ED90 of Norepinephrine and Phenylephrine Infusions Under Intensive Treatment

Completed 60 enrolled General Hospital of Ningxia Medical University

RandomizedParallel-groupDouble-blindTreatment

Summary

The objective of this study is to investigate the ED90 of norepinephrine and phenylephrine infusions for preventing postspinal anesthesia hypotension under intensive treatment during cesarean section

Timeline

Start: 2025-01-01
Primary completion: 2025-04-30
Completion: 2025-04-30

Publications

Shi Y, Ma R, Ma Y, Xi N, Chen Y. Determining the ED90 of prophylactic phenylephrine and norepinephrine infusions for higher blood pressure target maintenance during cesarean delivery: a randomized sequential allocation trial. Front Pharmacol. 2026 Apr 29;17:1781654. doi: 10.3389/fphar.2026.1781654. eCollection 2026.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Norepinephrine	Other / unclassified	0.05 ug/kg	Other
Subject	Phenylephrine	Small molecule	0.5 ug/kg	Other

Indications

No indication recorded.