drugset / Trial / NCT07296770

An Artificial Intelligence Driven Approach to Optimize Patient Selection for a Transitional Pain Service

NCT07296770 ↗

Phase 3 Not yet recruiting 474 enrolled University of California, San Francisco
RandomizedParallel-groupOpen-labelTreatment

Summary

The goal of this clinical trial is to learn whether a pain-management program called a Transitional Pain Service can help prevent long-term pain and reduce opioid needs after surgery in adult surgical patients who may be at higher risk for developing persistent pain. The main questions this trial aims to answer are: 1) Does the Transitional Pain Service help high-risk surgical patients manage pain better after surgery? 2) Can a computer tool (an algorithm) improve screening of patients for long-lasting pain after surgery? The investigators will compare patients who continue with their usual care to patients who receive support from the Transitional Pain Service to see if the program leads to better pain control and lower opioid use. Participants will share information about their pain levels and the pain-relief treatments they are using before and after surgery so researchers can better understand how the program affects recovery. Patients assigned to the Transitional Pain Service will also be offered additional coordinated support before and after their surgery to help optimize their pain control and overall recovery.

Timeline

Start
2026-10-01
Primary completion
2028-12-01
Completion
2029-12-01

Drugs

EvaluationDrugModalityDoseRoute
Background Acetaminophen Small molecule — —
Background Amitriptyline Small molecule — —
Background Baclofen Small molecule — —
Background Buprenorphine Other / unclassified — —
Background Celecoxib Other / unclassified — —
Background Clonidine Other / unclassified — —
Background Duloxetine Small molecule — —
Background Gabapentin Unknown — —
Background Hydrocodone bitartrate Unknown — —
Background Hydromorphone Other / unclassified — —
Background Ibuprofen Small molecule — —
Background Ketamine Small molecule — —
Background Ketorolac Other / unclassified — —
Background Meloxicam Small molecule — —
Background Methadone Other / unclassified — —
Background Methocarbamol Small molecule — —
Background Morphine Other / unclassified — —
Background Naproxen Small molecule — —
Background Nortriptyline Small molecule — —
Background Oxycodone Other / unclassified — —
Background Pregabalin Small molecule — —
Background Suzetrigine Small molecule — —
Background Tizanidine Small molecule — —
Background Venlafaxine Small molecule — —
Background alpha-lipoic acid Small molecule — —
Background cyclobenzaprine Unknown — —

Indications