drugset / Trial / NCT03781544
Effects of Opioids and NSAIDs on Sympathetic Nervous System and Vascular Function
RandomizedParallel-groupQuadruple-blindTreatment
Summary
Evaluation of the effect of different analgesic treatments (Tramadol, Paracetamol, Diclofenac) on sympathetic nerve activity, blood pressure, heart rate, heart rate, and vascular function in osteoarthritis patients and healthy subjects.
Timeline
- Start
- 2019-01-01
- Primary completion
- 2025-07-31
- Completion
- 2025-12-31
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Acetaminophen | Small molecule | 1 g | Intravenous |
| Subject | Diclofenac | Other / unclassified | 75 mg | Intravenous |
| Subject | Tramadol | Other / unclassified | 400 mg | Intravenous |