Drugs / Aspirin
last change 5 days ago re-read 8 days ago

Aspirin

English name Acetylsalicylic Acid

Small molecule targets CDX2, PTGS1 via inhibition

Developed for
coronary artery disorder · preeclampsia · ischemic stroke · venous thromboembolism · acute coronary syndrome · cardiovascular disorder · colorectal cancer · atrial fibrillation
+232 more · myocardial infarction · thrombotic disease · hypertensive disorder · atherosclerosis · type 2 diabetes mellitus · cerebral infarction · COVID-19 · peripheral arterial disease · diabetes mellitus · myocardial ischemia · stroke disorder · breast cancer · fetal growth restriction · platelet aggregation, spontaneous · transient ischemic attack · brain aneurysm · colon carcinoma · intermediate coronary syndrome · ST-elevation myocardial infarction · carotid stenosis · common cold · hypertension, pregnancy-induced · intracerebral hemorrhage · meningeal tuberculosis · migraine disorder · nicotine dependence · non-small cell lung carcinoma · pregnancy disorder · acute myocardial infarction · adenomatous colon polyp · atherosclerotic cardiovascular disease · Barrett esophagus · brain ischemia · cancer · cardiac valvular defect · cerebrovascular disorder · coronary atherosclerosis · cutaneous melanoma · esophageal cancer · heart disorder · HIV infectious disease · infertility disorder · obesity disorder · periodontitis · pharyngitis · prostate cancer · sickle cell disease · systemic lupus erythematosus · vascular disorder · age-related macular degeneration · aortic valve stenosis · arterial disorder · arteriosclerosis disorder · brain infarction · cataract · chronic kidney disease · chronic obstructive pulmonary disease · colon adenoma · coronary stenosis · diabetic kidney disease · diabetic retinopathy · female infertility · habitual spontaneous abortion · head and neck cancer · headache disorder · idiopathic spontaneous coronary artery dissection · intracranial arteriosclerosis · intracranial embolism · ischemic disease · NAFLD1 · nasopharyngeal carcinoma · ovarian carcinoma · peptic ulcer disease · periodontitis, aggressive · placental insufficiency · pneumonia · pulmonary embolism · severe pre-eclampsia · thrombocytopenia · tonsillitis · ulcer of lower limbs · acoustic neuroma · acquired aneurysmal subarachnoid hemorrhage · acute chest syndrome · acute respiratory distress syndrome · acute subendocardial myocardial infarction · adhesions of uterus · adult acute respiratory distress syndrome · antiphospholipid syndrome · aortic disorder · aortic valve disorder · aortic valve insufficiency · aspirin-induced respiratory disease · asthma · autoimmune thyroid disease · basilar artery occlusion · bleeding disorder, vascular-type · brain small vessel disease 4 · breast carcinoma · carotid artery disorder · cervical artery dissection · chronic rhinosinusitis · cirrhosis of liver · colorectal adenoma · colorectal carcinoma · colorectal neoplasm · congenital vascular malformation · coronary thrombosis · critical illness polyneuropathy · dry age related macular degeneration · early-onset schizophrenia · end stage renal failure · endometrial carcinoma · epilepsy · erythropoietin polycythemia · essential hypertension · estrogen-receptor positive breast cancer · exercise-induced malignant hyperthermia · extrahepatic cholestasis · fallopian tube carcinoma · gastroesophageal reflux disease · hepatocellular carcinoma · Her2-receptor negative breast cancer · herpes simplex infectious disease · idiopathic avascular necrosis · inflammatory disease · Kawasaki disease · low density lipoprotein cholesterol, mild elevation of · lung adenocarcinoma · lung carcinoma · major depressive disorder · metastasis from malignant tumor of colon · metastatic malignant neoplasm · mitral valve insufficiency · Moyamoya disease · MRI defined brain infarct · multidrug-resistant tuberculosis · multiple sclerosis · NF2-related schwannomatosis · nonobstructive coronary artery disease · obstetric disorder · oral cavity cancer · ovarian cancer · ovarian neoplasm · pancreas disorder · pelvis syndrome · perinatal disease · peritoneal carcinoma · persistent atrial fibrillation · placental abruption · platinum-induced ototoxicity · polyp of colon · postherpetic neuralgia · postoperative ventricular dysfunction · pregnancy disorder with abortive outcome · pregnancy loss, recurrent, 4 · preneoplastic lesion · prostate adenocarcinoma · prostate carcinoma · protein S deficiency · pulmonary arterial hypertension · pulmonary emphysema · pulmonary tuberculosis · rectal cancer · rectum adenocarcinoma · recurrent acute pancreatitis · relapsing-remitting multiple sclerosis · residual stage angle-closure glaucoma · schizophrenia · severe acute respiratory syndrome · small cell lung carcinoma · squamous cell carcinoma · sudden sensorineural hearing loss · thrombophilia · thrombotic thrombocytopenic purpura · tuberous sclerosis · vascular brain injury · vein disorder · Achoo syndrome · acquired polycythemia vera · acute lung injury · adenomyosis · alcohol-induced mental disorder · alpha 1-antitrypsin deficiency · bipolar depression · bipolar disorder · breast disorder · calcinosis · carotid artery dissection · carotid artery occlusion · central retinal artery occlusion · cerebral artery occlusion · cerebral atherosclerosis · Chagas cardiomyopathy · chronic periodontitis · cognitive impairment with or without cerebellar ataxia · coronary aneurysm · diabetes mellitus, noninsulin-dependent, 2 · diabetic peripheral angiopathy · essential thrombocythemia · flushing of ears and somnolence · frozen shoulder · gastric cancer · gastroesophageal cancer · glioblastoma · glucose intolerance · heart failure · heart valve disorder · infectious disease with sepsis · intermittent vascular claudication · limb ischemia · Lynch syndrome · Lynch syndrome 1 · metabolic dysfunction-associated steatotic liver disease · mood disorder · myeloproliferative neoplasm · ovarian hyperstimulation syndrome · pericarditis · portal vein thrombosis · prediabetes syndrome · primary myelofibrosis · retinal vein occlusion · rheumatic heart disease · rhinitis · schizoaffective disorder · selective intrauterine growth restriction · systemic sclerosis · type 1 diabetes mellitus · vascular dementia · vascular ectasia · vascular occlusion disorder · vertebral artery dissection
Investigated by
Bayer · National Cancer Institute (NCI) · National Heart, Lung, and Blood Institute (NHLBI) · AstraZeneca · Assistance Publique - Hôpitaux de Paris · Boehringer Ingelheim
+704 more · Bristol-Myers Squibb · Johns Hopkins University · UMC Utrecht · Second Affiliated Hospital, School of Medicine, Zhejiang University · Vanderbilt University · Beijing Tiantan Hospital · Brigham and Women's Hospital · Canadian Institutes of Health Research (CIHR) · Medical University of Vienna · University of Florida · Yonsei University · CardioVascular Research Foundation, Korea · Columbia University · Ferrer Internacional S.A. · Massachusetts General Hospital · National Eye Institute (NEI) · Abbott · Asan Medical Center · Beijing Chao Yang Hospital · Beth Israel Deaconess Medical Center · Centre Hospitalier Universitaire de Besancon · Daping Hospital and the Research Institute of Surgery of the Third Military Medical University · Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) · Hamilton Health Sciences Corporation · Merck Sharp & Dohme LLC · PLx Pharma · POZEN · Population Health Research Institute · Royal College of Surgeons, Ireland · Sanofi · Tehran University of Medical Sciences · The First Affiliated Hospital with Nanjing Medical University · United States Department of Defense · Xijing Hospital · Xuanwu Hospital, Beijing · Beijing Friendship Hospital · Boston Scientific Corporation · Capital Medical University · Chinese University of Hong Kong · Daiichi Sankyo · Dartmouth-Hitchcock Medical Center · First Affiliated Hospital Xi'an Jiaotong University · General Hospital of Shenyang Military Region · Imperial College London · Janssen Research & Development, LLC · London School of Hygiene and Tropical Medicine · Mayo Clinic · Medtronic · Ministry of Health, France · Montreal Heart Institute · NYU Langone Health · National Institute of Neurological Disorders and Stroke (NINDS) · National Institutes of Health (NIH) · Odense University Hospital · Peking Union Medical College Hospital · Peking University First Hospital · Samsung Medical Center · Seoul National University Bundang Hospital · Seoul National University Hospital · Shanghai First Maternity and Infant Hospital · University of Aarhus · University of Calgary · University of Maryland, Baltimore · University of Miami · University of Pennsylvania · University of Rochester · University of Roma La Sapienza · Wake Forest University Health Sciences · Abbott Medical Devices · Aga Khan University · Alliance for Clinical Trials in Oncology · Aragon Institute of Health Sciences · Assiut University · Astellas Pharma Inc · all 710 on the full record

Regulatory milestones approvals, filings & regulatory actions · 2 recorded

MilestoneJurisdictionBrandIndicationDateSentence it was read from
Approved EU (EMA) DuoPlavin — 2010-03-14 europa.eu ↗
Approved US (FDA) PERCODAN — 1950-04-12 fda.gov ↗

Trials 600 · started per year

today
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EU approved 2010
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PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 034 trials · 1 missed
Phase 0 NCT03590821 Dec 2027 → Jan 2028 expected — University of Pennsylvania Not yet recruiting No outcome recorded
Phase 0 NCT07525635 Apr 2026 → Aug 2027 expected preeclampsia NYU Langone Health Recruiting No outcome recorded
Phase 0 NCT07205250 Feb 2026 → Jan 2028 expected aortic disorder The General Hospital of Western Theater Command Not yet recruiting No outcome recorded
Phase 0 NCT06933056 Sep 2025 → Sep 2026 overdue — University of Michigan Recruiting No outcome recorded
Phase 0 NCT06378398 Jun 2024 → Feb 2026 colorectal neoplasm University of Michigan Rogel Cancer Center Completed No outcome recorded
Phase 0 NCT06383650 Jun 2024 → May 2025 arterial disorder, vascular brain injury London Health Sciences Centre Unknown No outcome recorded
Phase 0 NCT06168461 Nov 2023 → Jun 2026 overdue preeclampsia Anna Stanhewicz, PhD Recruiting No outcome recorded
Phase 0 NCT05709483 Apr 2023 → Nov 2026 expected preeclampsia Rockefeller University Recruiting No outcome recorded
Phase 0 NCT05308030 Aug 2022 → May 2023 peripheral arterial disease Assiut University Unknown No outcome recorded
Phase 0 NCT05056896 Jun 2022 → Nov 2024 overdue colorectal cancer Massachusetts General Hospital Active not recruiting No outcome recorded
Phase 161 trials · 2 met primary
Phase 1 NCT07853248 Oct 2026 → Jan 2027 expected — HK inno.N Corporation Not yet recruiting No outcome recorded
Phase 1 NCT07652723 May → Dec 2026 expected — Bayer Recruiting No outcome recorded
Phase 1 NCT07265466 Nov 2025 → Mar 2026 overdue — Onconic Therapeutics Inc. Recruiting No outcome recorded
Phase 1 NCT07323680 Jun → Jul 2025 — Rhoshan Pharmaceuticals Inc Completed No outcome recorded
Phase 1 NCT06655194 Feb → Apr 2025 platelet aggregation, spontaneous Bayer Completed No outcome recorded
Phase 1 NCT07444164 Jan 2025 — Laboratorios Silanes S.A. de C.V. Completed No outcome recorded
Phase 1 NCT06444178 Sep 2024 → Apr 2025 — Regeneron Pharmaceuticals Completed No outcome recorded
Phase 1 NCT06277609 Feb → May 2024 — H. Lundbeck A/S Completed No outcome recorded
Phase 1 NCT05702463 Jun 2023 → Jun 2027 expected aspirin resistance, platelet aggregation, spontaneous, type 2 diabetes mellitus Montreal Heart Institute Recruiting No outcome recorded
Phase 1 NCT05625347 Mar → Jun 2023 obstructive lung disease, restrictive pulmonary disease Vectura Limited Terminated No outcome recorded
Phase 1/27 trials · 2 met primary
Phase 1/2 NCT06417411 Mar 2024 → Mar 2026 overdue preeclampsia, sickle cell disease Instituto Nacional de Investigacao em Saude, Angola Active not recruiting No outcome recorded
Phase 1/2 NCT04645004 Dec 2020 → Jan 2024 preeclampsia Thomas Jefferson University Completed No outcome recorded
Phase 1/2 NCT04031729 Sep 2019 → Feb 2023 NAFLD1, metabolic dysfunction-associated steatohepatitis Massachusetts General Hospital Completed Met primary
Phase 1/2 NCT02401269 Apr 2015 → Jan 2016 — University of Pittsburgh Completed No outcome recorded
Phase 1/2 NCT00872534 Jan → Jul 2009 gastrointestinal mucositis PLx Pharma Completed No outcome recorded
Phase 1/2 NCT00771914 Nov 2008 → Jan 2009 — University of Rochester Completed Met primary
Phase 1/2 NCT00174902 Oct 2003 → Aug 2004 arteriosclerosis disorder Swiss Federal Institute of Technology Unknown No outcome recorded
Phase 289 trials · 2 met primary · 18 missed
Phase 2 NCT07663825 Sep 2026 → Sep 2030 expected congenital vascular malformation University Hospital, Tours Not yet recruiting No outcome recorded
Phase 2 NCT07661459 Jun 2026 → Jul 2027 expected cancer Val Adams Not yet recruiting No outcome recorded
Phase 2 NCT06866964 Aug 2025 → Aug 2029 expected germ cell tumor, testicular cancer Wake Forest University Health Sciences Recruiting No outcome recorded
Phase 2 NCT06728072 Mar 2025 → Jul 2035 expected colorectal cancer Virginia Commonwealth University Recruiting No outcome recorded
Phase 2 NCT06554535 Oct 2024 → Oct 2026 expected small cell lung carcinoma Daping Hospital and the Research Institute of Surgery of the Third Military Medical University Not yet recruiting No outcome recorded
Phase 2 NCT06531525 Aug 2024 → Dec 2026 expected pregnancy disorder, protein S deficiency Peking University People's Hospital Not yet recruiting No outcome recorded
Phase 2 NCT06425133 Jul 2024 → Sep 2027 expected colorectal cancer Centre Hospitalier Universitaire de Besancon Recruiting No outcome recorded
Phase 2 NCT05775965 May 2024 → Mar 2027 expected — University of Calgary Recruiting No outcome recorded
Phase 2 NCT05637567 Apr 2024 → Sep 2028 expected pancreas disorder German Cancer Research Center Not yet recruiting No outcome recorded
Phase 2 NCT05567562 Mar 2024 → Feb 2025 pulmonary emphysema Brigham and Women's Hospital Completed Missed primary
Phase 2/322 trials · 1 met primary · 3 missed
Phase 2/3 NCT07337655 Oct 2026 → Sep 2030 expected — Stanford University Not yet recruiting No outcome recorded
Phase 2/3 NCT06068439 Jan 2024 → Jan 2027 expected diabetic kidney disease Second Affiliated Hospital, School of Medicine, Zhejiang University Not yet recruiting No outcome recorded
Phase 2/3 NCT05865548 May 2023 → Aug 2024 oral cavity cancer Banaras Hindu University Completed No outcome recorded
Phase 2/3 NCT05462613 May 2023 → Nov 2029 expected colorectal cancer Centre Hospitalier Universitaire de Besancon Recruiting No outcome recorded
Phase 2/3 NCT05568147 Oct 2022 → Sep 2027 expected thrombotic thrombocytopenic purpura The First Affiliated Hospital of Soochow University Not yet recruiting No outcome recorded
Phase 2/3 NCT04802785 Jun → Jul 2021 — Dinara Zhumanbayeva Unknown No outcome recorded
Phase 2/3 NCT04768179 Feb → Jun 2021 COVID-19 Makerere University Unknown No outcome recorded
Phase 2/3 NCT04491695 Sep 2020 → Dec 2022 stroke disorder Capital Medical University Unknown No outcome recorded
Phase 2/3 NCT04365309 Feb → Apr 2020 COVID-19 Xijing Hospital Unknown No outcome recorded
Phase 2/3 NCT03961360 May 2019 → Apr 2023 obesity disorder, preeclampsia The University of Texas Health Science Center, Houston Completed No outcome recorded
Phase 3129 trials · 9 met primary · 23 missed
Phase 3 NCT06774846 Jul 2028 → Oct 2031 expected pneumonia Centre Hospitalier Universitaire Dijon Not yet recruiting No outcome recorded
Phase 3 NCT07524335 Jul 2026 → Jul 2027 expected atherosclerotic cardiovascular disease, coronary artery disorder Montreal Heart Institute Recruiting No outcome recorded
Phase 3 NCT07665853 Jul 2026 → May 2028 expected preeclampsia Hospital Universitari Vall d'Hebron Research Institute Not yet recruiting No outcome recorded
Phase 3 NCT07113158 Apr 2026 → Apr 2029 expected sudden sensorineural hearing loss Assistance Publique - Hôpitaux de Paris Not yet recruiting No outcome recorded
Phase 3 NCT05963568 Apr 2026 → Jan 2029 expected stroke disorder Northern California Institute of Research and Education Recruiting No outcome recorded
Phase 3 NCT06980025 Jul 2025 → Dec 2028 expected obstetric disorder The George Washington University Biostatistics Center Recruiting No outcome recorded
Phase 3 NCT06930885 Jun 2025 → May 2031 expected atherosclerotic cardiovascular disease Hospital do Coracao Recruiting No outcome recorded
Phase 3 NCT06952712 May 2025 → May 2028 expected preeclampsia FANG HE Not yet recruiting No outcome recorded
Phase 3 NCT06494878 Apr 2025 → Aug 2030 expected venous thromboembolism University of Calgary Not yet recruiting No outcome recorded
Phase 3 NCT06518317 Nov 2024 → Nov 2028 expected — University Hospital, Caen Recruiting No outcome recorded
Show all 129 trials opens the full record — a long page
Phase 4155 trials · 11 met primary · 17 missed
Phase 4 NCT07496281 Mar 2027 → Feb 2032 expected atrial fibrillation, coronary artery disorder Ewha Womans University Mokdong Hospital Not yet recruiting No outcome recorded
Phase 4 NCT07683923 Mar 2027 → Feb 2033 expected acute coronary syndrome, idiopathic spontaneous coronary artery dissection University Medical Center Hamburg-Eppendorf Not yet recruiting No outcome recorded
Phase 4 NCT07854795 Feb 2027 → Dec 2030 expected coronary artery disorder Vestre Viken Hospital Trust Not yet recruiting No outcome recorded
Phase 4 NCT07602257 Oct 2026 → Dec 2029 expected — Ottawa Heart Institute Research Corporation Not yet recruiting No outcome recorded
Phase 4 NCT07281547 Aug 2026 → Jun 2027 expected endometrial carcinoma Mayo Clinic Not yet recruiting No outcome recorded
Phase 4 NCT07431762 Jun 2026 → Oct 2030 expected cardiac valvular defect Asan Medical Center Recruiting No outcome recorded
Phase 4 NCT07642427 Jun 2026 → May 2029 expected acquired aneurysmal subarachnoid hemorrhage, brain ischemia Ganzhou City People's Hospital Not yet recruiting No outcome recorded
Phase 4 NCT07644234 Jun 2026 → Dec 2028 expected transient ischemic attack Sichuan Provincial People's Hospital Not yet recruiting No outcome recorded
Phase 4 NCT07563673 May 2026 → Sep 2027 expected cerebral infarction Beijing Chao Yang Hospital Not yet recruiting No outcome recorded
Phase 4 NCT07592507 May 2026 → Feb 2032 expected coronary artery disorder Daejeon St. Mary's hospital Not yet recruiting No outcome recorded
Show all 155 trials opens the full record — a long page
Phase not applicable103 trials · 7 met primary · 3 missed
— NCT07677410 Jul 2026 → Jul 2029 expected aortic valve insufficiency Shanghai Zhongshan Hospital Not yet recruiting No outcome recorded
— NCT06937372 Jul 2026 → Oct 2027 expected venous thromboembolism Queen Mary University of London Recruiting No outcome recorded
— NCT07658989 May 2026 → Jan 2030 expected cardiac valvular defect, pregnancy disorder Mount Sinai Hospital, Canada Recruiting No outcome recorded
— NCT07846462 Mar 2026 → Mar 2029 expected acute coronary syndrome, coronary artery disorder Jilin University Recruiting No outcome recorded
— NCT07432516 Feb 2026 → Jun 2033 expected coronary artery disorder Yonsei University Not yet recruiting No outcome recorded
— NCT06535568 Jan 2026 → Jan 2028 expected acute coronary syndrome, arterial occlusion, atherosclerosis, coronary stenosis Fondazione Ricerca e Innovazione Cardiovascolare ETS Recruiting No outcome recorded
— NCT07041385 Nov 2025 → Jun 2027 expected preeclampsia Shalamar Hospital Not yet recruiting No outcome recorded
— NCT07240454 Oct 2025 → Dec 2027 expected — Tao Liu Recruiting No outcome recorded
— NCT07198529 Sep 2025 → Sep 2029 expected coronary artery disorder Korea University Guro Hospital Recruiting No outcome recorded
— NCT07852585 Aug 2025 → Jun 2026 preeclampsia Muhammad Aamir Latif Completed No outcome recorded
Comparator or background therapy733 trials
Phase 0 NCT07832578 Comparator Jun → Dec 2026 expected limb ischemia King Edward Medical University Recruiting No outcome recorded
Phase 0 NCT06339021 Background Apr 2024 → Dec 2026 expected ST-elevation myocardial infarction Shenyang Northern Hospital Not yet recruiting No outcome recorded
Phase 0 NCT04040465 Comparator Feb → Oct 2021 aspirin resistance University of Utah Completed No outcome recorded
Phase 0 NCT04153760 Comparator Oct 2020 → Sep 2023 venous thromboembolism University of Calgary Completed No outcome recorded
Phase 0 NCT04535804 Comparator Oct 2020 → Sep 2022 adenomyosis Shanghai First Maternity and Infant Hospital Unknown No outcome recorded
Show all 733 trials opens the full record — a long page

Press releases naming this drug 33 releases

DateIssuerRelease
2025-02-18 Bayer New Research Highlights the Role of Aspirin and Advanced Ultrasound Techniques in Cardiovascular Health bayer.com ↗
2024-08-21 Abbott Abbott Advances Heart Failure Management with Aspirin Free Regimen for Patients Receiving the HeartMate 3™ Heart Pump mediaroom.com ↗
2023-11-14 Janssen Research & Development, LLC New VOYAGER PAD Analyses Reinforce Benefit of XARELTO® (rivaroxaban) Plus Aspirin Across High-Risk and Complex Patient Populations with Peripheral Artery Disease (PAD) jnj.com ↗
2023-11-13 Abbott Late-Breaking Data Show an Aspirin-Free Medication Regimen Benefits People with Abbott's HeartMate 3™ Heart Pump mediaroom.com ↗
2023-03-05 Janssen Research & Development, LLC New VOYAGER PAD Analysis Confirms Consistent Benefit of XARELTO® (rivaroxaban) Plus Aspirin Following Lower Extremity Revascularization (LER) jnj.com ↗
2022-05-23 Janssen Research & Development, LLC New Data From Two Large Studies Reinforce Effectiveness of Dual Pathway Inhibition (DPI) with XARELTO® (rivaroxaban) Plus Aspirin in Patients with Coronary Artery Disease (CAD) and/or Peripheral Artery Disease (PAD) jnj.com ↗
2022-05-23 Janssen Research & Development, LLC New Data From Two Large Studies Reinforce Effectiveness of Dual Pathway Inhibition (DPI) with XARELTO® (rivaroxaban) Plus Aspirin in Patients with Coronary Artery Disease (CAD) and/or Peripheral Artery Disease (PAD) jnj.com ↗
2022-04-01 Janssen Research & Development, LLC Data from New VOYAGER PAD Analyses at ACC.22 Reinforce Benefit of XARELTO® (rivaroxaban) Plus Aspirin in Patients with Peripheral Artery Disease (PAD) and Various Co-Morbid Conditions jnj.com ↗
2021-10-13 Hyloris Developments Hyloris Acquires Breakthrough, Patented Technology to Develop and Market Aspirin IV in the U.S. in Acute Coronary Syndrome hyloris.com ↗
2021-09-27 Janssen Research & Development, LLC New Phase 3 Data Suggest Positive Effect and Show Similar Safety with XARELTO® (rivaroxaban) Compared to Aspirin in Pediatric Fontan Procedure Patients at Risk for Blood Clots and Blood Clot-Related Events jnj.com ↗
2021-09-27 Janssen Research & Development, LLC New Phase 3 Data Suggest Positive Effect and Show Similar Safety with XARELTO® (rivaroxaban) Compared to Aspirin in Pediatric Fontan Procedure Patients at Risk for Blood Clots and Blood Clot-Related Events jnj.com ↗
2021-08-24 Janssen Research & Development, LLC FDA Approves Expanded Peripheral Artery Disease (PAD) Indication for XARELTO® (rivaroxaban) Plus Aspirin to Include Patients After Lower-Extremity Revascularization (LER) Due to Symptomatic PAD jnj.com ↗

Evidence & citations 75 cited values

Every value below carries the sentence it was read from. 1,352 sources stand behind the page.

FieldValueCited text
Known as Aspirin “patients aged 18 years or older with an acute coronary syndrome who completed the IVUS-ACS study and who had no major ischaemic or bleeding events after 1-month treatment with...” PMID 38599220 ↗ Apr 2024
1145

“The purpose of this pilot study is to collect data on pregnancies with mechanical heart valves to see if using a blood thinner called low molecular weight heparin (LMWH) and...” NCT07658989 ↗

“Thromboprophylactic regimens Aspirin®(acetylsalicylic acid, AA, Bayer) 300mg/day or Xarelto® (rivaroxaban, factor Xa-inhibitor, Bayer) 10mg/day will be randomly(according to...” NCT02271399 ↗

“This is a research study to compare the efficacy of aspirin (acetylsalicylic acid) and pneumatic compression devices versus enoxaparin (also known as Lovenox) and pneumatic...” NCT01696760 ↗

“Eligible patients, who have a history or new onset paroxysmal, persistent, or permanent non-valvular AF, referred to the study centers with indications for PCI will be randomly...” PMID 26003433 ↗ May 2015

“Dual antiplatelet therapy (DAPT) with aspirin and a P2Y12 receptor inhibitor, more frequently clopidogrel, represents the standard of care for the long-term secondary...” NCT02548650 ↗

“A total of 2268 STEMI patients indicated for primary PCI with current generation platinum‑chromium everolimus-eluting stents were randomized 1:1 to either prasugrel monotherapy...” PMID 41436299 ↗ Dec 2025

“Aspirin 100mg once/day during the follow-up period, Clopidogrel 75mg once/day for at least 90 days, Atorvastatin 20-80mg once/day as the situation requires and risk factors...” NCT03703635 ↗

“The Investigator will decide if to use aspirin or clopidogrel, whereas ticagrelor or prasugrel are not recommended in our study population since no benefit (or even harm) has...” NCT06535568 ↗

“Every antiplatelet-naïve patient undergoing an elective procedure will be given 300 mg aspirin and loading dose of one of P2Y12 receptor inhibitors (e.g., 600 mg clopidogrel,...” NCT02601157 ↗

“Participants were randomly assigned (1:1) to receive DAPT (ticagrelor 90 mg twice daily plus aspirin 100 mg once daily) for 12 months or the same dual antiplatelet regimen for...” PMID 42120081 ↗ May 2026

Show 1,135 more sources

Known as acetylsalicyclic acid “Patients will be randomized to dabigatran or acetylsalicyclic acid (ASA) (1:1 ratio)” NCT02239120 ↗
Known as Acetylsalicylate ClinicalTrials.gov intervention name — accepted as the source's own label NCT01681615 ↗
Known as acetylsalicylic acid “To investigate the relative bioavailability of telmisartan respectively of dipyridamole after concomitant administration of 80 mg telmisartan in Micardis® and 25 mg...” NCT02262793 ↗
240

“The goal of this clinical trial is to compare the pharmacokinetics (PK) pharmacodynamics (PD), safety and tolerability of acetylsalicylic acid powder for oral inhalation...” NCT05625347 ↗

“An Open-label, Randomized, Single-center, 2-way Cross-over Interaction Study, Evaluating the Effect of Esomeprazole 20 mg/Acetylsalicylic Acid 81 mg on the Pharmacodynamics and...” NCT01210339 ↗

“This study aims to evaluate the benefits of Acetylsalicylic acid (ASA) as an add-on treatment to local non-steroidal anti-inflammatory drug for the management of thrombotic...” NCT07663825 ↗

“Cardiovascular Fixed Dose Combination Pill: A Pharmacodynamic Interaction Study to Evaluate the Effect of a Fixed Dose Combination of Acetylsalicylic Acid, Simvastatin and...” NCT01005290 ↗

“Open-label Randomized, Three-fold Cross-over, Single-center Interaction Study to Investigate the Influence of Multiple Doses of Acetylsalicylic Acid (ASA) (Aspirin) on the...” NCT07652723 ↗

“We investigated whether low-dose acetylsalicylic acid (ASA, aspirin) administration prior to and during exposure to an experimental sleep restriction challenge affects cellular...” PMID 41686719 ↗ Feb 2026

“Intervention group will discontinuate of Acetyl Salicylic acid at 24-28 weeks of gestation while Control Group will continue Acetyl Salicylic acid 150 mg/day until 36 weeks of...” NCT07665853 ↗

“Using the minimisation method in an online randomisation system, patients were randomly assigned (1:1) to receive 100 mg acetylsalicylic acid once per day in either the...” PMID 39577920 ↗ Dec 2024

“The present randomised controlled trial tests aspirin (acetylsalicylic acid (ASA)) as a convenient method to prevent overheating and improve exercise performance in persons with MS.” PMID 33191260 ↗ Nov 2020

“Durability of Antiplatelet Effect of a Novel Extended-Release Formulation of Acetylsalicylic Acid, Durlaza in CVD (Cardiovascular Disease) Patients at Risk of High Platelet Turnover” NCT02370680 ↗

Show 230 more sources

Known as Acetylsalicylic acid (ASA) “Acetylsalicylic acid (ASA)” NCT04575519 ↗
4

NCT00789308 ↗

NCT01424332 ↗

NCT01486433 ↗

NCT02217501 ↗

Known as Albyl-E “Trombyl® or Albyl-E® (Acetylsalicylicacid- ASA)” NCT00789308 ↗
Known as ASA “To investigate the relative bioavailability of telmisartan respectively of dipyridamole after concomitant administration of 80 mg telmisartan in Micardis® and 25 mg...” NCT02262793 ↗
94

“Study 2: subjects received clopidogrel alone (75 mg/day for 9 days) and clopidogrel alone for 4 days followed by clopidogrel plus fixed-combination esomeprazole 20 mg/low-dose...” PMID 24677117 ↗ Jun 2014

“This study aims to evaluate the benefits of Acetylsalicylic acid (ASA) as an add-on treatment to local non-steroidal anti-inflammatory drug for the management of thrombotic...” NCT07663825 ↗

“Subjects will continue DAPT with clopidogrel and Aspirin (ASA) up to 1 month, after which patients will be given ASA and placebo in next 5 months and then continue on...” NCT03287167 ↗

“Open-label Randomized, Three-fold Cross-over, Single-center Interaction Study to Investigate the Influence of Multiple Doses of Acetylsalicylic Acid (ASA) (Aspirin) on the...” NCT07652723 ↗

“We investigated whether low-dose acetylsalicylic acid (ASA, aspirin) administration prior to and during exposure to an experimental sleep restriction challenge affects cellular...” PMID 41686719 ↗ Feb 2026

“Apixaban Versus Acetylsalicylic Acid (ASA) to Prevent Stroke in Atrial Fibrillation Patients Who Have Failed or Are Unsuitable for Vitamin K Antagonist Treatment: A Randomized...” NCT00496769 ↗

“However, single anti-platelet therapy with acetylsalicylic acid (ASA) without clopidogrel has been reported to improve bleeding outcomes and a composite of bleeding and...” NCT05035277 ↗

“The present randomised controlled trial tests aspirin (acetylsalicylic acid (ASA)) as a convenient method to prevent overheating and improve exercise performance in persons with MS.” PMID 33191260 ↗ Nov 2020

“Daily dose of 0.5 mg calcitriol (1a -25-dihydroxycholecalciferol, Rocaltrol; Roche, Basel, Switzerland), 75 mg acetylsalicylic acid (ASA), and 1250 mg calcium carbonate (CaCO3).” NCT00486512 ↗

“Fifty patients with T2D and carotid atherosclerotic plaques were randomly assigned to either a 200 mg/d cilostazol (CTZ) group or a 100 mg/d aspirin (ASA) group for 6 months.” PMID 32700396 ↗ Sep 2020

Show 84 more sources

Known as Ascriptin “Drug: aspirin 81 mg by mouth, daily for 3 months (on aspirin for 1 month prior to starting study and 2 months with Choline supplementation during study) Other Names: Ecotrin,...” NCT01731236 ↗
Known as ASP “Aspirin 100mg, po, once per day (Qd) prescribed if needed and adjusted due to patient response to 32 weeks of pregnancy. 75mg po, once per day (Qd) to 34 weeks of pregnancy....” NCT04976465 ↗
1

“Aspirin (ASP), originally extracted from willow bark, is a small molecule compound with various effects such as antipyretic, anti-inflammatory, analgesic, and antiplatelet aggregation.” NCT06554535 ↗

Known as Aspegic “Aspegic ® (Aspirin),100 mg/day” NCT00986765 ↗
Known as Aspir Low “Drug: aspirin 81 mg by mouth, daily for 3 months (on aspirin for 1 month prior to starting study and 2 months with Choline supplementation during study) Other Names: Ecotrin,...” NCT01731236 ↗
Known as Aspir-Trin “Drug: aspirin 81 mg by mouth, daily for 3 months (on aspirin for 1 month prior to starting study and 2 months with Choline supplementation during study) Other Names: Ecotrin,...” NCT01731236 ↗
Known as Aspirin (ASA) “Aspirin (ASA)” NCT01823510 ↗
1

“Aspirin (ASA)” NCT01642238 ↗

Known as Aspirin 325Mg Tab “Aspirin 325Mg Tab, Aspirin 81Mg Tab” NCT05868525 ↗
Known as aspirin 81mg EC tab “aspirin 81mg EC tab” NCT05567562 ↗
Known as Aspirin 81Mg Tab “Aspirin 325Mg Tab, Aspirin 81Mg Tab” NCT05868525 ↗
Known as Aspirin cardio “Aspirin® cardio (CH) or Aspirin® protect (DE, AT) Film coated tablets Acetylsalicylic acid 100 mg Once daily oral intake for 6 months” NCT04128956 ↗
Known as Aspirin Enteric-coated Tablets “Aspirin Group: Antiplatelet therapy was initiated on the second day after surgery with oral administration of Aspirin Enteric-coated Tablets (Bayer Aspirin) at a dose of 100 mg...” NCT06738992 ↗
2

“Aspirin Enteric-coated Tablets, 0.1g/d by mouth” NCT03176498 ↗

“Drug: Aspirin Enteric-Coated Tablets” NCT07378228 ↗

Known as aspirin lysine “Provided with supply of aspirin (aspirin lysine) for periods 1, 2 and 3 (2 boxes of 30 sachets)” NCT04990791 ↗
Known as Aspirin protect “Aspirin® cardio (CH) or Aspirin® protect (DE, AT) Film coated tablets Acetylsalicylic acid 100 mg Once daily oral intake for 6 months” NCT04128956 ↗
Known as Aspirin tablet “Drug: Aspirin Tablet, 100 mg/d” NCT03186456 ↗
2

“Drug: Aspirin tablet” NCT05568147 ↗

“Drug: Aspirin Tablet” NCT03306550 ↗

Known as Aspirin: acid acetylsalycilic “Aspirin: acid acetylsalycilic” NCT00822536 ↗
Known as Aspirin: Aspirin Protect (Bayer) 100mg “Aspirin: Aspirin Protect (Bayer) 100mg” NCT00947843 ↗
Known as Aspirin: Astrix “Aspirin: Astrix” NCT01663038 ↗
Known as ASPIRINA “A single dose 500 milligrams of Acetylsalicylic acid (ASPIRINA®, 500 mg) will be intravenously administered.” NCT05225961 ↗