drugset / Trial / NCT03586934

Multimodal Analgesia in Shoulder Arthroplasty

NCT03586934

Phase 3 Withdrawn Rush University Medical Center
RandomizedParallel-groupDouble-blindTreatment

Summary

Opioid medications are associated with many side effects and the risk of abuse or overdose. Orthopaedic surgeons are currently investigating ways to control pain after surgery while limiting the amount of opioid medications prescribed. One way to reduce the amount of opioid medications prescribed, and potentially avoid opioid-associated adverse events, is to use multiple non-opioid medications and anesthetic drugs before surgery, during surgery, and after surgery. This study aims to evaluate a protocol with non-opioid pain medications to reduce the need for opioid medication after shoulder surgery.

Timeline

Start
2018-06-01
Primary completion
2019-06-01
Completion
2019-06-01

Publications

Drugs

EvaluationDrugModalityDoseRoute
Subject Acetaminophen Small molecule 325 mg
Subject Acetaminophen Small molecule 500 mg
Subject Acetaminophen Small molecule 1000 mg
Subject Celecoxib Other / unclassified 200 mg
Subject Celecoxib Other / unclassified 400 mg
Subject Hydrocodone Unknown 5 mg Oral
Subject Hydrocodone Unknown 10 mg Oral
Subject Ketorolac Other / unclassified 15 mg Intravenous
Subject Meloxicam Small molecule 15 mg Oral
Subject Morphine Other / unclassified 1 mg Intravenous
Subject Morphine Other / unclassified 2 mg Intravenous
Subject Oxycodone Other / unclassified 5 mg Oral
Subject Oxycodone Other / unclassified 10 mg Oral
Subject Tramadol Other / unclassified 100 mg Oral
Background Ropivacaine Other / unclassified 30 ml Other