drugset / Trial / NCT00879437
Valproic Acid, Radiation, and Bevacizumab in Children With High Grade Gliomas or Diffuse Intrinsic Pontine Glioma
Phase 2
Completed
38 enrolled
Baylor College of Medicine
Cook Children's Medical Center · collabM.D. Anderson Cancer Center · collabThe University of Texas Health Science Center at San Antonio · collabUniversity of Oklahoma · collabUniversity of Texas, Southwestern Medical Center at Dallas · collab
NaSingle-groupOpen-labelTreatment
Summary
Currently, there are few effective treatments for the following aggressive brain tumors: glioblastoma multiforme, anaplastic astrocytoma, gliomatosis cerebri, gliosarcoma, or brainstem glioma. Surgery and radiation can generally slow down these aggressive brain tumors, but in the majority of patients, these tumors will start growing again in 6-12 months. Adding chemotherapy drugs to surgery and radiation does not clearly improve the cure rate of children with malignant gliomas. The investigators are conducting this study to see if the combination of valproic acid and bevacizumab (also known as AvastinTM) with surgery and radiation will shrink these brain tumors more effectively and improve the chance of cure.
Timeline
- Start
- 2009-09-01
- Primary completion
- 2015-08-30
- Completion
- 2017-10-02
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Bevacizumab | Monoclonal antibody | 10 mg/kg | Intravenous |
| Subject | Valproic Acid | Small molecule | 15 mg/kg | — |