Sex Differences in Sympathetic Vascular Reactivity at High Altitude

Completed 17 enrolled University of Alberta

Non-randomizedCrossoverOpen-labelBasic science

Summary

This study aims to investigate sex differences in blood pressure control associated with exposure to acute hypoxia (low oxygen), and short term acclimatization to hypoxia at high altitude.

Timeline

Start: 2022-07-28
Primary completion: 2023-02-05
Completion: 2023-02-05

Publications

Background Hart EC, Charkoudian N, Wallin BG, Curry TB, Eisenach JH, Joyner MJ. Sex differences in sympathetic neural-hemodynamic balance: implications for human blood pressure regulation. Hypertension. 2009 Mar;53(3):571-6. doi: 10.1161/HYPERTENSIONAHA.108.126391. Epub 2009 Jan 26.
Background Mazzeo RS, Child A, Butterfield GE, Mawson JT, Zamudio S, Moore LG. Catecholamine response during 12 days of high-altitude exposure (4, 300 m) in women. J Appl Physiol (1985). 1998 Apr;84(4):1151-7. doi: 10.1152/jappl.1998.84.4.1151.
Background Purdy GM, James MA, Rees JL, Ondrus P, Keess JL, Day TA, Steinback CD. Spleen reactivity during incremental ascent to altitude. J Appl Physiol (1985). 2019 Jan 1;126(1):152-159. doi: 10.1152/japplphysiol.00753.2018. Epub 2018 Nov 21.
Background Usselman CW, Gimon TI, Nielson CA, Luchyshyn TA, Coverdale NS, Van Uum SH, Shoemaker JK. Menstrual cycle and sex effects on sympathetic responses to acute chemoreflex stress. Am J Physiol Heart Circ Physiol. 2015 Mar 15;308(6):H664-71. doi: 10.1152/ajpheart.00345.2014. Epub 2014 Dec 19.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Norepinephrine	Other / unclassified	—	Other
Subject	Phentolamine	Small molecule	—	Other
Subject	Phenylephrine	Small molecule	—	Other
Subject	Propranolol	Small molecule	—	Other
Subject	Sodium Nitroprusside	Unknown	—	—

Indications

No indication recorded.