Drugs / Norepinephrine
last change yesterday re-read 8 days ago

Norepinephrine

Other / unclassified

Developed for
hypotensive disorder · infectious disease with sepsis · hypertensive disorder · arterial disorder · orthostatic hypotension 2 · radiodermatitis · acute kidney injury · cardiogenic shock
+18 more · heart failure · ischemic stroke · pulmonary arterial hypertension · acute respiratory distress syndrome · alopecia · brain ischemia · chronic thromboembolic pulmonary hypertension · essential hypertension · liver failure · acute myocardial infarction · brain injury · heart disorder · hepatorenal syndrome · neonatal respiratory failure · orthostatic hypotension · postoperative ventricular dysfunction · pulmonary hypertension · pulmonary hypertension, neonatal
Investigated by
General Hospital of Ningxia Medical University · Cairo University · Mansoura University · ProCertus BioPharm, Inc · Tanta University · University of Missouri-Columbia
+98 more · Assiut University · Beijing Tiantan Hospital · Centre Hospitalier Universitaire, Amiens · H. Lee Moffitt Cancer Center and Research Institute · Mayo Clinic · National Heart, Lung, and Blood Institute (NHLBI) · National Institutes of Health (NIH) · RenJi Hospital · Second Affiliated Hospital, School of Medicine, Zhejiang University · The Second Affiliated Hospital of Dalian Medical University · Universitas Sumatera Utara · University of Alberta · Yonsei University · Air Force Military Medical University, China · American Heart Association · Assistance Publique - Hôpitaux de Paris · Bach Mai Hospital · Beijing Anzhen Hospital · Brigham and Women's Hospital · Brugmann University Hospital · Canadian Critical Care Trials Group · Canadian Institutes of Health Research (CIHR) · Central Hospital, Nancy, France · Centre Hospitalier Régional d'Orléans · Children's Hospital of Fudan University · China International Neuroscience Institution · China National Center for Cardiovascular Diseases · Chonnam National University Hospital · D. Walter Wray · Dalian Municipal Central Hospital · Dow University of Health Sciences · Federal University of São Paulo · First Affiliated Hospital of Kunming Medical University · Fondazione Policlinico Universitario Agostino Gemelli IRCCS · Fonds de la Recherche en Santé du Québec · Francois Lamontagne · Fudan University · Guangdong Provincial People's Hospital · Hassan II University · HatYai Hospital · Herlev Hospital · Hospital dos Servidores do Estado do Rio de Janeiro · Indonesia University · Institute of Liver and Biliary Sciences, India · Jeju National University Hospital · Jennifer Cutler · Kalasin Hospital · Kasr El Aini Hospital · Khon Kaen Hospital · Koç University · London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's · Maharaj Nakorn Si Thammarat · Massachusetts General Hospital · Medical University of Vienna · Mongi Slim Hospital · National Cancer Institute, Egypt · Netherlands Organisation for Scientific Research · Ningbo No. 1 Hospital · Oxford University Hospitals NHS Trust · Peking Union Medical College Hospital · Peking University First Hospital · Polymun Scientific, Vienna, Austria · Pontificia Universidad Catolica de Chile · Radboud University Medical Center · Renmin Hospital of Wuhan University · Rennes University Hospital · Samuel Lunenfeld Research Institute, Mount Sinai Hospital · Seoul National University Hospital · Sepsis Occurrence in Acutely Ill Patients · Shanghai Zhongshan Hospital · Siriraj Hospital · Sohag University · Southeast University, China · Suez Canal University · all 104 on the full record

Trials 118 · started per year

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PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 05 trials
Phase 0 NCT06520982 Sep 2024 → Jun 2027 expected sympathetic nervous system disorder University of Missouri-Columbia Recruiting No outcome recorded
Phase 0 NCT05219799 Mar 2023 → Jun 2026 overdue isoproterenol-mediated vasodilatation, obesity disorder University of Missouri-Columbia Recruiting No outcome recorded
Phase 0 NCT04436731 Dec 2020 → Jun 2026 overdue obesity disorder University of Missouri-Columbia Active not recruiting No outcome recorded
Phase 0 NCT04218773 Sep 2020 → Aug 2026 hypertensive disorder, ischemic stroke Yale University Suspended No outcome recorded Stop: Business
Phase 0 NCT02759510 Jun 2016 heart failure RenJi Hospital Unknown No outcome recorded
Phase 16 trials
Phase 1 NCT03684213 Oct 2018 → May 2024 cardiovascular disorder The University of Texas at Arlington Completed No outcome recorded
Phase 1 NCT01367990 Jul 2011 → Feb 2012 alopecia, radiodermatitis ProCertus BioPharm, Inc Terminated No outcome recorded
Phase 1 NCT01263366 Jan 2011 → Apr 2013 radiodermatitis ProCertus BioPharm, Inc Terminated No outcome recorded Stop: Enrollment
Phase 1 NCT01426529 Oct 2010 → Oct 2026 expected hypertensive disorder Brigham and Women's Hospital Active not recruiting No outcome recorded
Phase 1 NCT02966665 Sep 2008 → Aug 2030 expected chronic obstructive pulmonary disease, heart failure, pulmonary arterial hypertension D. Walter Wray Recruiting No outcome recorded
Phase 1 NCT00264186 Jun 2005 → ? — Medical University of Vienna Completed No outcome recorded
Phase 1/22 trials
Phase 1/2 NCT03773276 Dec 2018 → Apr 2020 — Mansoura University Completed No outcome recorded
Phase 1/2 NCT01544504 Mar → May 2012 radiodermatitis ProCertus BioPharm, Inc Withdrawn No outcome recorded
Phase 22 trials
Phase 2 NCT03702400 Oct 2018 → Jun 2020 hypotensive disorder Hospital dos Servidores do Estado do Rio de Janeiro Completed No outcome recorded
Phase 2 NCT00134212 Mar 2002 → Jun 2004 infectious disease with sepsis Rennes University Hospital Completed No outcome recorded
Phase 2/33 trials · 1 missed
Phase 2/3 NCT06461390 Mar → May 2024 infectious disease with sepsis Indonesia University Completed No outcome recorded
Phase 2/3 NCT03833895 Feb → Sep 2019 — China International Neuroscience Institution Completed No outcome recorded
Phase 2/3 NCT00148278 Oct 1999 → Dec 2004 infectious disease with sepsis University of Versailles Completed Missed primary
Phase 314 trials · 2 met primary · 2 missed
Phase 3 NCT06059144 Nov 2024 → Aug 2027 expected ischemic stroke University Hospital, Bordeaux Recruiting No outcome recorded
Phase 3 NCT05497700 Sep 2022 → Sep 2023 orthostatic hypotension 2 Brugmann University Hospital Unknown No outcome recorded
Phase 3 NCT05521152 Aug 2022 → Jul 2024 biliary atresia Kasr El Aini Hospital Completed Met primary
Phase 3 NCT05355974 Aug 2022 → Jul 2024 hypotensive disorder, orthostatic hypotension 2, respiratory failure Wright State University Completed No outcome recorded
Phase 3 NCT05276596 Nov 2021 → Dec 2024 hypotensive disorder Centre Hospitalier Universitaire, Amiens Completed No outcome recorded
Phase 3 NCT04536194 Oct 2020 → Aug 2021 congenital heart disease, infant botulism Children's Hospital of Fudan University Completed No outcome recorded
Phase 3 NCT04789005 Nov 2019 → May 2020 — Tribhuvan University Teaching Hospital, Institute Of Medicine. Completed No outcome recorded
Phase 3 NCT04067817 Oct → Dec 2019 hypotensive disorder The Second Affiliated Hospital of Dalian Medical University Unknown No outcome recorded
Phase 3 NCT03434028 Mar 2018 → May 2022 infectious disease with sepsis Massachusetts General Hospital Completed Missed primary
Phase 3 NCT03340779 Jan 2018 → Nov 2019 cardiogenic shock Central Hospital, Nancy, France Unknown No outcome recorded
Phase 433 trials · 1 met primary · 2 missed
Phase 4 NCT07796282 Sep 2026 → May 2028 expected — Mayo Clinic Not yet recruiting No outcome recorded
Phase 4 NCT07633600 Jun 2026 → Jun 2027 expected — Jennifer Cutler Not yet recruiting No outcome recorded
Phase 4 NCT07662408 May 2026 → Mar 2027 expected — Sohag University Recruiting No outcome recorded
Phase 4 NCT07529795 Apr → Sep 2026 overdue hypotensive disorder, peritonitis Bach Mai Hospital Not yet recruiting No outcome recorded
Phase 4 NCT07322419 Jan → Dec 2026 expected — Mansoura University Recruiting No outcome recorded
Phase 4 NCT06921473 Sep → Dec 2025 acidosis disorder mehmet özkılıç Completed No outcome recorded
Phase 4 NCT06574555 Apr → Aug 2025 cardiac rhythm disease, hypertensive disorder, hypotensive disorder Pontificia Universidad Catolica de Chile Completed No outcome recorded
Phase 4 NCT06248593 Jan 2025 → Mar 2026 overdue hypotensive disorder Hassan II University Recruiting No outcome recorded
Phase 4 NCT06498115 Jul → Sep 2024 overdue — The Third People's Hospital of Bengbu Recruiting No outcome recorded
Phase 4 NCT07327320 Jun 2024 → Oct 2025 hypotensive disorder Tam Anh Research Institute Completed No outcome recorded
Phase not applicable53 trials · 3 met primary
— NCT07869693 Oct 2026 → Oct 2027 expected hypotensive disorder, infectious disease with sepsis Assiut University Not yet recruiting No outcome recorded
— NCT07627360 Jul → Oct 2026 expected — Suez Canal University Not yet recruiting No outcome recorded
— NCT07667829 Jun 2026 → Dec 2028 expected chronic thromboembolic pulmonary hypertension, pulmonary arterial hypertension China National Center for Cardiovascular Diseases Not yet recruiting No outcome recorded
— NCT07562932 May 2026 → May 2031 expected cardiogenic shock Chonnam National University Hospital Not yet recruiting No outcome recorded
— NCT07418541 Apr → Dec 2026 expected acute kidney injury, infectious disease with sepsis Universitas Sumatera Utara Not yet recruiting No outcome recorded
— NCT07343206 Jan 2026 → Jan 2028 expected infectious disease with sepsis Siriraj Hospital Recruiting No outcome recorded
— NCT06508359 Aug 2025 → Apr 2026 — General Hospital of Ningxia Medical University Completed No outcome recorded
— NCT06158035 Jul → Dec 2025 — General Hospital of Ningxia Medical University Unknown No outcome recorded
— NCT06158009 Apr → Jun 2025 — General Hospital of Ningxia Medical University Unknown No outcome recorded
— NCT07153601 Feb → May 2025 hypotensive disorder, pregnancy disorder Universitas Sumatera Utara Completed No outcome recorded
Comparator or background therapy113 trials
Phase 0 NCT06053398 Comparator Nov 2023 → Dec 2024 hypotensive disorder University of Texas Southwestern Medical Center Completed No outcome recorded
Phase 0 NCT02789150 Comparator Jan 2015 → Jan 2018 hepatorenal syndrome University of Louisville Completed No outcome recorded
Phase 1/2 NCT06977659 Comparator May 2025 → Jul 2027 expected — Visarat Palitnonkiat Enrolling by invitation No outcome recorded
Phase 1/2 NCT07296029 Background Jul 2022 → Feb 2025 critical illness polyneuropathy, delirium, respiratory failure Queen's University Completed No outcome recorded
Phase 1/2 NCT01285908 Comparator Jan 2011 → Sep 2012 orthostatic hypotension National Institute of Neurological Disorders and Stroke (NINDS) Completed No outcome recorded
Show all 113 trials opens the full record — a long page

News releases announcing trial results or a regulatory action · 1

DateIssuerRelease
2022-07-21 Zydus Lifesciences Limited Regulatory Zydus receives final approval from the USFDA for Norepinephrine Bitartrate Injection zyduslife.com ↗
Zydus Lifesciences Limited (formerly known as Cadila Healthcare Limited), has received final approval from the United States Food and Drug Administration (USFDA) to market Norepinephrine Bitartrate Injection USP,4 mg/4 mL (1 mg/mL) Single -Dose Vial.

All press releases naming this drug 2 releases

DateIssuerRelease

Evidence & citations 12 cited values

Every value below carries the sentence it was read from. 232 sources stand behind the page.

FieldValueCited text
Known as norepinephrine “Norepinephrine will be used as preferred vasopressor and titrated to achieve mean arterial pressure (MAP) between 65 mmHg and 75 mmHg. "Rescue fluids" may be administered as...” NCT03434028 ↗
231

“Blood pressure is raised or lowered via norepinephrine (dose range 1-10 mcg/min) and labetalol (dose range 0-2 mg/min), respectively, to match the researched blood pressure targets.” NCT07296029 ↗

“10 ml/kg 6% Hydroxyethyl starch (130/0.4) coload combined with an initial infusion dose of prophylactic norepinephrine (0.025 ug/kg/min) simultaneous with spinal anesthesia.” NCT05475990 ↗

“Protocol-directed vasopressor administration based on hemodynamic monitoring data. Agents included norepinephrine, phenylephrine, epinephrine, dopamine, and vasopressin.” NCT02742974 ↗

“If hypotension was present it was treated with vasopressor as 10 mcg bolus or continuous infusion of norepinephrine (Arterenol® Sanofi, Germany).” NCT02337010 ↗

“The main outcomes of the study are in-hospital mortality, norepinephrine equivalent dose, ICU scores, and inflammatory markers.” NCT06302998 ↗

“Norepinephrine as a vasopressor and dobutamine - if needed - as an inotrope will be administered by the attending physician.” NCT04742764 ↗

“Protocolized treatment with fluid administration, norepinephrine, and dobutamine to prevent intraoperative hypotension.” NCT06631482 ↗

“An initial infusion dose of prophylactic norepinephrine (0.025 ug/kg/min) simultaneous with spinal anesthesia.” NCT05712018 ↗

“An initial infusion dose of prophylactic norepinephrine (0.05 ug/kg/min) simultaneous with spinal anesthesia.” NCT06151509 ↗

“An initial infusion dose of prophylactic norepinephrine (0.05 ug/kg/min) simultaneous with spinal anesthesia.” NCT06151457 ↗

Show 221 more sources

Known as Arterenol “15 mg of Norepinephrine (Arterenol; Sanofi-Aventis, Frankfurt, Germany) in 250 ml D5W infused at the rate of 10 ml/h for 10 mcg/min using infusion pump.” NCT04302584 ↗
1

“If hypotension was present it was treated with vasopressor as 10 mcg bolus or continuous infusion of norepinephrine (Arterenol® Sanofi, Germany).” NCT02337010 ↗

Known as Levophed “Norepinephrine (Levophed)” NCT02789150 ↗
Known as LEVOPHEDR “Norepinephrine bitartrate (LEVOPHEDR, Pfizer inc.) 4 mg/4ml + 5% Dextrose in water 246 ml (total volume 250 ml, final concentration 16 mcg/ml) infuses intravenously via a...” NCT06977659 ↗
Known as NOR “Esmolol, Sodium Nitroprussiate (NPS) or Norepinephrine (NOR)” NCT00848770 ↗
Known as noradrenaline “We compared the effects of dopexamine and norepinephrine (noradrenaline) with those of epinephrine (adrenaline) on gastric mucosal blood flow (GMBF) in patients with septic shock.” PMID 16507156 ↗ Feb 2006
1

“will receive noradrenaline (norepinephrine) a bolus of 0,25 mcg/kg once” NCT03421860 ↗

Known as Norepienphrine “Continuous infusion of Norepienphrine 20 μg/mL (=NE 4mg” NCT04214145 ↗
Known as norepinephrine bitartrate “Norepinephrine bitartrate (LEVOPHEDR, Pfizer inc.) 4 mg/4ml + 5% Dextrose in water 246 ml (total volume 250 ml, final concentration 16 mcg/ml) infuses intravenously via a...” NCT06977659 ↗
4

“Drug: norepinephrine bitartrate” NCT05637164 ↗

“Drug: Norepinephrine Bitartrate” NCT05836272 ↗

“Drug: Norepinephrine Bitartrate” NCT05997732 ↗

“Drug: Norepinephrine Bitartrate” NCT05521152 ↗

Known as Norepinephrine Hydrochloride “Drug: Norepinephrine Hydrochloride” NCT06028256 ↗
Action Activate “Norepinephrine acts not only as an α adrenoceptor receptor agonist, but also as a weaker β adrenergic receptor agonist.” NCT02759510 ↗
Modality Other / unclassified “In septic shock, when volume resuscitation fails to restore mean arterial pressure, catecholamines such as dopamine, dobutamine, epinephrine, or norepinephrine are used, either...” NCT00134212 ↗
Route Intravenous “Norepinephrine is administered through the central venous catheter.” NCT00841633 ↗