drugset / Trial / NCT00536068
Platelet Inhibition by Aspirin, Acetaminophen and NSAID
RandomizedParallel-groupSingle-blindTreatment
Summary
Nonsteroidal antiinflammatory drugs such as diclofenac or naproxen may interfere with the inhibition of platelet aggregation by aspirin, because they all interact with the platelet cyclooxygenase.This may be of great clinical importance because of an increased cardiovascular event rate (myocardial infarction, stroke). The present randomized, controlled study analyses in vitro platelet aggregation under a combined treatment of healthy volunteers with aspirin and either acetaminophen, diclofenac, naproxen, or placebo.
Timeline
- Start
- 2006-08
- Primary completion
- —
- Completion
- 2007-08
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Acetaminophen | Small molecule | 1 g | Oral |
| Subject | Aspirin | Small molecule | 100 mg | Oral |
| Subject | Diclofenac | Other / unclassified | 50 mg | Oral |
| Subject | Naproxen | Small molecule | 250 mg | Oral |