ED90 of Norepinephrine and Phenylephrine Infusions in Preeclamptic Patients

Completed 60 enrolled General Hospital of Ningxia Medical University

RandomizedParallel-groupDouble-blindTreatment

Summary

The objective of this study is to investigate the ED90 of norepinephrine and phenylephrine infusions for preventing postspinal anesthesia hypotension under intensive treatment in preeclamptic patients during cesarean section

Timeline

Start: 2024-10-03
Primary completion: 2025-05-20
Completion: 2025-05-20

Publications

Ma Y, Ma R, Shi Y, Qin R, Chen Y. Determination of ED90s of Phenylephrine and Norepinephrine Infusion for Strict Blood Pressure Management Targets in Preeclamptic Patients Undergoing Cesarean Section: A Randomized Sequential Allocation Study. Drug Des Devel Ther. 2025 Nov 1;19:9751-9757. doi: 10.2147/DDDT.S545813. eCollection 2025.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Norepinephrine	Other / unclassified	0.05 ug/kg	Other
Subject	Phenylephrine	Small molecule	0.5 ug/kg	Other

Indications

No indication recorded.