LRAs United as a Novel Anti-HIV Strategy.

Summary

A translational proof of concept study in humans on the primary research question whether novel anti-human immunodeficiency virus (HIV) latency strategies, including a BAF inhibitor and a histone deacetylase inhibitor, result in HIV reservoir reduction in HIV patients on antiretroviral therapy.

Timeline

Start

2018-04-18

Primary completion

2019-07-25

Completion

2020-10-01

Publications

• Bollen PDJ, Prins HAB, Colbers A, Velthoven-Graafland K, Rijnders BJA, de Vries-Sluijs TEMS, van Nood E, Nouwen J, Bax H, de Mendonca Melo M, Verbon A, Burger DM, Rokx C. The dolutegravir/valproic acid drug-drug interaction is primarily based on protein displacement. J Antimicrob Chemother. 2021 Apr 13;76(5):1273-1276. doi: 10.1093/jac/dkab021.

Drugs

Indications