Drugs / Meloxicam
last change Aug 2026 re-read 2 minutes ago

Meloxicam

also known as N1539 · Mobic · Movatec · Acticam · ANJESO · Anticox · Contacera · Coxicam · +30 more

Small molecule targets PTGS2 via inhibition

Developed for
osteoarthritis · osteoarthritis, knee · neuropathy, painful · migraine disorder · juvenile idiopathic arthritis · non-Hodgkin lymphoma · pharyngitis · plasma cell myeloma
+14 more · primary dysmenorrhea · rheumatoid arthritis · temporomandibular joint disorder · ankylosing spondylitis · arthropathy · biliary atresia · prostate neoplasm · spondyloarthropathy · tuberculosis · dental pulp disorder · frozen shoulder · puerperal disorder · pulpitis · sciatica
Investigated by
Boehringer Ingelheim · Baudax Bio · Heron Therapeutics · Alkermes, Inc. · Axsome Therapeutics, Inc. · Iroko Pharmaceuticals, LLC
+48 more · Rothman Institute Orthopaedics · Instituto Chileno de Medicina Reproductiva · Laboratorios Andromaco S.A. · Mylan Pharmaceuticals Inc · Teva Pharmaceuticals USA · University of Miami · Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute) · Baptist Health South Florida · Beijing Tide Pharmaceutical Co., Ltd · Beijing Tongren Hospital · Beni-Suef University · CONRAD · CSPC ZhongQi Pharmaceutical Technology Co., Ltd. · Daewoong Pharmaceutical Co. LTD. · Dr. Yannis Raftopoulos · Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) · Eurofarma Laboratorios S.A. · InnovaGyn, Inc. · Janssen Korea, Ltd., Korea · Joint Stock Company "Farmak" · Massachusetts General Hospital · Merck Sharp & Dohme LLC · Montefiore Medical Center · National Cancer Institute (NCI) · National Center for Advancing Translational Sciences (NCATS) · National Heart, Lung, and Blood Institute (NHLBI) · Onconic Therapeutics Inc. · OrthoCarolina Research Institute, Inc. · Pfizer · Princess Margaret Hospital, Canada · Rizzoli Orthopaedic Institute · Rush University Medical Center · Sherif S. Farag · Stanford University · Suez Canal University · Texas Tech University Health Sciences Center · The Leukemia and Lymphoma Society · The Third Xiangya Hospital of Central South University · The University of Texas Health Science Center, Houston · TriHealth Inc. · University Health Network, Toronto · University of Oklahoma · University of Pittsburgh · University of Stellenbosch · VA Office of Research and Development · Vanderbilt University · Yangtze River Pharmaceutical Group Co., Ltd. · Yonsei University

Regulatory milestones approvals, filings & regulatory actions · 5 recorded

MilestoneJurisdictionBrandIndicationDateSentence it was read from
Withdrawn EU (EMA) Zynrelef 2023-10-05 europa.eu
Approved EU (EMA) Zynrelef 2020-09-24 europa.eu
Label expansions (2) US (FDA) MOBIC 2004-07-16 – 2005-08-11 fda.gov
Approved US (FDA) MOBIC 2000-04-13 fda.gov

Trials 87 · started per year

today
US approved 2000
EU approved 2020
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1998199920002001200220032004200520062007200820092010201120122013201420152016201720182019202020212022202320242025202620272028
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 01 trial
Phase 0 NCT06349772 Nov 2024 → Nov 2027 expected Texas Tech University Health Sciences Center Recruiting No outcome recorded
Phase 119 trials
Phase 1 NCT05181124 Mar 2021 active peptic ulcer disease Onconic Therapeutics Inc. Completed No outcome recorded
Phase 1 NCT04490434 Jun → Aug 2020 Daewoong Pharmaceutical Co. LTD. Unknown No outcome recorded
Phase 1 NCT04322175 Dec 2019 → Jun 2020 Beijing Tongren Hospital Unknown No outcome recorded
Phase 1 NCT03684265 Oct 2018 Boehringer Ingelheim Completed No outcome recorded
Phase 1 NCT03354117 Mar 2018 → May 2019 Stanford University Completed No outcome recorded
Phase 1 NCT05125588 Jan → Feb 2014 Joint Stock Company "Farmak" Completed No outcome recorded
Phase 1 NCT01839643 Jan → May 2013 Laboratorios Andromaco S.A. Completed No outcome recorded
Phase 1 NCT00731302 Apr 2005 → Apr 2017 systemic lupus erythematosus Vanderbilt University Completed No outcome recorded
Phase 1 NCT00649675 Aug → Sep 2004 Mylan Pharmaceuticals Inc Completed No outcome recorded
Phase 1 NCT00649077 Aug → Sep 2004 Mylan Pharmaceuticals Inc Completed No outcome recorded
Phase 1/22 trials
Phase 1/2 NCT06403046 Jun 2024 → May 2025 temporomandibular joint disorder Beni-Suef University Completed No outcome recorded
Phase 1/2 NCT04398329 May 2020 → Jul 2021 Heron Therapeutics Completed No outcome recorded
Phase 216 trials
Phase 2 NCT05950152 Jul → Dec 2023 neuropathy, painful Beijing Tide Pharmaceutical Co., Ltd Unknown No outcome recorded
Phase 2 NCT05695352 Jun 2022 → Nov 2024 InnovaGyn, Inc. Completed No outcome recorded
Phase 2 NCT04911062 Apr → Jul 2022 Heron Therapeutics Completed No outcome recorded
Phase 2 NCT04115098 Jun 2020 → Aug 2023 spondyloarthropathy The University of Texas Health Science Center, Houston Terminated No outcome recorded
Phase 2 NCT03695367 Oct → Nov 2018 Heron Therapeutics Completed No outcome recorded
Phase 2 NCT02540265 Aug → Nov 2015 Baudax Bio Completed No outcome recorded
Phase 2 NCT02405793 May → Jul 2015 osteoarthritis Iroko Pharmaceuticals, LLC Withdrawn No outcome recorded
Phase 2 NCT02078102 Mar 2014 → Nov 2018 non-Hodgkin lymphoma, plasma cell myeloma Sherif S. Farag Completed No outcome recorded
Phase 2 NCT02003625 Oct 2013 → Feb 2019 Hodgkins lymphoma, non-Hodgkin lymphoma, plasma cell myeloma Massachusetts General Hospital Completed No outcome recorded
Phase 2 NCT01799213 Sep 2013 → Oct 2018 osteoarthritis, knee VA Office of Research and Development Completed No outcome recorded
Phase 2/31 trial
Phase 2/3 NCT02255045 Jun 2014 → Feb 2016 primary dysmenorrhea Laboratorios Andromaco S.A. Completed No outcome recorded
Phase 332 trials
Phase 3 NCT06904248 Jan → Nov 2024 Yangtze River Pharmaceutical Group Co., Ltd. Completed No outcome recorded
Phase 3 NCT07463404 Dec 2023 → Jun 2025 temporomandibular joint disorder Suez Canal University Completed No outcome recorded
Phase 3 NCT06379165 May → Jul 2023 CSPC ZhongQi Pharmaceutical Technology Co., Ltd. Completed No outcome recorded
Phase 3 NCT05751421 Feb 2023 → Feb 2024 neuropathy, painful Rothman Institute Orthopaedics Unknown No outcome recorded
Phase 3 NCT05702827 Jan 2023 → Mar 2024 female stress incontinence, vulvar disease TriHealth Inc. Completed No outcome recorded
Phase 3 NCT05550207 Aug 2022 → Nov 2024 migraine disorder Axsome Therapeutics, Inc. Completed No outcome recorded
Phase 3 NCT05291598 May 2022 → May 2023 University of Miami Completed No outcome recorded
Phase 3 NCT04725357 Jan 2021 → Jan 2022 arthropathy Rothman Institute Orthopaedics Unknown No outcome recorded
Phase 3 NCT04163185 Oct 2019 → Mar 2020 migraine disorder Axsome Therapeutics, Inc. Completed No outcome recorded
Phase 3 NCT04068051 Jul 2019 → Sep 2020 migraine disorder Axsome Therapeutics, Inc. Completed No outcome recorded
Phase 413 trials
Phase 4 NCT07216586 Jan 2027 → Jan 2028 expected osteoarthritis, knee University of Miami Not yet recruiting No outcome recorded
Phase 4 NCT07430085 Jul 2026 → Jan 2028 expected osteoarthritis, knee Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute) Not yet recruiting No outcome recorded
Phase 4 NCT07200544 Oct 2025 → Jun 2026 overdue skin cancer University of Oklahoma Recruiting No outcome recorded
Phase 4 NCT07076069 Jul 2025 → Jun 2028 expected rotator cuff syndrome Montefiore Medical Center Recruiting No outcome recorded
Phase 4 NCT05863221 May 2023 → Oct 2024 Dr. Yannis Raftopoulos Unknown No outcome recorded
Phase 4 NCT05644496 Mar 2023 → Dec 2025 osteoarthritis, knee Baptist Health South Florida Terminated No outcome recorded
Phase 4 NCT05315479 Feb → Jul 2022 Baudax Bio Terminated No outcome recorded
Phase 4 NCT02298218 Sep 2009 → Jun 2011 biliary atresia Yonsei University Completed No outcome recorded
Phase 4 NCT00635349 May 2007 → Apr 2009 osteoarthritis Janssen Korea, Ltd., Korea Completed No outcome recorded
Phase 4 NCT02229747 Aug 2001 → Feb 2002 pharyngitis Boehringer Ingelheim Completed No outcome recorded
Phase not applicable3 trials
NCT04176783 Mar 2018 → Jul 2021 OrthoCarolina Research Institute, Inc. Completed No outcome recorded
NCT04003350 Dec 2017 → Nov 2018 osteoarthritis, knee Rothman Institute Orthopaedics Completed No outcome recorded
NCT01430559 Oct 2011 → Mar 2013 osteoarthritis, knee Pfizer Completed No outcome recorded
Also used as a comparator or background therapy in 24 trials
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 12 trials
Phase 1 NCT06902090 Comparator Jul 2023 Yangtze River Pharmaceutical Group Co., Ltd. Completed No outcome recorded
Phase 1 NCT02183090 Comparator Nov → Dec 1998 Boehringer Ingelheim Completed No outcome recorded
Phase 22 trials
Phase 2 NCT06306131 Comparator Dec 2023 → Nov 2025 InnovaGyn, Inc. Completed No outcome recorded
Phase 2 NCT02456363 Background Nov 2009 → Oct 2019 ankylosing spondylitis Chung Shan Medical University Unknown No outcome recorded
Phase 2/31 trial
Phase 2/3 NCT04480359 Comparator Oct 2017 → Aug 2020 ankylosing spondylitis Shanghai University of Traditional Chinese Medicine Unknown No outcome recorded
Phase 38 trials
Phase 3 NCT07549386 Comparator May 2024 → Mar 2025 osteoarthritis Laboratorios Liomont Completed No outcome recorded
Phase 3 NCT03907176 Background Apr 2019 → Oct 2021 Heron Therapeutics Completed No outcome recorded
Phase 3 NCT03896009 Comparator Mar → Dec 2019 migraine disorder Axsome Therapeutics, Inc. Completed No outcome recorded
Phase 3 NCT03146000 Comparator May 2017 → Aug 2018 puerperal disorder Assiut University Completed No outcome recorded
Phase 3 NCT02448199 Comparator Jul 2015 → Jun 2016 osteoarthritis Zodiac Produtos Farmaceuticos S.A. Unknown No outcome recorded
Phase 45 trials
Phase 4 NCT07158476 Comparator Oct 2025 → Sep 2030 expected St. Louis University Recruiting No outcome recorded
Phase 4 NCT06704113 Comparator Dec 2024 → Jan 2025 overdue dental pulp disorder, perceptual disorders Universidad Austral de Chile Not yet recruiting No outcome recorded
Phase 4 NCT05974501 Background Sep 2023 → Jan 2024 osteoarthritis, knee University of Miami Completed No outcome recorded
Phase 4 NCT04766996 Background May → Dec 2021 substance-related disorder Emory University Terminated No outcome recorded
Phase 4 NCT03473665 Comparator Mar 2018 → Aug 2019 ankylosing spondylitis Columbia University Terminated No outcome recorded
Phase not applicable6 trials
NCT07493226 Comparator Apr 2026 → Feb 2027 expected frozen shoulder, neuropathy, painful Konya Beyhekim Training and Research Hospital Recruiting No outcome recorded
NCT07462988 Comparator Jan → Jun 2025 Istanbul Medeniyet University Completed No outcome recorded
NCT05672784 Comparator Nov 2022 → Dec 2024 overdue Zagazig University Recruiting No outcome recorded
NCT05097768 Comparator Aug 2021 → Jan 2022 pulpitis Alfarabi Colleges Completed No outcome recorded
NCT04538391 Comparator Mar 2019 → Mar 2020 Menoufia University Completed No outcome recorded

Press releases naming this drug 4 releases

DateIssuerRelease
2026-05-18 Pfizer's Upjohn has merged with Mylan to form Viatris Inc. U.S. FDA Accepts Viatris New Drug Application for Fast-Acting Meloxicam for the Treatment of Moderate-to-Severe Acute Pain viatris.com
2025-08-01 Pfizer's Upjohn has merged with Mylan to form Viatris Inc. Viatris Announces Five Data Presentations on Novel Fast-Acting Meloxicam (MR-107A-02) at PAINWeek 2025 Conference viatris.com
2025-05-08 Pfizer's Upjohn has merged with Mylan to form Viatris Inc. Viatris Announces Positive Top-Line Results from Two Pivotal Phase 3 Studies of Novel Fast-Acting Meloxicam (MR-107A-02) for the Treatment of Moderate-to-Severe Acute Pain viatris.com
2006-07-20 Teva Branded Pharmaceutical Products R&D, Inc. Teva Announces Final Approval of Meloxicam Tablets tevapharm.com

Evidence & citations 43 cited values

Every value below carries the sentence it was read from. 114 sources stand behind the page.

FieldValueCited text
Known as meloxicam “Specific Aim 3: Estimate the incremental cost effectiveness of each adjunctive analgesic therapy relative to standard of care analgesic therapy in the treatment of severe limb...” NCT01789216
99

“The aim of the study was to compare the bioavailability of two formulations of meloxicam given to healthy volunteers and to demonstrate bioequivalence. The test product,...” NCT05125588

“The study aims to design a randomized controlled trial that compares the effect of intra-articular injection of the non-selective (NSAID) Tenoxicam versus the selective COX-2...” NCT06403046

“The purpose of this study is to evaluate the use of an injectable combination of bupivacaine and meloxicam (Zynrelef) vs injectable liposomal bupivacaine (Exparel), two...” NCT06349772

“ZYNRELEF® is an extended-release, fixed-ratio combination product that contains bupivacaine (a local anesthetic as the free base) and low-dose meloxicam (an NSAID) incorporated...” NCT05863221

“Acetaminophen 975mg every 4 hours, Meloxicam 7.5mg once per day, Pregabalin 50mg twice per day, Magnesium 400mg once per day, along with rescue Oxycodone 5mg every 4 hours, as needed” NCT07076069

“Relative Bioavailability of Meloxicam 2 x 7.5 mg Tablets Compared to 15 mg Tablet and Dose Proportionality Over a Dose Range of 7.5 mg and 15 mg in Healthy Volunteers” NCT02276352

“Each study participant will receive one dose of the study medication (ulipristal acetate 30mg plus meloxicam 15mg) at peak fertility in the treatment cycle.” NCT03354117

“A single 14 mL dose of HTX-011 containing 400 mg bupivacaine and 12 mg meloxicam will be applied intraoperatively to the surgical site.” NCT07216586

“Patients randomized into this group (n=40) will, again by simple randomization, be given oral tablets of meloxicam or lornoxicam” NCT07493226

“Inject Combination of Platelet-Rich Plasma and Cyclooxygenase Enzyme-2 Inhibitor meloxicam (Mobitil 15mg) after arthrocentesis” NCT07463404

“HTX-011 (bupivacaine and meloxicam in Biochronomerpolymer technology), an extended-release, dual-acting local anesthetic” PMID 31113830 May 2019

“HTX-011 (bupivacaine/meloxicam) dose up to 200 mg/6 mg administered via application into the surgical site.” NCT04911062

“AXS-07 (MoSEIC meloxicam and rizatriptan) taken by mouth for the acute treatment of migraine.” NCT04068051

“medications such as Gabapentin, Tylenol, Meloxicam, Bupivacaine, or Ketorolac.” NCT04176783

“Bupivacaine Versus Meloxicam Infiltration on Post Cesarean Section Pain Relief” NCT04538391

“HTX-034 (bupivacaine/aprepitant/meloxicam) fixed dose: 21.7 mg/4.3 mg/0.6 mg” NCT04398329

“HTX-011 (bupivacaine/meloxicam), 300 mg/ 9 mg via instillation.” NCT03695367

“DOLOCAM PLUS® (meloxicam 7.5mg/methocarbamol 215mg)” NCT01979510

“N1539 (meloxicam injection for IV use)” NCT03434275

“300 mg bupivacaine/9 mg meloxicamNCT03907176

MeloxicamNCT01638962

NCT06704113

NCT01430559

NCT04480359

NCT01346137

NCT04322175

NCT04725357

NCT02183168

NCT02405793

NCT03896009

NCT02183155

NCT02255045

NCT04003350

NCT06379165

NCT06904248

NCT04490434

NCT02183116

NCT02183103

NCT02183077

NCT05672784

NCT07549386

NCT02183064

NCT02181309

NCT07158476

NCT00239395

NCT02181322

NCT03684265

NCT03936192

NCT02187562

NCT00239382

NCT02448199

NCT05950152

NCT02183051

NCT01799213

NCT00279747

NCT02183038

NCT02183025

NCT01787188

NCT01147289

NCT04163185

NCT05181124

NCT02183129

NCT05644496

NCT04115098

NCT05695352

NCT02003625

NCT01801735

NCT02229747

NCT03473665

NCT00840879

NCT05751421

NCT00649077

NCT06902090

NCT07200544

NCT02183090

NCT02060006

NCT05702827

NCT00731302

NCT07462988

NCT05550207

NCT01587508

NCT02078102

NCT00152919

NCT05291598

NCT00034853

NCT00840476

NCT01839643

NCT03586934

NCT07430085

NCT05974501

NCT00042068

NCT04766996

NCT00635349

NCT06306131

NCT05097768

NCT00649675

NCT02298218

NCT02706054

NCT03146000

Known as Acticam ChEMBL registry synonym — accepted as the source's own label CHEMBL599
Known as ANJESO “Meloxicam Nanocrystal Injection (ANJESO®)” NCT06902090
Known as Anticox “meloxicam 15mg (Anticox 2 ampoule 15mg/3ml, ADWIA Pharmaceuticals)” NCT04538391
Known as Contacera ChEMBL registry synonym — accepted as the source's own label CHEMBL599
Known as Coxicam ChEMBL registry synonym — accepted as the source's own label CHEMBL599
Known as Drug: Mobic Drug: MobicNCT02456363
Known as Emdocam ChEMBL registry synonym — accepted as the source's own label CHEMBL599
Known as Flexicam ChEMBL registry synonym — accepted as the source's own label CHEMBL599
Known as Inflacam ChEMBL registry synonym — accepted as the source's own label CHEMBL599
Known as Loxicom ChEMBL registry synonym — accepted as the source's own label CHEMBL599
Known as Loxitab ChEMBL registry synonym — accepted as the source's own label CHEMBL599
Known as Melfax ChEMBL registry synonym — accepted as the source's own label CHEMBL599
Known as Melosus ChEMBL registry synonym — accepted as the source's own label CHEMBL599
Known as Melovem ChEMBL registry synonym — accepted as the source's own label CHEMBL599
Known as Meloxicam component of zeleris ChEMBL registry synonym — accepted as the source's own label CHEMBL599
Known as Meloxicam component of zynrelef ChEMBL registry synonym — accepted as the source's own label CHEMBL599
Known as MELOXICAM SODIUM ChEMBL registry synonym — accepted as the source's own label CHEMBL599
Known as Meloxicam/Mobic (NDC 68382-000-01; manufacturer: Zydus; encapsulated in size AA Meloxicam/Mobic (NDC 68382-000-01; manufacturer: Zydus; encapsulated in size AANCT01789216
Known as Meloxidolor ChEMBL registry synonym — accepted as the source's own label CHEMBL599
Known as Meloxidyl ChEMBL registry synonym — accepted as the source's own label CHEMBL599
Known as Meloxivet ChEMBL registry synonym — accepted as the source's own label CHEMBL599
Known as Meloxoral ChEMBL registry synonym — accepted as the source's own label CHEMBL599
Known as Metacam ChEMBL registry synonym — accepted as the source's own label CHEMBL599
Known as Mobic “The objective of this study was to investigate the bioequivalence of Mylan's meloxicam 15 mg tablets and Boehringer Ingelheim's Mobic® 15 mg tablets following a single, oral 15...” NCT00649077
3

“Mylan's meloxicam 15 mg tablets and Boehringer Ingelheim's Mobic® 15 mg tablets” NCT00649675

“Drug: MobicNCT02456363

NCT02183142