Variability in Adrenergic Response

Completed 106 enrolled Vanderbilt University National Center for Research Resources (NCRR) · collab National Heart, Lung, and Blood Institute (NHLBI) · collab

Non-randomizedParallel-groupOpen-labelOther

Summary

The goal of this project is to determine the genetic factors contributing to interindividual differences in response to physiological and pharmacological vasoconstrictors and vasodilators.

Timeline

Start: 2009-01
Primary completion: 2010-12
Completion: 2011-12

Publications

Results Adefurin A, Ghimire LV, Kohli U, Muszkat M, Sofowora GG, Paranjape SY, Stein CM, Kurnik D. Blacks have a greater sensitivity to alpha1-adrenoceptor-mediated venoconstriction compared with whites. Hypertension. 2013 Apr;61(4):915-20. doi: 10.1161/HYPERTENSIONAHA.111.00854. Epub 2013 Feb 11.
Results Adefurin A, Ghimire LV, Kohli U, Muszkat M, Sofowora GG, Li C, Paranjape SY, Stein CM, Kurnik D. Genetic variation in the alpha1A-adrenergic receptor and phenylephrine-mediated venoconstriction. Pharmacogenomics J. 2015 Aug;15(4):310-5. doi: 10.1038/tpj.2014.69. Epub 2014 Nov 25.
Results Adefurin A, Ghimire LV, Kohli U, Muszkat M, Sofowora GG, Li C, Levinson RT, Paranjape SY, Stein CM, Kurnik D. Genetic variation in the alpha1B-adrenergic receptor and vascular response. Pharmacogenomics J. 2017 Jul;17(4):366-371. doi: 10.1038/tpj.2016.29. Epub 2016 Apr 19.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Nitroglycerin	Unknown	100 ng	Intravenous
Subject	Phenylephrine	Small molecule	5000 ng	Intravenous

Indications

No indication recorded.