Coronary Artery Disease After Heart Transplantation

Summary

This study evaluates coronary artery disease after heart transplantation and its relation to platelet function. Furthermore, we will evaluate extracorporeal photopheresis as treatment of coronary artery disease after heart transplantation.

Timeline

Start

2016-10-13

Primary completion

2021-10-01

Completion

2021-10-01

Publications

• Background Clemmensen TS, Munk K, Tram EM, Ilkjaer LB, Severinsen IK, Eiskjaer H. Twenty years' experience at the Heart Transplant Center, Aarhus University Hospital, Skejby, Denmark. Scand Cardiovasc J. 2013 Dec;47(6):322-8. doi: 10.3109/14017431.2013.845688. Epub 2013 Oct 16.
• Background Stehlik J, Edwards LB, Kucheryavaya AY, Benden C, Christie JD, Dipchand AI, Dobbels F, Kirk R, Rahmel AO, Hertz MI; International Society of Heart and Lung Transplantation. The Registry of the International Society for Heart and Lung Transplantation: 29th official adult heart transplant report--2012. J Heart Lung Transplant. 2012 Oct;31(10):1052-64. doi: 10.1016/j.healun.2012.08.002. No abstract available.
• Background Berry GJ, Burke MM, Andersen C, Bruneval P, Fedrigo M, Fishbein MC, Goddard M, Hammond EH, Leone O, Marboe C, Miller D, Neil D, Rassl D, Revelo MP, Rice A, Rene Rodriguez E, Stewart S, Tan CD, Winters GL, West L, Mehra MR, Angelini A. The 2013 International Society for Heart and Lung Transplantation Working Formulation for the standardization of nomenclature in the pathologic diagnosis of antibody-mediated rejection in heart transplantation. J Heart Lung Transplant. 2013 Dec;32(12):1147-62. doi: 10.1016/j.healun.2013.08.011.
• Background Patel J, Klapper E, Shafi H, Kobashigawa JA. Extracorporeal photopheresis in heart transplant rejection. Transfus Apher Sci. 2015 Apr;52(2):167-70. doi: 10.1016/j.transci.2015.02.004. Epub 2015 Feb 11.
• Background Barten MJ, Dieterlen MT. Extracorporeal photopheresis after heart transplantation. Immunotherapy. 2014;6(8):927-44. doi: 10.2217/imt.14.69.
• Background Matsuo Y, Cassar A, Li J, Flammer AJ, Choi BJ, Herrmann J, Gulati R, Lennon RJ, Kang SJ, Maehara A, Kitabata H, Akasaka T, Lerman LO, Kushwaha SS, Lerman A. Repeated episodes of thrombosis as a potential mechanism of plaque progression in cardiac allograft vasculopathy. Eur Heart J. 2013 Oct;34(37):2905-15. doi: 10.1093/eurheartj/eht209. Epub 2013 Jun 19.
• Background Cassar A, Matsuo Y, Herrmann J, Li J, Lennon RJ, Gulati R, Lerman LO, Kushwaha SS, Lerman A. Coronary atherosclerosis with vulnerable plaque and complicated lesions in transplant recipients: new insight into cardiac allograft vasculopathy by optical coherence tomography. Eur Heart J. 2013 Sep;34(33):2610-7. doi: 10.1093/eurheartj/eht236. Epub 2013 Jun 25.
• Background Arbustini E, Dal Bello B, Morbini P, Gavazzi A, Specchia G, Vigano M. Multiple coronary thrombosis and allograft vascular disease. Transplant Proc. 1998 Aug;30(5):1922-4. doi: 10.1016/s0041-1345(98)00526-0. No abstract available.
• Background Modjeski KL, Morrell CN. Small cells, big effects: the role of platelets in transplant vasculopathy. J Thromb Thrombolysis. 2014 Jan;37(1):17-23. doi: 10.1007/s11239-013-0999-4.
• Background Maeda A. Extracorporeal photochemotherapy. J Dermatol Sci. 2009 Jun;54(3):150-6. doi: 10.1016/j.jdermsci.2009.03.002. Epub 2009 Apr 14.
• Background Ward DM. Extracorporeal photopheresis: how, when, and why. J Clin Apher. 2011;26(5):276-85. doi: 10.1002/jca.20300. Epub 2011 Sep 5.
• Background Lu WH, Palatnik K, Fishbein GA, Lai C, Levi DS, Perens G, Alejos J, Kobashigawa J, Fishbein MC. Diverse morphologic manifestations of cardiac allograft vasculopathy: a pathologic study of 64 allograft hearts. J Heart Lung Transplant. 2011 Sep;30(9):1044-50. doi: 10.1016/j.healun.2011.04.008. Epub 2011 Jun 2.
• Background Gould KL, Lipscomb K. Effects of coronary stenoses on coronary flow reserve and resistance. Am J Cardiol. 1974 Jul;34(1):48-55. doi: 10.1016/0002-9149(74)90092-7. No abstract available.

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