Clonidine

also known as Clonidine HCL · Clonidine Hydrochloride · Catapresan · CLON · Clonidin · Clonidine Gel · Duraclon · ARC-4558 · +32 more

Other / unclassified

Developed for: delirium · hypertensive disorder · attention deficit-hyperactivity disorder · neonatal abstinence syndrome · neuropathy, painful · anxiety · radiculopathy · cardiovascular disorder
+54 more
· diabetic neuropathy · intervertebral disk degenerative disorder · lumbar spinal stenosis · osteoarthritis, knee · post-traumatic stress disorder · pregnancy disorder · spondylolisthesis · autism spectrum disorder · brain hypoxia - ischemia · cancer-related condition · cannabis dependence · cardiac rhythm disease · chemotherapy-induced oral mucositis · chronic kidney disease · cirrhosis of liver · cocaine abuse · dermatitis · diabetic kidney disease · diabetic polyneuropathy · drug-induced akathisia · ganglion or cyst of synovium/tendon/bursa · heart disorder · heart failure · hyperemesis gravidarum · intracranial vasospasm · lumbar disk disease · manic bipolar affective disorder · myalgic encephalomeyelitis/chronic fatigue syndrome · opiate dependence · opioid abuse · posterior dislocation of lens · preeclampsia · pulpitis · schizophrenia · scoliosis · secondary hypertension · sickle cell disease · soft tissue neoplasm · spondylosis · subjective cognitive decline · substance dependence · substance withdrawal syndrome · substance-related disorder · Tourette syndrome · traumatic brain injury · ventricular tachycardia · benign shuddering attacks · bicipital tenosynovitis · oppositional defiant disorder · osteoarthritis · Parkinson disease · peripheral neuropathy · psychogenic movement disorders · secondary erythromelalgia
Investigated by: National Institute on Drug Abuse (NIDA) · Johns Hopkins University · Oslo University Hospital · BioDelivery Sciences International · Charite University, Berlin, Germany · Columbia University
+180 more
· McMaster University · National Center for Research Resources (NCRR) · Weill Medical College of Cornell University · Centre Hospitalier Universitaire Saint Pierre · Deventer Ziekenhuis · Hamilton Health Sciences Corporation · Hospices Civils de Lyon · Makassed General Hospital · Mayo Clinic · Mclean Hospital · Medical University of Vienna · PHARMAFINA · Rigshospitalet, Denmark · University College, London · University Health Network, Toronto · University Hospital, Basel, Switzerland · University Hospital, Clermont-Ferrand · University of Iowa · University of Sao Paulo General Hospital · Vanderbilt University · Vanderbilt University Medical Center · Wake Forest University Health Sciences · Yale University · A.O.U. Città della Salute e della Scienza · ARAMU Association · ARNAS Civico Di Cristina Benfratelli Hospital · Aarhus University Hospital · Addrenex Pharmaceuticals, Inc. · American Heart Association · Ann & Robert H Lurie Children's Hospital of Chicago · Annette C. Toledano MD · Arthroplasty Foundation, Inc. · Atlantic Health System · Autism Intervention Research Network on Physical Health · Autism Treatment Network · Bambino Gesù Hospital and Research Institute · Baystate Medical Center · Birte Glenthoj · Brain & Behavior Research Foundation · Brian Williams · Brugmann University Hospital · CES University · CHU de Charleroi · Cambridge University Hospitals NHS Foundation Trust · Canadian Anesthesiologists' Society · Canadian Network and Centre for Trials Internationally · Centre Hospitalier Universitaire Dijon · Centro Neurológico de Pesquisa e Reabiitação, Brazil · Children's Hospital of Eastern Ontario · Cork University Hospital · Dr. Jean A. Ouellet, MD, FRCSC · Eastern Association for the Surgery of Trauma (EAST) · Edinburgh Napier University · Egymedicalpedia · Erasme University Hospital · Erasmus Medical Center · Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) · European Commission · Faculdade de Ciências Médicas da Santa Casa de São Paulo · Federal University of Espirito Santo · Federal University of Minas Gerais · Federal University of São Paulo · Gary L. Pierce · German Federal Ministry of Education and Research · Gianni Benzi Pharmacological Research Foundation · Glostrup University Hospital, Copenhagen · Grace Lim, MD, MS · Haukeland University Hospital · Imperial College London · Insel Gruppe AG, University Hospital Bern · Instituto Materno Infantil Prof. Fernando Figueira · Irmandade da Santa Casa de Misericordia de Sao Paulo · James Martins · Jing Liu · all 186 on the full record

Regulatory milestones approvals, filings & regulatory actions · 4 recorded

Milestone	Jurisdiction	Brand	Indication	Date	Sentence it was read from
Label expansions (2)	US (FDA)	KAPVAY	—	2010-09-28 – 2014-11-20	fda.gov ↗
Label expansion	US (FDA)	CATAPRES	—	1979-09-20	fda.gov ↗
Approved	US (FDA)	CATAPRES	—	1974-09-03	fda.gov ↗

Trials 151 · started per year

today

US approved 1974

19741975197619771978197919801981198219831984198519861987198819891990199119921993199419951996199719981999200020012002200320042005200620072008200920102011201220132014201520162017201820192020202120222023202420252026202720282029

Phase	Registry id	Dates	Indication	Sponsor	Status	Outcome
Phase 07 trials
Phase 0	NCT04423627	Jun 2021 → Jul 2025	hypertensive disorder	University of Iowa	Completed	No outcome recorded
Phase 0	NCT04737512	Feb 2021 → Oct 2024	attention deficit-hyperactivity disorder	Yale University	Completed	No outcome recorded
Phase 0	NCT04263064	Mar 2020 → Aug 2022	—	Medical University of South Carolina	Completed	No outcome recorded
Phase 0	NCT04030572	Dec 2019 → Mar 2020	cancer, neurodegenerative disease	Weill Medical College of Cornell University	Terminated	No outcome recorded
Phase 0	NCT04032691	Aug 2019 → May 2021	—	Weill Medical College of Cornell University	Withdrawn	No outcome recorded
Phase 0	NCT05037812	Mar 2019 → Mar 2028 expected	—	University of Utah	Active not recruiting	No outcome recorded
Phase 0	NCT03147092	Feb 2018 → Jun 2020	hypertensive disorder	Centro Neurológico de Pesquisa e Reabiitação, Brazil	Unknown	No outcome recorded
Phase 112 trials
Phase 1	NCT06781632	Nov 2024 → Feb 2025	—	PHARMAFINA	Completed	No outcome recorded
Phase 1	NCT05592379	Nov 2023 → Feb 2025	—	University of Wisconsin, Madison	Completed	No outcome recorded
Phase 1	NCT04934228	Jul 2021 → Aug 2026 overdue	diabetes mellitus, hypertensive disorder, obesity disorder	University of Kansas Medical Center	Recruiting	No outcome recorded
Phase 1	NCT05536362	Feb 2021 → Jan 2022	colon carcinoma	Egymedicalpedia	Completed	No outcome recorded
Phase 1	NCT03520543	May → Jul 2018	—	Hospices Civils de Lyon	Completed	No outcome recorded
Phase 1	NCT02249039	Sep 2015 → Dec 2019	—	Johns Hopkins University	Completed	No outcome recorded
Phase 1	NCT02548806	Sep → Dec 2015	—	Valerio Therapeutics	Completed	No outcome recorded
Phase 1	NCT02268448	Jul 2015 → Sep 2022	dermatitis	University of Minnesota	Completed	No outcome recorded
Phase 1	NCT01136278	Jul → Dec 2010	amphetamine abuse, mood disorder	University Hospital, Basel, Switzerland	Completed	No outcome recorded
Phase 1	NCT00295308	Nov 2005 → Jul 2014	opiate dependence	National Institute on Drug Abuse (NIDA)	Completed	No outcome recorded
Phase 1	NCT00318760	Jun 2005 → Aug 2013	cocaine abuse, opioid abuse	National Institute on Drug Abuse (NIDA)	Completed	No outcome recorded
Phase 1	NCT00223717	Jan 2001 → Jan 2017	hypertensive disorder	Vanderbilt University	Completed	No outcome recorded

Phase 1/27 trials
Phase 1/2	NCT06447194	Oct 2025 → Jan 2027	intervertebral disk degenerative disorder, lumbar spinal stenosis, spondylolisthesis	University of Maryland, Baltimore	Withdrawn	No outcome recorded
Phase 1/2	NCT01986751	Jan 2014 → Dec 2015	—	University of Alabama at Birmingham	Terminated	No outcome recorded
Phase 1/2	NCT01862250	Oct 2013 → Apr 2015	brain hypoxia - ischemia	Johns Hopkins University	Completed	No outcome recorded
Phase 1/2	NCT00730054	Feb → May 2005	—	Oslo University Hospital	Completed	No outcome recorded
Phase 1/2	NCT00194974	Jul 2004 → Mar 2005	proteinuria, toxemia of pregnancy	Weill Medical College of Cornell University	Withdrawn	No outcome recorded
Phase 1/2	NCT00262470	Apr 1997 → Dec 2029 expected	cardiac rhythm disease	Satish R. Raj	Active not recruiting	No outcome recorded
Phase 1/2	NCT00166686	—	cancer-related condition	Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)	Withdrawn	No outcome recorded
Phase 225 trials
Phase 2	NCT07131657	Sep → Dec 2025	—	PHARMAFINA	Completed	No outcome recorded
Phase 2	NCT05487196	Sep 2022 → Jul 2023	pregnancy disorder	Grace Lim, MD, MS	Completed	No outcome recorded
Phase 2	NCT05360953	Jun 2022 → Aug 2025	post-traumatic stress disorder	Charite University, Berlin, Germany	Suspended	No outcome recorded
Phase 2	NCT05355597	Jan 2021 → Mar 2025	musculoskeletal system disorder, soft tissue neoplasm	Atlantic Health System	Terminated	No outcome recorded
Phase 2	NCT02812368	Aug 2016 → Jan 2017	autism spectrum disorder	Ohio State University	Withdrawn	No outcome recorded
Phase 2	NCT02643251	Dec 2015 → Nov 2016	diabetic neuropathy, neuropathy, painful	BioDelivery Sciences International	Completed	No outcome recorded
Phase 2	NCT02444559	May → Jun 2015	—	Zealand University Hospital	Completed	No outcome recorded
Phase 2	NCT02355158	Jun 2014 → Aug 2015	diabetes mellitus, neuropathy, painful	BioDelivery Sciences International	Completed	No outcome recorded
Phase 2	NCT01956604	Apr 2014 → Sep 2017	delirium	Oslo University Hospital	Terminated	No outcome recorded
Phase 2	NCT02068027	Mar 2014 → Mar 2015	diabetic polyneuropathy	BioDelivery Sciences International	Completed	No outcome recorded
Phase 2	NCT01983462	Oct 2013 → Jun 2020	hypertensive disorder, obesity disorder	Gary L. Pierce	Terminated	No outcome recorded
Phase 2	NCT01963299	Aug → Oct 2013	posterior dislocation of lens	Centre Hospitalier Universitaire Dijon	Completed	No outcome recorded
Phase 2	NCT02733757	May 2013 → Oct 2015	—	Federal University of Minas Gerais	Completed	No outcome recorded
Phase 2	NCT01784250	Aug 2012 → Apr 2013	anxiety	CES University	Unknown	No outcome recorded
Phase 2	NCT01322048	Aug 2011 → Jan 2015	traumatic brain injury	Vanderbilt University	Completed	No outcome recorded
Phase 2	NCT01370811	Aug 2011 → Sep 2012	—	Orient Pharma Co., Ltd.	Completed	No outcome recorded
Phase 2	NCT01415895	Jul 2011 → Feb 2013	—	Annette C. Toledano MD	Completed	No outcome recorded
Phase 2	NCT01293149	Apr 2011 → Mar 2013	—	Nationwide Children's Hospital	Withdrawn	No outcome recorded
Phase 2	NCT01297335	Feb 2011 → Jul 2012	hypertensive disorder	The Center for Clinical Research, Winston-Salem, NC	Completed	No outcome recorded
Phase 2	NCT00130091	Sep 2009 → Feb 2014	hydrocele	Children's Hospital of Eastern Ontario	Completed	No outcome recorded
Phase 2	NCT00930072	Apr 2009 → Dec 2014	intracranial vasospasm	University of Washington	Terminated	No outcome recorded
Phase 2	NCT00884832	Oct 2008 → Aug 2012	—	Mayo Clinic	Completed	No outcome recorded
Phase 2	NCT01638052	Feb 2006 → Mar 2008	cholesteatoma, otorhinolaryngologic disease	Ann & Robert H Lurie Children's Hospital of Chicago	Completed	No outcome recorded
Phase 2	NCT00510016	Jul 2002 → Dec 2005	neonatal abstinence syndrome	National Institute on Drug Abuse (NIDA)	Completed	No outcome recorded
Phase 2	NCT00000279	Sep 1994 → Aug 1999	substance-related disorder	Yale University	Completed	No outcome recorded

Phase 2/35 trials
Phase 2/3	NCT05091242	Oct 2021 → Jan 2026	delirium	Rigshospitalet, Denmark	Unknown	No outcome recorded
Phase 2/3	NCT04648020	Feb 2021 → May 2023	chemotherapy-induced oral mucositis	Monopar Therapeutics	Terminated	No outcome recorded
Phase 2/3	NCT01598896	May 2012 → Aug 2017	cannabis dependence	Mclean Hospital	Terminated	No outcome recorded
Phase 2/3	NCT02030717	Feb 2012 → May 2015	renal cell carcinoma	Umeå University	Completed	No outcome recorded
Phase 2/3	NCT01360450	Jul 2011	neonatal abstinence syndrome	Johns Hopkins University	Terminated	No outcome recorded
Phase 323 trials
Phase 3	NCT01876355	Jan → Dec 2024	delirium	Deventer Ziekenhuis	Unknown	No outcome recorded
Phase 3	NCT06137924	Dec 2023 → Apr 2024	—	Universidad Simón Bolívar	Unknown	No outcome recorded
Phase 3	NCT04877093	Jun 2023 → Mar 2027 expected	post-traumatic stress disorder	Wake Forest University Health Sciences	Recruiting	No outcome recorded
Phase 3	NCT03653832	Dec 2018 → Dec 2023	—	University of Edinburgh	Completed	No outcome recorded
Phase 3	NCT03727100	Oct 2018 → Mar 2020	radiculopathy	Sollis Therapeutics, Inc.	Completed	No outcome recorded
Phase 3	NCT03537612	Jun 2018 → Apr 2022	scoliosis	Dr. Jean A. Ouellet, MD, FRCSC	Terminated	No outcome recorded
Phase 3	NCT02466373	Dec 2016 → Apr 2018	delirium	Deventer Ziekenhuis	Completed	No outcome recorded
Phase 3	NCT02891798	Oct 2016 → Jul 2021	—	Brian Williams	Completed	No outcome recorded
Phase 3	NCT02740127	Jun 2016 → May 2020	male reproductive organ cancer	M.D. Anderson Cancer Center	Completed	No outcome recorded
Phase 3	NCT02509273	May 2016 → Oct 2018	—	University of Erlangen-Nürnberg Medical School	Terminated	No outcome recorded
Phase 3	NCT02655965	May 2016 → Nov 2019	—	Jules Bordet Institute	Completed	No outcome recorded
Phase 3	NCT02592915	Oct 2015 → Dec 2022	—	Queen Fabiola Children's University Hospital	Unknown	No outcome recorded
Phase 3	NCT02181543	Aug 2013 → Dec 2014	—	Professor Fernando Figueira Integral Medicine Institute	Completed	No outcome recorded
Phase 3	NCT02371759	Jun 2013 → Jan 2016	diabetes mellitus	University of Belgrade	Completed	No outcome recorded
Phase 3	NCT01559012	Feb → Dec 2012	hyperemesis gravidarum	A.O.U. Città della Salute e della Scienza	Completed	No outcome recorded
Phase 3	NCT01082874	Jul 2010 → Mar 2014	cardiovascular disorder	Hamilton Health Sciences Corporation	Completed	No outcome recorded
Phase 3	NCT00678379	Apr 2008 → Nov 2009	—	Vanderbilt University Medical Center	Completed	No outcome recorded
Phase 3	NCT00661063	Apr 2008 → Apr 2009	diabetic neuropathy	Irmandade da Santa Casa de Misericordia de Sao Paulo	Unknown	No outcome recorded
Phase 3	NCT00723190	Jan 2008 → Mar 2010	attention deficit-hyperactivity disorder	Shionogi	Completed	No outcome recorded
Phase 3	NCT00417443	Dec 2007 → Dec 2009	—	Cambridge University Hospitals NHS Foundation Trust	Withdrawn	No outcome recorded
Phase 3	NCT00556959	Oct 2007 → Aug 2008	attention deficit-hyperactivity disorder	Addrenex Pharmaceuticals, Inc.	Completed	No outcome recorded
Phase 3	NCT00437996	Feb 2007 → Jan 2008	—	Hospices Civils de Lyon	Completed	No outcome recorded
Phase 3	NCT00287326	Jan → Jun 2006	—	University of North Carolina, Chapel Hill	Terminated	No outcome recorded

Phase 452 trials
Phase 4	NCT07567495	Jun 2026 → May 2028 expected	—	Columbia University	Not yet recruiting	No outcome recorded
Phase 4	NCT07313371	Jan → Jul 2026 overdue	substance dependence	University of Sao Paulo General Hospital	Recruiting	No outcome recorded
Phase 4	NCT05416840	Jan 2024 → Nov 2026 expected	hypertensive disorder	Jing Liu	Not yet recruiting	No outcome recorded
Phase 4	NCT05848531	Apr → Dec 2023	sickle cell disease	Centre Hospitalier Universitaire Saint Pierre	Unknown	No outcome recorded
Phase 4	NCT05676814	Mar → Jun 2023	—	Wake Forest University Health Sciences	Completed	No outcome recorded
Phase 4	NCT05824832	Feb 2023 → Jun 2026 overdue	neuropathy, painful	Loyola University	Recruiting	No outcome recorded
Phase 4	NCT05575219	Oct 2022 → Feb 2024	substance withdrawal syndrome	The University of Texas Health Science Center, Houston	Completed	No outcome recorded
Phase 4	NCT05560230	Oct 2022 → Aug 2024	endometriosis	University of Aarhus	Completed	No outcome recorded
Phase 4	NCT04902859	Apr 2022 → Dec 2024	retinopathy of prematurity	Region Örebro County	Unknown	No outcome recorded
Phase 4	NCT05029726	Feb 2022 → Feb 2027 expected	ganglion or cyst of synovium/tendon/bursa, intervertebral disk degenerative disorder, lumbar disk disease, lumbar spinal stenosis +3	John O'Toole	Recruiting	No outcome recorded
Phase 4	NCT05029050	Jan 2022 → Jul 2024	delirium, subjective cognitive decline	Oslo University Hospital	Unknown	No outcome recorded
Phase 4	NCT04186299	Aug 2021 → Aug 2022	pulpitis	University of California, San Francisco	Withdrawn	No outcome recorded
Phase 4	NCT04828226	Apr 2021 → May 2026	bipolar disorder, catatonia, delirium, major depressive disorder	Insel Gruppe AG, University Hospital Bern	Completed	No outcome recorded
Phase 4	NCT04564430	Mar → Dec 2021	arthropathy, clubfoot, congenital deformities of limbs, exostosis, Dupuytren subungual +8	Odense University Hospital	Unknown	No outcome recorded
Phase 4	NCT04758936	Feb 2021 → Feb 2022	delirium	Erasme University Hospital	Unknown	No outcome recorded
Phase 4	NCT04530903	Sep 2020 → Jan 2021	—	Centre Hospitalier Universitaire Saint Pierre	Unknown	No outcome recorded
Phase 4	NCT03696199	Sep 2020 → Sep 2026 expected	—	Lahey Clinic	Recruiting	No outcome recorded
Phase 4	NCT04026074	Jul → Oct 2019	arthropathy	Medical University of Graz	Completed	No outcome recorded
Phase 4	NCT03092011	Feb 2018 → Oct 2024 overdue	neonatal abstinence syndrome	The Cooper Health System	Active not recruiting	No outcome recorded
Phase 4	NCT03057015	May 2017 → Feb 2019	—	University of Vermont	Unknown	No outcome recorded
Phase 4	NCT03121261	May 2017 → Sep 2027 expected	—	University Hospital Dubrava	Active not recruiting	No outcome recorded
Phase 4	NCT03109795	Apr 2017 → Jun 2023	anxiety, hypertensive disorder	University of Iowa	Terminated	No outcome recorded
Phase 4	NCT03124082	Jan → Dec 2017	—	University of Parma	Unknown	No outcome recorded
Phase 4	NCT03018171	Jan → Jun 2017	—	San Giovanni Calibita Fatebenefratelli Hospital	Unknown	No outcome recorded
Phase 4	NCT02953210	Nov 2016	neuropathy, painful, paralytic ileus	Federal University of São Paulo	Unknown	No outcome recorded
Phase 4	NCT02778178	May 2016 → Apr 2017	—	University Hospital, Lille	Completed	No outcome recorded
Phase 4	NCT02530151	Nov 2015 → May 2017	—	Northwestern University	Completed	No outcome recorded
Phase 4	NCT02571283	Oct 2015 → May 2016	—	University of Louisville	Withdrawn	No outcome recorded
Phase 4	NCT02570503	Oct 2015 → Feb 2021	osteoarthritis, knee	Virginia Commonwealth University	Terminated	No outcome recorded
Phase 4	NCT02365727	Apr → Aug 2015	osteoarthritis, knee	The Hawkins Foundation	Withdrawn	No outcome recorded
Phase 4	NCT02361476	Jan → Dec 2015	drug-induced akathisia	Rigshospitalet, Denmark	Completed	No outcome recorded
Phase 4	NCT01846221	Jul 2014 → Jan 2017	—	Columbia University	Completed	No outcome recorded
Phase 4	NCT02026687	Mar 2014 → Apr 2016	female reproductive organ cancer	Lena Nilsson	Completed	No outcome recorded
Phase 4	NCT02067078	Feb → Dec 2014	—	Regionshospitalet Silkeborg	Completed	No outcome recorded
Phase 4	NCT03117140	Dec 2013 → Mar 2017	—	Melinda Seering	Completed	No outcome recorded
Phase 4	NCT01785693	Jan 2013 → Nov 2016	peripheral arterial occlusive disease 1	University Hospital, Clermont-Ferrand	Completed	No outcome recorded
Phase 4	NCT01902108	Jan 2013 → Dec 2015	—	St Joseph University, Beirut, Lebanon	Completed	No outcome recorded
Phase 4	NCT01761916	Jan → Jun 2013	preeclampsia	Instituto Materno Infantil Prof. Fernando Figueira	Completed	No outcome recorded
Phase 4	NCT03065933	Jan 2012 → Jan 2013	manic bipolar affective disorder	Mclean Hospital	Terminated	No outcome recorded
Phase 4	NCT01759524	Oct 2011 → Jan 2013	—	Cork University Hospital	Completed	No outcome recorded
Phase 4	NCT01139996	May 2010 → Aug 2012	delirium	Memorial Health University Medical Center	Terminated	No outcome recorded
Phase 4	NCT00959062	Jan 2010 → Sep 2012	—	Hamilton Health Sciences Corporation	Completed	No outcome recorded
Phase 4	NCT01052623	Jan 2010 → Dec 2011	ataxia telangiectasia	Johann Wolfgang Goethe University Hospital	Unknown	No outcome recorded
Phase 4	NCT00983125	Aug 2009 → Mar 2010	—	University Hospital, Clermont-Ferrand	Completed	No outcome recorded
Phase 4	NCT00860925	May → Dec 2009	cardiovascular disorder	McMaster University	Completed	No outcome recorded
Phase 4	NCT00858845	May 2008 → Mar 2011	heart failure	University of California, Los Angeles	Completed	No outcome recorded
Phase 4	NCT00152750	Sep 2006 → Oct 2008	Tourette syndrome, attention deficit-hyperactivity disorder	University Health Network, Toronto	Unknown	No outcome recorded
Phase 4	NCT00335582	Jun 2006 → Aug 2009	heart disorder	University Health Network, Toronto	Unknown	No outcome recorded
Phase 4	NCT00535925	Oct 2005 → Dec 2011	diabetic kidney disease	University of Campania Luigi Vanvitelli	Completed	No outcome recorded
Phase 4	NCT00279253	Mar 2004 → Jan 2005	—	Medical University of Vienna	Completed	No outcome recorded
Phase 4	NCT00312416	Feb → Dec 2004	—	Medical University of Vienna	Completed	No outcome recorded
Phase 4	NCT00691795	? → Dec 2011	—	Columbia University	Withdrawn	No outcome recorded

Phase not applicable20 trials
—	NCT06780865	Jan 2025 → Dec 2028 expected	chronic kidney disease, secondary hypertension	Shanghai Institute of Hypertension	Not yet recruiting	No outcome recorded
—	NCT06507410	Jul → Sep 2024 overdue	—	Tanta University	Recruiting	No outcome recorded
—	NCT05485480	Nov 2022 → Feb 2024	—	University Hospital, Basel, Switzerland	Completed	No outcome recorded
—	NCT05318248	Mar 2022 → Mar 2023	—	Charite University, Berlin, Germany	Completed	No outcome recorded
—	NCT02539693	Oct 2016 → Apr 2022	pilonidal sinus	Makassed General Hospital	Unknown	No outcome recorded
—	NCT02439281	May 2015 → May 2018	—	Mihaela Visoiu	Terminated	No outcome recorded
—	NCT02550444	Apr → May 2015	pregnancy disorder	University of Sao Paulo General Hospital	Completed	No outcome recorded
—	NCT02355678	Jan → Aug 2015	—	Makassed General Hospital	Completed	No outcome recorded
—	NCT02239627	Sep 2014 → Jun 2015	—	West Virginia University	Terminated	No outcome recorded
—	NCT02541071	Nov 2013 → Oct 2014	—	Charite University, Berlin, Germany	Completed	No outcome recorded
—	NCT01813149	Aug 2012 → Jun 2016	complex regional pain syndrome	The Cleveland Clinic	Terminated	No outcome recorded
—	NCT01205204	Aug 2010 → Jul 2011	—	Pravara Institute of Medical Sciences University	Withdrawn	No outcome recorded
—	NCT01175668	Jul 2010 → Aug 2012	neonatal abstinence syndrome	Baystate Medical Center	Terminated	No outcome recorded
—	NCT01507701	Jan → Mar 2010	myalgic encephalomeyelitis/chronic fatigue syndrome	Oslo University Hospital	Completed	No outcome recorded
—	NCT05831761	Sep 2009 → Oct 2011	—	University Medical Centre Ljubljana	Completed	No outcome recorded
—	NCT00588354	Oct 2006 → Feb 2009	radiculopathy	Mayo Clinic	Terminated	No outcome recorded
—	NCT00585871	May 2006 → Jan 2012	ventricular tachycardia	James Martins	Withdrawn	No outcome recorded
—	NCT00206986	May 2005 → Dec 2011	schizophrenia	Birte Glenthoj	Completed	No outcome recorded
—	NCT00580151	Jun 2004 → Jun 2014	anxiety	The University of Texas Medical Branch, Galveston	Terminated	No outcome recorded
—	NCT00356226	Oct 2000 → ?	cirrhosis of liver	CHU de Charleroi	Completed	No outcome recorded

Also used as a comparator or background therapy in 100 trials

Phase	Registry id	Dates	Indication	Sponsor	Status	Outcome
Phase 03 trials
Phase 0	NCT04833218 Comparator	Jan 2020 → Jun 2021	traumatic brain injury	Minia University	Unknown	No outcome recorded
Phase 0	NCT03388814 Background	Nov 2018 → Jun 2020	breast cancer, neuropathy, painful, substance-related disorder	Wake Forest University Health Sciences	Withdrawn	No outcome recorded
Phase 0	NCT02991404 Background	Feb → Nov 2017	—	Wake Forest University Health Sciences	Completed	No outcome recorded
Phase 15 trials
Phase 1	NCT07360301 Background	Sep 2026 → Feb 2028 expected	—	University of Wisconsin, Madison	Not yet recruiting	No outcome recorded
Phase 1	NCT05943613 Comparator	Dec 2023 → Sep 2025	—	Assiut University	Unknown	No outcome recorded
Phase 1	NCT05371574 Comparator	Jan → Aug 2022	—	Uwakwe Emmanuel Chijioke	Unknown	No outcome recorded
Phase 1	NCT04445337 Background	Nov 2020 → Oct 2021	COVID-19, acute respiratory distress syndrome	University of Nebraska	Terminated	No outcome recorded
Phase 1	NCT00748059 Background	Dec 1996 → Dec 2020	autonomic nervous system disorder, disorder of catecholamine synthesis, orthostatic hypotension	Vanderbilt University Medical Center	Completed	No outcome recorded
Phase 1/23 trials
Phase 1/2	NCT01425658 Comparator	Aug 2011 → Jan 2012	—	Qazvin University Of Medical Sciences	Completed	No outcome recorded
Phase 1/2	NCT01188421 Comparator	Oct 2010 → Jun 2015	opiate dependence	Johns Hopkins University	Completed	No outcome recorded
Phase 1/2	NCT00672347 Comparator	Jul → Sep 2008	—	Federal University of Minas Gerais	Completed	No outcome recorded
Phase 217 trials
Phase 2	NCT06031090 Comparator	Mar → Oct 2023	benign shuddering attacks	Zagazig University	Unknown	No outcome recorded
Phase 2	NCT04603911 Comparator	Dec 2020 → Apr 2023	breast cancer	Tufts Medical Center	Completed	No outcome recorded
Phase 2	NCT03552068 Comparator	May 2019 → Jul 2021	Parkinson disease, psychogenic movement disorders	Hospices Civils de Lyon	Completed	No outcome recorded
Phase 2	NCT03342950 Comparator	Feb 2019 → Oct 2021	peripheral neuropathy	Terence J. Coderre	Terminated	No outcome recorded
Phase 2	NCT03670160 Comparator	Oct 2018 → May 2020	neonatal abstinence syndrome	University of Tennessee Medical Center	Completed	No outcome recorded
Phase 2	NCT03007966 Background	Jan 2017 → Feb 2018	hernia, double inguinal	Wake Forest University Health Sciences	Completed	No outcome recorded
Phase 2	NCT02769390 Comparator	Jul → Nov 2015	—	Federal University of Minas Gerais	Completed	No outcome recorded
Phase 2	NCT01530373 Comparator	Feb 2012 → Jul 2027 expected	breast cancer	University of Arkansas	Recruiting	No outcome recorded
Phase 2	NCT01677351 Comparator	Jul 2011 → Sep 2012	cardiac rhythm disease	Federal University of São Paulo	Unknown	No outcome recorded
Phase 2	NCT01385748 Comparator	Apr 2010 → Oct 2014	chemotherapy-induced oral mucositis	Valerio Therapeutics	Completed	No outcome recorded
Phase 2	NCT01040429 Comparator	Feb 2010 → Jun 2012	myalgic encephalomeyelitis/chronic fatigue syndrome	Oslo University Hospital	Completed	No outcome recorded
Phase 2	NCT01597427 Comparator	Mar 2009 → Apr 2011	—	Federal University of São Paulo	Completed	No outcome recorded
Phase 2	NCT01620112 Comparator	Feb 2009 → Jul 2011	—	Federal University of Rio de Janeiro	Completed	No outcome recorded
Phase 2	NCT00695565 Comparator	May 2008 → Dec 2009	diabetic polyneuropathy	Arcion Therapeutics Inc	Completed	No outcome recorded
Phase 2	NCT00350532 Comparator	Sep 2004 → Mar 2008	—	Wake Forest University Health Sciences	Completed	No outcome recorded
Phase 2	NCT00349921 Comparator	Aug 2004 → Jan 2008	—	Wake Forest University Health Sciences	Completed	No outcome recorded
Phase 2	NCT00414921 Comparator	Sep 2003 → Jun 2007	attention deficit-hyperactivity disorder	University of Cincinnati	Completed	No outcome recorded

Phase 2/35 trials
Phase 2/3	NCT07151417 Background	Sep 2025 → Aug 2026 overdue	osteoarthritis, knee	Walter Reed National Military Medical Center	Not yet recruiting	No outcome recorded
Phase 2/3	NCT07062497 Comparator	Jan → Dec 2025 overdue	abdominal wall malformation	Federal University of Rio de Janeiro	Recruiting	No outcome recorded
Phase 2/3	NCT03155646 Comparator	Jun 2017 → Aug 2019	—	Assiut University	Completed	No outcome recorded
Phase 2/3	NCT02543944 Comparator	Feb 2016 → May 2021	drug dependence	University of Arkansas	Completed	No outcome recorded
Phase 2/3	NCT01856517 Comparator	Aug 2013	infectious disease with sepsis	Central Directorate of the Army Health Service	Terminated	No outcome recorded
Phase 310 trials
Phase 3	NCT07092566 Comparator	Nov 2025 → Oct 2027 expected	renal carcinoma	Wake Forest University Health Sciences	Recruiting	No outcome recorded
Phase 3	NCT05614648 Comparator	Jun 2023 → Mar 2024	radiculopathy	Sollis Therapeutics, Inc.	Terminated	No outcome recorded
Phase 3	NCT04797312 Background	Jul 2021 → Nov 2022	local anesthetic poisoning	University Hospital, Angers	Unknown	No outcome recorded
Phase 3	NCT03725930 Comparator	Mar 2019 → Nov 2021	—	University Hospital, Lille	Completed	No outcome recorded
Phase 3	NCT03396588 Comparator	Dec 2017 → Apr 2024	neonatal abstinence syndrome	Henrietta Bada	Completed	No outcome recorded
Phase 3	NCT02741713 Comparator	Apr 2016 → Jun 2017	bicipital tenosynovitis	Wake Forest University Health Sciences	Completed	No outcome recorded
Phase 3	NCT02563821 Comparator	Nov 2015 → Dec 2018	—	University Hospital, Limoges	Completed	No outcome recorded
Phase 3	NCT02628626 Comparator	Nov 2015 → Apr 2022	malabsorption syndrome	Mayo Clinic	Completed	No outcome recorded
Phase 3	NCT02324413 Comparator	Oct 2013 → Mar 2014	—	Richard Beringer	Completed	No outcome recorded
Phase 3	NCT00031395 Comparator	Sep 1999 → Jun 2007	attention deficit-hyperactivity disorder	University of Cincinnati	Completed	No outcome recorded

Phase 432 trials
Phase 4	NCT07097493 Comparator	Aug → Dec 2026 expected	osteoarthritis, knee	Wake Forest University Health Sciences	Not yet recruiting	No outcome recorded
Phase 4	NCT07350252 Comparator	Mar 2026 → Mar 2027 expected	osteoarthritis, knee	Region Skane	Recruiting	No outcome recorded
Phase 4	NCT07377630 Comparator	Mar 2026 → Mar 2027 expected	pregnancy disorder	Gaslini Institute	Not yet recruiting	No outcome recorded
Phase 4	NCT07256938 Comparator	Dec 2025 → Dec 2026 expected	—	Assiut University	Not yet recruiting	No outcome recorded
Phase 4	NCT06935331 Background	Oct 2025 → Dec 2026 expected	adolescent idiopathic scoliosis	OrthoCarolina Research Institute, Inc.	Enrolling by invitation	No outcome recorded
Phase 4	NCT07044609 Comparator	Jul 2025 → Dec 2026 expected	attention deficit-hyperactivity disorder, oppositional defiant disorder	Las Vegas Medical Research, LLC DBA Vector Clinical Trials	Not yet recruiting	No outcome recorded
Phase 4	NCT05916339 Comparator	Oct 2023 → Jan 2027 expected	attention deficit-hyperactivity disorder, autism spectrum disorder	Daniel Coury	Recruiting	No outcome recorded
Phase 4	NCT05172739 Comparator	Oct 2021 → Nov 2025 overdue	chronic pain syndrome, non-small cell lung carcinoma, substance-related disorder	University of Crete	Recruiting	No outcome recorded
Phase 4	NCT04894864 Comparator	Oct 2020 → Sep 2026 expected	abdominal aortic aneurysm	University of Crete	Recruiting	No outcome recorded
Phase 4	NCT03845894 Comparator	Mar 2020 → Jun 2022	—	Wake Forest University Health Sciences	Terminated	No outcome recorded
Phase 4	NCT03762317 Comparator	Apr → Dec 2018	neonatal abstinence syndrome	Hennepin County Medical Center, Minneapolis	Terminated	No outcome recorded
Phase 4	NCT03679052 Comparator	Mar → Aug 2018	benign shuddering attacks	Ain Shams University	Completed	No outcome recorded
Phase 4	NCT03119038 Comparator	Apr 2016 → Oct 2022	osteoarthritis	Rush University Medical Center	Withdrawn	No outcome recorded
Phase 4	NCT03704376 Comparator	Feb 2016 → Nov 2017	—	The University of Texas Health Science Center, Houston	Completed	No outcome recorded
Phase 4	NCT02543801 Comparator	Jan 2016 → Aug 2018	—	Kootenai Health	Completed	No outcome recorded
Phase 4	NCT01112878 Comparator	Jun 2015	—	Cedars-Sinai Medical Center	Withdrawn	No outcome recorded
Phase 4	NCT02365961 Background	Apr 2015 → Jun 2017	developmental dysplasia of the hip	The Hawkins Foundation	Completed	No outcome recorded
Phase 4	NCT02128451 Comparator	Apr → Oct 2014	—	Tanta University	Completed	No outcome recorded
Phase 4	NCT03017430 Comparator	Jan 2014 → Dec 2019	substance withdrawal syndrome	St. Petersburg Bekhterev Research Psychoneurological Institute	Completed	No outcome recorded
Phase 4	NCT02682498 Comparator	Oct 2013 → Jul 2015	osteoarthritis, knee	University of California, Irvine	Completed	No outcome recorded
Phase 4	NCT03174067 Comparator	Mar 2013 → Apr 2016	opiate dependence, substance withdrawal syndrome	St. Joseph's Health Centre Toronto	Completed	No outcome recorded
Phase 4	NCT01643434 Comparator	Aug 2012 → Dec 2013	hypertensive disorder	Instituto do Coracao	Unknown	No outcome recorded
Phase 4	NCT01734551 Comparator	Sep 2011 → Dec 2014	neonatal abstinence syndrome	Henrietta Bada	Completed	No outcome recorded
Phase 4	NCT01439126 Comparator	Aug 2011 → Oct 2012	attention deficit-hyperactivity disorder	Concordia Pharmaceuticals Inc., Barbados	Completed	No outcome recorded
Phase 4	NCT02773602 Comparator	May 2011 → Dec 2016	—	The University of Texas Health Science Center, Houston	Unknown	No outcome recorded
Phase 4	NCT01619436 Comparator	Jan 2011 → Jan 2012	—	Federal University of Juiz de Fora	Completed	No outcome recorded
Phase 4	NCT00860899 Comparator	Dec 2007 → Oct 2008	—	University Hospital Dubrava	Completed	No outcome recorded
Phase 4	NCT00370838 Comparator	Feb 2007 → Jul 2008	Tourette syndrome	Harvey S. Singer	Completed	No outcome recorded
Phase 4	NCT01075490 Comparator	Nov 2006	—	University Hospital, Montpellier	Unknown	No outcome recorded
Phase 4	NCT00661895 Background	Aug 2005 → Aug 2009	hypertensive disorder	Creighton University	Completed	No outcome recorded
Phase 4	NCT00421863 Background	Feb 2005 → Jan 2009	hypertensive disorder	Heart Care Foundation	Completed	No outcome recorded
Phase 4	NCT02177461 Background	Apr 2000 → Aug 2002	hypertensive disorder	Boehringer Ingelheim	Completed	No outcome recorded

Phase not applicable25 trials
—	NCT07461376 Comparator	Apr 2025 → Jun 2026 overdue	—	Cairo University	Recruiting	No outcome recorded
—	NCT06230081 Comparator	Feb 2024 → Mar 2025 overdue	osteoarthritis	Region Skane	Active not recruiting	No outcome recorded
—	NCT06180941 Comparator	Dec 2023 → Jun 2024	—	Assiut University	Unknown	No outcome recorded
—	NCT05790044 Comparator	Oct 2023 → Oct 2024	—	Assiut University	Unknown	No outcome recorded
—	NCT06287151 Comparator	Aug 2023 → Feb 2025	—	Nationwide Children's Hospital	Completed	No outcome recorded
—	NCT07297888 Comparator	Jul 2022 → Jan 2024	—	Shri Guru Ram Rai Institute of Medical and Health Sciences	Completed	No outcome recorded
—	NCT04538573 Comparator	May 2022 → Aug 2023	—	St. Justine's Hospital	Unknown	No outcome recorded
—	NCT04436250 Background	Oct 2020 → Aug 2024	fibromyalgia	Grand Hôpital de Charleroi	Terminated	No outcome recorded
—	NCT03770013 Comparator	Jan 2019 → Jun 2020	—	Aswan University Hospital	Completed	No outcome recorded
—	NCT03477994 Comparator	Dec 2018 → Feb 2019	delirium	Ain Shams University	Completed	No outcome recorded
—	NCT02643355 Comparator	Nov 2015 → Jun 2017	substance withdrawal syndrome	Hennepin Healthcare Research Institute	Completed	No outcome recorded
—	NCT02545530 Comparator	May 2015 → May 2016	—	Peking University People's Hospital	Unknown	No outcome recorded
—	NCT02276495 Background	Jan 2015 → Jun 2020	—	University of California, Irvine	Completed	No outcome recorded
—	NCT02362256 Background	May → Jun 2014	opiate dependence	Vilnius University	Completed	No outcome recorded
—	NCT02410460 Background	Sep 2013 → Jun 2014	—	Mercy Facial Plastic Surgery Center	Completed	No outcome recorded
—	NCT01851486 Comparator	Jan 2013 → Sep 2016	—	Rambam Health Care Campus	Withdrawn	No outcome recorded
—	NCT01179009 Background	Apr 2012 → Jun 2014	mood disorder	Washington University School of Medicine	Completed	No outcome recorded
—	NCT01042093 Comparator	Jan 2010 → Jul 2011	osteoarthritis, knee	Towson Orthopaedic Associates	Completed	No outcome recorded
—	NCT01015807 Comparator	Nov 2009 → Aug 2010	secondary erythromelalgia	University of Washington	Completed	No outcome recorded
—	NCT00413582 Comparator	Oct 2006 → May 2010	—	Children's Mercy Hospital Kansas City	Completed	No outcome recorded
—	NCT00492973 Background	Mar 2006 → Feb 2008	osteoarthritis, knee	New Lexington Clinic	Completed	No outcome recorded
—	NCT00226096 Background	Nov 2005 → Sep 2007	intracerebral hemorrhage	The George Institute	Completed	No outcome recorded
—	NCT00638729 Comparator	Aug 2005 → Mar 2007	anxiety	University Hospital Schleswig-Holstein	Completed	No outcome recorded
—	NCT00329511 Comparator	Sep 2004 → Dec 2008	hypertensive disorder	Afshan B. Hameed, M.D.	Withdrawn	No outcome recorded
—	NCT00684489 Comparator	Sep 2003 → Mar 2005	essential hypertension	Medical University of South Carolina	Completed	No outcome recorded

Evidence & citations 44 cited values

Every value below carries the sentence it was read from. 254 sources stand behind the page.

Field	Value	Cited text
Known as	Clonidine	“Patients assigned to the pectoralis block group will receive a total of 20 ml 0.25% bupivacaine (with 1:200,000 epinephrine and 1.67 mcg clonidine per ml) in the tissue plane...” NCT03388814 ↗ 242 “The "Treatment Arm" receive a single shot adductor canal block containing 20 milliliters (ml) of solution including 0.25% bupivacaine, 150 mcg of buprenorphine, 2 mg of...” NCT02991404 ↗ “Postoperative patient controlled epidural analgesia (epidural cathterer inserted into Th7-8 intervertebral space, 200 ml of 0.125% levobupivacaine, 4 mg of morphine, 0.075 mg...” NCT05831761 ↗ “A standard joint injection of 100ml (Clonidine 80 mcg, Epinephrine 0.5mg, Ketorolac 30mg, Ropivacaine 246.25mg, and Sodium Chloride 0.9% 48.45 ml) will be injected into the...” NCT02682498 ↗ “The patient is given one intrathecal dose of plain bupivacaine (Marcain® spinal) 5 mg/ml, 15 mg together with morphine (Morphine Special®) 0,4 mg/ml, 0.2 mg and clonidine...” NCT02026687 ↗ “In addition to propofol as a hypnotic and rocuronium as a muscle relaxant, patients in the opioid-sparing group will receive Ketamine, Fentanyl, Lidocaine, Magnesium,...” NCT05485480 ↗ “Topical Solution of Clonidine (0.01%) + Pentoxifylline (5%) in anhydrous ethanol (6.5%), polyethylene glycol 400 (20%), propylene glycol (53.5%), and oleyl alcohol (20%)” NCT03342950 ↗ “The medication used for the block are clonidine 100 mcg, Decadron PF 5mg and 0.25% bupivacaine 5 mL. This medication will be administered once during the block.” NCT04445337 ↗ “The active comparator is composed of clonidine 1 microg/kg combined with magnesium sulfate 40 mg/kg diluted in 45 ml of sodium chloride” NCT04436250 ↗ “Interscalene brachial plexus blockade using plain bupivacaine with adjuvants: clonidine, epinephrine, buprenorphine, dexamethasone.” NCT03845894 ↗ “bupivacaine HCl 80 mg, morphine 4 mg, epinephrine 300 micrograms, clonidine 100 micrograms, cefuroxime 750 mg, and normal saline” NCT00492973 ↗ “The unit's protocol includes drugs such as Morphine, Hydromorphone, Fentanyl, Clonidine, Ketamine, Midazolam and Acetaminophen.” NCT04538573 ↗ “All participants who successfully taper off buprenorphine receive Clonidine (0.1 mg) prior to induction onto oral naltrexone.” NCT02543944 ↗ “Mechanically ventilated infants and children receive intravenous intermittent Clonidine instead of dexmedetomidine” NCT02249039 ↗ “The study group (OFA group) will receive a combination of clonidine, magnesium sulfate, ketamine, and lidocaine.” PMID 34838109 ↗ Nov 2021 “Propranolol Versus Propranolol and Clonidine in Sympathetic Hyperactivity After Moderate Traumatic Brain Injury” NCT04833218 ↗ “15ml 0.5% bupivacaine,25 mg of meperdine and 1 ml of clonidine will be injected epidurally in meperdine Group.” NCT02128451 ↗ “The anesthetist prepares two sy-ringes with 20 ml each with ropivacaine 0.25% with 75 μg of clonidine.” NCT07377630 ↗ “2.5mg morphine, 40 micrograms clonidine, 15mg ketorolac, and 4ml normal saline (deep injection).” NCT05037812 ↗ “PCA pump with Ketamine, Lidocaine, Clonidine and Midazolam for the first 3 postoperative days.” NCT04894864 ↗ “Clonidine (Brand Names: Kapvay, Catapres, Duraclon, Nexiclon) 0.1 mg/ml (0.08 mg = 0.8 ml)” NCT02571283 ↗ “Intrafascial injection of clonidine, epinephrine, ropivacaine, and toradol solution” NCT06935331 ↗ “20mL of 0.25% bupivacaine with 1:400,000 epinephrine and 1:600,000 clonidine” NCT02741713 ↗ “In this group the investigators have given clonidine to the participants” NCT07297888 ↗ “PCA pump with Ketamine, Lidocaine, Clonidine, Droperidol and Midazolam” NCT05172739 ↗ “Maxillary anesthesia obtained by 2% lidocaine + clonidine (15 mcg/ml)” NCT02371759 ↗ “Clonidine is a selective partial agonist of the alpha-2 receptors” NCT03121261 ↗ “PIFB with bupivacaine, epinephrine, clonidine, and dexamethasone” NCT05676814 ↗ “Ropivacaine HCl - Betamethasone Sodium Phosphate - Clonidine HCl” NCT06781632 ↗ “prazosin, terazosin, clonidine, clonidine patch, methyldopa” NCT00684489 ↗ “Catapres, Clonidine, Guanfacine, Intuniv, Kapvay, Tenex” NCT05916339 ↗ “fentanyl 1 - 1.2 mcg/kg and clonidine 1.8 - 2mcg/kg.” NCT00413582 ↗ “TCI propofol mixed with clonidine and ketamine” NCT05536362 ↗ “2% lidocaine + 1.5 mcg/kg clonidine” NCT01759524 ↗ “and 0.3 ml clonidine 150 µg ml-1” NCT02355678 ↗ “0.8 ml clonidine (0.1mg/ml)” NCT07151417 ↗ “Clonidine 100 mcg/mL, 0.4mL” NCT03696199 ↗ “Clonidine” NCT02628626 ↗ NCT00691795 ↗ NCT00287326 ↗ NCT03119038 ↗ NCT01677351 ↗ NCT03679052 ↗ NCT06507410 ↗ NCT00672347 ↗ NCT00748059 ↗ NCT07461376 ↗ NCT01297335 ↗ NCT01876355 ↗ NCT04530903 ↗ NCT02545530 ↗ NCT01956604 ↗ NCT05560230 ↗ NCT07360301 ↗ NCT07062497 ↗ NCT00335582 ↗ NCT00262470 ↗ NCT02570503 ↗ NCT00588354 ↗ NCT07097493 ↗ NCT01813149 ↗ NCT05592379 ↗ NCT00678379 ↗ NCT04758936 ↗ NCT03537612 ↗ NCT06230081 ↗ NCT00695565 ↗ NCT01734551 ↗ NCT01293149 ↗ NCT01082874 ↗ NCT03552068 ↗ NCT01112878 ↗ NCT01902108 ↗ NCT02365961 ↗ NCT00959062 ↗ NCT05848531 ↗ NCT02444559 ↗ NCT02643355 ↗ NCT00329511 ↗ NCT05355597 ↗ NCT05360953 ↗ NCT03174067 ↗ NCT02643251 ↗ NCT01507701 ↗ NCT00226096 ↗ NCT00723190 ↗ NCT02362256 ↗ NCT02891798 ↗ NCT04648020 ↗ NCT00223717 ↗ NCT05790044 ↗ NCT05091242 ↗ NCT03704376 ↗ NCT01052623 ↗ NCT05371574 ↗ NCT02740127 ↗ NCT01075490 ↗ NCT01597427 ↗ NCT01963299 ↗ NCT00661895 ↗ NCT03147092 ↗ NCT01862250 ↗ NCT01559012 ↗ NCT02769390 ↗ NCT02268448 ↗ NCT02177461 ↗ NCT02543801 ↗ NCT03155646 ↗ NCT02410460 ↗ NCT00194974 ↗ NCT07350252 ↗ NCT02530151 ↗ NCT00510016 ↗ NCT03520543 ↗ NCT01530373 ↗ NCT07313371 ↗ NCT02324413 ↗ NCT00417443 ↗ NCT02068027 ↗ NCT00318760 ↗ NCT03762317 ↗ NCT01643434 ↗ NCT00858845 ↗ NCT00884832 ↗ NCT02773602 ↗ NCT00730054 ↗ NCT00279253 ↗ NCT02365727 ↗ NCT06447194 ↗ NCT00930072 ↗ NCT00370838 ↗ NCT03124082 ↗ NCT02067078 ↗ NCT01042093 ↗ NCT07044609 ↗ NCT04263064 ↗ NCT01856517 ↗ NCT01986751 ↗ NCT02563821 ↗ NCT04877093 ↗ NCT00295308 ↗ NCT03065933 ↗ NCT00000279 ↗ NCT03770013 ↗ NCT07567495 ↗ NCT01415895 ↗ NCT05575219 ↗ NCT01620112 ↗ NCT00585871 ↗ NCT05943613 ↗ NCT06180941 ↗ NCT02953210 ↗ NCT03117140 ↗ NCT03396588 ↗ NCT03018171 ↗ NCT02466373 ↗ NCT05824832 ↗ NCT00356226 ↗ NCT01040429 ↗ NCT02509273 ↗ NCT00166686 ↗ NCT01175668 ↗ NCT00437996 ↗ NCT02361476 ↗ NCT03017430 ↗ NCT04186299 ↗ NCT04423627 ↗ NCT02541071 ↗ NCT02812368 ↗ NCT01761916 ↗ NCT02239627 ↗ NCT01638052 ↗ NCT00661063 ↗ NCT05416840 ↗ NCT04902859 ↗ NCT01205204 ↗ NCT01425658 ↗ NCT03057015 ↗ NCT02548806 ↗ NCT03109795 ↗ NCT01983462 ↗ NCT01785693 ↗ NCT03007966 ↗ NCT01322048 ↗ NCT03653832 ↗ NCT01784250 ↗ NCT00580151 ↗ NCT02733757 ↗ NCT05614648 ↗ NCT02355158 ↗ NCT01619436 ↗ NCT01188421 ↗ NCT04934228 ↗ NCT01360450 ↗ NCT02539693 ↗ NCT04828226 ↗ NCT03092011 ↗ NCT01385748 ↗ NCT00031395 ↗ NCT06780865 ↗ NCT00556959 ↗ NCT04603911 ↗ NCT00130091 ↗ NCT04032691 ↗ NCT02181543 ↗ NCT05487196 ↗ NCT06137924 ↗ NCT02439281 ↗ NCT01139996 ↗ NCT00860925 ↗ NCT05029726 ↗ NCT03670160 ↗ NCT01851486 ↗ NCT00206986 ↗ NCT05029050 ↗ NCT00983125 ↗ NCT00638729 ↗ NCT02276495 ↗ NCT04030572 ↗ NCT00152750 ↗ NCT03725930 ↗ NCT04026074 ↗ NCT02778178 ↗ NCT01846221 ↗ NCT00350532 ↗ NCT06031090 ↗ NCT00860899 ↗ NCT00535925 ↗ NCT07131657 ↗ NCT02550444 ↗ NCT07256938 ↗ NCT01015807 ↗ NCT06287151 ↗ NCT01370811 ↗ NCT00349921 ↗ NCT03727100 ↗ NCT07092566 ↗ NCT02655965 ↗ NCT01179009 ↗ NCT01598896 ↗ NCT03477994 ↗ NCT00414921 ↗ NCT01136278 ↗
Known as	ARC-4558	“Drug: Clonidine Topical Gel (ARC-4558)” NCT00695565 ↗
Known as	Catapres	ChEMBL registry synonym — accepted as the source's own label CHEMBL134 ↗
Known as	Catapres p.l.	ChEMBL registry synonym — accepted as the source's own label CHEMBL134 ↗
Known as	Catapres tts 1	ChEMBL registry synonym — accepted as the source's own label CHEMBL134 ↗
Known as	Catapres tts 2	ChEMBL registry synonym — accepted as the source's own label CHEMBL134 ↗
Known as	Catapres TTS-3	“Patients enrolled in the treatment group will receive an oral loading dose of Clonidine 0.3 mg and placement of a Clonidine Transdermal system at a dose of 0.3-mg/day (Catapres...” NCT01139996 ↗
Known as	Catapres, Kapvay (clonidine)	“Catapres, Kapvay (clonidine)” NCT05037812 ↗
Known as	Catapres-TTS	“Transdermal clonidine (Catapres-TTS®) is a preparation of clonidine hydrochloride that can be released and absorbed transdermally over a 7-day period.” NCT00329511 ↗
Known as	Catapresan	“The patient is given one intrathecal dose of plain bupivacaine (Marcain® spinal) 5 mg/ml, 15 mg together with morphine (Morphine Special®) 0,4 mg/ml, 0.2 mg and clonidine...” NCT02026687 ↗ 4 “Clonidine was approved by the FDA in 1974 and is registered in Austria with the brand name "Catapresan".” NCT00279253 ↗ “Clonidine (Catapresan®) 0,150 mg/ml, ampoule 1 ml” NCT02466373 ↗ NCT04564430 ↗ NCT00421863 ↗
Known as	Catapress	“Intervention Group: Start oral (PO/NG/OG) Clonidine HCl (Catapress) at 0.38 mcg/kg/dose every 3 hours or 0.5 mcg/kg/dose every 4 hours depending on baby's feeding schedule.” NCT03092011 ↗
Known as	Catapressan	“Currently, two pharmacological α-2 agonists, clonidine (Catapressan®, Boehringer Ingelheim) and dexmedetomidine (Dexdor®, Orion Corporation), are marketed and commonly used in...” NCT04758936 ↗
Known as	Catarpres-tts	ChEMBL registry synonym — accepted as the source's own label CHEMBL134 ↗
Known as	CLON	“The aim of this study was to determine the effect on family quality of life (QOL) of clonidine (CLON) and methylphenidate (MPH), used alone and in combination, in treating...” PMID 19877975 ↗ Oct 2009 2 “Alpha 2-adrenergic receptor agonists, dexmedetomidine (DEX) and clonidine (CLON) have excellent sedative-analgesics effects, do not cause respiratory depression and are...” NCT02249039 ↗ “investigational study drug, Clonidine Hydrochloride ( CLON).” NCT01862250 ↗
Known as	CLON-XR	“This study examined the efficacy and safety of clonidine hydrochloride extended-release tablets (CLON-XR) in children and adolescents with attention-deficit/hyperactivity...” PMID 21241954 ↗ Feb 2011
Known as	CLONICEL	“CLONICEL (Clonidine HCl sustained release)” NCT00723190 ↗
Known as	Clonidin	ClinicalTrials.gov intervention name — accepted as the source's own label NCT05318248 ↗ 1 NCT00312416 ↗
Known as	Clonidina	ChEMBL registry synonym — accepted as the source's own label CHEMBL134 ↗
Known as	clonidine [Catapres, Boehringer Ingelheim, Germany]	“clonidine [Catapres®, Boehringer Ingelheim, Germany]” NCT00860899 ↗
Known as	Clonidine extended release	ChEMBL registry synonym — accepted as the source's own label CHEMBL134 ↗
Known as	Clonidine Gel	“Study CLO-311 is a multicenter, open-label, single-arm study to assess the long-term use of Clonidine Gel in the treatment of pain associated with PDN.” NCT02355158 ↗ 1 “Clonidine Gel” NCT02643251 ↗
Known as	Clonidine HCL	“Interventions: Infants will receive intravenous or oral clonidine(Duraclon) for the treatment of pain and sedation: Duration: (Clonidine HCL) 1 mcg/kg/dose q4 either iv or po.” NCT01360450 ↗ 5 “Intervention Group: Start oral (PO/NG/OG) Clonidine HCl (Catapress) at 0.38 mcg/kg/dose every 3 hours or 0.5 mcg/kg/dose every 4 hours depending on baby's feeding schedule.” NCT03092011 ↗ “Then, the drug test article, clonidine HCl, 0.1 mg tabs, will be administered once daily by mouth at bedtime for one week.” NCT04030572 ↗ “high dose clonidine HCl sustained release tablets for 8 weeks” NCT00556959 ↗ “Drug: Clonidine HCL” NCT07092566 ↗ “Drug: Clonidine HCL” NCT00510016 ↗
Known as	Clonidine HCl sustained release	“CLONICEL (Clonidine HCl sustained release)” NCT00723190 ↗
Known as	Clonidine Hydrochloride	“This study examined the efficacy and safety of clonidine hydrochloride extended-release tablets (CLON-XR) in children and adolescents with attention-deficit/hyperactivity...” PMID 21241954 ↗ Feb 2011 5 “investigational study drug, Clonidine Hydrochloride ( CLON).” NCT01862250 ↗ “Clonidine Hydrochloride Topical Gel, 0.1%” NCT02643251 ↗ “Drug: Clonidine Hydrochloride” NCT02953210 ↗ NCT02592915 ↗ NCT01439126 ↗
Known as	Clonidine hydrochloride component of clorpres	ChEMBL registry synonym — accepted as the source's own label CHEMBL134 ↗
Known as	Clonidine hydrochloride component of combipres	ChEMBL registry synonym — accepted as the source's own label CHEMBL134 ↗
Known as	Clonidine Lauriad	“Clonidine Lauriad® 50 μg and 100 μg Mucoadhesive Buccal Tablet (MBT)” NCT01385748 ↗
Known as	Clorpres	ChEMBL registry synonym — accepted as the source's own label CHEMBL134 ↗
Known as	Combipres	ChEMBL registry synonym — accepted as the source's own label CHEMBL134 ↗
Known as	Dichloranilino imidazolin	ChEMBL registry synonym — accepted as the source's own label CHEMBL134 ↗
Known as	Dixarit	ChEMBL registry synonym — accepted as the source's own label CHEMBL134 ↗
Known as	Duraclon	“Interventions: Infants will receive intravenous or oral clonidine(Duraclon) for the treatment of pain and sedation: Duration: (Clonidine HCL) 1 mcg/kg/dose q4 either iv or po.” NCT01360450 ↗ 1 “Clonidine (Duraclon®)” NCT01862250 ↗
Known as	Jenloga	ChEMBL registry synonym — accepted as the source's own label CHEMBL134 ↗
Known as	Kapvay	“If Vyvanse +/- Adderall is also ineffective or not tolerated, participants will progress to Kapvay;” NCT04737512 ↗
Known as	klonidin	ClinicalTrials.gov intervention name — accepted as the source's own label NCT02030717 ↗
Known as	Nexiclon xr	ChEMBL registry synonym — accepted as the source's own label CHEMBL134 ↗
Known as	NSC-756699	ChEMBL registry synonym — accepted as the source's own label CHEMBL134 ↗
Known as	Onyda xr	ChEMBL registry synonym — accepted as the source's own label CHEMBL134 ↗
Known as	OnydaTM XR	“A Study to Assess the Effectiveness and Safety of Clonidine Extended-Release OnydaTM XR in Children With ADHD and ODD” NCT07044609 ↗
Known as	ST-155	ChEMBL registry synonym — accepted as the source's own label CHEMBL134 ↗
Known as	ST-155-BS	ChEMBL registry synonym — accepted as the source's own label CHEMBL134 ↗
Action	Activate	“It acts by stimulating adrenergic receptors on nerves in the brain and Imidazol-receptors.” NCT00279253 ↗
Modality	Other / unclassified	“clonidine (an alpha-2 adrenergic agonist)” NCT02643355 ↗
Route	Oral	“Clonidine 0.05-0.3 mg PO x 1 dose” NCT00262470 ↗