Drugs / Tramadol
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Tramadol

Other / unclassified

Developed for
chronic pain syndrome · osteoarthritis · neuropathy, painful · osteoarthritis, knee · opiate dependence · pulpitis · substance-related disorder · premature ejaculation
+30 more · ankylosing spondylitis · benign shuddering attacks · substance withdrawal syndrome · acute pancreatitis · benign prostatic hyperplasia · bone disorder · COVID-19 · diabetic neuropathy · diabetic polyneuropathy · fibromyalgia · inflammatory disease · intervertebral disk degenerative disorder · major depressive disorder · migraine disorder · nephrolithiasis · pain agnosia · peritonsillar abscess · post-traumatic stress disorder · postherpetic neuralgia · primary dysmenorrhea · rheumatoid arthritis · suppurative periapical periodontitis · urinary tract obstruction · akinetic mutism · brain injury · disease of the tendon · opioid-induced constipation · oral cavity squamous cell carcinoma · osteoarthritis, hand · rotator cuff syndrome
Investigated by
Labopharm Inc. · Bausch Health Americas, Inc. · Johnson & Johnson Pharmaceutical Research & Development, L.L.C. · Janssen Korea, Ltd., Korea · PriCara, Unit of Ortho-McNeil, Inc. · Cairo University
+147 more · Janssen Pharmaceutical K.K. · Menarini Group · National Institute on Drug Abuse (NIDA) · Aga Khan University · Assiut University · Daewon Pharmaceutical Co., Ltd. · Grünenthal GmbH · HaEmek Medical Center, Israel · Johnson & Johnson Taiwan Ltd · Al-Azhar University · Armed Forces Institute of Urology, Rawalpindi · Big Leap Research · Cipher Pharmaceuticals Inc. · Federal University of São Paulo · Grünenthal Colombiana S.A. · Haiphong University of Medicine and Pharmacy · Janssen Scientific Affairs, LLC · Johns Hopkins University · Nanjing Medical University · Tanta University · University Hospital, Ghent · University of Southern Denmark · Viatris Inc. · Yooyoung Pharmaceutical Co., Ltd. · Yuzuncu Yil University · AAI Clinic · Addpharma Inc. · Affiliated Cancer Hospital of Shantou University Medical College · Albert B. Sabin Vaccine Institute · Algazeerah hospital · Andalas University · Ankara Etlik City Hospital · Anti Doping Danmark · Aristotle University Of Thessaloniki · Arzu Esen Tekeli · Astellas Pharma Inc · Ataturk University · Avenue Therapeutics, Inc. · Azad University of Medical Sciences · Bagcilar Training and Research Hospital · Bakirkoy Dr. Dr. Sadi Konuk Research and Training Hospital · Cape Fear Valley Health System · Centre Hospitalier Universitaire Dijon · Chonbuk National University Hospital · Chung Shan Medical University · Chungnam National University Hospital · CliPS Co., Ltd · CliPSBnC · Coordenação de Aperfeiçoamento de Pessoal de Nível Superior. · Daniel Chavarría Bolaños · Department of medical education · Dow University of Health Sciences · Farjad Zafar · Federal University of Rio Grande do Sul · Fondazione IRCCS Policlinico San Matteo di Pavia · Frederiksberg University Hospital · Fundación de Investigación Biomédica - Hospital Universitario de La Princesa · Grumental · Grünenthal, S.A. · H. Lundbeck A/S · HRSA/Maternal and Child Health Bureau · Hadassah Medical Organization · Haisco Pharmaceutical Group Co., Ltd. · Hayatabad Medical Complex · Hopital Foch · Hospital San Carlos, Madrid · Hospital Universitario Fundación Jiménez Díaz · Hospital Universitario La Paz · Hospital Universitario Ramon y Cajal · Hospital Universitario San Juan de Alicante · Hospital Universitario de Burgos · Hørslev-Fonden · INTRuST, Post-Traumatic Stress Disorder - Traumatic Brain Injury Clinical Consortium · IRCCS Burlo Garofolo · all 153 on the full record

Regulatory milestones approvals, filings & regulatory actions · 4 recorded

MilestoneJurisdictionBrandIndicationDateSentence it was read from
Label expansion US (FDA) TRAMADOL HYDROCHLORIDE 2011-09-20 fda.gov
Label expansions (2) US (FDA) ULTRAM 1998-08-21 – 1999-12-23 fda.gov
Approved US (FDA) ULTRAM 1995-03-03 fda.gov

Trials 173 · started per year

today
US approved 1995
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1995199619971998199920002001200220032004200520062007200820092010201120122013201420152016201720182019202020212022202320242025202620272028
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 03 trials
Phase 0 NCT06561672 Sep 2024 → Mar 2025 overdue Zagazig University Enrolling by invitation No outcome recorded
Phase 0 NCT05756504 Feb 2023 → Jan 2024 acute pancreatitis Hayatabad Medical Complex Unknown No outcome recorded
Phase 0 NCT05614440 May 2012 → Nov 2013 Marmara University Completed No outcome recorded
Phase 121 trials
Phase 1 NCT07060209 Sep → Oct 2025 overdue Haiphong University of Medicine and Pharmacy Recruiting No outcome recorded
Phase 1 NCT07032558 Sep 2025 overdue Haiphong University of Medicine and Pharmacy Recruiting No outcome recorded
Phase 1 NCT05925686 Jun → Oct 2023 Parc de Salut Mar Completed No outcome recorded
Phase 1 NCT04375865 May → Jul 2020 Addpharma Inc. Completed No outcome recorded
Phase 1 NCT03767036 Jun 2017 Grünenthal GmbH Completed No outcome recorded
Phase 1 NCT03766984 Jun 2015 Grünenthal GmbH Completed No outcome recorded
Phase 1 NCT02307864 Dec 2014 → Aug 2015 Janssen Scientific Affairs, LLC Completed No outcome recorded
Phase 1 NCT01947920 Aug → Nov 2013 Janssen Scientific Affairs, LLC Completed No outcome recorded
Phase 1 NCT01606059 May → Jun 2012 Daewon Pharmaceutical Co., Ltd. Completed No outcome recorded
Phase 1 NCT01880125 Jan → May 2012 Yungjin Pharm. Co., Ltd. Completed No outcome recorded
Phase 1/26 trials
Phase 1/2 NCT04454307 Jul → Aug 2020 COVID-19 Tanta University Unknown No outcome recorded
Phase 1/2 NCT03121547 May 2015 → Jan 2016 drug-induced dyskinesia Frederiksberg University Hospital Completed No outcome recorded
Phase 1/2 NCT01188421 Oct 2010 → Jun 2015 opiate dependence Johns Hopkins University Completed No outcome recorded
Phase 1/2 NCT01178203 Jul 2010 pulpitis Azad University of Medical Sciences Completed No outcome recorded
Phase 1/2 NCT00301210 Jan 2006 → Oct 2007 substance-related disorder Johns Hopkins University Completed No outcome recorded
Phase 1/2 NCT00111046 Feb 2001 → Feb 2004 malignant choroid melanoma Royal Liverpool University Hospital Unknown No outcome recorded
Phase 215 trials
Phase 2 NCT06345716 Apr 2024 → Mar 2025 overdue urinary tract obstruction University of Monastir Recruiting No outcome recorded
Phase 2 NCT05616364 Mar 2023 → Mar 2024 benign shuddering attacks Sana Bahadur Unknown No outcome recorded
Phase 2 NCT04752384 Jul 2021 → Apr 2024 head and neck squamous cell carcinoma Medical College of Wisconsin Completed No outcome recorded
Phase 2 NCT05463367 Jan 2021 → Jun 2025 overdue chronic pain syndrome, opiate dependence, substance abuse Northwestern University Active not recruiting No outcome recorded
Phase 2 NCT03850587 Aug 2018 → May 2020 osteoarthritis, knee Yooyoung Pharmaceutical Co., Ltd. Completed No outcome recorded
Phase 2 NCT02999594 Dec 2016 → Apr 2018 Maulana Azad Medical College Unknown No outcome recorded
Phase 2 NCT02014363 Oct 2013 → Oct 2015 major depressive disorder e-Therapeutics PLC Completed No outcome recorded
Phase 2 NCT02247648 Jun 2013 → Dec 2017 University of Montreal Hospital Centre (CHUM) Terminated No outcome recorded
Phase 2 NCT01552096 Dec 2011 → Oct 2013 inflammatory disease Imam Abdulrahman Bin Faisal University Completed No outcome recorded
Phase 2 NCT01307020 Feb → Oct 2011 Menarini Group Completed No outcome recorded
Phase 2/32 trials
Phase 2/3 NCT06735443 Mar 2021 → Apr 2022 hernia, double inguinal Sahiwal medical college sahiwal Completed No outcome recorded
Phase 2/3 NCT00980044 Oct 2009 → Feb 2012 substance withdrawal syndrome Michelle Lofwall Completed No outcome recorded
Phase 338 trials
Phase 3 NCT05928520 Aug 2023 → Sep 2024 Al-Azhar University Unknown No outcome recorded
Phase 3 NCT07469826 Oct 2022 → Apr 2023 Jinnah Postgraduate Medical Centre Completed No outcome recorded
Phase 3 NCT05324059 Jul 2022 → Apr 2023 neuropathy, painful Laboratorios Silanes S.A. de C.V. Completed No outcome recorded
Phase 3 NCT07043049 Jun → Dec 2022 benign shuddering attacks Syed Muhammad Abbas Completed No outcome recorded
Phase 3 NCT05390905 Jun → Dec 2022 Haisco Pharmaceutical Group Co., Ltd. Completed No outcome recorded
Phase 3 NCT05311722 Apr → Dec 2022 Sheikh Zayed Medical College Unknown No outcome recorded
Phase 3 NCT05362851 Nov 2021 → Jan 2023 osteoarthritis, knee Yooyoung Pharmaceutical Co., Ltd. Unknown No outcome recorded
Phase 3 NCT04312061 Mar → Jul 2020 Cairo University Unknown No outcome recorded
Phase 3 NCT03678792 Nov 2019 → Sep 2020 opiate dependence, substance withdrawal syndrome University of Alabama at Birmingham Withdrawn No outcome recorded
Phase 3 NCT03586934 Jun 2018 → Jun 2019 substance-related disorder Rush University Medical Center Withdrawn No outcome recorded
Phase 459 trials
Phase 4 NCT07064993 Jul 2026 → Feb 2027 expected Arzu Esen Tekeli Not yet recruiting No outcome recorded
Phase 4 NCT07440069 Feb → Aug 2026 overdue Universidad Nacional Autonoma de Honduras Recruiting No outcome recorded
Phase 4 NCT07113782 Nov 2024 → Apr 2025 benign prostatic hyperplasia Armed Forces Institute of Urology, Rawalpindi Completed No outcome recorded
Phase 4 NCT06612996 Oct 2024 → Jan 2025 overdue ulcer of lower limbs, varicose disease Al-Azhar University Not yet recruiting No outcome recorded
Phase 4 NCT06495632 Aug 2024 → Jul 2026 overdue Cape Fear Valley Health System Recruiting No outcome recorded
Phase 4 NCT06076707 Nov 2023 → May 2024 Wollo University Unknown No outcome recorded
Phase 4 NCT06113497 Nov 2023 → Oct 2024 Kyunghee University Medical Center Unknown No outcome recorded
Phase 4 NCT05825560 May 2023 → Jun 2026 Nîmes University Hospital Completed No outcome recorded
Phase 4 NCT05657704 Oct 2022 → Dec 2023 Fundación de Investigación Biomédica - Hospital Universitario de La Princesa Unknown No outcome recorded
Phase 4 NCT06231043 Apr 2022 → Mar 2023 Lampang Hospital Completed No outcome recorded
Phase not applicable29 trials
NCT07610408 Jun → Sep 2026 expected Ankara Etlik City Hospital Recruiting No outcome recorded
NCT06860100 Nov 2025 → Jun 2026 overdue hemorrhoid Yuzuncu Yil University Active not recruiting No outcome recorded
NCT07264309 Nov 2025 → Dec 2026 expected Zohar Nachum Recruiting No outcome recorded
NCT07036237 Mar → Nov 2025 overdue Dow University of Health Sciences Enrolling by invitation No outcome recorded
NCT07386288 Nov 2024 → Apr 2025 Ataturk University Completed No outcome recorded
NCT06240390 May → Aug 2024 neuropathy, painful Universidad Europea de Canarias Withdrawn No outcome recorded
NCT06608056 Jan → Jun 2024 Pakistan Air Force (PAF) Hospital Islamabad Completed No outcome recorded
NCT06112223 Apr → Sep 2023 Tanta University Completed No outcome recorded
NCT05538052 Apr → Nov 2022 pulpitis Jamia Millia Islamia Completed No outcome recorded
NCT05311774 Apr 2022 → Oct 2025 Assiut University Completed No outcome recorded
Also used as a comparator or background therapy in 218 trials
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 01 trial
Phase 0 NCT07204379 Comparator Jan → Jul 2023 Armed Forces Institute of Dentistry, Pakistan Completed No outcome recorded
Phase 112 trials
Phase 1 NCT05256108 Comparator Mar → Jul 2022 substance abuse Tris Pharma, Inc. Completed No outcome recorded
Phase 1 NCT05533073 Comparator Aug → Sep 2020 Laboratorios Silanes S.A. de C.V. Completed No outcome recorded
Phase 1 NCT05389150 Comparator Jan → Feb 2019 Laboratorios Silanes S.A. de C.V. Completed No outcome recorded
Phase 1 NCT03775629 Comparator Dec 2018 → Apr 2019 CrystalGenomics, Inc. Completed No outcome recorded
Phase 1 NCT03640247 Background Nov 2018 → Dec 2019 parathyroid gland disorder, thyroid gland disorder MetroHealth Medical Center Completed No outcome recorded
Phase 1/22 trials
Phase 1/2 NCT06780267 Comparator Mar 2025 → Mar 2026 Shandong Suncadia Medicine Co., Ltd. Completed No outcome recorded
Phase 1/2 NCT00499746 Comparator Nov 2007 → Apr 2010 opiate dependence, opioid abuse National Institute on Drug Abuse (NIDA) Completed No outcome recorded
Phase 218 trials
Phase 2 NCT05125978 Comparator Sep 2026 → Jul 2028 chronic pain syndrome EMS Withdrawn No outcome recorded
Phase 2 NCT06232577 Background Mar 2024 → May 2027 expected M.D. Anderson Cancer Center Active not recruiting No outcome recorded
Phase 2 NCT06334198 Comparator Mar 2024 → Mar 2025 opioid-induced constipation Asbjørn Mohr Drewes Unknown No outcome recorded
Phase 2 NCT04593329 Comparator Mar → Aug 2023 EMS Withdrawn No outcome recorded
Phase 2 NCT06385561 Comparator Aug 2022 → May 2023 opioid-induced constipation Asbjørn Mohr Drewes Completed No outcome recorded
Phase 2/310 trials
Phase 2/3 NCT07185594 Comparator Oct → Dec 2025 overdue Shandong Suncadia Medicine Co., Ltd. Recruiting No outcome recorded
Phase 2/3 NCT07098962 Comparator Aug → Dec 2025 Kastamonu University Completed No outcome recorded
Phase 2/3 NCT05982392 Comparator Mar → Aug 2023 pulpitis Dow University of Health Sciences Completed No outcome recorded
Phase 2/3 NCT04939987 Comparator Aug → Oct 2022 Wake Forest University Health Sciences Withdrawn No outcome recorded
Phase 2/3 NCT04813016 Comparator Mar 2021 → Apr 2022 National Cancer Institute, Egypt Completed No outcome recorded
Phase 333 trials
Phase 3 NCT06237231 Comparator Feb → Mar 2025 overdue EMS Not yet recruiting No outcome recorded
Phase 3 NCT07666178 Comparator Dec 2024 → Dec 2027 expected Instituto do Coracao Recruiting No outcome recorded
Phase 3 NCT06722742 Comparator Sep → Dec 2024 overdue Liaquat National Hospital & Medical College Recruiting No outcome recorded
Phase 3 NCT06561035 Background Sep 2024 → Aug 2025 overdue Campbell Clinic Enrolling by invitation No outcome recorded
Phase 3 NCT06274333 Comparator Feb 2024 → Aug 2026 overdue nephrolithiasis Al-Azhar University Recruiting No outcome recorded
Phase 462 trials
Phase 4 NCT07600697 Comparator Jul 2026 → Jul 2027 expected female stress incontinence, pelvic organ prolapse University of California, Los Angeles Not yet recruiting No outcome recorded
Phase 4 NCT07153003 Comparator Feb 2026 → Sep 2030 expected Mayo Clinic Enrolling by invitation No outcome recorded
Phase 4 NCT07066111 Comparator Jul 2025 → Dec 2026 expected delirium Nanjing First Hospital, Nanjing Medical University Not yet recruiting No outcome recorded
Phase 4 NCT07332572 Comparator Jun → Dec 2025 Liaquat National Hospital & Medical College Completed No outcome recorded
Phase 4 NCT06742554 Comparator Dec 2024 → Apr 2025 overdue medina medical center Active not recruiting No outcome recorded
Phase not applicable80 trials
NCT07672808 Background Jun → Dec 2026 expected osteoarthritis, hip Henry Ford Health System Not yet recruiting No outcome recorded
NCT07534488 Comparator Apr → Jun 2026 overdue pilonidal sinus Medipol University Not yet recruiting No outcome recorded
NCT07606638 Comparator Feb → Jul 2026 overdue oral cavity squamous cell carcinoma Mayo Hospital Lahore Enrolling by invitation No outcome recorded
NCT07294352 Comparator Jan → Jul 2026 overdue CMH Lahore Medical College and Institute of Dentistry Active not recruiting No outcome recorded
NCT07346872 Comparator Dec 2025 → Aug 2026 overdue Bursa Yuksek Ihtisas Training and Research Hospital Active not recruiting No outcome recorded

Press releases naming this drug 2 releases

DateIssuerRelease
2002-06-20 Teva Branded Pharmaceutical Products R&D, Inc. Teva Announces Approval of Tramadol HCl Tablets tevapharm.com
2002-01-17 Teva Branded Pharmaceutical Products R&D, Inc. Teva Announces Approvable Status of ANDA for Tramadol HCl Tablets tevapharm.com

Evidence & citations 47 cited values

Every value below carries the sentence it was read from. 404 sources stand behind the page.

FieldValueCited text
Known as Tramadol “The purpose of this study is to compare the pharmacokinetic (PK) of single oral doses of ULTRAM Extended Release (ER) at 2 dose levels in adolescents between 12 and 17 years...” NCT01586507
359

“Eligible patients were randomized (1:1) to receive low-dose 7-day BTDS (5, 10, and 20 μg/h, maximum dosage of 20 μg/h) or sustained-release tramadol tablets (100 mg, maximum...” PMID 25503600 Jul 2015

“All patients will be submitted to the institution's standard management: multimodal analgesia with common analgesic (dipyrone 4 to 8 g / day or paracetamol 1500 to 2250 mg /...” NCT07666178

“400 mg tramadol, IV 4 mg/ mL tramadol solution into 100 mL normal saline; PCA (patient-controlled analgesia): 0.3 mg/kg bolus, 10 mg Demand dose and 20 min lock out interval,...” NCT05474014

“Purpose: pharmacokinetic interactions and safety of AD-2111 and AD-2112 in healthy adult volunteers Condition or disease : Pain Intervention/treatment Drug : AD-2111(Celecoxib...” NCT04375865

“Afterward of the operation, patients will be treated with patient-controlled analgesia with intravenous tramadol, with 20 mg bolus 20 minutes lock time, 4-hour limit 100 mg and...” NCT05943015

“initially receiving nefopam and tramadol, implementing with ketamine if patients remain painful, and then implementing with remifentanil with escalating doses in case of...” PMID 39832962 Jan 2025

“A patient controlled device prepared with 5 mg/ ml tramadol will be attached to all patients with a protocol included 10 mg bolus without infusion dose, 20 min lockout time and...” NCT05630404

“Nonsteroidal anti-inflammatory drug celecoxib (200 mg on request, up to two times daily)27 and tramadol (100 mg on request, up to 400mg daily) will be available for as-needed analgesia.” NCT06344403

“Both groups will receive intravenous 400 mg ibuprofen and 100 mg tramadol 20 minutes before the end of the surgery, and routine 1000 mg paracetamol every 8 hours postoperatively” NCT07534488

“Intravenous paracetamol 1 gr and a dose of 0,5 mg/kg-1 tramadol intravenously will be performed on all patients 30 min before the end of the surgery for postoperative analgesia.” NCT05621161

Tramadol at a concentration of 5 mg/mL is included in our PCA protocol (total volume 100 mL.) PCAs were set to no basal infusion and 10 mg bolus doses with a 20 min lock time.” NCT03719157

“Morphine 5 mg, ropivacaine 150 mg, tramadol 40 mg, epinephrine 1 mg, ketorolac 60 mg, and ketamine 1 g will be mixed with normal saline to prepare a total volume of 60 ml” NCT06113497

Tramadol is prescribed but the prescription is printed and given to the patient rather than sent to the pharmacy, requiring the patient to actively choose to fill it.” NCT07672808

Tramadol immediate release formulation (IR, one intake every 6 hours) or prolonged release formulation (PR, one intake every 12 hours); maximum posology 400mg/24h.” NCT03902340

“DW-1021 is a fixed-dose combination tablet containing Pelubiprofen 45 mg and Tramadol 45.9 mg (as a salt), formulated as a controlled-release film-coated tablet.” NCT07032558

“(n=30) will receive a submucosal infiltration with 2 mg kg-1 tramadol in 3 mL of normal saline (1.5 ml around each tonsil), 3 minutes before surgical incision.” NCT01552096

“When the NRS score was ≥4, flurbiprofen axetil 50 mg was administered intravenously, with intramuscular tramadol 100 mg added if analgesia was inadequate.” NCT07315022

“The regimen includes Paracetamol (oral or intravenous) 1g/24 hour, Ibuprofen IV 1200 mg/24 hour, or Parecoxib 80 mg/24 hour IV, and Tramadol 100 mg IV.” NCT07139691

“continuous wound inflitration with ropivacaine + tramadol patient-controlled analgesia + additional ketorolac or propacetamol for postoperative 48 hour” NCT02012244

“Cytochrome P450 2D6 (CYP2D6) is an important enzyme in metabolizing commonly used drugs such as Tramadol hydrochloride (widely used opioid analgesic).” NCT06642480

“All patients will receive rescue analgesia with intravenous patient controlled analgesia with tramadol (20 mg bolus dose and 20 minutes lockout time)” NCT03543202

“Routine prescriptions for rescue opioids (tramadol) and NSAIDs according to pain level recommended by the pharmacy department will be administered.” NCT06015165

“An extended-release (ER) fixed-dose combination (FDC) of tramadol 37.5 mg/acetaminophen 325 mg was developed due to the demand for varying dosages.” PMID 35800670 Jun 2022

“Intravenous 0.5 mg/kg tramadol and 400 mg ibuprofen will be administered to all patients 30 minutes before the end of the surgical procedure.” NCT05566561

“Ultracet (tramadol/acetaminophen) 37.5/325 mg/mg capsules twice daily on Day 1, a first dose at t = 0 hrs, and a second dose at t = 12 hrs.” NCT00772967

Tramadol 37.5 mg/APAP 325 mg combination tablets (Ultracet®) one tablet twice a day plus aceclofenac tablet per oral 100 mg twice a day.” NCT00647517

“All patients were followed using a standardized postoperative analgesia protocol which includes tramadol patient controlled analgesia.” NCT06326281

“A Pharmacokinetic Study to Evaluate the Dose-Proportionality of Tramadol (ULTRAM) Extended-Release (ER) in Healthy Participants” NCT01800682

“A fixed-dose combination controlled release film-coated tablet containing pelubiprofen 45 mg and tramadol 45.9 mg (salt form)” NCT07060209

“In the preemptive tramadol (n = 158) group, patients received an iv injection of tramadol 100 mg 15 min before operation.” PMID 18622068 May 2008

“Continous postoperative infusion of tramadol 300 mg and metamizole 2,5 g (in 500 ml 0.9% NaCl, rate of infusion 40 ml/h)” NCT05831761

“100 mg of tramadol hydrochloride was placed in 150 cc isotonic saline and given as a 15-minute intravenous infusion.” NCT05500677

“Drug: intravenous injection Tramadol 50 mg and then oral capsule Tramadol 50 mg, once patient starts taking orally.” NCT05507554

“Patients in Group A received injection tramadol 50mg intravenously every 8 hours following surgery.” NCT06608056

tramadol 50 mg intravenously up to a maximum dose of 400 mg / 24 h and other analgesics if needed.” NCT04172272

Tramadol 100 mg in the first hour followed by tramadol 300 mg continuously for the next 24 hours.” NCT04587505

Tramadol 100 mg in the first hour followed by tramadol 300 mg continuously for the next 24 hours.” NCT04521556

Tramadol is a synthetic opioid pain medication used to treat moderate to moderately severe pain.” NCT04813016

“medications in the opioid family such as Hydromorphone, Hydrocodone, Tramadol, or Oxycodone.” NCT04176783

“rescue analgesia with tramadol 37,5 mg + acetaminophen 325 mg oral fix combination (Patrol)” NCT02035904

“and intravenous opioids (buprenorphine 3 mcg / kg or tramadol 1mg/ kg in continuos infusion” NCT02617199

“patients in iv analgesia group were given 100 mg tramadol iv 30 minutes before extubation.” NCT03204708

“Drug: Tramadol 400 mg tramadol, IV 4 mg/ mL tramadol solution into 100 mL normal saline” NCT07096765

“This includes tylenol 650 mg oral, robaxin 500 mg oral, and tramadol 25-50 mg oral.” NCT05144828

“Drug: Tramadol Women will receive oral Tramadol 100 mg 2 hours before the procedure” NCT03585036

“Multi-modal with as needed oxycodone and tramadol provided for break-through pain” NCT03358888

“In case of severe pain tramadol 0,5 mg/kg will be administered iv every 8 hours.” NCT04294537

“9. 10 tablets of Tramadol 50mg as needed for moderate breakthrough pain only.” NCT06561035

Tramadol 100mg (For pain, the patient may take a rescue medication as needed)” NCT07568938

Tramadol is a unique opioid with two modes of action for inhibition of pain” NCT04551833

“Patient will receive intravenous patient controlled analgesia with tramadolNCT04457986

“If the VAS score will be ≥ 4, 0.5 mg/ kg tramadol IV will be administered.” NCT04189640

“2 capsules of Ixprim® given orally (1000 mg Paracetamol + 75 mg Tramadol)” NCT01782846

“TAB. Zaldiar (Paracetamol 650 milligrams + Tramadol 75 milligrams).” NCT01764048

“Regular Tramadol, Metamizol, +/- Ibuprofen/Dexketorpofen/Parecoxib” NCT07604376

Tramadol 100 mg if Weight over 50 kg, 50 mg if weight below 50 kg” NCT01345162

“the PK parameter AUC∞ (area under the curve) of racemic tramadol.” NCT01586494

“Aceclofenac 100mg or tramadol37.5mg/acetaminophen 325mg on demand” NCT01952314

“Celebrex 400mg PO, Lyrica 75mg x1 dose pre-op, Tramadol 50mg x 1” NCT06113211

“Adjunctive analgesics: acetaminophen, tramadol, or gabapentin” NCT01943435

Tramadol 2mg/Kg IV in 100mL of normal saline, if pain NRS\>3.” NCT03534895

“immediate-release tramadol 100 mg four times daily (QID)” PMID 35974668 Sep 2022

“100 mg tramadol will be performed for rescue analgesia.” NCT05476510

Tramadol 50 mg BID or TID and titrate to 100 mg QID” NCT00386243

“Morphine, oxycodone, metadone, fentanyl, tramadolNCT03365817

“with tramadol and/or morphine provided as rescue.” NCT07337135

tramadol hydrochloride (Drug class: Opioids)” NCT02384928

“YYC301-1: Tramadol 37.5Mg+ Celecoxib 200mg” NCT05362851

Tramadol 50 mg every 6 hours prn for pain” NCT03640247

“Rescue therapy only: Tramadol 50-100mg.” NCT04894864

“50 mg tramadol IV if pain persisted” NCT07057934

“Rescue therapy only: TramadolNCT05172739

“with 100 mg tramadol as PE” NCT03785041

tramadol administration” NCT04814745

“Level 2: Tramadol 50mg.” NCT04330547

tramadol/acetominophen” NCT02361567

Tramadol 50mg IV q6h” NCT04058444

Tramadol (Ultram®)” NCT06240390

Tramadol 100 mg” NCT05657704

Tramadol 50mg” NCT06495632

TramadolNCT02094807

TramadolNCT02132416

tramadolNCT05463367

NCT01776515

NCT06269770

NCT01598753

NCT02497326

NCT03395808

NCT02824770

NCT05389150

NCT02670954

NCT05237492

NCT03260439

NCT05956275

NCT00692263

NCT02428777

NCT03622489

NCT07294352

NCT05928520

NCT02839668

NCT05840406

NCT04110665

NCT03781544

NCT06345716

NCT02246712

NCT06373978

NCT00950651

NCT00348452

NCT05390905

NCT00743587

NCT02247648

NCT00653315

NCT03383315

NCT06601530

NCT00348010

NCT02625506

NCT02499341

NCT04961268

NCT01916915

NCT07394491

NCT02658721

NCT01904149

NCT00301210

NCT02706509

NCT00347724

NCT04835116

NCT00347685

NCT02248493

NCT07064993

NCT02982161

NCT03850587

NCT01116531

NCT01019265

NCT03774836

NCT00852917

NCT02674737

NCT06722742

NCT04968158

NCT00834288

NCT01178203

NCT00973232

NCT00246168

NCT02999594

NCT03934411

NCT02327923

NCT00833911

NCT02914028

NCT01943760

NCT03380533

NCT03767036

NCT05696886

NCT03766984

NCT03067103

NCT02110966

NCT06742554

NCT02465255

NCT07500454

NCT00426647

NCT04611685

NCT06860100

NCT00290901

NCT05401916

NCT01165814

NCT05925686

NCT07241949

NCT06172920

NCT03312777

NCT05756504

NCT00952068

NCT02182752

NCT03243006

NCT02528253

NCT02307305

NCT07346872

NCT02291705

NCT03678792

NCT04003350

NCT04766996

NCT05614440

NCT05995912

NCT00236535

NCT01636700

NCT07332572

NCT04593329

NCT01728246

NCT00766402

NCT00834808

NCT03255330

NCT02595190

NCT00499746

NCT07264309

NCT02777970

NCT00643383

NCT00111046

NCT05616364

NCT03308955

NCT03509740

NCT00785603

NCT05820685

NCT02850211

NCT03324035

NCT05533073

NCT04761029

NCT03277599

NCT00210847

NCT01983111

NCT03532841

NCT02445599

NCT04443556

NCT02827487

NCT01416116

NCT07610408

NCT02412930

NCT02851394

NCT01880125

NCT06728033

NCT00893412

NCT02441673

NCT04694300

NCT05982392

NCT04991493

NCT00497562

NCT01024348

NCT02544282

NCT03309163

NCT03454217

NCT06232577

NCT05693454

NCT00980044

NCT00510666

NCT00662558

NCT02329561

NCT07606638

NCT04837924

NCT00310908

NCT02518438

NCT04809532

NCT01947920

NCT02703415

NCT00981929

NCT03217292

NCT01887951

NCT06561672

NCT00297375

NCT05170841

NCT00634543

NCT07469826

NCT06385561

NCT01267136

NCT06076707

NCT01902134

NCT04178109

NCT03653520

NCT07036237

NCT01526525

NCT01889979

NCT02736019

NCT07204379

NCT05256108

NCT02425709

NCT02683070

NCT00911742

NCT06656299

NCT06215820

NCT03809442

NCT02205554

NCT06237231

NCT00833794

NCT00983151

NCT04037878

NCT01721031

NCT02971540

NCT04939987

NCT05488925

NCT05311774

NCT03469310

NCT00983736

NCT02389361

NCT02416141

NCT00713726

NCT04391855

NCT00733421

NCT07600697

NCT04718116

NCT02736071

NCT04454307

NCT02068209

NCT02760888

NCT04752384

NCT02484859

NCT01188421

NCT06112223

NCT03472469

NCT05488847

NCT02071303

NCT00325858

NCT05311722

NCT00832416

NCT01112267

NCT02375100

NCT07098962

NCT00912015

NCT01263652

NCT02436980

NCT06134895

NCT07066111

NCT06112548

NCT02883569

NCT00942565

NCT02440399

NCT02964416

NCT07043049

NCT07113782

NCT00610155

NCT07440069

NCT03714672

NCT06612996

NCT02722603

NCT01227200

NCT02750696

NCT06231043

NCT00361686

NCT02076893

NCT06215859

NCT00737048

NCT03482492

NCT06735443

NCT03586934

NCT00736853

NCT02419651

NCT01517711

NCT00142896

NCT02449954

NCT04312061

NCT03290378

NCT03694873

NCT03054220

NCT07386288

NCT00487175

NCT06334198

NCT02416804

NCT00735748

NCT05324059

NCT07110051

NCT06274333

NCT03496389

NCT07153003

NCT06780267

NCT05905757

NCT03494426

NCT00333346

NCT00560443

NCT06008002

NCT04314050

NCT03108482

NCT01843660

NCT01630343

NCT02958566

NCT03701984

Known as AD-2112 “Purpose: pharmacokinetic interactions and safety of AD-2111 and AD-2112 in healthy adult volunteers Condition or disease : Pain Intervention/treatment Drug : AD-2111(Celecoxib...” NCT04375865
Known as contramal “patients were given intravenously 100 mg of tramadol (contramal) 30 minutes before extubation after modified radical mastectomy.” NCT03204708
Known as ETS6103 ClinicalTrials.gov intervention name — accepted as the source's own label NCT02014363
Known as Extended Release Tramadol Extended Release Tramadol (Tramadol ER)” NCT00347724
Known as TA-ER “OBJECTIVE: To evaluate the relative efficacy and safety of extended-release tramadol HCl 75 mg/acetaminophen 650 mg (TA-ER) and immediate-release tramadol HCl...” PMID 25299350 Oct 2014
Known as TA-IR “OBJECTIVE: To evaluate the relative efficacy and safety of extended-release tramadol HCl 75 mg/acetaminophen 650 mg (TA-ER) and immediate-release tramadol HCl...” PMID 25299350 Oct 2014
Known as Tradonal Odis “Tramadol per os (Tradonal Odis® orodispersible tablets)” NCT00735748
Known as TRAM “Since JNS013 is a combination of tramadol hydrochloride (TRAM) acting as a weak opioid with acetaminophen (APAP) inhibiting central COX-3” NCT00752661
2

“fixed combination of dexketoprofen trometamol (DKP) and tramadol hydrochloride (TRAM)” NCT01902134

tramadol hydrochloride (TRAM)” NCT00736957

Known as Tram (Tradol) “Tram (Tradol®)” NCT05389150
Known as Trama “Women will receive Tramadol 100mg (Trama®, Global Napi, Giza, Egypt) orally 2 hours before IUD insertion.” NCT02827487
2

Tramadol 100mg (Trama®, Global Napi, Giza, Egypt) orally in addition to a placebo similar to Celecoxib” NCT02736019

Tramadol 100mg (Trama®, Global Napi, Giza, Egypt) orally” NCT03585036

Known as Trama SR “Group I who will receive Tramadol 100mg (Trama SR®, Global Napi) orally 1 hour before the procedure, group II who will receive Celecoxib 200mg (Celebrex® 200, Pfizer) 1 hour...” NCT02071303
1

“Group I who will receive Tramadol 100mg (Trama SR®, Global Napi) orally 1 hour before the procedure” NCT02419651

Known as Tramadol 100 MG/ML Tramadol 100 MG/MLNCT03785041
Known as Tramadol 50 MG/ML Tramadol 50 MG/MLNCT03785041
Known as Tramadol BID “A Comparison of the Analgesic Efficacy and Safety of Once Daily Tramadol OAD Tablets to Twice Daily Tramadol BID for the Treatment of Osteoarthritis of the Knee (Extension...” NCT00912015
Known as Tramadol Contramid OAD “A three-way crossover study in 27 human volunteers was conducted to characterize the pharmacokinetics and to assess the dose proportionality of 100 mg, 200 mg and 300 mg...” PMID 17575561 Sep 2007
5

“CONCLUSIONS: The results of this exploratory study suggest that similar to immediate-release tramadol, onset of analgesia for this controlled-release formulation of tramadol...” PMID 19070266 Sep 2008

“This placebo-controlled study examined the analgesic efficacy, safety, and clinical benefit of Tramadol Contramid OAD, a once-daily formulation with both immediate- and...” PMID 18181382 Sep 2007

“An open-label phase was followed by a double-blind phase, in which a total of 646 patients were randomized to double-blind treatment with placebo or Tramadol Contramid OAD.” PMID 17583466 Jun 2007

“two Tramadol Contramid® OAD 300 mg controlled-release tablets from two different manufacturing sites” NCT00834912

“once-daily formulation of tramadol (Tramadol Contramid OAD 200-mg tablets)” PMID 20051587 Jan 2010

Known as Tramadol Contramid once-a-day “The primary objective of this study is to determine the time of onset of analgesic effect of Tramadol Contramid® Once-A-Day (OAD) in acute low back pain.” NCT00952068
Known as Tramadol Contramid once-daily “The aim of this study was to compare the pharmacokinetic profile and oral bioavailability of Tramadol Contramid once-daily (o.d.) 200 mg tablets (Labopharm, Canada) with that...” PMID 16894407 Jul 2006
Known as tramadol ER “A 7-day taper using clonidine (n = 36), tramadol ER (n = 36), or buprenorphine (n = 31) was then instituted, and patients were crossed-over to double-blind placebo during a...” PMID 28700791 Sep 2017
2

“Open-label Assessment of the Safety and Effectiveness of Extended Release Tramadol (Tramadol ER) in the Treatment of Chronic Non-malignant Pain.” NCT00347685

“Extended Release Tramadol (Tramadol ER)” NCT00347724

Known as Tramadol HC1 IR “Some participants will receive a medication approved by the Food and Drug Administration for treatment of moderate to moderately severe pain called Tramadol HC1 IR.” NCT01598753
Known as Tramadol HCl “Participants will receive 1 tablet containing 75 mg of tramadol HCl and 650 mg of acetaminophen, once daily on Days 1to 3, then 1 tablet twice daily on Days 4 to 7” NCT01112267
15

“The reference treatment consists of two separate controlled-release film-coated tablets: Pelubi CR (Pelubiprofen 45 mg) and Zytram CR (Tramadol HCl 75 mg).” NCT07032558

“Cases were assessed as intravenous opioid with 1 mg/kg tramadol HCl (Group O, n=20) or ultrasonography-guided quadratus lumborum block (Group B, n=20).” NCT03693222

“A Two-Arm Study Comparing the Analgesic Efficacy and Safety of Tramadol HCl Once-a-Day Versus Placebo for the Treatment of Pain Due to Osteoarthritis” NCT00833794

“the test product, Tramadol HCl Once-A-Day (OAD) 200 mg tablets and the reference product, Tramadol HCl 50 mg (IR) tablets (Ortho-McNeil Ultram®).” NCT00834288

“Patients will be equally assigned to receive a total dose of either tramadol HCl 75 mg/acetaminophen 650 mg or tramadol HCl 100 mg or placebo.” NCT00236483

“Patients will receive infusion of Tramadol HCl (Tramosel®) via patient-controlled analgesia system (Gemstar®)” NCT02824770

Tramadol HCL. Dosage form: Injection Strength: 50mg/ampoule Frequency: 1 time” NCT01887951

“DDS-06C (650 mg acetaminophen and 75 mg tramadol HCl)” NCT00973232

“Group II:received IV 2 mg/kg tramadol HCL.” NCT02449954

Tramadol HCl, 50 mg” NCT01947920

“Drug: Tramadol HClNCT00834912

“Drug: tramadol HCLNCT00662558

NCT00834366

NCT02307864

NCT03126084

Known as Tramadol HCl ER “The purpose of this study is to compare the analgesic efficacy and safety of tramadol HCl ER 100 mg, 200 mg and 300 mg once a day (QD), with placebo in patients with moderate...” NCT00348452
2

“Extended-release Tramadol Hydrochloride(Tramadol HCl ER)100 Mg, 200 Mg, 300 Mg, And 400 Mg With Placebo” NCT00325858

“Extended Release Tramadol Hydrochloride (Tramadol HCl ER)” NCT00348010

Known as Tramadol HCl ODT “The purpose of this clinical trial is to test an experimental drug therapy called Tramadol Hydrochloride (HCl) Orally Disintegrating Tablets (ODT) ("Tramadol HCl ODT" or the...” NCT00983736
1

“The purpose of this clinical trial is to test an experimental drug therapy called Tramadol Hydrochloride (HCl) Orally Disintegrating Tablets (ODT) ("Tramadol HCl ODT" or the...” NCT00983151

Known as Tramadol HCl/Acetaminophen ER ClinicalTrials.gov intervention name — accepted as the source's own label NCT01814878
Known as Tramadol HCl/Acetaminophen IR ClinicalTrials.gov intervention name — accepted as the source's own label NCT01814878