drugset / Trial / NCT02670161
Quality Improvement and Practice Based Research in Neurology Using the EMR
Non-randomizedParallel-groupOpen-labelTreatment
Summary
The investigators will conduct at NorthShore University HealthSystem pragmatic trials using the EMR for 10 common neurological disorders. They will demonstrate the feasibility of subgroup based adaptive assignment of treatments, electronic consenting, and outcomes data capture at the point of care using the EMR. They will identify the most effective treatments for common neurological disorders and seek replication by the NPBRN.
Timeline
- Start
- 2016-05
- Primary completion
- 2026-12
- Completion
- 2027-12
Publications
- Background Maraganore DM, Frigerio R, Kazmi N, Meyers SL, Sefa M, Walters SA, Silverstein JC. Quality improvement and practice-based research in neurology using the electronic medical record. Neurol Clin Pract. 2015 Oct;5(5):419-429. doi: 10.1212/CPJ.0000000000000176.
- Background Narayanan J, Dobrin S, Choi J, Rubin S, Pham A, Patel V, Frigerio R, Maurer D, Gupta P, Link L, Walters S, Wang C, Ji Y, Maraganore DM. Structured clinical documentation in the electronic medical record to improve quality and to support practice-based research in epilepsy. Epilepsia. 2017 Jan;58(1):68-76. doi: 10.1111/epi.13607. Epub 2016 Nov 19.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | ACTH | Unknown | — | — |
| Comparator | Amitriptyline | Small molecule | — | — |
| Comparator | Aspirin | Small molecule | — | — |
| Comparator | Clopidogrel | Small molecule | — | — |
| Comparator | Donepezil | Small molecule | — | — |
| Comparator | Duloxetine | Small molecule | — | — |
| Comparator | Lamotrigine | Small molecule | — | — |
| Comparator | Levetiracetam | Other / unclassified | — | — |
| Comparator | Memantine | Unknown | — | — |
| Comparator | Methylprednisolone | Other / unclassified | — | — |
| Comparator | Omega-3 fatty acids | Unknown | — | — |
| Comparator | Pramipexole | Unknown | — | — |
| Comparator | Pregabalin | Small molecule | — | — |
| Comparator | Propranolol | Small molecule | — | — |
| Comparator | Rivastigmine | Small molecule | — | — |
| Comparator | Rotigotine | Unknown | — | — |
| Comparator | Sumatriptan | Unknown | — | — |
| Comparator | Topiramate | Small molecule | — | — |
| Comparator | Valproic Acid | Small molecule | — | — |
| Comparator | Zolmitriptan | Small molecule | — | — |
| Comparator | rizatriptan | Unknown | — | — |
| Comparator | ropinerole | Unknown | — | — |