Comparison of 4 Methods of Eye Drops for Pupil Dilation in Diabetic Patients

Summary

Pupil dilation is required for many eye conditions. Diabetic patients may need more dilating eye drops to have pupil size large enough for eye exams. This study compares 4 methods of eye drops for pupil dilation in diabetic patients scheduled for retinopathy screening. Possible side effects of the eye drops are monitored during the study.

Timeline

Start

2024-11-04

Primary completion

2025-01-31

Completion

2025-01-31

Publications

• Background Bhatia J, Varghese M, Bhatia A. Effect of 10% phenylephrine eye drops on systemic blood pressure in normotensive & hypertensive patient. Oman Med J. 2009 Jan;24(1):30-2. doi: 10.5001/omj.2009.8.
• Background Kenawy NB, Jabir M. Phenylephrine 2.5% and 10% in phacoemulsification under topical anaesthesia: is there an effect on systemic blood pressure? Br J Ophthalmol. 2003 Apr;87(4):505-6. doi: 10.1136/bjo.87.4.505. No abstract available.
• Background Chin KW, Law NM, Chin MK. Phenylephrine eye drops in ophthalmic surgery--a clinical study on cardiovascular effects. Med J Malaysia. 1994 Jun;49(2):158-63.
• Background Brown MM, Brown GC, Spaeth GL. Lack of side effects from topically administered 10% phenylephrine eyedrops. A controlled study. Arch Ophthalmol. 1980 Mar;98(3):487-9. doi: 10.1001/archopht.1980.01020030483009.
• Background Leopold IH. The phenylephrine saga--a drug dilemma. Am J Ophthalmol. 1978 Apr;85(4):572-4. doi: 10.1016/s0002-9394(14)75261-4. No abstract available.
• Background Motta MM, Coblentz J, Fernandes BF, Burnier MN Jr. Mydriatic and cardiovascular effects of phenylephrine 2.5% versus phenylephrine 10%, both associated with tropicamide 1%. Ophthalmic Res. 2009;42(2):87-9. doi: 10.1159/000220601. Epub 2009 May 27.
• Background Shrivastava AK, Nayak S, Anto M. Efficacy of Nepafenac versus Flurbiprofen in Maintaining Intraoperative Mydriasis During Phacoemulsification: A Comparative Study. Clin Ophthalmol. 2021 Mar 9;15:1085-1093. doi: 10.2147/OPTH.S303480. eCollection 2021.
• Background Kergoat H, Lovasik JV, Doughty MJ. A pupillographic evaluation of a phenylephrine HCl 5%-tropicamide 0.8% combination mydriatic. J Ocul Pharmacol. 1989 Fall;5(3):199-216. doi: 10.1089/jop.1989.5.199.
• Background Trinavarat A, Pituksung A. Effective pupil dilatation with a mixture of 0.75% tropicamide and 2.5% phenylephrine: A randomized controlled trial. Indian J Ophthalmol. 2009 Sep-Oct;57(5):351-4. doi: 10.4103/0301-4738.55070.
• Background Pollack SL, Hunt JS, Polse KA. Dose-response effects of tropicamide HCl. Am J Optom Physiol Opt. 1981 May;58(5):361-6. doi: 10.1097/00006324-198105000-00003.
• Background Sinclair SH, Pelham V, Giovanoni R, Regan CD. Mydriatic solution for outpatient indirect ophthalmoscopy. Arch Ophthalmol. 1980 Sep;98(9):1572-4. doi: 10.1001/archopht.1980.01020040424004.
• Background Bhurayanontachai P, Saengkaew S, Apiromruck P. Efficacy of an eye drop mixture for pupillary dilatation: A randomized comparative study. J Optom. 2017 Apr-Jun;10(2):111-116. doi: 10.1016/j.optom.2016.04.007. Epub 2016 Jun 16.
• Background Park JH, Lee YC, Lee SY. The comparison of mydriatic effect between two drugs of different mechanism. Korean J Ophthalmol. 2009 Mar;23(1):40-2. doi: 10.3341/kjo.2009.23.1.40. Epub 2009 Mar 9.
• Background Ghose S, Garodia VK, Sachdev MS, Kumar H, Biswas NR, Pandey RM. Evaluation of potentiating effect of a drop of lignocaine on tropicamide-induced mydriasis. Invest Ophthalmol Vis Sci. 2001 Jun;42(7):1581-5.
• Background Apt L, Henrick A. Pupillary dilatation with single eyedrop mydriatic combinations. Am J Ophthalmol. 1980 Apr;89(4):553-9. doi: 10.1016/0002-9394(80)90065-3.
• Background Datta S, Biswas NR, Saxena R, Deepak KK, Menon V, Garg SP, Tandon R. Ocular and cardiovascular autonomic function in diabetic patients with varying severity of retinopathy. Indian J Physiol Pharmacol. 2005 Apr;49(2):171-8.
• Background Clark CV. Ocular autonomic nerve function in proliferative diabetic retinopathy. Eye (Lond). 1988;2 ( Pt 1):96-101. doi: 10.1038/eye.1988.20.
• Background Coblentz J, Motta MM, Fernandes BF, Burnier MN Jr, Vianna RN. Comparison between obtained mydriasis in type 2 diabetics and non-diabetic patients. Curr Eye Res. 2009 Nov;34(11):925-7. doi: 10.3109/02713680903205220.
• Background Lei HL, Yang KJ, Sun CC, Chen CH, Huang BY, Ng SC, Yeung L. Obtained mydriasis in long-term type 2 diabetic patients. J Ocul Pharmacol Ther. 2011 Dec;27(6):599-602. doi: 10.1089/jop.2011.0090. Epub 2011 Aug 31.
• Background Alio J, Hernandez I, Millan A, Sanchez J. Pupil responsiveness in diabetes mellitus. Ann Ophthalmol. 1989 Apr;21(4):132-7.
• Background Yang YB, Yu YB, Fu Q. [The autonomic pupillary dysfunction in type II diabetes mellitus]. Zhonghua Yan Ke Za Zhi. 2006 Jul;42(7):616-9. Chinese.
• Background Schwingshandl J, Simpson JM, Donaghue K, Bonney MA, Howard NJ, Silink M. Pupillary abnormalities in type I diabetes occurring during adolescence. Comparisons with cardiovascular reflexes. Diabetes Care. 1993 Apr;16(4):630-3. doi: 10.2337/diacare.16.4.630.
• Background Hreidarsson AB. Pupil size in insulin-dependent diabetes. Relationship to duration, metabolic control, and long-term manifestations. Diabetes. 1982 May;31(5 Pt 1):442-8. doi: 10.2337/diab.31.5.442.

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