Phenylephrine

also known as phenylephrine hydrochloride · Phenylephrine HCl · Mydfrin · BAY112476 · Biorphen · PE HCl · PEH · PHE · +6 more

Small molecule

Developed for: hypotensive disorder · hypertensive disorder · cataract · infectious disease with sepsis · seasonal allergic rhinitis · common cold · ischemic stroke · respiratory tract infectious disorder
+24 more
· rhinitis · acute kidney injury · allergic rhinitis · arterial disorder · brain hypoxia - ischemia · preeclampsia · syncope, familial vasovagal · Achoo syndrome · baldness, male pattern · bronchiolitis · heart failure · influenza · intraoperative floppy iris syndrome · mouth disorder · nasal cavity disorder · pulmonary arterial hypertension · telogen effluvium · vasomotor rhinitis · acute myocardial infarction · chemotherapy-induced alopecia · eye disorder · hemorrhoid · mucositis · traumatic brain injury
Investigated by: General Hospital of Ningxia Medical University · Bayer · Eyenovia Inc. · IWK Health Centre · Omeros Corporation · University of Alberta
+119 more
· Ache Laboratorios Farmaceuticos S.A. · GlaxoSmithKline · KK Women's and Children's Hospital · Seoul National University Hospital · University of Wisconsin, Madison · Aristotle University Of Thessaloniki · Beijing Tiantan Hospital · Cairo University · Inje University · Johns Hopkins University · Khon Kaen University · Mayo Clinic · National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) · National Institutes of Health (NIH) · Samsung Medical Center · Samuel Lunenfeld Research Institute, Mount Sinai Hospital · The Second Affiliated Hospital of Dalian Medical University · University Hospital, Ghent · University of California, San Francisco · University of Michigan · University of Roma La Sapienza · Wake Forest University Health Sciences · Xuzhou Medical University · Aarhus University Hospital · Akron Children's Hospital · Algemeen Ziekenhuis Maria Middelares · American University of Beirut Medical Center · Applied Biology, Inc. · AstraZeneca · Baylor College of Medicine · Burapha University · Cambridge University Hospitals NHS Foundation Trust · Canadian Critical Care Trials Group · Canadian Institutes of Health Research (CIHR) · Carilion Clinic · Central Hospital, Nancy, France · China International Neuroscience Institution · Colorado State University · Crystal A. Gadegbeku · DHS Consulting · Dalian Municipal Central Hospital · Daniel Alain, Inc. · Dar El Oyoun Hospital · Denver Health and Hospital Authority · Duke University · Eurofarma Laboratorios S.A. · Follea International Limited · Fonds de la Recherche en Santé du Québec · Francois Lamontagne · Georgetown University · Gyeongsang National University Hospital · Indonesia University · Jason Chui · Johnson & Johnson Consumer and Personal Products Worldwide · KIST Medical and Teaching Hospital · Keimyung University Dongsan Medical Center · London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's · Medical University of Vienna · Montefiore Medical Center · Murdoch University · NYU Langone Health · National Center for Research Resources (NCRR) · National Heart, Lung, and Blood Institute (NHLBI) · National and Kapodistrian University of Athens · Nepal Health Research Council · New York Medical College · New York Presbyterian Brooklyn Methodist Hospital · Northwestern University · Novartis · Organon and Co · Oslo University Hospital · Peking University First Hospital · Pfizer · Pontificia Universidad Catolica de Chile · all 125 on the full record

Regulatory milestones approvals, filings & regulatory actions · 3 recorded

Milestone	Jurisdiction	Brand	Indication	Date	Sentence it was read from
Label expansion	US (FDA)	BIORPHEN	—	2021-03-11	fda.gov ↗
Approved	EU (EMA)	Omidria	—	2015-07-28	europa.eu ↗
Approved	US (FDA)	PHENERGAN W/ CODEINE	—	1952-01-21	fda.gov ↗

Trials 146 · started per year

today

US approved 1952

EU approved 2015

19501951195219531954195519561957195819591960196119621963196419651966196719681969197019711972197319741975197619771978197919801981198219831984198519861987198819891990199119921993199419951996199719981999200020012002200320042005200620072008200920102011201220132014201520162017201820192020202120222023202420252026202720282029

Phase	Registry id	Dates	Indication	Sponsor	Status	Outcome
Phase 08 trials
Phase 0	NCT06539637	Sep 2023 → Nov 2025 overdue	cataract	DHS Consulting	Recruiting	No outcome recorded
Phase 0	NCT06288321	Aug 2022 → Mar 2023	retinopathy of prematurity	The University of Hong Kong	Completed	No outcome recorded
Phase 0	NCT05011357	Sep 2021 → Aug 2024	—	University of Texas Southwestern Medical Center	Completed	No outcome recorded
Phase 0	NCT04436731	Dec 2020 → Jun 2026 overdue	obesity disorder	University of Missouri-Columbia	Active not recruiting	No outcome recorded
Phase 0	NCT04218773	Sep 2020 → Aug 2026	hypertensive disorder, ischemic stroke	Yale University	Suspended	No outcome recorded
Phase 0	NCT03972683	Apr 2019 → Jul 2021	—	Colorado State University	Withdrawn	No outcome recorded
Phase 0	NCT03719001	Oct 2018 → Jun 2022	vascular disorder	University of California, San Francisco	Completed	No outcome recorded
Phase 0	NCT01791816	Feb 2013 → Dec 2022	postural orthostatic tachycardia syndrome, syncope, familial vasovagal	New York Medical College	Completed	No outcome recorded
Phase 16 trials
Phase 1	NCT03415243	Mar 2018	common cold	GlaxoSmithKline	Completed	No outcome recorded
Phase 1	NCT03098680	Apr 2017 → Feb 2020	cardiovascular disorder	Cambridge University Hospitals NHS Foundation Trust	Terminated	No outcome recorded
Phase 1	NCT01731444	Dec 2014 → Jun 2028 expected	—	University of Manitoba	Recruiting	No outcome recorded
Phase 1	NCT02009007	Dec 2012 → Jun 2014	brain hypoxia - ischemia, hypotensive disorder	Samsung Medical Center	Unknown	No outcome recorded
Phase 1	NCT01092975	Mar → Nov 2010	stomatitis	University of Wisconsin, Madison	Terminated	No outcome recorded
Phase 1	NCT00762567	Sep → Nov 2008	rhinitis	Johnson & Johnson Consumer and Personal Products Worldwide	Completed	No outcome recorded
Phase 1/24 trials
Phase 1/2	NCT07075224	Nov 2025	—	Unither Pharmaceuticals, France	Completed	No outcome recorded
Phase 1/2	NCT04500899	Dec 2020 → Jun 2026 overdue	mitral valve insufficiency	Montefiore Medical Center	Recruiting	No outcome recorded
Phase 1/2	NCT02434146	May 2015 → Apr 2016	disease related to transplantation, mouth disorder, neoplasm	University of Wisconsin, Madison	Terminated	No outcome recorded
Phase 1/2	NCT00972998	Sep → Dec 2009	—	RDD Pharma Ltd	Completed	No outcome recorded
Phase 210 trials
Phase 2	NCT04972123	Jul 2021 → Aug 2023	syncope, familial vasovagal	University of Wisconsin, Madison	Completed	No outcome recorded
Phase 2	NCT04089072	Dec 2019 → Oct 2024	infectious disease with sepsis	Carilion Clinic	Unknown	No outcome recorded
Phase 2	NCT02946125	Oct → Nov 2016	—	Eyenovia Inc.	Completed	No outcome recorded
Phase 2	NCT01330017	Mar → May 2011	seasonal allergic rhinitis	Bayer	Completed	No outcome recorded
Phase 2	NCT01533662	Mar 2011 → May 2013	—	University Hospital, Toulouse	Completed	No outcome recorded
Phase 2	NCT00639015	Nov 2007 → Jun 2008	infectious disease with sepsis	University of Roma La Sapienza	Completed	No outcome recorded
Phase 2	NCT00481442	Jan → Mar 2007	infectious disease with sepsis	University of Roma La Sapienza	Completed	No outcome recorded
Phase 2	NCT00373802	Jan → Jun 2005	bronchiolitis	Akron Children's Hospital	Completed	No outcome recorded
Phase 2	NCT00227448	Jun 2003 → Apr 2005	ischemic stroke	Johns Hopkins University	Completed	No outcome recorded
Phase 2	NCT00431392	Sep 2001 → ?	—	Medical University of Vienna	Completed	No outcome recorded
Phase 2/34 trials
Phase 2/3	NCT06648850	May 2026 → Mar 2027 expected	baldness, male pattern, telogen effluvium	Applied Biology, Inc.	Not yet recruiting	No outcome recorded
Phase 2/3	NCT03833895	Feb → Sep 2019	—	China International Neuroscience Institution	Completed	No outcome recorded
Phase 2/3	NCT02277730	May 2013 → Nov 2017	hypotensive disorder	KK Women's and Children's Hospital	Completed	No outcome recorded
Phase 2/3	NCT04025918	Oct 2011 → Jul 2012	hypotensive disorder	KK Women's and Children's Hospital	Completed	No outcome recorded
Phase 323 trials
Phase 3	NCT05118672	Mar → Aug 2025	influenza	Eurofarma Laboratorios S.A.	Completed	No outcome recorded
Phase 3	NCT05070650	Sep 2024 → Apr 2025	common cold	Sandoz	Withdrawn	No outcome recorded
Phase 3	NCT05706727	Mar 2023 → Apr 2024	—	KIST Medical and Teaching Hospital	Completed	No outcome recorded
Phase 3	NCT02904304	Dec 2020 → Jul 2021	—	Ache Laboratorios Farmaceuticos S.A.	Suspended	No outcome recorded
Phase 3	NCT04067817	Oct → Dec 2019	hypotensive disorder	The Second Affiliated Hospital of Dalian Medical University	Unknown	No outcome recorded
Phase 3	NCT03751631	Nov 2018 → Jan 2019	—	Eyenovia Inc.	Completed	No outcome recorded
Phase 3	NCT02730364	Feb → Apr 2017	respiratory tract infectious disorder	GlaxoSmithKline	Withdrawn	No outcome recorded
Phase 3	NCT02678234	Feb → Apr 2017	respiratory tract infectious disorder	GlaxoSmithKline	Withdrawn	No outcome recorded
Phase 3	NCT03215797	Sep → Dec 2016	hypotensive disorder	The Second Affiliated Hospital of Dalian Medical University	Completed	No outcome recorded
Phase 3	NCT01938144	Apr → Nov 2016	common cold	Pfizer	Withdrawn	No outcome recorded
Phase 3	NCT02401191	Mar → Jul 2015	allergic rhinitis	Sanofi	Completed	No outcome recorded
Phase 3	NCT01393548	Aug 2014 → Nov 2016	rhinitis	Ache Laboratorios Farmaceuticos S.A.	Completed	No outcome recorded
Phase 3	NCT01393561	Jul → Oct 2014	rhinitis	Ache Laboratorios Farmaceuticos S.A.	Completed	No outcome recorded
Phase 3	NCT02093689	Feb → Aug 2014	intraoperative floppy iris syndrome	Omeros Corporation	Terminated	No outcome recorded
Phase 3	NCT01448057	Jul 2013 → Aug 2015	Achoo syndrome, nasal cavity disorder, respiratory tract infectious disorder	Novartis	Completed	No outcome recorded
Phase 3	NCT01600235	Jun 2012 → Dec 2017	ischemic stroke	Samsung Medical Center	Unknown	No outcome recorded
Phase 3	NCT04534452	May → Jun 2012	allergic rhinitis	Bayer	Completed	No outcome recorded
Phase 3	NCT01579565	Apr → Nov 2012	—	Omeros Corporation	Completed	No outcome recorded
Phase 3	NCT01413958	Aug → Oct 2011	seasonal allergic rhinitis	Bayer	Completed	No outcome recorded
Phase 3	NCT00976209	Aug → Nov 2009	seasonal allergic rhinitis, vasomotor rhinitis	Bayer	Completed	No outcome recorded
Phase 3	NCT00874120	Dec 2008 → Feb 2009	hypertensive disorder	Bayer	Completed	No outcome recorded
Phase 3	NCT00420797	Feb → Nov 2007	—	S.L.A. Pharma AG	Withdrawn	No outcome recorded
Phase 3	NCT00276016	Jan → Feb 2006	seasonal allergic rhinitis	Organon and Co	Completed	No outcome recorded

Phase 443 trials
Phase 4	NCT07662408	May 2026 → Mar 2027 expected	—	Sohag University	Recruiting	No outcome recorded
Phase 4	NCT06366217	Sep → Dec 2024 overdue	abnormal pupillary function	University of California, San Francisco	Not yet recruiting	No outcome recorded
Phase 4	NCT07327320	Jun 2024 → Oct 2025	hypotensive disorder	Tam Anh Research Institute	Completed	No outcome recorded
Phase 4	NCT05890027	Mar 2024 → Apr 2025	ptosis	University of Miami	Completed	No outcome recorded
Phase 4	NCT06334549	Mar 2024 → Dec 2025 overdue	hypotensive disorder	Dalian Municipal Central Hospital	Recruiting	No outcome recorded
Phase 4	NCT06217796	Nov 2023 → Jan 2024	—	Eyenovia Inc.	Completed	No outcome recorded
Phase 4	NCT05997732	Oct 2023 → Dec 2027 expected	—	University of Alberta	Recruiting	No outcome recorded
Phase 4	NCT05941494	Oct 2023 → Dec 2025	—	Jason Chui	Unknown	No outcome recorded
Phase 4	NCT04829799	Feb 2022 → Aug 2023	—	University of Florida	Withdrawn	No outcome recorded
Phase 4	NCT04991662	Oct → Dec 2021	—	Xuzhou Medical University	Completed	No outcome recorded
Phase 4	NCT05043077	Sep 2021 → Jan 2023	retinopathy of prematurity	Aristotle University Of Thessaloniki	Completed	No outcome recorded
Phase 4	NCT04907474	May → Jun 2021	—	Eyenovia Inc.	Completed	No outcome recorded
Phase 4	NCT04602767	Oct 2020 → May 2024	acute kidney injury	Thomas Jefferson University	Unknown	No outcome recorded
Phase 4	NCT04419662	May 2020 → May 2021	—	Aarhus University Hospital	Completed	No outcome recorded
Phase 4	NCT04623684	Mar → Sep 2020	retinopathy of prematurity	Aristotle University Of Thessaloniki	Completed	No outcome recorded
Phase 4	NCT03864133	Jul 2019 → Jun 2021	cataract	Wake Forest University Health Sciences	Completed	No outcome recorded
Phase 4	NCT03846765	Jul 2019 → May 2021	—	University Hospital, Ghent	Completed	No outcome recorded
Phase 4	NCT03638726	Sep 2018 → Mar 2019	cataract	Dar El Oyoun Hospital	Unknown	No outcome recorded
Phase 4	NCT03615508	Sep 2018 → May 2019	Horner syndrome	Denver Health and Hospital Authority	Terminated	No outcome recorded
Phase 4	NCT03302039	Oct 2017 → Oct 2018	—	Cairo University	Completed	No outcome recorded
Phase 4	NCT03248817	Sep 2017 → May 2020	—	Cairo University	Unknown	No outcome recorded
Phase 4	NCT03767296	Feb → Sep 2017	—	University Hospital, Ghent	Completed	No outcome recorded
Phase 4	NCT02979405	Jan → Feb 2017	hypotensive disorder	Universidad Industrial de Santander	Completed	No outcome recorded
Phase 4	NCT02748265	Mar 2016 → Jul 2017	—	University Health Network, Toronto	Completed	No outcome recorded
Phase 4	NCT02739399	Feb → Jul 2016	hypotensive disorder	Algemeen Ziekenhuis Maria Middelares	Completed	No outcome recorded
Phase 4	NCT02802683	Sep 2015 → May 2016	hypotensive disorder	Seoul National University Hospital	Completed	No outcome recorded
Phase 4	NCT02665221	Jul 2015 → Sep 2016	multiple sclerosis	NYU Langone Health	Terminated	No outcome recorded
Phase 4	NCT02323399	Feb 2015 → Dec 2024 overdue	hypotensive disorder	West-Ward Pharmaceutical	Recruiting	No outcome recorded
Phase 4	NCT02354833	Aug 2014 → Aug 2015	—	West Virginia University	Completed	No outcome recorded
Phase 4	NCT02177539	May → Aug 2014	refractive error	Pontificia Universidad Catolica de Chile	Unknown	No outcome recorded
Phase 4	NCT02376192	Jan → Dec 2014	pregnancy disorder	IWK Health Centre	Completed	No outcome recorded
Phase 4	NCT01794273	Jul 2012 → Jul 2013	—	University Hospital, Clermont-Ferrand	Completed	No outcome recorded
Phase 4	NCT01378325	Jul 2012 → Jan 2013	—	American University of Beirut Medical Center	Completed	No outcome recorded
Phase 4	NCT05439460	Jan 2012 → Jun 2014	pulmonary arterial hypertension	Stanford University	Completed	No outcome recorded
Phase 4	NCT04838665	Sep 2011	retinopathy of prematurity	University of the Philippines	Completed	No outcome recorded
Phase 4	NCT01481740	Nov 2010 → Dec 2014	hypotensive disorder	IWK Health Centre	Completed	No outcome recorded
Phase 4	NCT00877175	Mar → May 2009	—	Khon Kaen University	Completed	No outcome recorded
Phase 4	NCT00846690	Jan → Mar 2009	—	The University of Texas Health Science Center, Houston	Unknown	No outcome recorded
Phase 4	NCT00796328	Nov 2008 → Feb 2009	—	IWK Health Centre	Terminated	No outcome recorded
Phase 4	NCT02885168	Feb 2008 → Apr 2009	infectious disease with sepsis	Central Hospital, Nancy, France	Completed	No outcome recorded
Phase 4	NCT00781157	Jan → Aug 2008	hypotensive disorder	IWK Health Centre	Completed	No outcome recorded
Phase 4	NCT00501878	May → Jul 2007	diabetes mellitus	Khon Kaen University	Completed	No outcome recorded
Phase 4	NCT00199784	Jun 2005 → Apr 2007	—	Oslo University Hospital	Completed	No outcome recorded

Phase not applicable48 trials
—	NCT07663149	Apr → Jun 2026	—	Indonesia University	Completed	No outcome recorded
—	NCT06508359	Aug 2025 → Apr 2026	—	General Hospital of Ningxia Medical University	Completed	No outcome recorded
—	NCT06151470	Jul → Dec 2025	—	General Hospital of Ningxia Medical University	Unknown	No outcome recorded
—	NCT06158035	Jul → Dec 2025	—	General Hospital of Ningxia Medical University	Unknown	No outcome recorded
—	NCT06151522	Apr → Jun 2025	—	General Hospital of Ningxia Medical University	Unknown	No outcome recorded
—	NCT06158009	Apr → Jun 2025	—	General Hospital of Ningxia Medical University	Unknown	No outcome recorded
—	NCT06914063	Mar → Jun 2025 overdue	cycloplegia	Superior University	Active not recruiting	No outcome recorded
—	NCT07153601	Feb → May 2025	hypotensive disorder, pregnancy disorder	Universitas Sumatera Utara	Completed	No outcome recorded
—	NCT06158048	Jan → Apr 2025	—	General Hospital of Ningxia Medical University	Completed	No outcome recorded
—	NCT07495670	Nov 2024 → Jan 2025	diabetes mellitus, diabetic retinopathy	Burapha University	Completed	No outcome recorded
—	NCT06158022	Oct 2024 → May 2025	—	General Hospital of Ningxia Medical University	Completed	No outcome recorded
—	NCT06711432	Sep 2024 → May 2026 overdue	neoplasm, stroke disorder	Zhejiang Cancer Hospital	Recruiting	No outcome recorded
—	NCT04576663	Oct 2023 → Sep 2025	—	General Hospital of Ningxia Medical University	Unknown	No outcome recorded
—	NCT05414877	Sep 2023 → Dec 2024	arterial disorder	Beijing Tiantan Hospital	Unknown	No outcome recorded
—	NCT05665881	Jan 2023 → Sep 2024	arterial disorder	Beijing Tiantan Hospital	Completed	No outcome recorded
—	NCT05525416	Jul 2022 → Feb 2023	—	University of Alberta	Completed	No outcome recorded
—	NCT04928183	Jun → Aug 2021	isoproterenol-mediated vasodilatation	University of Alberta	Completed	No outcome recorded
—	NCT04214145	Jan 2020 → Sep 2021	—	Seoul National University Hospital	Completed	No outcome recorded
—	NCT05001048	Aug 2019 → Dec 2021	isoproterenol-mediated vasodilatation	University of Alberta	Completed	No outcome recorded
—	NCT04053478	Jul 2019 → Dec 2026 expected	hypotensive disorder	Samuel Lunenfeld Research Institute, Mount Sinai Hospital	Recruiting	No outcome recorded
—	NCT04133961	Jun → Dec 2019	—	Universiti Kebangsaan Malaysia Medical Centre	Completed	No outcome recorded
—	NCT04777383	Apr 2019 → Oct 2021	vascular disorder	University Hospital, Linkoeping	Terminated	No outcome recorded
—	NCT03620942	Nov 2018 → Dec 2025 overdue	hypotensive disorder	KK Women's and Children's Hospital	Active not recruiting	No outcome recorded
—	NCT03682198	Sep 2018 → Oct 2020	—	University Hospital Bispebjerg and Frederiksberg	Completed	No outcome recorded
—	NCT03629418	Aug 2018 → Dec 2025 overdue	acute kidney injury	Peking University First Hospital	Recruiting	No outcome recorded
—	NCT03507387	Apr → Aug 2018	—	Xuzhou Medical University	Completed	No outcome recorded
—	NCT02965924	Oct 2016 → Oct 2018	—	Mayo Clinic	Completed	No outcome recorded
—	NCT02909140	Sep 2016 → Aug 2018	cataract	Johns Hopkins University	Terminated	No outcome recorded
—	NCT02725060	Feb 2016 → Oct 2026 expected	cardiac rhythm disease, postural orthostatic tachycardia syndrome, primary dysautonomia	Vanderbilt University Medical Center	Enrolling by invitation	No outcome recorded
—	NCT02585570	Oct 2015 → Sep 2016	—	Inje University	Completed	No outcome recorded
—	NCT02101047	Aug 2015 → Dec 2016	—	Wake Forest University Health Sciences	Withdrawn	No outcome recorded
—	NCT02382185	Jan 2015 → Sep 2017	—	York Teaching Hospitals NHS Foundation Trust	Completed	No outcome recorded
—	NCT02285634	Nov 2014 → Dec 2016	hypertensive disorder	Mayo Clinic	Completed	No outcome recorded
—	NCT02245191	Jul 2014	preeclampsia	University of Sao Paulo General Hospital	Unknown	No outcome recorded
—	NCT01866657	Jun 2013 → Nov 2016	brain hypoxia - ischemia	University Hospitals Cleveland Medical Center	Terminated	No outcome recorded
—	NCT01800877	Apr 2013 → Dec 2014	hypotensive disorder	Francois Lamontagne	Completed	No outcome recorded
—	NCT01813149	Aug 2012 → Jun 2016	complex regional pain syndrome	The Cleveland Clinic	Terminated	No outcome recorded
—	NCT01080625	Apr 2010 → Sep 2011	—	Seoul National University Hospital	Completed	No outcome recorded
—	NCT00838695	Jan 2009 → Dec 2010	—	Vanderbilt University	Completed	No outcome recorded
—	NCT01054027	Mar → Nov 2007	retinopathy of prematurity	Georgetown University	Completed	No outcome recorded
—	NCT00379691	Aug → Dec 2006	hypotensive disorder	Samuel Lunenfeld Research Institute, Mount Sinai Hospital	Completed	No outcome recorded
—	NCT00356265	Jul 2006 → Nov 2010	chronic kidney disease, hypertensive disorder	University of Michigan	Terminated	No outcome recorded
—	NCT00458003	Jul 2006 → Dec 2016	hypotensive disorder, preeclampsia	Northwestern University	Completed	No outcome recorded
—	NCT00294606	Feb 2006	—	London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's	Unknown	No outcome recorded
—	NCT00240058	Jul 2005 → Jun 2006	hypertensive disorder	Crystal A. Gadegbeku	Completed	No outcome recorded
—	NCT00225043	Jun 2005 → Aug 2007	—	New York Presbyterian Brooklyn Methodist Hospital	Completed	No outcome recorded
—	NCT00585091	Oct 2003 → Aug 2007	heart failure	University of Utah	Completed	No outcome recorded
—	NCT00100412	Oct 1999 → Sep 2002	myalgic encephalomeyelitis/chronic fatigue syndrome, persian gulf syndrome, post-traumatic stress disorder	US Department of Veterans Affairs	Completed	No outcome recorded

Also used as a comparator or background therapy in 107 trials

Phase	Registry id	Dates	Indication	Sponsor	Status	Outcome
Phase 02 trials
Phase 0	NCT06053398 Comparator	Nov 2023 → Dec 2024	hypotensive disorder	University of Texas Southwestern Medical Center	Completed	No outcome recorded
Phase 0	NCT02759510 Comparator	Jun 2016	heart failure	RenJi Hospital	Unknown	No outcome recorded
Phase 14 trials
Phase 1	NCT03680404 Comparator	Oct 2018 → Feb 2020	vascular disorder	The University of Texas at Arlington	Completed	No outcome recorded
Phase 1	NCT03139708 Background	Sep 2016 → Oct 2017	—	Wake Forest University Health Sciences	Completed	No outcome recorded
Phase 1	NCT02245230 Background	Jan 2015 → Dec 2023	essential hypertension	Vanderbilt University	Terminated	No outcome recorded
Phase 1	NCT00748059 Background	Dec 1996 → Dec 2020	autonomic nervous system disorder, disorder of catecholamine synthesis, orthostatic hypotension	Vanderbilt University Medical Center	Completed	No outcome recorded
Phase 1/23 trials
Phase 1/2	NCT01026961 Comparator	Sep → Nov 2010	—	Novartis	Withdrawn	No outcome recorded
Phase 1/2	NCT01431612 Comparator	Nov 2008 → Oct 2010	ovarian cyst	Sodertalje Hospital	Completed	No outcome recorded
Phase 1/2	NCT00374881 Comparator	Sep 2006 → Jun 2007	—	BioLineRx, Ltd.	Completed	No outcome recorded
Phase 27 trials
Phase 2	NCT03702400 Comparator	Oct 2018 → Jun 2020	hypotensive disorder	Hospital dos Servidores do Estado do Rio de Janeiro	Completed	No outcome recorded
Phase 2	NCT03339726 Comparator	Nov 2017 → Apr 2018	common cold	Johnson & Johnson Consumer Inc. (J&JCI)	Terminated	No outcome recorded
Phase 2	NCT03015857 Comparator	Jan → Mar 2017	—	Kasr El Aini Hospital	Completed	No outcome recorded
Phase 2	NCT02958215 Comparator	Jun 2016 → May 2017	—	Assiut University	Completed	No outcome recorded
Phase 2	NCT02560805 Background	Oct 2015 → Mar 2027 expected	post-traumatic stress disorder	Emory University	Recruiting	No outcome recorded
Phase 2	NCT00624650 Background	Feb 2008 → Jan 2011	acute lung injury	Oregon Health and Science University	Completed	No outcome recorded
Phase 2	NCT01006863 Comparator	Mar 2004 → Jun 2009	cardiac valvular defect, hypotensive disorder	King Faisal University	Completed	No outcome recorded

Phase 2/33 trials
Phase 2/3	NCT06083948 Comparator	Dec 2023 → Dec 2027 expected	hypotensive disorder	University of Aarhus	Recruiting	No outcome recorded
Phase 2/3	NCT03047109 Comparator	Feb 2017 → Mar 2020	hypotensive disorder	Assiut University	Completed	No outcome recorded
Phase 2/3	NCT02428062 Background	Oct 2014 → Dec 2018	—	Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico	Suspended	No outcome recorded
Phase 316 trials
Phase 3	NCT06762548 Comparator	Oct 2025 → Sep 2026 expected	chemotherapy-induced alopecia, chemotherapy-induced toxicity	Applied Biology, Inc.	Not yet recruiting	No outcome recorded
Phase 3	NCT06770426 Comparator	Feb 2025 → Sep 2027 expected	ischemic stroke	Yonsei University	Not yet recruiting	No outcome recorded
Phase 3	NCT06677970 Comparator	Oct 2024 → Dec 2029 expected	ischemic stroke	Yonsei University	Recruiting	No outcome recorded
Phase 3	NCT05157711 Comparator	Nov 2021 → Mar 2022	hemorrhoid	Church & Dwight Company, Inc.	Completed	No outcome recorded
Phase 3	NCT04839224 Comparator	Apr 2021 → Oct 2022	ischemic stroke	Yonsei University	Terminated	No outcome recorded
Phase 3	NCT04789005 Comparator	Nov 2019 → May 2020	—	Tribhuvan University Teaching Hospital, Institute Of Medicine.	Completed	No outcome recorded
Phase 3	NCT04396301 Comparator	Feb → Aug 2019	cataract, corneal disorder	Cairo University	Completed	No outcome recorded
Phase 3	NCT02735070 Comparator	Sep 2016 → Mar 2017	—	Brainfarma	Unknown	No outcome recorded
Phase 3	NCT02132312 Comparator	Jul 2014 → Sep 2016	cataract	Omeros Corporation	Completed	No outcome recorded
Phase 3	NCT01576809 Background	Mar → May 2012	respiratory tract infectious disorder	Novartis	Completed	No outcome recorded
Phase 3	NCT02101359 Comparator	Jun 2011 → Jan 2013	cataract	Laboratoires Thea	Completed	No outcome recorded
Phase 3	NCT01158326 Comparator	Aug 2010 → Sep 2011	common cold, influenza	Hospital de Clinicas de Porto Alegre	Completed	No outcome recorded
Phase 3	NCT00940836 Comparator	Jun → Nov 2009	common cold	Hospital de Clinicas de Porto Alegre	Unknown	No outcome recorded
Phase 3	NCT01389518 Comparator	May → Jul 2009	influenza	Hospital de Clinicas de Porto Alegre	Completed	No outcome recorded
Phase 3	NCT00642135 Comparator	Jan 2006 → Feb 2008	—	Assistance Publique - Hôpitaux de Paris	Terminated	No outcome recorded
Phase 3	NCT00120432 Comparator	Dec 2004 → Jun 2005	eye disorder	Khon Kaen University	Completed	No outcome recorded

Phase 435 trials
Phase 4	NCT07420127 Comparator	Feb → Jul 2026 overdue	—	Rawalpindi Medical College	Recruiting	No outcome recorded
Phase 4	NCT06802224 Comparator	Apr 2025 → Jul 2028 expected	acute kidney injury, acute myocardial infarction	University of California, San Francisco	Recruiting	No outcome recorded
Phase 4	NCT06248593 Comparator	Jan 2025 → Mar 2026 overdue	hypotensive disorder	Hassan II University	Recruiting	No outcome recorded
Phase 4	NCT05492968 Comparator	Sep 2022 → Aug 2024	high output heart failure	Medical University of Vienna	Unknown	No outcome recorded
Phase 4	NCT03864094 Comparator	Mar 2022 → Dec 2023	—	Helse Fonna	Completed	No outcome recorded
Phase 4	NCT04934748 Comparator	Jul 2021 → Dec 2026 expected	hypertensive disorder	The University of Texas Health Science Center, Houston	Enrolling by invitation	No outcome recorded
Phase 4	NCT04789330 Comparator	Jul 2021 → Apr 2022	hypotensive disorder	University of California, San Francisco	Completed	No outcome recorded
Phase 4	NCT04880928 Comparator	Aug 2020 → Sep 2021	cataract	Medical University of Graz	Completed	No outcome recorded
Phase 4	NCT05348980 Comparator	Jan → Jul 2020	hypotensive disorder	Rehman Medical Institute - RMI	Completed	No outcome recorded
Phase 4	NCT04195321 Comparator	Jan → Mar 2020	—	Kasr El Aini Hospital	Completed	No outcome recorded
Phase 4	NCT04316936 Background	Dec 2019 → Dec 2020	cataract	Silverstein Eye Centers	Completed	No outcome recorded
Phase 4	NCT03959176 Background	Jul 2019	ocular hypertension	Wake Forest University Health Sciences	Completed	No outcome recorded
Phase 4	NCT03872570 Comparator	Jun 2019 → Jun 2020	hypotensive disorder	Algemeen Ziekenhuis Maria Middelares	Unknown	No outcome recorded
Phase 4	NCT04631315 Comparator	Mar 2019 → May 2020	cataract	Laboratorios Poen	Completed	No outcome recorded
Phase 4	NCT03849508 Comparator	Feb 2019 → Dec 2020	—	Centre Hospitalier Régional d'Orléans	Completed	No outcome recorded
Phase 4	NCT03328533 Comparator	Nov 2017 → May 2018	—	Cairo University	Completed	No outcome recorded
Phase 4	NCT03248791 Comparator	Aug 2017 → Mar 2022	—	Cairo University	Unknown	No outcome recorded
Phase 4	NCT03163914 Comparator	Jul 2017 → Apr 2018	—	Cukurova University	Completed	No outcome recorded
Phase 4	NCT03421860 Comparator	Feb 2017 → Feb 2018	heart failure	University Tunis El Manar	Completed	No outcome recorded
Phase 4	NCT02895035 Comparator	Sep 2016 → Dec 2018	cataract	Milton S. Hershey Medical Center	Terminated	No outcome recorded
Phase 4	NCT02854787 Comparator	May → Sep 2016	hypotensive disorder	University Tunis El Manar	Completed	No outcome recorded
Phase 4	NCT02675868 Comparator	Jan → Jul 2016	—	Radboud University Medical Center	Completed	No outcome recorded
Phase 4	NCT02969239 Comparator	Jan 2016 → Jul 2017	hypotensive disorder	Jeju National University Hospital	Unknown	No outcome recorded
Phase 4	NCT02713087 Comparator	Sep 2015 → Nov 2017	brain neoplasm	University of Aarhus	Completed	No outcome recorded
Phase 4	NCT02414555 Comparator	Mar 2015 → Mar 2016	critical illness polyneuropathy	Medical University of Vienna	Terminated	No outcome recorded
Phase 4	NCT02373137 Background	Jan 2015 → Apr 2018	corneal disorder	Oregon Health and Science University	Unknown	No outcome recorded
Phase 4	NCT02203630 Comparator	Aug 2014 → Jan 2016	cardiac rhythm disease, infectious disease with sepsis	Vanderbilt University Medical Center	Terminated	No outcome recorded
Phase 4	NCT02118467 Comparator	May 2014 → Oct 2026 expected	—	University of Chicago	Recruiting	No outcome recorded
Phase 4	NCT02062710 Background	Jan → Jun 2014	—	Montefiore Medical Center	Completed	No outcome recorded
Phase 4	NCT02025426 Comparator	Sep 2012 → Jul 2016	preeclampsia	Duke University	Terminated	No outcome recorded
Phase 4	NCT01243970 Comparator	Apr 2012 → Jan 2016	—	University College London Hospitals	Terminated	No outcome recorded
Phase 4	NCT01509521 Comparator	Feb → Jul 2012	—	Naestved Hospital	Completed	No outcome recorded
Phase 4	NCT01332578 Background	May → Jun 2011	common cold, influenza	GlaxoSmithKline	Completed	No outcome recorded
Phase 4	NCT00996190 Comparator	Nov 2009 → Aug 2010	hypotensive disorder	Samuel Lunenfeld Research Institute, Mount Sinai Hospital	Completed	No outcome recorded
Phase 4	NCT00846651 Background	Feb → Dec 2009	hypotensive disorder	Milton S. Hershey Medical Center	Completed	No outcome recorded

Phase not applicable37 trials
—	NCT06836986 Comparator	Dec 2024 → Mar 2025 overdue	—	Dow University of Health Sciences	Recruiting	No outcome recorded
—	NCT06285396 Comparator	Mar 2024 → Dec 2026 expected	—	Samuel Lunenfeld Research Institute, Mount Sinai Hospital	Recruiting	No outcome recorded
—	NCT05035498 Comparator	Feb 2024 → Apr 2025	—	General Hospital of Ningxia Medical University	Unknown	No outcome recorded
—	NCT05881915 Comparator	Jun → Dec 2023	—	Cairo University	Completed	No outcome recorded
—	NCT05841251 Comparator	May → Sep 2023	—	Assiut University	Unknown	No outcome recorded
—	NCT05035472 Comparator	Jan → Dec 2023	—	General Hospital of Ningxia Medical University	Unknown	No outcome recorded
—	NCT05035485 Comparator	Sep 2022 → Jan 2024	—	General Hospital of Ningxia Medical University	Completed	No outcome recorded
—	NCT05035888 Comparator	Sep 2022 → Jan 2023	—	General Hospital of Ningxia Medical University	Completed	No outcome recorded
—	NCT05341167 Background	May 2022 → Nov 2023	—	Attikon Hospital	Completed	No outcome recorded
—	NCT05049278 Comparator	Sep 2021 → Feb 2022	ischemic disease	Seoul National University Hospital	Completed	No outcome recorded
—	NCT04367103 Comparator	Apr 2021 → May 2022	hypotensive disorder	Assiut University	Completed	No outcome recorded
—	NCT04556357 Comparator	Sep 2020 → Nov 2021	—	General Hospital of Ningxia Medical University	Completed	No outcome recorded
—	NCT04026685 Comparator	Jan 2020 → Feb 2021	—	University Hospital, Basel, Switzerland	Completed	No outcome recorded
—	NCT04144465 Comparator	Nov 2019 → Oct 2023	—	Suez Canal University	Completed	No outcome recorded
—	NCT04040790 Background	Sep 2019 → Jun 2021	vision disorder	University Ghent	Terminated	No outcome recorded
—	NCT03858465 Comparator	Feb 2019	—	Medical University of Warsaw	Completed	No outcome recorded
—	NCT03816072 Comparator	Jan → Sep 2019	cerebrovascular disorder	Academic Medical Center - University of Amsterdam	Completed	No outcome recorded
—	NCT04005664 Comparator	May → Dec 2018	—	University of KwaZulu	Completed	No outcome recorded
—	NCT02726620 Background	Jan → Dec 2017	hypotensive disorder	Vanderbilt University Medical Center	Completed	No outcome recorded
—	NCT02962986 Comparator	Jan → Apr 2017	hypotensive disorder	Samuel Lunenfeld Research Institute, Mount Sinai Hospital	Completed	No outcome recorded
—	NCT02857153 Background	Jul 2016 → Jul 2017	delirium	Hu Anmin	Unknown	No outcome recorded
—	NCT02635555 Background	Apr 2016 → Jun 2019	hypotensive disorder	London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's	Completed	No outcome recorded
—	NCT02532270 Background	Sep 2015 → May 2016	hypotensive disorder	Fudan University	Unknown	No outcome recorded
—	NCT02331108 Comparator	Aug 2014 → Oct 2015	—	Albert Einstein Healthcare Network	Completed	No outcome recorded
—	NCT02701582 Background	Mar 2014 → Jan 2016	brain aneurysm, brain edema, scoliosis	NYU Langone Health	Completed	No outcome recorded
—	NCT01333891 Comparator	Dec 2012	—	Medical University of Vienna	Terminated	No outcome recorded
—	NCT01511627 Comparator	Jan → Jul 2012	—	University of Saskatchewan	Withdrawn	No outcome recorded
—	NCT01609491 Comparator	Jan → Jun 2012	hypertensive disorder	University Medical Center Groningen	Completed	No outcome recorded
—	NCT01451294 Comparator	Nov 2011 → Mar 2012	carotid stenosis	G.J. de Borst	Unknown	No outcome recorded
—	NCT00914394 Comparator	Oct 2010 → Jul 2011	—	Medical University of Vienna	Terminated	No outcome recorded
—	NCT01278238 Comparator	Jan 2010 → Oct 2012	—	Anestesiavdelingen Baerum Sykehus	Completed	No outcome recorded
—	NCT00806741 Comparator	Sep 2009 → Mar 2010	—	Medical University of Vienna	Completed	No outcome recorded
—	NCT01048125 Background	Aug 2009 → Jul 2012	cardiomyopathy	University of Missouri-Columbia	Terminated	No outcome recorded
—	NCT01216410 Comparator	Dec 2008 → Apr 2011	—	Duke University	Completed	No outcome recorded
—	NCT00795366 Comparator	Sep 2008 → Sep 2014	traumatic brain injury	University of Miami	Completed	No outcome recorded
—	NCT01024543 Comparator	Oct 2006 → Nov 2009	—	Maastricht University Medical Center	Completed	No outcome recorded
—	NCT00603720 Comparator	Sep 2005 → Jun 2008	cardiovascular disorder	Washington University School of Medicine	Completed	No outcome recorded

Press releases naming this drug 5 releases

Date	Issuer	Release
2026-03-23	Novartis Pharmaceuticals	Novartis presents new data on early symptom relief and long-term control in complex skin diseases at AAD 2026 novartis.com ↗
2023-07-21	Pfizer	Pfizer Announces Post-Tornado Relief Plans for Rocky Mount Community and Manufacturing Facility pfizer.com ↗
2020-06-04	Novartis Pharmaceuticals	Novartis PREVENT data show Cosentyx® helps patients realize early and lasting relief in axial spondyloarthritis novartis.com ↗
2019-11-12	Novartis Pharmaceuticals	New Novartis PREVENT data show Cosentyx® delivers early relief in axial spondyloarthritis novartis.com ↗
2015-02-02	Novartis Pharmaceuticals	Alcon receives FDA approval of Pazeo(TM) Solution for ocular allergy itch relief novartis.com ↗

Evidence & citations 18 cited values

Every value below carries the sentence it was read from. 255 sources stand behind the page.

Field	Value	Cited text
Known as	Phenylephrine	“The active substances in Fydrane are: tropicamide 0.04 mg (anticholinergic), phenylephrine hydrochloride 0.62 mg (alpha sympathomimetic) and Lidocaine hydrochloride 2 mg (amide...” NCT04396301 ↗ 242 “Each vial contains a nominal 4.5 mL solution containing 60.75 millimolar (mM) phenylephrine hydrochloride (HCl) and 11.25 mM ketorolac tromethamine formulated in a 20 mM sodium...” NCT01579565 ↗ “Each vial contains a nominal 4.5-mL solution containing 60.75 mM phenylephrine HCl (12.37 mg/mL) and 11.25 mM ketorolac trometamol (4.24 mg/mL) formulated in a 20 mM sodium...” NCT02093689 ↗ “A fixed-dose combination of paracetamol, chlorphenamine and phenylephrine was safe and more effective than placebo in the symptomatic treatment of the common cold or flu-like...” PMID 24261438 ↗ Nov 2013 “standard Mydrin-P (0.5% tropicamide / 0.5% phenylephrine HCl) which is the standard eyedrops used for dilation of pupil before retinopathy of prematurity examination.” NCT06288321 ↗ “Rapid-Onset Cycloplegic Drops (e.g., tropicamide with phenylephrine) to assess patient comfort, anxiety, and satisfaction with quicker onset and shorter duration.” NCT06914063 ↗ “a combination topical anesthetic, consisting of 20% lidocaine, 4% tetracaine and 2% phenylephrine (TAC Alternate Gel, Compounding Arts Pharmacy, Lafayette, LA).” NCT00846690 ↗ “The tablets of Coristina® d contain 400 mg acetylsalicylic acid, dexchlorpheniramine 1 mg, 10 mg phenylephrine, and 30 mg of caffeine.” NCT02735070 ↗ “Phenylephrine infusion will be used to target a mean arterial blood pressure to within 30% of baseline (preoperative) value” NCT02382185 ↗ “Each capsule of the active drug contains 400mg of acetaminophen, 4mg of chlorpheniramine and 4mg of phenylephrine.” NCT00940836 ↗ “An initial infusion dose of prophylactic phenylephrine (0.625 ug/kg/min) simultaneous with spinal anesthesia.” NCT06151522 ↗ “An initial infusion dose of prophylactic phenylephrine (0.625 ug/kg/min) simultaneous with spinal anesthesia.” NCT06151470 ↗ “Phenylephrine and Ephedrine can be used to support blood pressure and heart rate within 20% of baseline” NCT01511627 ↗ “Fixed combination of 0.34 % tropicamide and 2.5 % phenylephrine Hydrochloride (HCl) Eye drop Solution.” NCT07075224 ↗ “Preparation H (phenylephrine) treatment first full dose incidence injection site reaction.” NCT02665221 ↗ “Group "Phnl/PROP" with 2.2 mg/kg propofol immediately preceded by 160 mcg phenylephrine.” PMID 31694576 ↗ Nov 2019 “Phenylephrine (100 ug/ml) infusion will be used to increase blood pressure by 20 mmHg” NCT03719001 ↗ “Phenylephrine (25-50 ug) is injected or vasopressors is infused only when necessary.” NCT03629418 ↗ “During the study, blood samples will be obtained for plasma Phenylephrine analysis.” NCT00972998 ↗ “Paracetamol (acetaminophen), chlorpheniramine maleate, phenylephrine hydrochloride.” NCT01158326 ↗ “3 drops of tropicamide and phenylephrine were instilled 30 minutes before surgery.” NCT02101359 ↗ “twice-daily fexofenadine 60 mg/phenylephrine 10 mg (FEX60/PE10) combination tablet” NCT02401191 ↗ “Phenylephrine and Ketorolac infusion of 1%/0.3% during cataract surgery.” NCT03864133 ↗ “Topical α1 agonist combination of Phenylephrine + Tyramine + Synephrine” NCT06762548 ↗ “tropicamide and phenylephrine hydrochloride ophthalmic spray 1%/2.5%” NCT06217796 ↗ “phenylephrine 1% and ketorolac 0.3% intraocular solution” NCT04316936 ↗ “Ibuprofen (IBU) 200 mg/ Phenylephrine (PE) 10 mg” NCT01938144 ↗ “Tropicamide 1% and phenylephrine HCl 2.5%” NCT06366217 ↗ “levophed, dopamine, phenylephrine)” NCT00795366 ↗ “phenylephrine, ephedrine, dopamine” NCT01866657 ↗ “Brompheniramine + phenylephrine” NCT01393561 ↗ “phenylephrine, norepinephrine” NCT02414555 ↗ “Phenylephrine 10%” NCT04880928 ↗ “phenylephrine” NCT01800877 ↗ “phenylephrine” NCT05341167 ↗ NCT00603720 ↗ NCT04040790 ↗ NCT00120432 ↗ NCT03833895 ↗ NCT02725060 ↗ NCT05439460 ↗ NCT03328533 ↗ NCT01731444 ↗ NCT03849508 ↗ NCT02203630 ↗ NCT01451294 ↗ NCT04067817 ↗ NCT01092975 ↗ NCT01509521 ↗ NCT05001048 ↗ NCT04053478 ↗ NCT01413958 ↗ NCT02979405 ↗ NCT04218773 ↗ NCT04972123 ↗ NCT01448057 ↗ NCT02434146 ↗ NCT01533662 ↗ NCT01431612 ↗ NCT06508359 ↗ NCT04556357 ↗ NCT04436731 ↗ NCT00379691 ↗ NCT07420127 ↗ NCT00100412 ↗ NCT02739399 ↗ NCT02857153 ↗ NCT00458003 ↗ NCT05881915 ↗ NCT07495670 ↗ NCT00227448 ↗ NCT06711432 ↗ NCT03858465 ↗ NCT02678234 ↗ NCT01026961 ↗ NCT01378325 ↗ NCT00748059 ↗ NCT01609491 ↗ NCT03015857 ↗ NCT00806741 ↗ NCT02132312 ↗ NCT02962986 ↗ NCT01576809 ↗ NCT03872570 ↗ NCT03415243 ↗ NCT02118467 ↗ NCT03620942 ↗ NCT07327320 ↗ NCT04991662 ↗ NCT04195321 ↗ NCT02245191 ↗ NCT01243970 ↗ NCT03767296 ↗ NCT02969239 ↗ NCT01024543 ↗ NCT03098680 ↗ NCT00781157 ↗ NCT03215797 ↗ NCT07153601 ↗ NCT01791816 ↗ NCT05043077 ↗ NCT02802683 ↗ NCT05997732 ↗ NCT02285634 ↗ NCT03615508 ↗ NCT02560805 ↗ NCT05525416 ↗ NCT02726620 ↗ NCT00373802 ↗ NCT02277730 ↗ NCT01393548 ↗ NCT01813149 ↗ NCT03339726 ↗ NCT04934748 ↗ NCT03959176 ↗ NCT02428062 ↗ NCT04144465 ↗ NCT01481740 ↗ NCT06539637 ↗ NCT02965924 ↗ NCT02759510 ↗ NCT01330017 ↗ NCT03248791 ↗ NCT02675868 ↗ NCT03680404 ↗ NCT00294606 ↗ NCT02748265 ↗ NCT01333891 ↗ NCT03248817 ↗ NCT06083948 ↗ NCT06053398 ↗ NCT05011357 ↗ NCT02062710 ↗ NCT00877175 ↗ NCT05492968 ↗ NCT00639015 ↗ NCT00838695 ↗ NCT06770426 ↗ NCT02323399 ↗ NCT04576663 ↗ NCT01278238 ↗ NCT02909140 ↗ NCT05706727 ↗ NCT04089072 ↗ NCT03846765 ↗ NCT00846651 ↗ NCT01054027 ↗ NCT00796328 ↗ NCT02532270 ↗ NCT05841251 ↗ NCT05414877 ↗ NCT01216410 ↗ NCT04133961 ↗ NCT06802224 ↗ NCT02376192 ↗ NCT04214145 ↗ NCT03139708 ↗ NCT06648850 ↗ NCT04829799 ↗ NCT00642135 ↗ NCT04025918 ↗ NCT02101047 ↗ NCT05035472 ↗ NCT05035485 ↗ NCT00624650 ↗ NCT06677970 ↗ NCT02713087 ↗ NCT00996190 ↗ NCT03047109 ↗ NCT05665881 ↗ NCT02245230 ↗ NCT04623684 ↗ NCT00276016 ↗ NCT05049278 ↗ NCT02854787 ↗ NCT01080625 ↗ NCT02904304 ↗ NCT01600235 ↗ NCT00481442 ↗ NCT06334549 ↗ NCT04026685 ↗ NCT03864094 ↗ NCT06158009 ↗ NCT00501878 ↗ NCT06158022 ↗ NCT00914394 ↗ NCT02585570 ↗ NCT04789005 ↗ NCT03507387 ↗ NCT05035498 ↗ NCT05348980 ↗ NCT00199784 ↗ NCT06158035 ↗ NCT06158048 ↗ NCT02177539 ↗ NCT04789330 ↗ NCT04838665 ↗ NCT06248593 ↗ NCT02895035 ↗ NCT01006863 ↗ NCT03163914 ↗ NCT00762567 ↗ NCT06836986 ↗ NCT02958215 ↗ NCT00374881 ↗ NCT01332578 ↗ NCT01794273 ↗ NCT02354833 ↗ NCT02009007 ↗ NCT05118672 ↗ NCT00240058 ↗ NCT04907474 ↗ NCT02373137 ↗ NCT04367103 ↗ NCT03421860 ↗ NCT04777383 ↗ NCT00225043 ↗ NCT02025426 ↗ NCT04005664 ↗ NCT07662408 ↗ NCT03816072 ↗ NCT05890027 ↗ NCT03638726 ↗ NCT00356265 ↗ NCT05941494 ↗ NCT04419662 ↗ NCT06285396 ↗ NCT03682198 ↗ NCT00431392 ↗ NCT02885168 ↗ NCT00420797 ↗ NCT03702400 ↗ NCT05035888 ↗ NCT02635555 ↗ NCT05070650 ↗ NCT03972683 ↗ NCT00585091 ↗ NCT03751631 ↗ NCT04602767 ↗ NCT07663149 ↗ NCT04839224 ↗ NCT03302039 ↗ NCT02701582 ↗
Known as	BAY112476	“Phenylephrine HCl (Sinus Comfort, BAY112476)” NCT04534452 ↗
Known as	Biorphen	“phenylephrine {Generic Name: Biorphen}” NCT06539637 ↗
Known as	Mydfrin	“Multiple Alternate Instillation of Cyclopentolate Hydrochloride Dilate® Micro Labs Limited Bangalore and Phenylephrine Hydrochloride Mydfrin™ 25mg/mL (2.5%) Alcon Fort Worth Texas” NCT04838665 ↗ 1 NCT04500899 ↗
Known as	PE HCl	“Phenylephrine hydrochloride (PE HCl) is widely used” PMID 26143019 ↗ Jul 2015
Known as	PEH	“Over-the-counter phenylephrine hydrochloride (PEH) is used for relief of nasal congestion caused by allergic rhinitis; however, data to support its efficacy are lacking.” PMID 26560899 ↗ Nov 2015
Known as	PHE	“the same infusion modalities of phenylephrine (PHE) with more stable blood pressure and less bradycardia” NCT06248593 ↗
Known as	Phenylenphrine	“Continuous infusion of Phenylenphrine 250 μg/mL (=Phenylephrine 10mg” NCT04214145 ↗
Known as	Phenylephrin	“eye drops (Phenylephrin)” NCT04880928 ↗
Known as	Phenylephrine HCl	“Phenylephrine HCL is considered to be the vasopressor of choice in parturients due to its propensity to cause less fetal acidosis.” NCT05348980 ↗ 5 “Phenylephrine HCl Extended-Release tablets 30 mg taken twice daily (12 hours apart) for 7 days.” NCT00874120 ↗ “Phenylephrine HCl ER tablets 30 mg taken every 12 hours, twice daily, for 3 days.” NCT00976209 ↗ “Oral Phenylephrine HCl for Nasal Congestion in Seasonal Allergic Rhinitis” PMID 26143019 ↗ Jul 2015 NCT02730364 ↗ NCT04534452 ↗
Known as	phenylephrine hydrochloride	“The active substances in Fydrane are: tropicamide 0.04 mg (anticholinergic), phenylephrine hydrochloride 0.62 mg (alpha sympathomimetic) and Lidocaine hydrochloride 2 mg (amide...” NCT04396301 ↗ 14 “Multiple Alternate Instillation of Cyclopentolate Hydrochloride Dilate® Micro Labs Limited Bangalore and Phenylephrine Hydrochloride Mydfrin™ 25mg/mL (2.5%) Alcon Fort Worth Texas” NCT04838665 ↗ “Over-the-counter phenylephrine hydrochloride (PEH) is used for relief of nasal congestion caused by allergic rhinitis; however, data to support its efficacy are lacking.” PMID 26560899 ↗ Nov 2015 “Sodium nitroprusside (100 µg) will be infused intravenously as a bolus, followed 60 seconds later by a bolus of phenylephrine hydrochloride (150 µg).” NCT01048125 ↗ “Phenylephrine hydrochloride ophthalmic solution 10% formulated for microdose spray delivery” NCT02946125 ↗ “Phenylephrine Hydrochloride (Phenylephrine HCl) extended release tablet” NCT04534452 ↗ “RELIEF® rectal ointment (phenylephrine hydrochloride 2.5mg/g), marketed” NCT05157711 ↗ “Phenylephrine hydrochloride (PE HCl) is widely used” PMID 26143019 ↗ Jul 2015 “10% Phenylephrine hydrochloride gel” NCT00420797 ↗ “Drug: Phenylephrine Hydrochloride” NCT05525416 ↗ “Drug: Phenylephrine Hydrochloride” NCT05997732 ↗ NCT00976209 ↗ NCT00874120 ↗ NCT04631315 ↗ NCT04928183 ↗
Known as	Preparation H	“Preparation H (phenylephrine) treatment first full dose incidence injection site reaction.” NCT02665221 ↗
Known as	RELIEF	“RELIEF® rectal ointment (phenylephrine hydrochloride 2.5mg/g), marketed” NCT05157711 ↗
Known as	RELIEF rectal ointment (phenylephrine hydrochloride)	“RELIEF rectal ointment (phenylephrine hydrochloride)” NCT05157711 ↗
Known as	Sinus Comfort	“Phenylephrine HCl (Sinus Comfort, BAY112476)” NCT04534452 ↗
Action	Activate	“Phenylephrine is an alpha-adrenergic agonist that increases blood pressure by constricting peripheral blood vessels.” NCT00100412 ↗
Modality	Small molecule	“Phenylephrine and dobutamine are synthetic catecholamines, analogues of endogenous chemical messenger substances released by sympathetic nerve fibers and by adrenal medulla...” NCT00100412 ↗
Route	Intravenous	“The hypotheses of target organ dysfunction are evaluated using graded intravenous infusions of two drugs, phenylephrine and dobutamine, and by measuring the resultant...” NCT00100412 ↗