Eggs for Gut Health

Completed 461 enrolled Washington University School of Medicine Ministry of Health and Sanitation, Sierra Leone · collab Project Peanut Butter · collab Thrasher Research Fund · collab

RandomizedParallel-groupDouble-blindTreatment

Summary

The goal of this clinical trial is to test egg powder supplementation in children with moderate acute malnutrition in Sierra Leone. The main question it aims to answer is: \- Will provision of 15g of whole egg powder per day during and after treatment for moderate acute malnutrition (for 24 weeks total) improve small intestinal permeability and linear growth among 6-30 month old Sierra Leonean children compared with daily corn powder supplementation?

Timeline

Start: 2023-10-09
Primary completion: 2024-12-19
Completion: 2024-12-19

Publications

Stephenson KB, Greenfeld A, Ryan MG, Kleban E, Kwak L, Lee A, Wegner DR, Jiang X, Hendrixson DT, Kamara MT, Koroma AS, Manary MJ. Egg supplementation for 24 weeks does not improve linear growth or reduce small intestinal permeability in Sierra Leonean children with moderate wasting: a randomized, blinded, controlled trial. Am J Clin Nutr. 2025 Nov;122(5):1326-1337. doi: 10.1016/j.ajcnut.2025.08.019. Epub 2025 Oct 14.

Drugs

Evaluation	Drug	Modality	Dose	Route
Background	pyrimethamine	Small molecule	12.5 mg	—
Background	pyrimethamine	Small molecule	25 mg	—
Background	sulfadoxine	Small molecule	250 mg	—
Background	sulfadoxine	Small molecule	500 mg	—

Eggs for Gut Health

Summary

Timeline

Publications

Drugs

Indications