Drugs / Diclofenac
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Diclofenac

Other / unclassified targets KMO, MYC, PPARG via inhibition

Developed for
osteoarthritis, knee · osteoarthritis · pulpitis · actinic keratosis · chronic pain syndrome · neuropathy, painful · osteoarthritis, hip · primary dysmenorrhea
+83 more · breast cancer · cataract · cystoid macular edema · macular retinal edema · migraine disorder · osteoarthritis, hand · periapical periodontitis · acute apical periodontitis · acute pancreatitis · anal fistula · aphthous stomatitis · arthritic joint disease · benign neoplasm of skin · breast disorder · carpal tunnel syndrome · chronic periodontitis · COVID-19 · dental pulp disorder · diabetic retinopathy · disease of the tendon · dry eye syndrome · glaucoma · head and neck neoplasm · headache disorder · hemorrhoid · impacted teeth, multiple · intervertebral disk degenerative disorder · migraine with aura · migraine without aura · musculoskeletal system disorder · neurofibroma · neurofibromatosis type 1 · non-small cell lung carcinoma · pancreatitis · patellofemoral pain syndrome · photosensitivity disease · respiratory tract infectious disorder · rheumatoid arthritis · sciatica · senile cataract · subarachnoid hemorrhage · sunburn · temporomandibular joint dysfunction syndrome · tenosynovitis of foot and ankle · thrombophlebitis · tinea unguium · traumatic brain injury · urinary tract infection · urolithiasis · uveitis · akinetic mutism · alcohol dependence · ankylosing spondylitis · arthropathy · basal cell carcinoma · bicipital tenosynovitis · brain injury · cholecystitis · common bile duct disorder · complex regional pain syndrome type 1 · congenital patella dislocation, unilateral · de Quervain disease · dental pulp necrosis · diabetic macular edema · dysmenorrhea · epicondylitis · frozen shoulder · gastric ulcer · gout · Graves disease · hand-foot syndrome · otitis externa · pericardial effusion · pharyngitis · postherpetic neuralgia · pulmonary embolism · rotator cuff syndrome · skin cancer · synovial bursa disorder · temporomandibular joint disorder · ureterolithiasis · urinary tract obstruction · uterine inflammatory disease
Investigated by
Novartis · Cairo University · Organon and Co · Iroko Pharmaceuticals, LLC · Pfizer · Boehringer Ingelheim
+173 more · Depomed · GlaxoSmithKline · IBSA Institut Biochimique SA · Javelin Pharmaceuticals · Merck Sharp & Dohme LLC · Novartis Pharmaceuticals · Assiut University · Cerimon Pharmaceuticals · Mallinckrodt · Montefiore Medical Center · Noven Pharmaceuticals, Inc. · PPD Development, LP · Sandoz · ZetrOZ, Inc. · Aga Khan University · Almirall, S.A. · Amzell · BDD Pharma Ltd · Beth Israel Deaconess Medical Center · Brigham and Women's Hospital · Drug Delivery International Ltd · Food and Drug Administration (FDA) · Grünenthal GmbH · HALEON · HaEmek Medical Center, Israel · Hamad Medical Corporation · National Cancer Institute (NCI) · Novum Pharmaceutical Research Services · Nuvo Research Inc. · Pakistan Institute of Medical Sciences · University of Debrecen · University of Sao Paulo · Xanodyne Pharmaceuticals · A.O.U. Città della Salute e della Scienza · Actavis Inc. · Ain Shams University · Air Force Military Medical University, China · Al-Azhar University · Alabama Physical Therapy & Acupuncture · Albert Einstein College of Medicine · Amneal Pharmaceuticals, LLC · Anchen Pharmaceuticals, Inc · Anne Chang · Argentine Tennis Association · Armed Forces Institute of Dentistry, Pakistan · Arthritis Treatment Center, Maryland · Assumpta Nnenna Nweke · Ataturk University · Baskent University · Bezmialem Vakif University · British University In Egypt · Brown, Theodore R., M.D., MPH · CMH Multan Institute of Medical Sciences · Campbell Clinic · Chengdu University of Traditional Chinese Medicine · China Medical University Hospital · Clinic for Infectious Diseases, University Hospital Bern, Switzerland · Clinical Hospital Center, Split · Coordenação de Aperfeiçoamento de Pessoal de Nível Superior. · Cross Research S.A. · Dalia Salah Saif · Danish Headache Center · Daré Bioscience, Inc. · Eduardo Barbosa Coelho · Eisai Inc. · Emory University · Encube Ethicals Pvt. Ltd. · Endo USA Inc., a Keenova Therapeutics Company · Eye Clinic Medic Zuljan Jukic · FPR Specialty Pharmacy · Farjad Zafar · Farmoquimica S.A. · Federal University of the Valleys of Jequitinhonha and Mucuri · Fidia Farmaceutici s.p.a. · all 179 on the full record

Regulatory milestones approvals, filings & regulatory actions · 6 recorded

MilestoneJurisdictionBrandIndicationDateSentence it was read from
Label expansion US (FDA) ZIPSOR 2021-05-25 fda.gov
Label expansion US (FDA) VOLTAREN ARTHRITIS PAIN 2020-02-14 fda.gov
Label expansion US (FDA) ZORVOLEX 2014-08-22 fda.gov
Label expansions (2) US (FDA) VOLTAREN 1996-07-23 – 1998-02-25 fda.gov
Approved US (FDA) VOLTAREN 1988-07-28 fda.gov

Trials 224 · started per year

today
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PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 06 trials
Phase 0 NCT06500871 Aug 2024 → May 2025 overdue pulpitis Cairo University Not yet recruiting No outcome recorded
Phase 0 NCT06053411 Mar 2024 → Aug 2026 overdue Washington State University Recruiting No outcome recorded
Phase 0 NCT05413096 Jun 2021 → Oct 2022 aphthous stomatitis Al-Azhar University Completed No outcome recorded
Phase 0 NCT03145259 Apr 2017 → Aug 2019 University of Maryland, Baltimore Completed No outcome recorded
Phase 0 NCT02485145 Jul → Dec 2015 osteoarthritis, hand Transdermal Therapeutics, Inc. Unknown No outcome recorded
Phase 0 NCT01592019 Apr → Nov 2012 University of Florida Completed No outcome recorded
Phase 133 trials
Phase 1 NCT06510062 Jul → Sep 2024 ZetrOZ, Inc. Completed No outcome recorded
Phase 1 NCT05968482 Jul → Dec 2023 Amzell Completed No outcome recorded
Phase 1 NCT05752526 May → Oct 2023 primary dysmenorrhea Daré Bioscience, Inc. Completed No outcome recorded
Phase 1 NCT05254574 Feb 2022 → May 2026 overdue osteoarthritis ZetrOZ, Inc. Recruiting No outcome recorded
Phase 1 NCT04882319 Jun 2021 → Mar 2022 osteoarthritis, knee Noven Pharmaceuticals, Inc. Completed No outcome recorded
Phase 1 NCT04900129 Dec 2020 COVID-19 Sher-E-Bangla Medical College Completed No outcome recorded
Phase 1 NCT04391842 Sep → Dec 2019 osteoarthritis, knee ZetrOZ, Inc. Completed No outcome recorded
Phase 1 NCT04235426 Jan 2018 → Jan 2021 carpal tunnel syndrome Dalia Salah Saif Unknown No outcome recorded
Phase 1 NCT04585321 Nov 2017 → May 2018 Fidia Farmaceutici s.p.a. Completed No outcome recorded
Phase 1 NCT03074162 Apr → Jun 2017 Boehringer Ingelheim Completed No outcome recorded
Phase 1/22 trials
Phase 1/2 NCT06439251 Oct 2023 → Jun 2025 patellofemoral pain syndrome University of Lahore Completed No outcome recorded
Phase 1/2 NCT03519152 Mar 2016 → May 2017 chronic periodontitis Tatyasaheb Kore Dental College Completed No outcome recorded
Phase 222 trials
Phase 2 NCT06731270 Apr 2025 → Jan 2027 expected non-small cell lung carcinoma Emory University Recruiting No outcome recorded
Phase 2 NCT06184685 Oct → Nov 2021 osteoarthritis, knee Thammasat University Completed No outcome recorded
Phase 2 NCT04341402 May 2020 → Mar 2021 tinea unguium William N Handelman Unknown No outcome recorded
Phase 2 NCT03949673 Apr 2019 → Aug 2020 osteoarthritis, hip, osteoarthritis, knee Regeneron Pharmaceuticals Terminated No outcome recorded
Phase 2 NCT04591795 Jan 2018 → Oct 2020 osteoarthritis Mr NARIN KAKATUM Unknown No outcome recorded
Phase 2 NCT03277066 Sep 2017 → Sep 2019 osteoarthritis, knee Noven Pharmaceuticals, Inc. Completed No outcome recorded
Phase 2 NCT03825016 Aug 2017 → Jan 2020 Ain Shams University Completed No outcome recorded
Phase 2 NCT03090971 Feb → Mar 2017 neurofibroma, neurofibromatosis type 1 Fundação Educacional Serra dos Órgãos Completed No outcome recorded
Phase 2 NCT02424578 May 2015 → Apr 2016 Iroko Pharmaceuticals, LLC Completed No outcome recorded
Phase 2 NCT02598102 Apr → Aug 2015 Institute of Nephro Urology, Bangalore Completed No outcome recorded
Phase 2/36 trials
Phase 2/3 NCT06207253 Nov → Dec 2025 overdue dental pulp disorder British University In Egypt Recruiting No outcome recorded
Phase 2/3 NCT03341260 Dec 2016 → Feb 2018 pulpitis Cairo University Completed No outcome recorded
Phase 2/3 NCT03174860 Oct 2016 → Feb 2018 pulpitis Cairo University Completed No outcome recorded
Phase 2/3 NCT02714699 Oct 2016 → Mar 2017 Assiut University Completed No outcome recorded
Phase 2/3 NCT03163420 Jul 2016 → Jul 2017 pulpitis Cairo University Unknown No outcome recorded
Phase 2/3 NCT00276419 Jun 2005 → May 2009 breast disorder Mayo Clinic Terminated No outcome recorded
Phase 360 trials
Phase 3 NCT07145645 Apr 2026 → Sep 2027 expected musculoskeletal system disorder University of Calgary Recruiting No outcome recorded
Phase 3 NCT06693648 Feb → Dec 2025 osteoarthritis, knee Amzell Completed No outcome recorded
Phase 3 NCT06731556 Dec 2024 Bezmialem Vakif University Completed No outcome recorded
Phase 3 NCT06561035 Sep 2024 → Aug 2025 overdue Campbell Clinic Enrolling by invitation No outcome recorded
Phase 3 NCT05312645 Dec 2023 → Aug 2024 headache disorder Loma Linda University Withdrawn No outcome recorded
Phase 3 NCT05171673 Oct 2021 → Jun 2024 IBSA Institut Biochimique SA Completed No outcome recorded
Phase 3 NCT05626140 Sep 2021 → May 2022 sciatica Pakistan Institute of Medical Sciences Completed No outcome recorded
Phase 3 NCT04683627 Dec 2020 → Jul 2022 osteoarthritis, knee Noven Pharmaceuticals, Inc. Completed No outcome recorded
Phase 3 NCT03597867 Apr → Jul 2018 University of Trieste Completed No outcome recorded
Phase 3 NCT03826550 Jan → Jun 2018 actinic keratosis Encube Ethicals Pvt. Ltd. Completed No outcome recorded
Phase 453 trials
Phase 4 NCT07565012 Oct 2025 → Mar 2026 periapical periodontitis, pulpitis Armed Forces Institute of Dentistry, Pakistan Completed No outcome recorded
Phase 4 NCT07379762 Feb → Jul 2025 CMH Multan Institute of Medical Sciences Completed No outcome recorded
Phase 4 NCT06379893 Apr → Oct 2024 HALEON Completed No outcome recorded
Phase 4 NCT05761015 Dec 2023 → Apr 2028 expected chronic pain syndrome, osteoarthritis, hip, osteoarthritis, knee University Hospital, Clermont-Ferrand Recruiting No outcome recorded
Phase 4 NCT05211154 May 2022 → Apr 2025 migraine with aura, migraine without aura Danish Headache Center Terminated No outcome recorded
Phase 4 NCT06231043 Apr 2022 → Mar 2023 Lampang Hospital Completed No outcome recorded
Phase 4 NCT05188131 Oct → Dec 2021 hypopituitarism A.O.U. Città della Salute e della Scienza Completed No outcome recorded
Phase 4 NCT04585438 Sep 2021 → Sep 2022 pulpitis Cairo University Unknown No outcome recorded
Phase 4 NCT05488925 Jun 2021 → Feb 2022 pulpitis Farjad Zafar Completed No outcome recorded
Phase 4 NCT04611529 Mar 2021 → Jun 2023 Montefiore Medical Center Completed No outcome recorded
Phase not applicable41 trials
NCT07101016 Aug 2025 overdue periapical periodontitis Mariam Hesham Mahmoud Abdelfattah Eissa Not yet recruiting No outcome recorded
NCT07646093 May 2025 Hospital Universitario de Caracas Completed No outcome recorded
NCT06954181 Mar → Apr 2025 HALEON Completed No outcome recorded
NCT06905561 Feb 2025 → Jun 2026 overdue breast cancer, head and neck neoplasm The Second Affiliated Hospital of Hainan Medical University Recruiting No outcome recorded
NCT06574191 Jan 2025 → Jan 2028 expected osteoarthritis, knee University of California, Davis Recruiting No outcome recorded
NCT07203651 Jan → Jun 2025 overdue Pakistan Institute of Medical Sciences Active not recruiting No outcome recorded
NCT06453291 Jul 2024 → Apr 2025 overdue chronic pain syndrome Iffat Anwar Medical Complex Recruiting No outcome recorded
NCT06937853 May 2024 → Jul 2025 overdue Ataturk University Recruiting No outcome recorded
NCT06632015 Jan → May 2024 acute apical periodontitis Mustafa Kemal University Completed No outcome recorded
NCT06307106 Jan → Oct 2024 Zagazig University Completed No outcome recorded
Phase not stated1 trial
NCT01579890 osteoarthritis, hand Mallinckrodt Approved for marketing No outcome recorded
Also used as a comparator or background therapy in 211 trials
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 03 trials
Phase 0 NCT06029296 Comparator Jul 2024 → Aug 2026 overdue alcohol-related disorders University of Maryland, Baltimore Active not recruiting No outcome recorded
Phase 0 NCT07016451 Background Apr 2024 → Sep 2025 radiation cystitis Ramathibodi Hospital Completed No outcome recorded
Phase 0 NCT05582421 Comparator Dec 2022 → Oct 2023 dental pulp necrosis, periapical periodontitis Cairo University Unknown No outcome recorded
Phase 18 trials
Phase 1 NCT06752486 Comparator Dec 2024 → May 2025 overdue Research Institute of Ophthalmology, Egypt Recruiting No outcome recorded
Phase 1 NCT06636227 Comparator Dec 2024 → May 2026 overdue alcohol dependence University of Maryland, Baltimore Recruiting No outcome recorded
Phase 1 NCT06729073 Comparator Nov 2024 → Jun 2025 Amzell Completed No outcome recorded
Phase 1 NCT05883241 Background Jun 2023 → Feb 2026 overdue disease of bone structure ZetrOZ, Inc. Recruiting No outcome recorded
Phase 1 NCT04330547 Comparator Feb 2018 → Feb 2019 akinetic mutism, brain injury University of Liege Completed No outcome recorded
Phase 1/25 trials
Phase 1/2 NCT06158620 Comparator Mar 2025 → Apr 2027 expected ureterolithiasis, urolithiasis University of Texas Southwestern Medical Center Recruiting No outcome recorded
Phase 1/2 NCT06829030 Comparator Jul 2024 → Feb 2025 overdue Aksaray University Training and Research Hospital Enrolling by invitation No outcome recorded
Phase 1/2 NCT06252441 Comparator Mar 2024 → May 2025 pancreatitis Tanta University Completed No outcome recorded
Phase 1/2 NCT05050448 Comparator Aug 2021 → Dec 2022 osteoarthritis, knee ZetrOZ, Inc. Completed No outcome recorded
Phase 1/2 NCT01413854 Comparator Aug 2011 Region Skane Withdrawn No outcome recorded
Phase 224 trials
Phase 2 NCT07663825 Background Sep 2026 → Sep 2030 expected congenital vascular malformation University Hospital, Tours Not yet recruiting No outcome recorded
Phase 2 NCT06257537 Comparator Oct 2024 → Jun 2026 osteoarthritis, knee ZetrOZ, Inc. Completed No outcome recorded
Phase 2 NCT05882812 Comparator Jun → Dec 2023 osteoarthritis, knee ZetrOZ, Inc. Completed No outcome recorded
Phase 2 NCT05641246 Comparator Dec 2022 → Nov 2023 hand-foot syndrome German University in Cairo Completed No outcome recorded
Phase 2 NCT05653401 Comparator Nov 2022 → Aug 2023 urinary tract obstruction University of Monastir Completed No outcome recorded
Phase 2/310 trials
Phase 2/3 NCT03595150 Comparator Jan 2026 → Dec 2027 expected common bile duct disorder Karolinska Institutet Not yet recruiting No outcome recorded
Phase 2/3 NCT05871086 Background May → Dec 2023 juvenile idiopathic arthritis Nourhan Elsherif Unknown No outcome recorded
Phase 2/3 NCT03691844 Comparator Oct 2018 → Jul 2019 osteoarthritis, knee Amzell Completed No outcome recorded
Phase 2/3 NCT03178539 Comparator Jan 2017 → Dec 2018 Assiut University Completed No outcome recorded
Phase 2/3 NCT03380533 Comparator Sep 2016 → Dec 2017 rotator cuff syndrome Hospital Italiano de Buenos Aires Completed No outcome recorded
Phase 331 trials
Phase 3 NCT07475663 Comparator Nov 2025 → Feb 2026 epicondylitis, osteoarthritis, knee, patellofemoral pain syndrome, tenosynovitis of foot and ankle Taisho Pharmaceutical Indonesia Completed No outcome recorded
Phase 3 NCT07304882 Background Nov 2023 → Jan 2025 impacted teeth, multiple University of Science and Technology, Yemen Completed No outcome recorded
Phase 3 NCT06594822 Comparator Aug 2023 → Jan 2024 rheumatoid arthritis King Edward Medical University Completed No outcome recorded
Phase 3 NCT05816226 Comparator Jun 2023 → Jan 2026 overdue temporomandibular joint disorder University of the Pacific Recruiting No outcome recorded
Phase 3 NCT02985671 Comparator Jan → Sep 2021 Ache Laboratorios Farmaceuticos S.A. Unknown No outcome recorded
Phase 461 trials
Phase 4 NCT07506265 Comparator May → Dec 2025 pulpitis Fayoum University Completed No outcome recorded
Phase 4 NCT06918340 Comparator Nov → Dec 2024 overdue Haydarpasa Numune Training and Research Hospital Active not recruiting No outcome recorded
Phase 4 NCT07088042 Comparator Sep 2024 → Feb 2025 pulpitis Ain Shams University Completed No outcome recorded
Phase 4 NCT06373978 Comparator Aug 2024 → Jun 2026 overdue chronic pain syndrome The Cleveland Clinic Recruiting No outcome recorded
Phase 4 NCT06012097 Comparator Jun 2024 → Apr 2026 overdue de Quervain disease University Hospital, Strasbourg, France Recruiting No outcome recorded
Phase not applicable69 trials
NCT06942702 Comparator May → Aug 2026 overdue Mersin University Not yet recruiting No outcome recorded
NCT07493226 Comparator Apr 2026 → Feb 2027 expected frozen shoulder, neuropathy, painful Konya Beyhekim Training and Research Hospital Recruiting No outcome recorded
NCT07598994 Comparator Aug 2025 → Apr 2026 temporomandibular joint disorder Istanbul University Completed No outcome recorded
NCT07071012 Comparator Aug 2025 → Feb 2026 Hacettepe University Completed No outcome recorded
NCT07178639 Comparator Aug 2025 → Feb 2026 overdue cataract, cystoid macular edema Nemocnice Kolín Recruiting No outcome recorded

Press releases naming this drug 2 releases

DateIssuerRelease
2019-03-01 Teva Branded Pharmaceutical Products R&D, Inc. Teva Announces Launch of an Authorized Generic of Flector® Patch (diclofenac epolamine topical patch) in the United States tevapharm.com
2000-02-22 Teva Branded Pharmaceutical Products R&D, Inc. Teva Pharmaceutical Industries Ltd. to Launch Generic Equivalent of Voltaren XR Immediately tevapharm.com

Evidence & citations 62 cited values

Every value below carries the sentence it was read from. 446 sources stand behind the page.

FieldValueCited text
Known as Diclofenac “This study evaluated the proarrhythmic potential of hydroxypropyl-β-cyclodextrin (HPβCD)-diclofenac, a novel injectable diclofenac formulation solubilized with...” PMID 23578606 Apr 2013
356

“Patients will use the preservative-free dexamethasone 0.1% 4 times a day in the first week after cataract surgery, 3 times a day in the second week, twice daily in the third...” NCT04050644

“(VOLTAREN®) Emulgel 1% contain the active ingredient diclofenac which belongs to the NSAIDS.it has analgesic and anti-inflammatory properties and due to its alcohol base it has...” NCT05641246

“An Evaluator-blinded, Randomized Within-subject Repeat Insult Study to Evaluate Potential Skin Irritation and Sensitization of HP-5000 (Diclofenac Sodium Topical System) in...” NCT04882319

“Voltaren® (diclofenac) orally with water at the dose 50 mg thrice daily for 3 days (150 mg total daily dose), then 25 mg thrice daily for 9 days (75 mg total daily dose)” NCT04067492

“Purpose: This is a randomized clinical trial comparing the effects of three different medications for acute low back pain (LBP):Ketorolac, Ibuprofen, DiclofenacNCT03861611

“Intraoperative administration intravenous of dipyrone 30-50 mg/Kg and or intravenous ketoprofen 100 mg or diclofenac 75 mg or ketorolac 30 mg” NCT01734954

“Solaraze-topical diclofenac 3% and Vaniqa-topical eflornithine hydrochloride Cream, 13.9% applied to bilateral arms for a period of 9 months” NCT04091022

Diclofenac sodium gel in 3 different concentrations as- Diclofenac sodium 1%, 1.16% and 2.32% whichever was available in the given region.” NCT06379893

“The participants will receive non-steroidal anti- inflammatory drugs (NSAID), Diclofenac 20 mg/ day for 3 consecutive menstrual cycles.” NCT06976151

“Drug: intra muscular injection Diclofenac Sodium 50 mg and then oral Tablet Diclofenac Sodium 50 mg, once patient starts taking orally.” NCT05507554

diclofenac (Voltaren) 3 X 50mg per day for 4 weeks. If the patient's TMJ pain improves, the dosage may be reduced to 2 X 50mg per day.” NCT03409874

“The purpose of this study is to see if the drug Pennsaid (Diclofenac) can help reduce pain felt by people with chronic nerve pain.” NCT01508676

“All patients without contraindications should receive 100mg rectal indomethacin or diclofenac within 30mins before ERCP procedure” NCT07117318

“Tandrilax (caffeine, carisoprodol, sodium diclofenac, paracetamol). Tablets, administered 3 times a day, for 7 consecutive days.” NCT01421433

“Patients randomized into this group (n=40) will, again by simple randomization, be given oral tablets of etodolac or diclofenacNCT07493226

“A solution including both ropivacain and diclofenac continuously delivered to the wound is used for post-cesarean pain control” NCT01211431

“Infiltration of 40 mg of methylprednisolone acetate plus 1 mL of xylocaine and Diclofenac sodium 100 mg PO QD for 10 days” NCT01205477

“Oral acetaminophen (1 g) and diclofenac (50 mg) administered during the first 24 hours postpartum together every 8 houers” NCT07534969

“Patients with AS were randomised for treatment with either continuous (150 mg/day) or on-demand diclofenac for 2 years.” PMID 26242443 Aug 2015

diclofenac 50 mg twice a day, prednisone 5mg once daily, methotrexate 10mg once weekly or sulfasalazine 500 twice daily” NCT06594822

“G1 (CONTROL): Oral NSAID (diclofenac, three times a day) administrated pre-operatively and for 3 days after surgery.” NCT00935116

“a product containing the non-steroidal anti-inflammatory drug diclofenac (Voltaren) on trapezius trigger point pain.” NCT03939884

“IMP would have been either placebo, tanezumab, celecoxib, naproxen or diclofenac administered in parent study.” NCT02674386

“patients will be randomized to either receive an unmarked suppository of Diclofenac or a placebo suppository.” NCT01542567

“IMP would have been either placebo, tanezumab, celecoxib, naproxen, diclofenac, administered in parent study” NCT03031938

“Orally administered NSAID (naproxen 500 mg, celecoxib 100 mg or diclofenac 75 mg) twice daily for 56 weeks” NCT02528188

“GGA 50mg three times daily plus diclofenac sodium 75mg once a day for patients with rheumatic diseases.” NCT01547559

“All patients had oral paracetamol 500mg, 4 times/day and diclofenac 75mg, 1 times/day after surgery.” NCT06630520

“Efficiency and Safety a Fixed Combination of Orphenadrine and Diclofenac for Postoperative Analgesia” NCT05322603

Diclofenac is one of potent, standard and most unique NSAID for the therapy of postoperative pain.” NCT03520595

“NSAIDs include Ibuprofen, Naproxen, Diclofenac, and Piroxicam. Oral contraceptives include Yasmin.” NCT03881319

Diclofenac sodium 75mg sustained release tablet once daily was given to both groups for 3 months.” NCT01120015

Diclofenac Na 0.1% Oph Soln, "Dicloftil®", NSAID eyedrops administered three days before surgery” NCT03597867

“2. Diclofenac 75 milligram (mg) twice per day from postoperative day 7 to postoperative day 14.” NCT06561035

“participants received 1% topical diclofenac gel on the tender points 3 times /day for 4 weeks.” NCT04270968

“IM diclofenac sodium (75 mg amp) (Voltaren, Novartis Pharmaceuticals Corporation, Switzerland)” NCT04508894

“Topical spray containing Diclofenac 1.16%, Linseed Oil 3%, Menthol 5%, Methyl salicylate 10%.” NCT02400320

“the amount of the drug diclofenac which penetrates (enters) the fatty tissue under the skin” NCT01592019

“all patients were received intraoperative diclofenac sodium 0.5 mg/kg intramuscular” NCT04614259

“with Group A receiving additional Phonophoresis using ultrasound and diclofenac gel” NCT06439251

“gastric/duodenal risk only: diclofenac, 50-100 mg per intake, plus lansoprazole” NCT05761015

“Voltaren® Schmerzgel forte; 2.32% containing 2.32% Diclofenac-N-Ethylethanamin.” NCT06954181

“After 12, 24 and 48 hours from patient arrival: TAB. Diclofenac 100 milligrams.” NCT01764048

“oral Voltaren sustained-release tablets (diclofenac) at 0.5 mg/kg twice daily.” NCT07613346

“including oral celecoxib, topical diclofenac, and other skin protectants” NCT06602167

“* Diclofenac - 2 to 3 mg/kg/day in divided doses 2 to 3 times daily” NCT05871086

“preservative-free dexamethasone (DEX), diclofenac (DICLO) eye drops” PMID 36602718 Jan 2023

“NSAIDs include Ibuprofen, Naproxen, Diclofenac, and Piroxicam.” NCT04296422

Diclofenac 100 mg / 12h / 5 days by mouth (Post-operatively).” NCT04110587

“Topical gel containing lidocaine (2%) plus diclofenac (0.5%)” NCT02961855

“Ultrasound (BM1-1039) Ultrasonic massage with Diclofenac gel” NCT04082793

“NSAIDs: ibuprofen, celecoxib, or diclofenac/misoprostol” NCT01943435

“intravenous diclofenac 75 mg twice daily will be added.” NCT04657952

“Rectal diclofenac 100mg and misoprostol 400mcg stat” NCT03518463

“transdermal diclofenac patch - 200mg for group B” NCT06146491

“Topical diclofenac emulgel (Voltaren) 11.6 mg/g.” NCT07145645

“Medications: Ibuprofen, Naproxen, or Diclofenac.” NCT06453291

“Intramuscular diclofenac will be administered” NCT03413163

“75 mg of Diclofenac intramuscular Injection” NCT06276231

“100 mg of suppository diclofenac 12 hourly” NCT04539249

Diclofenac 75mg c 12h Tramadol 50mg c 12h.” NCT03380533

diclofenac sodium (Drug class: NSAIDs)” NCT02384928

“NSAIDs (e.g., Ibuprofen, Diclofenac)” NCT07016451

“75 mg (3ml) intramuscular DiclofenacNCT04849468

Diclofenac gel on the target knee” NCT03691844

diclofenac (Diclobene) 100mg” NCT06710600

“Eye drops diclofenac 1mg/ml” NCT02059018

Diclofenac 3% - an NSAID.” NCT02485145

Diclofenac 5%” NCT00530387

DiclofenacNCT01638962

DiclofenacNCT02094807

DiclofenacNCT02132416

NCT00171665

NCT01067430

NCT00171652

NCT00171626

NCT02445599

NCT06829030

NCT00931866

NCT04511195

NCT02752971

NCT02027792

NCT00507026

NCT01066520

NCT05653401

NCT06845930

NCT03041779

NCT00171691

NCT00171678

NCT00174317

NCT00377806

NCT03473665

NCT05254574

NCT01335724

NCT02476422

NCT00640432

NCT03472339

NCT03471507

NCT02088411

NCT03199924

NCT05968482

NCT01666197

NCT00640705

NCT01946984

NCT01939743

NCT07610265

NCT00943098

NCT00942448

NCT02709590

NCT06857110

NCT00471393

NCT07475663

NCT01350622

NCT00509743

NCT04585438

NCT05752526

NCT04511832

NCT00640939

NCT00474136

NCT00371696

NCT02417337

NCT01860833

NCT05211154

NCT06257537

NCT07178639

NCT01358045

NCT06252441

NCT00092742

NCT02547896

NCT00766402

NCT00092703

NCT02121002

NCT07203651

NCT04500509

NCT03090971

NCT05188131

NCT06864078

NCT05312645

NCT04585321

NCT03949673

NCT03781544

NCT06158620

NCT03605914

NCT00548678

NCT02689024

NCT03277066

NCT00914160

NCT00913887

NCT00954785

NCT01935531

NCT00276419

NCT02556970

NCT01300312

NCT02194088

NCT03458923

NCT06231043

NCT02760888

NCT05171673

NCT02428777

NCT01694212

NCT06373978

NCT03145259

NCT06220279

NCT03298646

NCT00913224

NCT04199572

NCT06192420

NCT00476593

NCT05398874

NCT00542087

NCT03341260

NCT03039426

NCT04591795

NCT01272947

NCT02193620

NCT04593160

NCT01019980

NCT02100670

NCT01039545

NCT02666846

NCT02440399

NCT02192203

NCT06184685

NCT07500454

NCT05413096

NCT02287376

NCT02287350

NCT00601640

NCT03362216

NCT04421911

NCT02876432

NCT02506348

NCT03745599

NCT06905561

NCT07598994

NCT00204542

NCT03174860

NCT04402047

NCT02286453

NCT02132247

NCT03493490

NCT01383954

NCT01812928

NCT02636569

NCT03766984

NCT02837770

NCT00648141

NCT03269591

NCT04611529

NCT03996564

NCT00777127

NCT05121233

NCT00141102

NCT05882812

NCT02306031

NCT01876615

NCT02187614

NCT07071012

NCT00649610

NCT00140972

NCT00726388

NCT07071441

NCT00140933

NCT00140920

NCT01255423

NCT06918340

NCT04391842

NCT00650598

NCT01717599

NCT00139646

NCT03506763

NCT01246180

NCT01967550

NCT00985439

NCT07646093

NCT00894790

NCT02183129

NCT01413854

NCT00428025

NCT02181920

NCT00484120

NCT02419651

NCT03595150

NCT02007161

NCT01229774

NCT02918812

NCT02714231

NCT05050448

NCT00221052

NCT01054820

NCT07696104

NCT02598102

NCT00671320

NCT04235426

NCT03116672

NCT06731556

NCT05026320

NCT00869180

NCT06729073

NCT00869063

NCT03910088

NCT00619034

NCT00999791

NCT00448110

NCT02229747

NCT02596451

NCT00792376

NCT03519152

NCT00447759

NCT01596647

NCT07131527

NCT03072485

NCT03831321

NCT02495831

NCT00090181

NCT00536068

NCT01055470

NCT03221946

NCT00264147

NCT02361619

NCT06937853

NCT05883241

NCT01590342

NCT02714842

NCT06500871

NCT00441051

NCT02332057

NCT06012097

NCT02952898

NCT06510062

NCT06942702

NCT01453179

NCT01202799

NCT06943092

NCT02779530

NCT02068859

NCT03074162

NCT01454791

NCT01456611

NCT00800527

NCT06693648

NCT05582421

NCT00864097

NCT01579890

NCT03528824

NCT01458600

NCT00801528

NCT07379762

NCT04976088

NCT01461369

NCT04330547

NCT02425709

NCT00491192

NCT01462435

NCT03714672

NCT01761071

NCT05947461

NCT00568217

NCT00805090

NCT00108992

NCT02255045

NCT06029296

NCT02169154

NCT03081728

NCT01762306

NCT01891435

NCT02171507

NCT01481610

NCT01907984

NCT02528201

NCT00595543

NCT06566794

NCT01009021

NCT00242489

NCT00523120

NCT06574191

NCT04900129

NCT03020368

NCT02424578

NCT01190722

NCT07663825

NCT02700815

NCT03178539

NCT05626140

NCT00247052

NCT04874675

NCT06053411

NCT01541137

NCT00250445

NCT06636227

NCT02433418

NCT04860167

NCT04819828

NCT01510912

NCT05816226

NCT00825864

Known as AMZ001 AMZ001 (Diclofenac Sodium Gel 3.06%)” NCT05968482
1

AMZ001 Diclofenac gel” NCT06693648

Known as Cataflam “Diclofenac group, which received diclofenac 50 mg capsules (Cataflam) and placebo sprays.” NCT03745599
4

“Drug: diclofenac sodium (cataflam)” NCT02714231

“oral diclofenac (Cataflam)” NCT00548678

NCT02674191

NCT07088042

Known as DCS “Diclofenac Sodium (DCS)” NCT07506265
1

“Diclofenac Sodium (DCS)” NCT06632015

Known as DF-ME DF-ME, which consists of 2% diclofenac sodium, was compounded according to the published instructions by RS Therapeutics Inc. (Canada) and stored in the same containers as SHT-ME.” NCT06184685
Known as DIC075V “intravenous diclofenac sodium (DIC075V) in adult volunteers” NCT00509743
3

“Intravenous Diclofenac (DIC075V): 1 of 2 dosage levels” NCT00448110

“Intravenous diclofenac sodium (DIC075V) 18.75 mg” NCT00474136

“intravenous diclofenac sodium (DIC075V)” NCT00548678

Known as DICL-SR “with Diclofenac Sodium Sustained Release Tablets (DICL-SR) 75mg, quaque die(QD)” NCT02826031
Known as DICLO “preservative-free dexamethasone (DEX), diclofenac (DICLO) eye drops” PMID 36602718 Jan 2023
Known as Dicloabak “Dexamethasone 0.1% (Monofree Dexamethason) and Diclofenac 0.1% (Dicloabak) Eye Drops Versus Preserved Dexamethasone 0.1% (Maxidex) and Diclofenac 0.1% (Voltaren Ophtha) Eye...” NCT04050644
Known as Diclobene “diclofenac (Diclobene) 100mg” NCT06710600
Known as Diclofenac 50 mg oral tablet Diclofenac 50 mg oral tabletNCT03506763
Known as Diclofenac diethylamine 1.16% gel “Drug: Diclofenac diethylamine 1.16% gelNCT06729073
Known as Diclofenac epolamine “A topical formulation of diclofenac (FLECTOR diclofenac epolamine topical system (FDETS)) is approved in adults for the treatment of acute pain due to minor strains, sprains,...” PMID 34826122 Nov 2021
2

“Reference product: Active-comparator, Diclofenac epolamine (DIEP) 180 mg medicated plaster, Flector®, topical application once a day” NCT04976088

“FLECTOR® Patch (diclofenac epolamine topical patch) 1.3%” NCT01054820

Known as Diclofenac Epolamine Patch “Drug: Diclofenac Epolamine PatchNCT03145259
Known as Diclofenac hydroxyethylpyrrolidine “Drug: Diclofenac hydroxyethylpyrrolidineNCT01946984
Known as Diclofenac Microemulsion “Drug: Diclofenac MicroemulsionNCT06184685
Known as Diclofenac Na “Preservative- free Diclofenac Na 0.1% eye drops (Voltaren Ophta SDU;Novartis Pharms). One drop four times daily in one eys for three days.” NCT00476593
1

Diclofenac Na gel” NCT00601640

Known as Diclofenac Na 0.1% Oph Soln Diclofenac Na 0.1% Oph SolnNCT03597867
Known as diclofenac potassium “BACKGROUND: Diclofenac potassium for oral solution (CAMBIA®) may be an alternative for patients who would otherwise need to be seen in a healthcare setting for parenteral ketorolac.” PMID 31833000 Dec 2019
18

“The first group will be given gabapentin orally in a dose of 300mg Tid for 72 hours and the second group will be given oral diclofenac potassium 50mg Tid for 72 hours.” NCT06752486

“NSAIDs, Diclofenac Potassium in this study, is known as a drug which is effective for pain control and is as effective as coxib in acute pain management.” NCT01762306

“The tablets being tested will contain the drug, diclofenac potassium.” NCT02004301

“preoperative Diclofenac Potassium (50 mg Cataflam)” NCT03174860

Diclofenac Potassium for Oral Solution 50 mg” NCT02287376

“Oral diclofenac potassium 50 mg” NCT00474136

“Drug: Diclofenac PotassiumNCT02255045

“Drug: Diclofenac potassiumNCT02476422

NCT06298383

NCT00375934

NCT00366444

NCT01257126

NCT04608981

NCT04622488

NCT06731270

NCT03163420

NCT02714699

NCT02658799

Known as Diclofenac Sodium “In a randomized, double-blind, placebo-controlled trial, men and women aged > or = 40 years diagnosed with primary OA in the dominant hand were randomly assigned to self-apply...” PMID 19648310 Jul 2009
89

“A Randomized, Double-blind, Multi-site, Comparator-controlled, Phase III Trial to Evaluate the Efficacy and Safety of a Fixed-dose Combination of Tramadol Hydrochloride and...” NCT03714672

Diclofenac sodium gel (DSG) is one of the commonly used topical NSAIDs, which can provide local pain relief for patients with hand OA with reduced systemic exposure,...” NCT04402047

“From one week before surgery, case group received diclofenac sodium drop 0.1% (Sina Darou Laboratories Company, Tehran, Iran) every 6 hours.Theses drops continued up to 6 weeks...” NCT02306031

“The objective of this study was to investigate the efficacy and safety of diclofenac sodium 2% topical solution BID versus vehicle control solution for treating pain associated...” PMID 26506138 Nov 2015

“An Evaluator-blinded, Randomized Within-subject Repeat Insult Study to Evaluate Potential Skin Irritation and Sensitization of HP-5000 (Diclofenac Sodium Topical System) in...” NCT04882319

“Cerimon Pharmaceuticals is investigating a topical patch formulation of diclofenac sodium containing 15 mg of diclofenac sodium for the local treatment of acute musculoskeletal pain.” NCT00640939

“Cerimon Pharmaceuticals is investigating a topical patch formulation of diclofenac sodium containing 15 mg of diclofenac sodium for the local treatment of acute musculoskeletal pain.” NCT00640705

“OBJECTIVE: To evaluate the safety and efficacy of topical diclofenac sodium 1% gel (DSG) versus vehicle in patients aged 25-64 or ≥65 years who have been diagnosed with knee OA.” PMID 21174485 Jan 2011

Diclofenac sodium 140 mg medicated plaster (Itami®) will be applied twice daily (12 hours apart) for 15 days starting from the evening of Day 0 (visit 2), i.e. 30 applications” NCT04585334

“Objective: To compare the analgesic effectiveness of diclofenac sodium, bupivacaine or bupivacaine plus diclofenac sodium infiltrating wound appendectomies.” NCT02752971

“A single oral dose of 100 mg diclofenac sodium will be administered to participants in the Diclofenac Sodium Group prior to the endodontic procedure.” NCT06937853

“Patients received 75 mg of inj. Diclofenac sodium (diluted in 100 ml of 0.9 % normal saline) intravenously 30 mins before the start of procedure” NCT04860167

Diclofenac sodium gel in 3 different concentrations as- Diclofenac sodium 1%, 1.16% and 2.32% whichever was available in the given region.” NCT06379893

“Treatment of Acute Pseudophakic Cystoid Macular Edema: Bromfenac 0.09% Versus Diclofenac Sodium 0.1% Versus Ketorolac Tromethamine 0.5%” NCT00595543

“Intravenous Infusion of Diclofenac Sodium is administered at the dose of 75 mg, diluted in 100 ml of isotonic saline, over 15 minutes.” NCT05188131

“To demonstrate the relative bioavailability of Diclofenac Sodium 75 mg enteric-coated tablets under non-fasting conditions.” NCT00913887

“Patients will receive approximately 2 h prior to the procedure 1 tablet of diclofenac sodium 50 mg and 1 tablet of placebo.” NCT03506763

“0.1 microgram morphine (IV) and diclofenac sodium 75 mg intramuscularly will perform for postoperative analgesia.” NCT04148729

“Daily Application antifungal gel of miconazole 3% and diclofenac sodium 1% and urea 40% to infected nails.” NCT04341402

“Over-encapsulated ARTHROTEC® 75 (75 mg diclofenac sodium/200 mcg misoprostol) capsules given by mouth bid.” NCT00594854

“injectable diclofenac sodium, Dyloject®, is solubilized with hydroxypropyl β-cyclodextrin (HPβCD)” PMID 22886837 Aug 2012

“IM diclofenac sodium (75 mg amp) (Voltaren, Novartis Pharmaceuticals Corporation, Switzerland)” NCT04508894

“Test product: Diclofenac Sodium 140 mg medicated plaster, topical application once a day” NCT04976088

diclofenac sodium delayed release tablets 75 mg by mouth twice daily (BID) for 6 days” NCT00650598

“with Diclofenac Sodium Sustained Release Tablets (DICL-SR) 75mg, quaque die(QD)” NCT02826031

“the sixth group consisted of 25 participants receiving diclofenac sodiumNCT01993589

diclofenac sodium topical solution, diclofenac topical solution 1.5%” NCT03471507

“Amoxicillin 500 mg, Metronidazole 500 mg, Diclofenac sodium 50 mg” NCT07304882

Diclofenac sodium topical gel 1% (Anchen Pharmaceuticals, Inc.)” NCT01456611

“Give antibiotics or diclofenac sodium suppository as needed.” NCT06105827

“intravenous diclofenac sodium (DIC075V) in adult volunteers” NCT00509743

“Solaraze® (Diclofenac sodium) 2x/day topical for 3 months” NCT00204542

Diclofenac Sodium 50 mg associated with Codeine 50 mg” NCT02665533

Diclofenac sodium gel, 3% is an FDA-approved drug.” NCT02952898

“Intravenous diclofenac sodium (DIC075V) 18.75 mg” NCT00474136

Diclofenac Sodium Active Topical Patch 1” NCT03277066

“intravenous diclofenac sodium (DIC075V)” NCT00548678

“DIC075V (intravenous diclofenac sodium)” NCT00726388

“topical diclofenac sodium 1% gel (DSG)” PMID 22030938 Sep 2011

diclofenac sodium (Drug class: NSAIDs)” NCT02384928

“AMZ001 (Diclofenac Sodium Gel 3.06%)” NCT05968482

“Drug: diclofenac sodium (cataflam)” NCT02714231

Diclofenac Sodium Topical Gel, 1%” NCT02121002

Diclofenac sodium topical gel 1%” NCT01272947

“topical diclofenac sodium gel” NCT00601640

diclofenac sodium (25mg/ml)” NCT06186921

Diclofenac Sodium gel, 1%” NCT02596451

Diclofenac sodium gel 1%” NCT00171652

“Drug: Diclofenac SodiumNCT07131527

“Drug: Diclofenac SodiumNCT03221946

“Drug: Diclofenac SodiumNCT05626140

Diclofenac Sodium Patch” NCT00931866

NCT03826550

NCT06307106

NCT02201238

NCT02087748

NCT02985671

NCT00546832

NCT01858090

NCT02611804

NCT03825016

NCT06342648

NCT03449940

NCT06207253

NCT05387525

NCT01272934

NCT04592016

NCT07101016

NCT01706588

NCT01962987

NCT02271854

NCT07506265

NCT06632015

NCT05488925

NCT02769572

NCT06111573

NCT01742663

NCT07267182

NCT04683627

NCT03520595

NCT02253446

NCT02698306

NCT02658721

NCT04331210

NCT05829707

NCT00092378

NCT02406014

NCT07565012

NCT00426621

Known as Diclofenac sodium gel “Drug: Diclofenac sodium gelNCT06729073
Known as diclofenac sodium solution “Drug: diclofenac sodium solutionNCT03145259
Known as diclofenac-cholestyramine “continuous (daily) treatment of diclofenac cholestyramine 150 mg, divided into 75mg twice daily” NCT00715091
Known as Dicloftil “Diclofenac Na 0.1% Oph Soln, "Dicloftil®", NSAID eyedrops administered three days before surgery” NCT03597867
Known as Diclophenac ClinicalTrials.gov intervention name — accepted as the source's own label NCT00893854
2

NCT00226538

NCT02339428