Valproic Acid

also known as VPA · Depakote · Depakote ER · 2-propylpentanoic acid · Depakine · Depakine-Chrono · Depakote (Valproic Acid) · Epival · +11 more

Small molecule targets GSK3B, UGT2B7 via inhibition

Developed for: myelodysplastic syndrome · acute myeloid leukemia · HIV infectious disease · bipolar disorder · cancer · epilepsy · glioblastoma · anaplastic astrocytoma
+106 more
· chronic lymphocytic leukemia/small lymphocytic lymphoma · head and neck squamous cell carcinoma · sarcoma · acute kidney injury · brain neoplasm · breast cancer · central nervous system neoplasm · childhood malignant neoplasm · colorectal cancer · gliomatosis cerebri · ischemic disease · leukemia · lymphoma · non-small cell lung carcinoma · soft tissue sarcoma · spinal muscular atrophy · tropical spastic paraparesis · acute graft versus host disease · acute myeloid leukemia with 11q23 abnormalities · acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22) · acute myeloid leukemia with t(8;21)(q22;q22) translocation · acute promyelocytic leukemia · Alzheimer disease · anal squamous cell carcinoma · astrocytoma, IDH-mutant, grade 4 · autoimmune lymphoproliferative syndrome · B-cell chronic lymphocytic leukemia · baldness, male pattern · borderline epithelial tumor of ovary · brain cancer · breast carcinoma · breath-holding Spells · Burkitt lymphoma · cancer of unknown primary site · carcinoma of pharynx · Castleman disease · cervical squamous cell carcinoma · childhood medulloblastoma · chronic myeloid leukemia · delirium · Dengue hemorrhagic fever · diffuse intrinsic pontine glioma · diffuse large B-cell lymphoma · diffuse midline glioma, H3 K27M-mutant · endometrioid tumor · Epstein-Barr virus-related tumor · Erdheim-Chester disease · female breast carcinoma · female reproductive system neoplasm · focal epilepsy · focal segmental glomerulosclerosis · gliosarcoma · grade III glioma · head and neck cancer · hypersplenism · idiopathic nephrotic syndrome · infantile spasms · iris melanoma · ischemic stroke · lip and oral cavity carcinoma · lung cancer · lymph node disorder · lymphangioleiomyomatosis · male reproductive system neoplasm · malignant glioma · malignant pancreatic neoplasm · mantle cell lymphoma · medium/large size posterior uveal melanoma · melanoma · mesothelial neoplasm · metastatic malignant neoplasm · metastatic malignant neoplasm in the brain · minimal change disease · mood disorder · nasopharyngeal carcinoma · neoplasm · neuroblastoma · neuropathy, painful · NF2-related schwannomatosis · oral cavity cancer · oropharynx squamous cell carcinoma · ovarian carcinoma · ovarian clear cell tumor · ovarian serous tumor · pancreatic adenocarcinoma · photosensitive epilepsy · progressive supranuclear palsy · prostate cancer · respiratory tract neoplasm · small cell lung carcinoma · small size posterior uveal melanoma · specific phobia · spinal muscular atrophy, type 1 · squamous cell carcinoma of penis · thyroid cancer · thyroid gland carcinoma · traumatic brain injury · urinary bladder cancer · urothelial carcinoma · bipolar I disorder · childhood absence epilepsy · epilepsy with generalized tonic-clonic seizures · glioma · intracerebral hemorrhage · migraine disorder · retinitis pigmentosa
Investigated by: National Cancer Institute (NCI) · M.D. Anderson Cancer Center · Abbott · H. Lee Moffitt Cancer Center and Research Institute · National Cancer Institute, Naples · United States Department of Defense
+125 more
· University of Utah · Celgene Corporation · Families of Spinal Muscular Atrophy · Leadiant Biosciences, Inc. · University of Bergen · Assistance Publique - Hôpitaux de Paris · Clinipace Worldwide · Dr. Hasan Alam · Eisai Inc. · Hannover Medical School · National Institute of Allergy and Infectious Diseases (NIAID) · New Mexico Cancer Research Alliance · Pfizer · Soroka University Medical Center · University of California, San Francisco · University of North Carolina, Chapel Hill · University of Sao Paulo · Westat · AHS Cancer Control Alberta · AIDS Malignancy Consortium · Academic Medical Center - University of Amsterdam · All India Institute of Medical Sciences · Amorepacific Corporation · Assiut University · Auxilio Mutuo Cancer Center · Barbara Ann Karmanos Cancer Institute · Barretos Cancer Hospital · Basque Health Service · Baylor College of Medicine · BioNumerik Pharmaceuticals, Inc. · BioPharma Services Inc. · Biogen · CIHR Canadian HIV Trials Network · Canadian Foundation for AIDS Research (CANFAR) · Cancer Institute of the State of São Paulo · CancerCare Manitoba · Canisius-Wilhelmina Hospital · Cerebral Therapeutics LLC · Children's Hospital of Orange County · Children's Oncology Group · Chonbuk National University · Cliniques universitaires Saint-Luc- Université Catholique de Louvain · Columbia University · Cook Children's Medical Center · Desitin Arzneimittel GmbH · Deutsche Kinderkrebsstiftung · Dr Cipto Mangunkusumo General Hospital · Duke University · EMD Serono · Erasmus Medical Center · Estetra · European Lung Cancer Working Party · GIMEMA Foundation · Genentech, Inc. · Gia Dinh People Hospital · Gregory Jicha, 323-5550 · Heinrich-Heine University, Duesseldorf · IRCCS National Neurological Institute "C. Mondino" Foundation · Inflammatory Breast Cancer Network Foundation · Inova Health Care Services · Jean-Pierre Routy · Johns Hopkins University · Joliet Center for Clinical Research · Karuna Therapeutics, Inc. · Kentucky Alzheimer's Center · Koneti Rao · Maasstad Hospital · Maastricht University Medical Center · Medical University of South Carolina · Medisch Spectrum Twente · Merck Sharp & Dohme LLC · Miller Children's & Women's Hospital Long Beach · Ministry of Health, Italy · Mohammed M Milhem · all 131 on the full record

Regulatory milestones approvals, filings & regulatory actions · 1 recorded

Milestone	Jurisdiction	Brand	Indication	Date	Sentence it was read from
Approved	US (FDA)	DEPAKENE	—	1978-02-28	fda.gov ↗

Trials 110 · started per year

today

US approved 1978

19771978197919801981198219831984198519861987198819891990199119921993199419951996199719981999200020012002200320042005200620072008200920102011201220132014201520162017201820192020202120222023202420252026202720282029

Phase	Registry id	Dates	Indication	Sponsor	Status	Outcome
Phase 04 trials · 1 missed
Phase 0	NCT02608736	Dec 2015 → Dec 2016	head and neck squamous cell carcinoma	Barretos Cancer Hospital	Completed	No outcome recorded
Phase 0	NCT02446431	Jul 2014 → Jul 2024 overdue	cancer	Miller Children's & Women's Hospital Long Beach	Recruiting	No outcome recorded
Phase 0	NCT01729598	Apr 2012 → Oct 2014	Alzheimer disease	Gregory Jicha, 323-5550	Completed	Missed primary
Phase 0	NCT01738815	Dec 2011 → May 2013	urinary bladder cancer	State University of New York - Upstate Medical University	Completed	No outcome recorded
Phase 130 trials
Phase 1	NCT06729970	Dec 2024 → Jan 2026	—	Karuna Therapeutics, Inc.	Completed	No outcome recorded
Phase 1	NCT06214130	Sep → Nov 2023	—	Desitin Arzneimittel GmbH	Completed	No outcome recorded
Phase 1	NCT03512860	Apr → Oct 2018	—	Estetra	Completed	No outcome recorded
Phase 1	NCT03385525	Sep → Oct 2017	—	Biogen	Completed	No outcome recorded
Phase 1	NCT04482764	Jan 2017 → Jan 2018	breath-holding Spells	Assiut University	Completed	No outcome recorded
Phase 1	NCT02872428	Nov 2016 → Sep 2017	Dengue hemorrhagic fever	Dr. Hasan Alam	Terminated	No outcome recorded Stop: Enrollment
Phase 1	NCT02520115	Aug 2015 → Sep 2018	borderline epithelial tumor of ovary, endometrioid tumor, ovarian carcinoma, ovarian clear cell tumor +1	Barbara Ann Karmanos Cancer Institute	Completed	No outcome recorded
Phase 1	NCT01951560	Sep 2013 → May 2016	—	Dr. Hasan Alam	Completed	No outcome recorded
Phase 1	NCT01861990	May → Dec 2013	anaplastic astrocytoma, brain cancer, childhood medulloblastoma, glioblastoma	Medical University of South Carolina	Withdrawn	No outcome recorded
Phase 1	NCT01552434	Oct 2012 → May 2026	Castleman disease, Erdheim-Chester disease, NF2-related schwannomatosis, breast carcinoma +11	M.D. Anderson Cancer Center	Terminated	No outcome recorded
Phase 1	NCT01106872	Sep 2010 → Jul 2017	soft tissue sarcoma	Mohammed M Milhem	Completed	No outcome recorded
Phase 1	NCT01007695	May 2010 → May 2015	cancer	University of Utah	Terminated	No outcome recorded Stop: Enrollment
Phase 1	NCT01204450	Nov 2009 → Nov 2012	central nervous system neoplasm, childhood malignant neoplasm, neuroblastoma, sarcoma	UNC Lineberger Comprehensive Cancer Center	Terminated	No outcome recorded Stop: Business
Phase 1	NCT01010958	Oct 2009 → Feb 2014	sarcoma	Columbia University	Terminated	No outcome recorded Stop: Enrollment
Phase 1	NCT01073059	Aug 2009 → ?	—	Chonbuk National University	Completed	No outcome recorded
Phase 1	NCT00996060	Jul 2008 → Dec 2012	lung cancer	New Mexico Cancer Research Alliance	Completed	No outcome recorded
Phase 1	NCT00529022	Aug 2007 → Oct 2012	cancer	M.D. Anderson Cancer Center	Completed	No outcome recorded
Phase 1	NCT00495872	Jun 2007 → Oct 2012	cancer	M.D. Anderson Cancer Center	Completed	No outcome recorded
Phase 1	NCT00437957	Dec 2006 → Apr 2009	metastatic malignant neoplasm in the brain	H. Lee Moffitt Cancer Center and Research Institute	Terminated	No outcome recorded Stop: Enrollment
Phase 1	NCT00312546	Jun 2006 → Apr 2009	HIV infectious disease	University of North Carolina, Chapel Hill	Terminated	No outcome recorded
Phase 1	NCT00109824	Mar 2006 → Mar 2009	Burkitt lymphoma, diffuse large B-cell lymphoma, mantle cell lymphoma	National Cancer Institute (NCI)	Completed	No outcome recorded
Phase 1	NCT00107458	May 2005 → Oct 2007	central nervous system neoplasm, childhood malignant neoplasm	Children's Oncology Group	Completed	No outcome recorded
Phase 1	NCT00496444	May 2005 → Oct 2009	cancer of unknown primary site	M.D. Anderson Cancer Center	Completed	No outcome recorded
Phase 1	NCT00084981	Apr 2004 → Feb 2013	non-small cell lung carcinoma	National Cancer Institute (NCI)	Completed	No outcome recorded
Phase 1	NCT00181220	Apr 2004 → Sep 2006	nasopharyngeal carcinoma	Johns Hopkins University	Withdrawn	No outcome recorded
Phase 1	NCT00246103	Mar 2004 → Apr 2008	neoplasm	H. Lee Moffitt Cancer Center and Research Institute	Completed	No outcome recorded
Phase 1	NCT00079378	Feb 2004 → May 2011	acute myeloid leukemia with 11q23 abnormalities, acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22), acute myeloid leukemia with t(8;21)(q22;q22) translocation, acute promyelocytic leukemia +1	National Cancer Institute (NCI)	Completed	No outcome recorded
Phase 1	NCT00374075	Sep 2003 → Feb 2006	spinal muscular atrophy	University of Utah	Completed	No outcome recorded
Phase 1	NCT00563992	Jan 2001 → Sep 2008	bipolar disorder	New York State Psychiatric Institute	Completed	No outcome recorded
Phase 1	NCT00000629	—	HIV infectious disease	National Institute of Allergy and Infectious Diseases (NIAID)	Completed	No outcome recorded

Phase 1/211 trials
Phase 1/2	NCT04529954	Jan 2021 → Mar 2024	focal epilepsy	Cerebral Therapeutics LLC	Terminated	No outcome recorded
Phase 1/2	NCT03525730	Apr 2018 → Jul 2019	HIV infectious disease	Erasmus Medical Center	Completed	No outcome recorded
Phase 1/2	NCT01369368	Aug 2013 → Oct 2017	acute myeloid leukemia	University of Bergen	Unknown	No outcome recorded
Phase 1/2	NCT01203735	Feb 2011 → Feb 2013	non-small cell lung carcinoma	Soroka University Medical Center	Unknown	No outcome recorded
Phase 1/2	NCT01295593	Dec 2010 → Apr 2013	B-cell chronic lymphocytic leukemia	Cliniques universitaires Saint-Luc- Université Catholique de Louvain	Unknown	No outcome recorded
Phase 1/2	NCT00995332	Sep 2009 → Feb 2013	acute myeloid leukemia	University of Bergen	Completed	No outcome recorded
Phase 1/2	NCT00661453	Apr 2008 → May 2012	spinal muscular atrophy, type 1	University of Utah	Completed	No outcome recorded
Phase 1/2	NCT00605657	Jan 2008 → Sep 2011	autoimmune lymphoproliferative syndrome, hypersplenism, lymph node disorder	Koneti Rao	Completed	No outcome recorded
Phase 1/2	NCT00358319	Mar 2005 → Apr 2007	melanoma	H. Lee Moffitt Cancer Center and Research Institute	Terminated	No outcome recorded
Phase 1/2	NCT00175812	Nov 2004 → May 2008	acute myeloid leukemia	University of Bergen	Completed	No outcome recorded
Phase 1/2	NCT00075010	Jan 2004 → Nov 2006	leukemia, myelodysplastic syndrome	M.D. Anderson Cancer Center	Completed	No outcome recorded

Phase 242 trials · 6 missed
Phase 2	NCT07831369	Sep 2026 → Sep 2027 expected	astrocytoma, IDH-mutant, grade 4, glioblastoma	Inova Health Care Services	Recruiting	No outcome recorded
Phase 2	NCT06714357	Mar 2025 → Dec 2026 expected	colorectal cancer	National Cancer Institute, Naples	Recruiting	No outcome recorded
Phase 2	NCT06020898	Sep 2023 → Apr 2024	ischemic stroke	RenJi Hospital	Unknown	No outcome recorded
Phase 2	NCT05821556	Jun 2023 → Aug 2026 overdue	pancreatic adenocarcinoma	National Cancer Institute, Naples	Recruiting	No outcome recorded
Phase 2	NCT04531579	Jan 2022 → Jun 2023	acute kidney injury, ischemic disease	Westat	Withdrawn	No outcome recorded
Phase 2	NCT04531592	Jan 2022 → Jun 2023	acute kidney injury, ischemic disease	Westat	Withdrawn	No outcome recorded
Phase 2	NCT04310176	May 2019 → Dec 2023	colorectal cancer	National Cancer Institute, Naples	Unknown	No outcome recorded
Phase 2	NCT03357757	Feb 2018 → Mar 2022	Epstein-Barr virus-related tumor, anal squamous cell carcinoma, cervical squamous cell carcinoma, head and neck squamous cell carcinoma +1	AHS Cancer Control Alberta	Completed	No outcome recorded
Phase 2	NCT02789813	Jul 2016 → Jun 2018	specific phobia	University of Basel	Completed	No outcome recorded
Phase 2	NCT02848105	Jul 2016 → Jul 2019	acute graft versus host disease	Shanghai Jiao Tong University School of Medicine	Unknown	No outcome recorded
Phase 2	NCT02624128	Feb 2015 → Apr 2019	head and neck squamous cell carcinoma	National Cancer Institute, Naples	Unknown	No outcome recorded
Phase 2	NCT02068586	Nov 2014 → Dec 2026 expected	iris melanoma, medium/large size posterior uveal melanoma, small size posterior uveal melanoma	Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University	Active not recruiting	No outcome recorded
Phase 2	NCT01900730	Jul 2014 → Jun 2018	breast cancer	M.D. Anderson Cancer Center	Terminated	No outcome recorded Stop: Enrollment
Phase 2	NCT01928849	Dec 2013 → Sep 2017	neuropathy, painful	Duke University	Completed	Missed primary
Phase 2	NCT01817751	Apr 2013 → Aug 2020	brain neoplasm, glioblastoma, grade III glioma	Virginia Commonwealth University	Completed	No outcome recorded
Phase 2	NCT01695122	Sep 2012 → Nov 2014	oral cavity cancer, oropharynx squamous cell carcinoma	Cancer Institute of the State of São Paulo	Completed	No outcome recorded
Phase 2	NCT02124174	Jan 2012 → Jan 2022	acute myeloid leukemia, myelodysplastic syndrome	Patrick Stiff	Unknown	No outcome recorded
Phase 2	NCT01548066	Sep 2011 → May 2012	baldness, male pattern	Seoul National University Hospital	Completed	No outcome recorded
Phase 2	NCT01356875	Sep 2011 → Sep 2014	myelodysplastic syndrome	Basque Health Service	Unknown	No outcome recorded
Phase 2	NCT01333631	Jun 2011 → Jun 2013	malignant pancreatic neoplasm	Soroka University Medical Center	Unknown	No outcome recorded
Phase 2	NCT01342692	Jun 2011 → Jul 2018	myelodysplastic syndrome	Assistance Publique - Hôpitaux de Paris	Unknown	No outcome recorded
Phase 2	NCT01182285	Sep 2010 → Sep 2015	thyroid cancer	National Cancer Institute (NCI)	Completed	Missed primary
Phase 2	NCT00977132	Oct 2009 → May 2013	myelodysplastic syndrome	Heinrich-Heine University, Duesseldorf	Terminated	No outcome recorded Stop: Enrollment
Phase 2	NCT00879437	Sep 2009 → Aug 2015	anaplastic astrocytoma, diffuse intrinsic pontine glioma, gliomatosis cerebri, gliosarcoma	Baylor College of Medicine	Completed	Missed primary
Phase 2	NCT01011998	Sep 2009 → Jun 2010	chronic myeloid leukemia	New Mexico Cancer Research Alliance	Withdrawn	No outcome recorded Stop: Enrollment
Phase 2	NCT01016990	Aug 2009 → Sep 2011	leukemia, lymphoma	Auxilio Mutuo Cancer Center	Unknown	No outcome recorded
Phase 2	NCT01010854	Dec 2008 → Dec 2010	breast cancer	University of California, San Francisco	Terminated	No outcome recorded
Phase 2	NCT00759824	Sep 2008 → Dec 2013	small cell lung carcinoma	European Lung Cancer Working Party	Completed	No outcome recorded
Phase 2	NCT00670046	May 2008 → Jul 2012	prostate cancer	Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins	Terminated	No outcome recorded
Phase 2	NCT00524667	Jan 2008 → Jul 2011	chronic lymphocytic leukemia/small lymphocytic lymphoma	CancerCare Manitoba	Terminated	No outcome recorded Stop: Enrollment
Phase 2	NCT00525135	Aug 2007 → Mar 2009	head and neck cancer	University of California, San Francisco	Terminated	No outcome recorded
Phase 2	NCT00439673	May 2007 → Jul 2010	myelodysplastic syndrome	GIMEMA Foundation	Completed	No outcome recorded
Phase 2	NCT00614458	Apr 2007 → Sep 2008	HIV infectious disease	University of North Carolina, Chapel Hill	Terminated	Missed primary Stop: Business
Phase 2	NCT00414310	Dec 2006 → May 2015	acute myeloid leukemia, myelodysplastic syndrome	M.D. Anderson Cancer Center	Completed	No outcome recorded
Phase 2	NCT00385710	Nov 2006 → Jul 2010	progressive supranuclear palsy	Nantes University Hospital	Completed	No outcome recorded
Phase 2	NCT00339196	Jul 2006 → Jul 2008	acute myeloid leukemia, myelodysplastic syndrome	Assistance Publique - Hôpitaux de Paris	Completed	No outcome recorded
Phase 2	NCT00289952	Jun 2006 → Dec 2012	HIV infectious disease	Jean-Pierre Routy	Completed	Missed primary
Phase 2	NCT00302159	Mar 2006 → Jun 2013	brain neoplasm, malignant glioma	National Cancer Institute (NCI)	Completed	No outcome recorded
Phase 2	NCT00227266	Sep 2005 → Nov 2007	spinal muscular atrophy	University of Utah	Completed	Missed primary
Phase 2	NCT00326170	Jul 2005 → Jul 2007	acute myeloid leukemia, myelodysplastic syndrome	M.D. Anderson Cancer Center	Completed	No outcome recorded
Phase 2	NCT00395655	Jun 2005 → Aug 2006	female breast carcinoma	National Institute of Cancerology	Terminated	No outcome recorded
Phase 2	NCT00004758	Nov 1993 → ?	infantile spasms	National Center for Research Resources (NCRR)	Completed	No outcome recorded

Phase 2/32 trials
Phase 2/3	NCT07166393	May 2026 → Feb 2030 expected	traumatic brain injury	Northwestern University	Not yet recruiting	No outcome recorded
Phase 2/3	NCT02896270	Oct 2016 → Oct 2019	focal segmental glomerulosclerosis, idiopathic nephrotic syndrome, minimal change disease	University Hospital Brussels	Unknown	No outcome recorded
Phase 34 trials
Phase 3	NCT03243461	Jul 2018 → Dec 2023	anaplastic astrocytoma, diffuse midline glioma, H3 K27M-mutant, glioblastoma, gliomatosis cerebri	University of Göttingen	Unknown	No outcome recorded
Phase 3	NCT02374567	Jan 2015 → Jun 2017	anxiety disorder, dementia, depressive disorder, schizophrenia +1	Hannover Medical School	Terminated	No outcome recorded
Phase 3	NCT00681980	Feb 2008 → Sep 2009	tropical spastic paraparesis	University of Sao Paulo	Completed	No outcome recorded
Phase 3	NCT02456454	Jan 2006 → Jun 2010	bipolar disorder	Nationwide Children's Hospital	Completed	No outcome recorded
Phase 410 trials · 2 met primary
Phase 4	NCT05697614	Mar → May 2023	epilepsy	Dr Cipto Mangunkusumo General Hospital	Unknown	No outcome recorded
Phase 4	NCT03161509	Jul 2017 → Dec 2018	—	Rambam Health Care Campus	Terminated	No outcome recorded
Phase 4	NCT04967326	Jan 2016 → Dec 2018	epilepsy	Gia Dinh People Hospital	Completed	Met primary
Phase 4	NCT02343575	Jan 2015 → Jan 2018	delirium	Stanford University	Terminated	No outcome recorded Stop: Enrollment
Phase 4	NCT02429596	May 2012 → May 2015	epilepsy	IRCCS National Neurological Institute "C. Mondino" Foundation	Unknown	No outcome recorded
Phase 4	NCT00609245	Dec 2007 → Dec 2008	photosensitive epilepsy	Vanderbilt University Medical Center	Completed	Met primary
Phase 4	NCT00854581	Nov 2007 → Jun 2011	lymphoma, precancerous condition	University of Miami	Terminated	No outcome recorded
Phase 4	NCT00298857	Mar 2006 → Mar 2007	obesity disorder	Northwell Health	Terminated	No outcome recorded Stop: Business
Phase 4	NCT00211250	Jul 2005 → Jul 2006	mood disorder	Joliet Center for Clinical Research	Completed	No outcome recorded
Phase 4	NCT00431522	Dec 2004 → Oct 2006	bipolar disorder	Sanofi	Completed	No outcome recorded
Phase not applicable7 trials · 1 missed
—	NCT07052136	Nov 2024 → Apr 2025	—	RESnTEC, Institute of Research	Completed	No outcome recorded
—	NCT05236166	Apr 2017 → May 2021	epilepsy	University Magna Graecia	Completed	No outcome recorded
—	NCT04486092	Feb 2015 → Jul 2021	bipolar disorder	National Cheng-Kung University Hospital	Unknown	No outcome recorded
—	NCT02056236	Apr 2014 → Apr 2021	cardiac arrest	University of Twente	Completed	Missed primary
—	NCT00810680	Sep 2008 → Mar 2009	chronic lymphocytic leukemia/small lymphocytic lymphoma	All India Institute of Medical Sciences	Unknown	No outcome recorded
—	NCT00519181	Mar 2006 → Jun 2007	tropical spastic paraparesis	University Hospital Pierre Zobda-Quitman	Terminated	No outcome recorded
—	NCT00075777	Feb 2005 → Jul 2007	sarcoma	AIDS Malignancy Consortium	Completed	No outcome recorded
Comparator or background therapy22 trials
Phase 1	NCT03885947 Background	Feb 2019 → Mar 2021	Hodgkins lymphoma, acute lymphoblastic leukemia, myelodysplastic syndrome	Alla Keyzner	Completed	No outcome recorded
Phase 1	NCT02761291 Background	May 2016 → Jun 2017	nasopharyngeal carcinoma	Chang Gung Memorial Hospital	Unknown	No outcome recorded
Phase 1	NCT00530907 Background	Jun 2007 → Nov 2013	—	M.D. Anderson Cancer Center	Completed	No outcome recorded
Phase 1/2	NCT06199557 Comparator	May 2024 → Nov 2025 overdue	acute myeloid leukemia, myelodysplastic syndrome	Haukeland University Hospital	Recruiting	No outcome recorded
Phase 1/2	NCT04729543 Background	Oct 2020 → Dec 2024 overdue	uveal melanoma	Erasmus Medical Center	Recruiting	No outcome recorded
Phase 1/2	NCT01898104 Comparator	May 2012 → Nov 2023	colorectal cancer	National Cancer Institute, Naples	Unknown	No outcome recorded
Phase 2	NCT03885154 Comparator	Oct 2017 → Mar 2019	migraine disorder	Kimberly S Jones	Terminated	No outcome recorded Stop: Enrollment
Phase 2	NCT01674010 Background	Aug 2012 → Jun 2014	bipolar I disorder	OPKO Health, Inc.	Terminated	No outcome recorded Stop: Business
Phase 2	NCT01399515 Comparator	Mar 2011 → Aug 2013	retinitis pigmentosa	Seoul National University Hospital	Completed	No outcome recorded
Phase 2	NCT01233609 Comparator	Nov 2010 → Dec 2015	retinitis pigmentosa	Foundation Fighting Blindness	Completed	No outcome recorded
Phase 2	NCT00481013 Comparator	Jul 2007 → Dec 2009	spinal muscular atrophy	University of Utah	Completed	No outcome recorded
Phase 2	NCT00382590 Comparator	Aug 2005 → Feb 2008	acute myeloid leukemia, myelodysplastic syndrome	M.D. Anderson Cancer Center	Completed	No outcome recorded
Phase 3	NCT06248931 Comparator	May 2022 → Jun 2024	migraine disorder	Kafrelsheikh University	Completed	No outcome recorded
Phase 3	NCT01960075 Comparator	Oct 2015 → Feb 2019	—	University of Virginia	Completed	No outcome recorded
Phase 3	NCT01586208 Comparator	Jan 2010 → May 2012	epilepsy with generalized tonic-clonic seizures	Hospital Universitari de Bellvitge	Completed	No outcome recorded
Phase 3	NCT00088452 Comparator	Jul 2004 → Jan 2013	childhood absence epilepsy	Children's Hospital Medical Center, Cincinnati	Completed	No outcome recorded
Phase 4	NCT06485726 Comparator	Jan 2023 → Jul 2024 overdue	migraine disorder	Kafrelsheikh University	Recruiting	No outcome recorded
Phase 4	NCT03048084 Comparator	Feb 2018 → Jul 2026 overdue	glioma	Leiden University Medical Center	Recruiting	No outcome recorded
Phase 4	NCT02670161 Comparator	May 2016 → Dec 2026 expected	Parkinson disease, brain neoplasm, cognitive impairment with or without cerebellar ataxia, epilepsy +6	Endeavor Health	Enrolling by invitation	No outcome recorded
Phase 4	NCT02870283 Comparator	May 2010 → Nov 2014	bipolar disorder	Federal University of Rio Grande do Sul	Completed	No outcome recorded
Phase 4	NCT00976794 Comparator	Jan 2009 → Jun 2012	bipolar I disorder	University of Sao Paulo	Completed	Missed primary
Phase 4	NCT01115959 Comparator	Feb 2003 → Oct 2008	intracerebral hemorrhage	Wolfson Medical Center	Completed	No outcome recorded

Press releases naming this drug 4 releases

Date	Issuer	Release
2011-02-17	Bristol-Myers Squibb	ABILIFY® (aripiprazole) Approved for Maintenance Treatment of Bipolar I Disorder as an Adjunct to Either Lithium or Valproate bms.com ↗
2008-07-30	Sun Pharmaceutical Industries, Inc.	Sun Pharma gets USFDA approval for generic Depakote® delayed release tablets sunpharma.com ↗
2008-05-08	Bristol-Myers Squibb	U.S. Food and Drug Administration Approves ABILIFY(R) (aripiprazole) for Add-On Treatment to Lithium or Valproate in the Acute Treatment of Adults With Manic and Mixed Episodes of Bipolar I Disorder With or Without Psychotic Features bms.com ↗
2008-02-14	Sun Pharmaceutical Industries, Inc.	Sun Pharma gets USFDA tentative approval for generic Depakote ® delayed release tablets sunpharma.com ↗

Evidence & citations 24 cited values

Every value below carries the sentence it was read from. 146 sources stand behind the page.

Field	Value	Cited text
Known as	VALPROIC acid	“In recent years, a number of preclinical studies have found that valproic acid has a potential neuroprotective effect in acute ischemic brain injury, which can decrease infarct...” NCT06020898 ↗ 132 “Valproic acid: Starting at 500mg daily, dose weekly adjusted according to blood serum level (50 and 125µg/ml), efficacy and tolerability.” NCT00976794 ↗ “Combination of Valproic Acid and Lenalidomide in the Treatment of Patients With Myelodysplastic Syndrome With Favorable Risk Profile” NCT00977132 ↗ “Drugs: carbamazepine, lamotrigine, levetiracetam, oxcarbazepine, phenobarbital, phenytoin, topiramate, valproic acid, zonisamide” NCT05236166 ↗ “Valproic acid with 1000mg loading dose with 500mg q12 4 hours later to maintain a trough level above 75ug/ml” NCT02848105 ↗ “5-azacytidine (Vidaza®) + Valproic Acid (Depakine ®) Before Administration of Retinoic Acid (Vesanoid®)” NCT00339196 ↗ “Option 2: valproic acid bolus 10-20 mg/kg in 30 min, followed by15 mg/kg/day in 2 dosages intravenously” NCT02056236 ↗ “carbamazepine, valproic acid, topiramate, oxcarbazepine, levetiracetam or lamotrigine” NCT02429596 ↗ “as well as the plasma levels of hydralazine and valproic acid.” NCT00395655 ↗ “brain tumors (lamotrigine, levetiracetam, valproic acid)” NCT02670161 ↗ “Valproic Acid (VPA) expanded cord blood stem cells” NCT03885947 ↗ Show 122 more sources
Known as	2-propylpentanoic acid	“Valproic acid (VPA, 2-propylpentanoic acid) is an established drug in the long-term therapy of epilepsy.” NCT00439673 ↗
Known as	Depakine	“5-azacytidine (Vidaza®) + Valproic Acid (Depakine ®) Before Administration of Retinoic Acid (Vesanoid®)” NCT00339196 ↗
Known as	Depakine-Chrono	“Valproic Acid (Depakine-Chrono®) (VPA) will be administered concomitantly for a minimum of 6 cycles.” NCT01342692 ↗
Known as	Depakote	“The purpose of this research study is to test the safety, tolerability, and effectiveness of the combination of three drugs, sorafenib (Nexavar®), valproic acid (Depakote®),...” NCT01817751 ↗ 1 “Valproic Acid (Depakote[Registered Trademark]) to Treat Autoimmune Lymphoproliferative Syndrome (ALPS)” NCT00605657 ↗
Known as	Depakote (Valproic Acid)	“Depakote (Valproic Acid)” NCT00996060 ↗
Known as	Depakote ER	“Patients with plasma HIV RNA<50 c/mL added sustained-release VPA (Depakote ER) twice daily, RAL 400 mg twice daily, or ENF 90 mcg twice daily.” PMID 20186346 ↗ Feb 2010 1 “Valproic Acid (Depakote ER) in Patients With Advanced Thyroid Cancer” NCT00525135 ↗
Known as	Epival	“The purpose of this study is to examine whether the co-administration of valproic acid (Epival®), with highly active antiretroviral therapy (HAART) can reduce the size of HIV...” NCT00289952 ↗
Known as	Ergenyl	“E.g. Valproat-neuraxpharm®, Valproat-neuraxpharm® Lösung, Ergenyl®, Ergenyl®-Lösung oder Orfiril® Saft (Valproic acid);” NCT03243461 ↗
Known as	Ergenyl-Lösung	“E.g. Valproat-neuraxpharm®, Valproat-neuraxpharm® Lösung, Ergenyl®, Ergenyl®-Lösung oder Orfiril® Saft (Valproic acid);” NCT03243461 ↗
Known as	Orfiril Saft	“E.g. Valproat-neuraxpharm®, Valproat-neuraxpharm® Lösung, Ergenyl®, Ergenyl®-Lösung oder Orfiril® Saft (Valproic acid);” NCT03243461 ↗
Known as	sodium valproate	“The aim of the present study was therefore to determine the effects of sodium valproate (VPA), a GSK-3 inhibitor, on disease progression in progressive supranuclear palsy (PSP).” PMID 27136096 ↗ Apr 2016
Known as	Sodium valproate or valproic acid (Depakote)	“Sodium valproate or valproic acid (Depakote)” NCT00563992 ↗
Known as	VAL	“valproic acid (VAL, a UGT2B7 inhibiting drug)” NCT03512860 ↗
Known as	Valproat-neuraxpharm	“E.g. Valproat-neuraxpharm®, Valproat-neuraxpharm® Lösung, Ergenyl®, Ergenyl®-Lösung oder Orfiril® Saft (Valproic acid);” NCT03243461 ↗
Known as	Valproat-neuraxpharm Lösung	“E.g. Valproat-neuraxpharm®, Valproat-neuraxpharm® Lösung, Ergenyl®, Ergenyl®-Lösung oder Orfiril® Saft (Valproic acid);” NCT03243461 ↗
Known as	valproate	“We used valproate (VPA), a histone deacetylase inhibitor that has been used for decades as a chronic, safe treatment for epileptic disorders.” PMID 17717136 ↗ Aug 2007
Known as	Valproic acid (VP)	“Valproic acid (VP)” NCT04729543 ↗
Known as	Valproic acid (VPA) (depakote)	“Valproic acid (VPA) (depakote)” NCT00614458 ↗
Known as	VPA	“The objectives of this study are to evaluate the efficacy of Valproic Acid (VPA) to both slow the progression of visual function loss and/or to restore visual function in...” NCT01233609 ↗ 38 “Owing to its HDACi activity and its safe use for epileptic disorders, valproic acid (VPA) is a good candidate for anticancer therapy that we have largely explored preclinically...” PMID 32849914 ↗ Aug 2020 “Valproic acid (VPA), a branched short-chain fatty acid, is widely used in clinical as an antiepileptic drug and a mood stabilizer, primarily in the treatment of epilepsy,...” NCT02761291 ↗ “PURPOSE: To study the efficacy and tolerability of valproic acid (VPA) and radiation, followed by VPA and bevacizumab in children with newly diagnosed diffuse intrinsic pontine...” PMID 32285998 ↗ Apr 2020 “We conducted a phase 1/2 study of the combination of 5-aza-2'-deoxycytidine (decitabine) and the histone deacetylase inhibitor valproic acid (VPA) in patients with advanced...” PMID 16882711 ↗ Aug 2006 “histone deacetylase (HDAC) inhibitor valproic acid (VPA; Barker et al. 2013; Wolff et al. 2008, 2011; Felix et al. 2011; Su et al. 2011; Rokes et al. 2010; Masoudi et al. 2008;...” NCT03243461 ↗ “Due to its histone deacetylase (HDAC) inhibiting activity and its safe use as a chronic therapy for epileptic disorders, valproic acid (VPA) has been considered a good...” PMID 27884140 ↗ Nov 2016 “Conflicting results have been reported regarding the ability of valproic acid (VPA) to reduce the size of HIV reservoirs in patients receiving suppressive highly active...” PMID 22276680 ↗ Jan 2012 “The trial investigates the use of VPA (Valproic Acid) for the treatment of adult patients with biopsy proven idiopathic focal segmentel glomerulosclerosis (FSGS) or minimal...” NCT02896270 ↗ “The aim of the present study was therefore to determine the effects of sodium valproate (VPA), a GSK-3 inhibitor, on disease progression in progressive supranuclear palsy (PSP).” PMID 27136096 ↗ Apr 2016 “Valproic acid (VPA) is a generic low-cost anticonvulsant and mood stabilizer with HDAC inhibitory activity, and anticancer properties also demonstrated in PDAC models.” PMID 39300376 ↗ Sep 2024 Show 28 more sources
Action	Inhibit	“the histone deacetylase inhibitor valproic acid (VPA)” PMID 16882711 ↗ Aug 2006
Modality	Small molecule	“Valproic acid is a short chained fatty acid” NCT00339196 ↗
Route	Oral	“valproic acid (lowest dose in the first 5 patients and a higher dose in patients 6 and 7) orally every 8 hours” NCT00000629 ↗
Target	GSK3B	“valproic acid was able to inhibit the activity of GSK3b” NCT00385710 ↗