drugset
drugset / Trial / NCT00748059

The Pathophysiology of Orthostatic Hypotension

NCT00748059 ↗

Phase 1 Completed 10 enrolled Vanderbilt University Medical Center
NaSingle-groupOpen-labelScreening

Summary

The purpose of this study is to determine the cause of low blood pressure in selective patients who have problems with their involuntary (autonomic) nervous system. These patients frequently have had symptoms throughout their life, and their disorder might have a genetic basis. The biochemical, physiological and pharmacological procedures in this study should help us define the problem and perhaps lead to more effective treatment.

Timeline

Start
1996-12
Primary completion
2020-12
Completion
2020-12

Publications

Drugs

EvaluationDrugModalityDoseRoute
Background Atropine Other / unclassified 0.01 mg/kg Intravenous
Background Clonidine Other / unclassified 0.1 mg Oral
Background Clonidine Other / unclassified 0.3 mg Oral
Background Isoproterenol Small molecule 0.1 ug Intravenous
Background Isoproterenol Small molecule 0.4 ug Intravenous
Background Metoclopramide Small molecule 10 mg Oral
Background Phenylephrine Small molecule 12.5 ug Intravenous
Background Phenylephrine Small molecule 400 ug Intravenous
Background Propranolol Small molecule 1.1 mg Intravenous
Background Tyramine Small molecule 250 ug Intravenous
Background Tyramine Small molecule 4000 ug Intravenous
Background Yohimbine Small molecule 5 mg Oral
Background Yohimbine Small molecule 10 mg Oral
Background alpha methyldopa Unknown 62.5 mg Oral
Background edrophonium Small molecule 10 mg Intravenous
Background nitroprusside Other / unclassified 0.1 ug/kg Intravenous
Background nitroprusside Other / unclassified 1.6 ug/kg Intravenous

Indications

autonomic nervous system disorder disorder of catecholamine synthesis orthostatic hypotension