↗
Known as Pirimetamina ChEMBL registry synonym — accepted as the source's own label CHEMBL36 ↗
Known as PYR “either pyrimethamine (PYR) or chloroquine as a partner drug” NCT03952650 ↗
2

“Drug: Pyrimethamine (PYR)” NCT07384624 ↗

“Pyrimethamine (PYR)” NCT02511054 ↗

Known as Pyrimethamine = Malocide “Pyrimethamine = Malocide®” NCT01189448 ↗
Known as Pyrimethamine component of fansidar ChEMBL registry synonym — accepted as the source's own label CHEMBL36 ↗
Known as Pyrimethaminum ChEMBL registry synonym — accepted as the source's own label CHEMBL36 ↗
Known as RP-4753 ChEMBL registry synonym — accepted as the source's own label CHEMBL36 ↗
Known as TCMDC-123831 ChEMBL registry synonym — accepted as the source's own label CHEMBL36 ↗
Known as TCMDC-125860 ChEMBL registry synonym — accepted as the source's own label CHEMBL36 ↗
Known as WR-2978 ChEMBL registry synonym — accepted as the source's own label CHEMBL36 ↗
Action Restore “If Hex A can function normally in presence of Pyrimethamine, this drug should be able restore the brain malfunction of these patients since Hex A can now efficiently break down...” NCT00679744 ↗
Modality Small molecule — CHEMBL36 ↗
Route Oral “oral azithromycin and pyrimethamine” NCT00000966 ↗
Target STAT3 “pyrimethamine may target a protein in tumor cells, called STAT3” NCT01066663 ↗