Comparison of Preoperative Analgesics on the Efficacy of Inferior Alveolar Nerve Block.

Phase 4 Completed 120 enrolled Farjad Zafar

RandomizedParallel-groupDouble-blindSupportive care

Summary

The purpose of this study is to see how preoperative oral diclofenac sodium, piroxicam, and tramadol affects inferior alveolar nerve block efficacy during root canal treatment of mandibular molars with symptomatic irreversible pulpitis. The proposed hypothesis is that the tested drug groups will improve the efficacy of inferior alveolar nerve block in comparison to the control group.

Timeline

Start: 2021-06-21
Primary completion: 2022-02-18
Completion: 2022-02-18

Outcome

Met primary endpoint

paper Pre-operative administration of LNX significantly improved the efficacy of IANB in patients with irreversible pulpitis PMID 21692235 ↗

Publications

Results Prasanna N, Subbarao CV, Gutmann JL. The efficacy of pre-operative oral medication of lornoxicam and diclofenac potassium on the success of inferior alveolar nerve block in patients with irreversible pulpitis: a double-blind, randomised controlled clinical trial. Int Endod J. 2011 Apr;44(4):330-6. doi: 10.1111/j.1365-2591.2010.01833.x.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Diclofenac	Other / unclassified	100 mg	Oral
Subject	Piroxicam	Unknown	20 mg	Oral
Subject	Tramadol	Other / unclassified	50 mg	Oral