Early Prevention of Preeclampsia Study

Terminated 104 enrolled Washington University School of Medicine

RandomizedParallel-groupQuadruple-blindTreatment

Summary

This is a randomized controlled trial to estimate the efficacy of low dose aspirin for preventing preeclampsia in women identified as high risk. The investigators hypothesize that the risk of preeclampsia in women identified by a first trimester multiparameter predictive model to be at high risk will be significantly reduced by initiating low dose aspirin early in pregnancy.

Timeline

Start: 2012-03
Primary completion: 2015-07-20
Completion: 2015-07-20

Outcome

Missed primary endpoint

Stopped: “Terminated after Aspirin was recommended by the USPTF to Prevent Preeclampsia.”

paper There was no evidence that the primary outcome of pre-eclampsia was prevented by low-dose aspirin (relative risk (RR) 0.88, 95% CI 0.21-3.66). PMID 25914193 ↗

Publications

Odibo AO, Goetzinger KR, Odibo L, Tuuli MG. Early prediction and aspirin for prevention of pre-eclampsia (EPAPP) study: a randomized controlled trial. Ultrasound Obstet Gynecol. 2015 Oct;46(4):414-8. doi: 10.1002/uog.14889. Epub 2015 Aug 31.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Aspirin	Small molecule	81 mg	—